메뉴 건너뛰기




Volumn 9, Issue 6, 2013, Pages

CYLD Enhances Severe Listeriosis by Impairing IL-6/STAT3-Dependent Fibrin Production

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FIBRIN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; JANUS KINASE 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; STAT3 PROTEIN; SYNAPTOTAGMIN I;

EID: 84879534780     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003455     Document Type: Article
Times cited : (27)

References (52)
  • 2
    • 0030587153 scopus 로고    scopus 로고
    • Bacteria in the bloodstream are trapped in the liver and killed by immigrating neutrophils
    • Gregory SH, Sagnimeni AJ, Wing EJ, (1996) Bacteria in the bloodstream are trapped in the liver and killed by immigrating neutrophils. J Immunol 157: 2514-2520.
    • (1996) J Immunol , vol.157 , pp. 2514-2520
    • Gregory, S.H.1    Sagnimeni, A.J.2    Wing, E.J.3
  • 3
    • 0010228473 scopus 로고
    • Requirement of endogenous interferon-gamma production for resolution of Listeria monocytogenes infection
    • Buchmeier NA, Schreiber RD, (1985) Requirement of endogenous interferon-gamma production for resolution of Listeria monocytogenes infection. Proc Natl Acad Sci U S A 82: 7404-7408.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 7404-7408
    • Buchmeier, N.A.1    Schreiber, R.D.2
  • 4
    • 0027297663 scopus 로고
    • Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
    • Pfeffer K, Matsuyama T, Kundig TM, Wakeham A, Kishihara K, et al. (1993) Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73: 457-467.
    • (1993) Cell , vol.73 , pp. 457-467
    • Pfeffer, K.1    Matsuyama, T.2    Kundig, T.M.3    Wakeham, A.4    Kishihara, K.5
  • 5
    • 0024438465 scopus 로고
    • Evidence that tumor necrosis factor has an important role in antibacterial resistance
    • Havell EA, (1989) Evidence that tumor necrosis factor has an important role in antibacterial resistance. J Immunol 143: 2894-2899.
    • (1989) J Immunol , vol.143 , pp. 2894-2899
    • Havell, E.A.1
  • 6
    • 0035348175 scopus 로고    scopus 로고
    • Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells
    • Kaech SM, Ahmed R, (2001) Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat Immunol 2: 415-422.
    • (2001) Nat Immunol , vol.2 , pp. 415-422
    • Kaech, S.M.1    Ahmed, R.2
  • 7
    • 0029007193 scopus 로고
    • Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia
    • Dalrymple SA, Lucian LA, Slattery R, McNeil T, Aud DM, et al. (1995) Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia. Infect Immun 63: 2262-2268.
    • (1995) Infect Immun , vol.63 , pp. 2262-2268
    • Dalrymple, S.A.1    Lucian, L.A.2    Slattery, R.3    McNeil, T.4    Aud, D.M.5
  • 8
    • 78650703319 scopus 로고    scopus 로고
    • IL-17A-producing gammadeltaT cells promote CTL responses against Listeria monocytogenes infection by enhancing dendritic cell cross-presentation
    • Xu S, Han Y, Xu X, Bao Y, Zhang M, et al. (2010) IL-17A-producing gammadeltaT cells promote CTL responses against Listeria monocytogenes infection by enhancing dendritic cell cross-presentation. J Immunol 185: 5879-5887.
    • (2010) J Immunol , vol.185 , pp. 5879-5887
    • Xu, S.1    Han, Y.2    Xu, X.3    Bao, Y.4    Zhang, M.5
  • 9
    • 0032984248 scopus 로고    scopus 로고
    • Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase
    • Shiloh MU, MacMicking JD, Nicholson S, Brause JE, Potter S, et al. (1999) Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity 10: 29-38.
    • (1999) Immunity , vol.10 , pp. 29-38
    • Shiloh, M.U.1    MacMicking, J.D.2    Nicholson, S.3    Brause, J.E.4    Potter, S.5
  • 10
    • 0031570504 scopus 로고    scopus 로고
    • Mice lacking reduced nicotinamide adenine dinucleotide phosphate oxidase activity show increased susceptibility to early infection with Listeria monocytogenes
    • Dinauer MC, Deck MB, Unanue ER, (1997) Mice lacking reduced nicotinamide adenine dinucleotide phosphate oxidase activity show increased susceptibility to early infection with Listeria monocytogenes. J Immunol 158: 5581-5583.
