Synthesis and antitumor activity of new pyrido[2,3-d]pyrimidine derivatives

Medicinal Chemistry Research

Volumn 22, Issue 8, 2013, Pages 3943-3952

  Gineinah, Magdy M ^a   Nasr, Magda N A ^a   Badr, Sahar M I ^a   El Husseiny, Walaa M ^a  

^a University of Mansoura   (Egypt)

Author keywords

Antitumor activity; Piperazines; Pyrido 2,3 d pyrimidines; Synthesis; Triazoles

Indexed keywords

2 CHLORO [3 (2,4,7 TRIOXO 1,2,3,4,7,8 HEXAHYDROPYRIDO[2,3 D]PYRIMIDIN 5 YL) 4 (PHENYL) 4H [1,2,4]TRIAZOL 4 YL]ETHANETHIOATE; 2 CHLORO [3 (2,4,7 TRIOXO 1,2,3,4,7,8 HEXAHYDROPYRIDO[3 D]PYRIMIDIN 5 YL) 4 (4 FLUOROPHENYL) 4H [1,2,4]TRIAZOL 4 YL]ETHANETHIOATE; 2,4,7 TRIOXO N' [(4 BENZYLPIPERAZIN 1 YL)ACETYL] 1,2,3,4,7,8 HEXAHYDROPYRIDO[2,3 D]PYRIMIDINE 5 CARBOHYDRAZIDE; 2,4,7 TRIOXO N' [(4 PHENYLPIPERAZIN 1 YL)ACETYL] 1,2,3,4,7,8 HEXAHYDROPYRIDO[2,3 D]PYRIMIDINE 5 CARBOHYDRAZIDE; 2,4,7 TRIOXO N' [4 (4 ETHOXYPHENYLPIPERAZIN 1 YL)ACETYL] 1,2,3,4,7,8 HEXAHYDROPYRIDO[2,3 D]PYRIMIDINE 5 CARBOHYDRAZIDE; 2,4,7 TRIOXO N' [4 (4 METHOXYPHENYLPIPERAZIN 1 YL)ACETYL] 1,2,3,4,7,8 HEXAHYDROPYRIDO[2,3 D]PYRIMIDINE 5 CARBOHYDRAZIDE; 5 (4 PHENYL 5 SULFANYL 4H [1,2,4]TRIAZOL 3 YL)1H,3H,8H PYRIDO[2,3 D]PYRIMIDINE 2,4,7 TRIONE; 5 [4 (4 FLUOROPHENYL) 5 SULFANYL 4H [1,2,4]TRIAZOL 3 YL]1H,3H,8H PYRIDO[2,3 D]PYRIMIDINE 2,4,7 TRIONE; [3 (2,4,7 TRIOXO 1,2,3,4,7,8 HEXAHYDROPYRIDO[2,3 D]PYRIMIDIN 5 YL) 4 (4 FLUOROPHENYL) 4H [1,2,4]TRIAZOL 5 YL] 2 (4 PHENYLPIPERAZIN 1 YL)ETHANETHIOATE; [3 (2,4,7 TRIOXO 1,2,3,4,7,8 HEXAHYDROPYRIDO[2,3 D]PYRIMIDIN 5 YL) 4 (PHENYL) 4H [1,2,4]TRIAZOL 5 YL] 2 (4 PHENYLPIPERAZIN 1 YL)ETHANETHIOATE; ANTINEOPLASTIC AGENT; BLEOMYCIN; FLUOROURACIL; N' (3 NITROBENZYLIDENE) 2,4,7 TRIOXO 1,2,3,4,7,8 HEXAHYDROPYRIDO[2,3 D]PYRIMIDINE 5 CARBOHYDRAZIDE; N' (4 CHLOROBENZYLIDENE)-2,4,7 TRIOXO 1,2,3,4,7,8 HEXAHYDROPYRIDO[2,3 D]PYRIMIDINE 5 CARBOHYDRAZIDE; N' (4 METHOXYBENZYLIDENE) 2,4,7 TRIOXO 1,2,3,4,7,8 HEXAHYDROPYRIDO[2,3 D]PYRIMIDINE 5 CARBOHYDRAZIDE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DNA DAMAGE; DNA DETERMINATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EHRLICH ASCITES TUMOR; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MALE; MASS SPECTROMETRY; MICROANALYSIS; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 84879500477     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-012-0396-0     Document Type: Article

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