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How do enzymes activate oxygen without inactivating themselves?
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A comparative analysis from computer simulation of myoglobins indicates that diffusion pathways are not evolutionarily conserved. This study additionally presents an analysis of the relative propensities of residue types to form oxygen migration pathways that is of general interest.
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This study present results from x-ray crystallography under high pressure of oxygen and demonstrates the presence of a binding site for dioxygen that can be competitively occupied by a water molecule or a chloride ion. The polar environment of this oxygen site questions the use of xenon as probe for oxygen-binding sites.
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A comprehensive analysis of the oxygen trajectories in the family of copper-dependent amine oxidases. Implicit ligand sampling simulations and the presence of multiple pathways were validated by site-directed mutagenesis and kinetics experiments.
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