    • (1997) J Immunol , vol.158 , pp. 5581-5583
    • Dinauer, M.C.1    Deck, M.B.2    Unanue, E.R.3
  • 12
    • 0029133459 scopus 로고
    • Specific immunity to Listeria monocytogenes in the absence of IFN gamma
    • Harty JT, Bevan MJ, (1995) Specific immunity to Listeria monocytogenes in the absence of IFN gamma. Immunity 3: 109-117.
    • (1995) Immunity , vol.3 , pp. 109-117
    • Harty, J.T.1    Bevan, M.J.2
  • 13
    • 0032526358 scopus 로고    scopus 로고
    • IL-6 produced by Kupffer Cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections
    • Gregory SH, Wing EJ, Danowski KL, van Rooijen N, Dyer KF, et al. (1998) IL-6 produced by Kupffer Cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections. J Immunol 160: 6056-6061.
    • (1998) J Immunol , vol.160 , pp. 6056-6061
    • Gregory, S.H.1    Wing, E.J.2    Danowski, K.L.3    van Rooijen, N.4    Dyer, K.F.5
  • 14
    • 0034977176 scopus 로고    scopus 로고
    • Endogenous Interleukin-10 is required for prevention of a hyperinflammatory intracerebral immune response in Listeria monocytogenes meningoencephalitis
    • Deckert M, Soltek S, Geginat G, Lütjen S, Montesinos-Rongen M, et al. (2001) Endogenous Interleukin-10 is required for prevention of a hyperinflammatory intracerebral immune response in Listeria monocytogenes meningoencephalitis. Infect Immun 69: 4561-4571.
    • (2001) Infect Immun , vol.69 , pp. 4561-4571
    • Deckert, M.1    Soltek, S.2    Geginat, G.3    Lütjen, S.4    Montesinos-Rongen, M.5
  • 15
    • 21544436571 scopus 로고    scopus 로고
    • Infection-stimulated fibrin deposition controls hemorrhage and limits hepatic bacterial growth during listeriosis
    • Mullarky IK, Szaba FM, Berggren KN, Parent MA, Kummer LW, et al. (2005) Infection-stimulated fibrin deposition controls hemorrhage and limits hepatic bacterial growth during listeriosis. Infec Immun 73: 3888-3895.
    • (2005) Infec Immun , vol.73 , pp. 3888-3895
    • Mullarky, I.K.1    Szaba, F.M.2    Berggren, K.N.3    Parent, M.A.4    Kummer, L.W.5
  • 16
    • 34548038609 scopus 로고    scopus 로고
    • Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections
    • Lim JH, Stirling B, Derry J, Koga T, Jono H, et al. (2007) Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections. Immunity 27: 349-360.
    • (2007) Immunity , vol.27 , pp. 349-360
    • Lim, J.H.1    Stirling, B.2    Derry, J.3    Koga, T.4    Jono, H.5
  • 17
    • 77449150629 scopus 로고    scopus 로고
    • CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes
    • Sun SC, (2010) CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes. Cell Death Differ 17: 25-34.
    • (2010) Cell Death Differ , vol.17 , pp. 25-34
    • Sun, S.C.1
  • 18
    • 60549102324 scopus 로고    scopus 로고
    • Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma
    • Massoumi R, Kuphal S, Hellerbrand C, Haas B, Wild P, et al. (2009) Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma. J Exp Med 206: 221-232.
    • (2009) J Exp Med , vol.206 , pp. 221-232
    • Massoumi, R.1    Kuphal, S.2    Hellerbrand, C.3    Haas, B.4    Wild, P.5
  • 19
    • 78650834820 scopus 로고    scopus 로고
    • Down-regulation of CYLD as a trigger for NF-kappaB activation and a mechanism of apoptotic resistance in hepatocellular carcinoma cells
    • Urbanik T, Kohler BC, Boger RJ, Worns MA, Heeger S, et al. (2011) Down-regulation of CYLD as a trigger for NF-kappaB activation and a mechanism of apoptotic resistance in hepatocellular carcinoma cells. Int J Oncol 38: 121-131.
    • (2011) Int J Oncol , vol.38 , pp. 121-131
    • Urbanik, T.1    Kohler, B.C.2    Boger, R.J.3    Worns, M.A.4    Heeger, S.5
  • 21
    • 36148955443 scopus 로고    scopus 로고
    • Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma
    • Jenner MW, Leone PE, Walker BA, Ross FM, Johnson DC, et al. (2007) Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma. Blood 110: 3291-3300.
