Structure-activity relationships of Bacillus cereus and Bacillus anthracis dihydrofolate reductase: Toward the identification of new potent drug leads

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 10, 2006, Pages 3435-3443

  Joska, Tammy M ^a   Anderson, Amy C ^b  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; METHOTREXATE; PTERIDINE DERIVATIVE; PYRIMETHAMINE; PYRROLOPYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; TRIMETHOPRIM;

ANTHRAX; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS ANTHRACIS; BACILLUS CEREUS; DRUG POTENCY; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; HUMAN; IC 50; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

4-AMINOPYRIDINE; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACILLUS ANTHRACIS; BACILLUS CEREUS; BINDING SITES; DRUG DESIGN; FOLIC ACID ANTAGONISTS; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 33749534304     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00386-06     Document Type: Article

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