Uncovering a dynamically formed substrate access tunnel in carbon monoxide dehydrogenase/acetyl-CoA synthase

Journal of the American Chemical Society

Volumn 135, Issue 25, 2013, Pages 9493-9502

  Wang, Po Hung ^a   Bruschi, Maurizio ^b   De Gioia, Luca ^b   Blumberger, Jochen ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE DEHYDROGENASE; DIFFUSION-REACTION MODEL; ENZYMATIC CATALYSIS; HYDROGEN BOND NETWORKS; LIGAND TRANSPORT; MULTI-SUBUNIT ENZYMES; PROTEIN FLUCTUATIONS; SECOND TIME SCALE;

CARBON DIOXIDE; CARBON MONOXIDE; COMPLEX NETWORKS; MOLECULAR DYNAMICS; PROTEINS; REACTION KINETICS;

LIGANDS;

CARBON DIOXIDE; CARBON MONOXIDE DEHYDROGENASE; LIGAND; SYNTHETASE;

ARTICLE; BINDING SITE; CALCULATION; CATALYST; CRYSTAL STRUCTURE; DENSITY FUNCTIONAL THEORY; DIFFUSION; HYDROGEN BOND; INTRACELLULAR SIGNALING; MOLECULAR DYNAMICS; PROTEIN ANALYSIS; PROTEIN SUBUNIT; PROTEIN TRANSPORT; X RAY CRYSTALLOGRAPHY;

ACETATE-COA LIGASE; ALDEHYDE OXIDOREDUCTASES; CARBON DIOXIDE; CARBON MONOXIDE; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MULTIENZYME COMPLEXES; QUANTUM THEORY; SUBSTRATE SPECIFICITY;

EID: 84879515133     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja403110s     Document Type: Article

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