    • (2007) Blood , vol.110 , pp. 3291-3300
    • Jenner, M.W.1    Leone, P.E.2    Walker, B.A.3    Ross, F.M.4    Johnson, D.C.5
  • 22
    • 84858725584 scopus 로고    scopus 로고
    • Regulation of NF-kappaB by deubiquitinases
    • Harhaj EW, Dixit VM, (2012) Regulation of NF-kappaB by deubiquitinases. Immunol Rev 246: 107-124.
    • (2012) Immunol Rev , vol.246 , pp. 107-124
    • Harhaj, E.W.1    Dixit, V.M.2
  • 23
    • 33646531810 scopus 로고    scopus 로고
    • Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kB signaling
    • Massoumi R, Chmielarska K, Hennecke K, Pfeifer A, Fässler R, (2006) Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kB signaling. Cell 125: 665-677.
    • (2006) Cell , vol.125 , pp. 665-677
    • Massoumi, R.1    Chmielarska, K.2    Hennecke, K.3    Pfeifer, A.4    Fässler, R.5
  • 24
    • 33750598021 scopus 로고    scopus 로고
    • Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice
    • Zhang J, Stirling B, Temmerman ST, Ma CA, Fuss IJ, et al. (2006) Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice. J Clin Invest 116: 3042-3049.
    • (2006) J Clin Invest , vol.116 , pp. 3042-3049
    • Zhang, J.1    Stirling, B.2    Temmerman, S.T.3    Ma, C.A.4    Fuss, I.J.5
  • 25
    • 33645103440 scopus 로고    scopus 로고
    • Regulation of T cell development by the deubiquitinating enzyme CYLD
    • Reiley WW, Zhang M, Jin W, Losiewicz M, Donohue KB, et al. (2006) Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat Immunol 7: 411-417.
    • (2006) Nat Immunol , vol.7 , pp. 411-417
    • Reiley, W.W.1    Zhang, M.2    Jin, W.3    Losiewicz, M.4    Donohue, K.B.5
  • 26
    • 54049112664 scopus 로고    scopus 로고
    • CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia
    • Lim JH, Ha UH, Woo CH, Xu H, Li JD, (2008) CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia. Cell Microbiol 10: 2247-2256.
    • (2008) Cell Microbiol , vol.10 , pp. 2247-2256
    • Lim, J.H.1    Ha, U.H.2    Woo, C.H.3    Xu, H.4    Li, J.D.5
  • 27
    • 42049086290 scopus 로고    scopus 로고
    • Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice
    • Lim JH, Jono H, Koga T, Woo CH, Ishinaga H, et al. (2007) Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice. PLoS One 2: e1032.
    • (2007) PLoS One , vol.2
    • Lim, J.H.1    Jono, H.2    Koga, T.3    Woo, C.H.4    Ishinaga, H.5
  • 28
    • 20444400857 scopus 로고    scopus 로고
    • STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3
    • Liu L, McBride KM, Reich NC, (2005) STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3. Proc Natl Acad Sci U S A 102: 8150-8155.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 8150-8155
    • Liu, L.1    McBride, K.M.2    Reich, N.C.3
  • 29
    • 0028880704 scopus 로고
    • Characterization of the IL-6 responsive elements in the gamma fibrinogen gene promoter
    • Zhang Z, Fuentes NL, Fuller GM, (1995) Characterization of the IL-6 responsive elements in the gamma fibrinogen gene promoter. J Biol Chem 270: 24287-24291.
    • (1995) J Biol Chem , vol.270 , pp. 24287-24291
    • Zhang, Z.1    Fuentes, N.L.2    Fuller, G.M.3
  • 30
    • 64149112132 scopus 로고    scopus 로고
    • STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria
    • Samavati L, Rastogi R, Du W, Hüttemann M, Fite A, et al. (2009) STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria. Mol Immunol 46: 1867-1877.
    • (2009) Mol Immunol , vol.46 , pp. 1867-1877
    • Samavati, L.1    Rastogi, R.2    Du, W.3    Hüttemann, M.4    Fite, A.5
  • 31
    • 0042467554 scopus 로고    scopus 로고
    • Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB
    • Brummelkamp TR, Nijman SM, Dirac AM, Bernards R, (2003) Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature 424: 797-801.
    • (2003) Nature , vol.424 , pp. 797-801
    • Brummelkamp, T.R.1    Nijman, S.M.2    Dirac, A.M.3    Bernards, R.4
  • 32
    • 0042467558 scopus 로고    scopus 로고
    • CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members
    • Trompouki E, Hatzivassiliou E, Tsichritzis T, Farmer H, Ashworth A, et al. (2003) CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. Nature 424: 793-796.
