Utility of 6-amino-2-thiouracil as a precursor for the synthesis of bioactive pyrimidine derivatives

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 18, 2007, Pages 6227-6235

  Mohamed, Nadia Ragab ^a   El Saidi, Manal Mohamed Talaat ^a   Ali, Yasser Mahmoud ^a   Elnagdi, Mohamed Hilmy ^b  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

2 Azadiene; 6 Amino 2 thiouracil; Amidines; Antimicrobial; Antitumor activity; Diels Alder cycloaddition; Enaminone; Pyrido 2,3 d pyrimidine

Indexed keywords

6 AMINOTHIOURACIL; 7 (4 METHOXYPHENYL) 4 OXO 2 THIOXO 1,2,3,4 TETRAHYDROPYRIDO[2,3 D]PYRIMIDINE 5 CARBONITRILE; 7 PHENYL 5 (THIOPHENE 2 CARBONYL) 2 THIOXO 2,3 DIHYDRO 1H PYRIDO[2,3 D]PYRIMIDIN 4 ONE; ACETYLENE DERIVATIVE; ALDEHYDE; AMINOPHENOL DERIVATIVE; AMINOTHIOPHENOL DERIVATIVE; AMPICILLIN; AZOMETHINE YLIDE; CISPLATIN; DIETHYL 4 OXO 7 PHENYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIDO[2,3 D]PYRIMIDINE 5,6 DICARBOXYLATE; DIMETHYL 4 OXO 7 PHENYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIDO[2,3 D]PYRIMIDINE 5,6 DICARBOXYLATE; DIMETHYL 7 (4 METHOXYPHENYL) 4 OXO 2 THIOXO 1,2,3,4 TETRAHYDROPYRIDO[2,3 D]PYRIMIDINE 5,6 DICARBOXYLATE; ETHYL 7 (4 METHOXYPHENYL) 4 OXO 2 THIOXO 1,2,3,4 TETRAHYDROPYRIDO[2,3 D]PYRIMIDINE 5 CARBOXYLATE; NYSTATIN; PYRIDO[2,3 D]PYRIMIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYCLOADDITION; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; POLYMERIZATION; PRECURSOR;

ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; LIVER NEOPLASMS; LUNG NEOPLASMS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOURACIL; TUMOR CELLS, CULTURED;

ALNUS;

EID: 34447627912     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.06.023     Document Type: Article

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