    • (2003) Nature , vol.424 , pp. 793-796
    • Trompouki, E.1    Hatzivassiliou, E.2    Tsichritzis, T.3    Farmer, H.4    Ashworth, A.5
  • 33
    • 35548974703 scopus 로고    scopus 로고
    • Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD
    • Wright A, Reiley WW, Chang M, Jin W, Lee AJ, et al. (2007) Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD. Dev Cell 13: 705-716.
    • (2007) Dev Cell , vol.13 , pp. 705-716
    • Wright, A.1    Reiley, W.W.2    Chang, M.3    Jin, W.4    Lee, A.J.5
  • 34
    • 0041967054 scopus 로고    scopus 로고
    • The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
    • Kovalenko A, Chable-Bessia C, Cantarella G, Israel A, Wallach D, et al. (2003) The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature 424: 801-805.
    • (2003) Nature , vol.424 , pp. 801-805
    • Kovalenko, A.1    Chable-Bessia, C.2    Cantarella, G.3    Israel, A.4    Wallach, D.5
  • 35
    • 84869767938 scopus 로고    scopus 로고
    • The ubiquitin ligase TRAF6 negatively regulates the JAK-STAT signaling pathway by binding to STAT3 and mediating its ubiquitination
    • Wei J, Yuan Y, Jin C, Chen H, Leng L, et al. (2012) The ubiquitin ligase TRAF6 negatively regulates the JAK-STAT signaling pathway by binding to STAT3 and mediating its ubiquitination. PLOS ONE 7: e49567.
    • (2012) PLOS ONE , vol.7
    • Wei, J.1    Yuan, Y.2    Jin, C.3    Chen, H.4    Leng, L.5
  • 36
    • 33847351136 scopus 로고    scopus 로고
    • The JAK-STAT Signaling Pathway: input and output integration
    • Murray PJ, (2007) The JAK-STAT Signaling Pathway: input and output integration. J Immunol 178: 2623-2629.
    • (2007) J Immunol , vol.178 , pp. 2623-2629
    • Murray, P.J.1
  • 37
    • 78649741783 scopus 로고    scopus 로고
    • gp130 at the nexus of inflammation, autoimmunity, and cancer
    • Silver JS, Hunter CA, (2010) gp130 at the nexus of inflammation, autoimmunity, and cancer. J Leukoc Biol 88: 1145-1156.
    • (2010) J Leukoc Biol , vol.88 , pp. 1145-1156
    • Silver, J.S.1    Hunter, C.A.2
  • 38
    • 79960388683 scopus 로고    scopus 로고
    • IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii
    • Silver JS, Stumhofer JS, Passos S, Ernst M, Hunter CA, (2011) IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii. J Immunol 187: 350.
    • (2011) J Immunol , vol.187 , pp. 350
    • Silver, J.S.1    Stumhofer, J.S.2    Passos, S.3    Ernst, M.4    Hunter, C.A.5
  • 39
    • 0027404171 scopus 로고
    • The human beta fibrinogen promoter contains a hepatocyte nuclear factor 1-dependent interleukin-6-responsive element
    • Dalmon J, Laurent M, Courtois G, (1993) The human beta fibrinogen promoter contains a hepatocyte nuclear factor 1-dependent interleukin-6-responsive element. Mol Cell Biol 13: 1183-1193.
    • (1993) Mol Cell Biol , vol.13 , pp. 1183-1193
    • Dalmon, J.1    Laurent, M.2    Courtois, G.3
  • 40
    • 0028946158 scopus 로고
    • Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway
    • Heim MH, Kerr IM, Stark GR, Darnell JE Jr, (1995) Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. Science 267: 1347-1349.
    • (1995) Science , vol.267 , pp. 1347-1349
    • Heim, M.H.1    Kerr, I.M.2    Stark, G.R.3    Darnell Jr., J.E.4
  • 41
    • 77957861314 scopus 로고    scopus 로고
    • Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir
    • Hirano T, (2010) Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir. Proc Jpn Acad Ser B Phys Biol Sci 86: 717-730.
    • (2010) Proc Jpn Acad Ser B Phys Biol Sci , vol.86 , pp. 717-730
    • Hirano, T.1
  • 42
    • 0036561322 scopus 로고    scopus 로고
    • Tyrosine 759 of the cytokine receptor gp130 is involved in Listeria monocytogenes susceptibility
    • Kamimura D, Fu D, Matsuda Y, Atsumi T, Ohtani T, et al. (2002) Tyrosine 759 of the cytokine receptor gp130 is involved in Listeria monocytogenes susceptibility. Genes Immun 3: 136-143.
    • (2002) Genes Immun , vol.3 , pp. 136-143
    • Kamimura, D.1    Fu, D.2    Matsuda, Y.3    Atsumi, T.4    Ohtani, T.5
  • 43
    • 84860587432 scopus 로고    scopus 로고
    • Hepatocyte-specific mutation of both NF-kappaB RelA and STAT3 abrogates the acute phase response in mice
    • Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, et al. (2012) Hepatocyte-specific mutation of both NF-kappaB RelA and STAT3 abrogates the acute phase response in mice. J Clin Invest 122: 1758-1763.
    • (2012) J Clin Invest , vol.122 , pp. 1758-1763
    • Quinton, L.J.1    Blahna, M.T.2    Jones, M.R.3    Allen, E.4    Ferrari, J.D.5
  • 44
    • 0037451170 scopus 로고    scopus 로고
    • Fibrin-mediated protection against infection-stimulated immunopathology
    • Johnson LL, Berggren KN, Szaba FM, Chen W, Smiley ST, (2003) Fibrin-mediated protection against infection-stimulated immunopathology. J Exp Med 197: 801-806.
    • (2003) J Exp Med , vol.197 , pp. 801-806
    • Johnson, L.L.1    Berggren, K.N.2    Szaba, F.M.3    Chen, W.4    Smiley, S.T.5
  • 45
    • 80051919546 scopus 로고    scopus 로고
    • Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica
    • Luo D, Szaba FM, Kummer LW, Plow EF, Mackman N, et al. (2011) Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica. J Immunol 187: 1866-1876.
    • (2011) J Immunol , vol.187 , pp. 1866-1876
    • Luo, D.1    Szaba, F.M.2    Kummer, L.W.3    Plow, E.F.4    Mackman, N.5
  • 47
    • 0011545343 scopus 로고    scopus 로고
    • Cytokines in the induction and expression of T-cell-mediated granuloma formation and protection in the murine model of listeriosis
    • Mielke ME, Peters C, Hahn H, (1997) Cytokines in the induction and expression of T-cell-mediated granuloma formation and protection in the murine model of listeriosis. Immunol Rev 158: 79-93.
    • (1997) Immunol Rev , vol.158 , pp. 79-93
    • Mielke, M.E.1    Peters, C.2    Hahn, H.3
  • 48
    • 78650859531 scopus 로고    scopus 로고
    • NF-kappaB and STAT3 - key players in liver inflammation and cancer
    • He G, Karin M, (2011) NF-kappaB and STAT3- key players in liver inflammation and cancer. Cell Res 21: 159-168.
    • (2011) Cell Res , vol.21 , pp. 159-168
    • He, G.1    Karin, M.2
  • 49
    • 74549217325 scopus 로고    scopus 로고
    • Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation
    • He G, Yu GY, Temkin V, Ogata H, Kuntzen C, et al. (2010) Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell 17: 286-297.
    • (2010) Cancer Cell , vol.17 , pp. 286-297
    • He, G.1    Yu, G.Y.2    Temkin, V.3    Ogata, H.4    Kuntzen, C.5
  • 50
    • 0035883064 scopus 로고    scopus 로고
    • Variable protection of beta 3-integrin-deficient mice from thrombosis initiated by different mechanisms
    • Smyth SS, Reis ED, Väänänen H, Zhang W, Coller BS, (2001) Variable protection of beta 3-integrin-deficient mice from thrombosis initiated by different mechanisms. Blood 98: 1055-1062.
    • (2001) Blood , vol.98 , pp. 1055-1062
    • Smyth, S.S.1    Reis, E.D.2    Väänänen, H.3    Zhang, W.4    Coller, B.S.5
  • 51
    • 64249112624 scopus 로고    scopus 로고
    • Neither fibrin nor plasminogen activator inhibitor-1 deficiency protects lung function in a mouse model of acute lung injury
    • Allen GB, Cloutier ME, Larrabee YC, Tetenev K, Smiley ST, et al. (2009) Neither fibrin nor plasminogen activator inhibitor-1 deficiency protects lung function in a mouse model of acute lung injury. Am J Physiol Lung Cell Mol Physiol 296: L277-L285.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.296
    • Allen, G.B.1    Cloutier, M.E.2    Larrabee, Y.C.3    Tetenev, K.4    Smiley, S.T.5
  • 52
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402.
    • (2001) Methods , vol.25 , pp. 402
    • Livak, K.J.1    Schmittgen, T.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.