Antibodies against AT1 Receptors Are Associated with Vascular Endothelial and Smooth Muscle Function Impairment: Protective Effects of Hydroxysafflor Yellow A

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Jin, Zhu ^a   Zhang, Wenhui ^a   Chai, Weiran ^b   Zheng, Yanqian ^a   Zhi, Jianming ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANTIHYPERTENSIVE AGENT; AUTOANTIBODY; ENDOTHELIN; HYROXYSAFFLOR YELLOW A; INDOMETACIN; LOSARTAN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; OXIDIZED LOW DENSITY LIPOPROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; ANTIBODY TITER; AORTA; ARTICLE; BODY WEIGHT; CARDIOVASCULAR DISEASE; CELL INFILTRATION; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DIASTOLE; DIASTOLIC BLOOD PRESSURE; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART RATE; HISTOPATHOLOGY; HYPERTENSION; INFLAMMATORY CELL; MALE; MUSCLE DISEASE; NONHUMAN; RAT; SMOOTH MUSCLE; SMOOTH MUSCLE FIBER; SYSTOLE; SYSTOLIC BLOOD PRESSURE; TRANSMISSION ELECTRON MICROSCOPY; VASCULAR ENDOTHELIUM;

ACETYLCHOLINE; ANIMALS; ANTIBODIES; AORTA; BLOOD PRESSURE; CARDIOTONIC AGENTS; CHALCONE; DIASTOLE; ENDOTHELINS; ENDOTHELIUM, VASCULAR; HEART RATE; HUMANS; IMMUNIZATION; INDOMETHACIN; LIPOPROTEINS, LDL; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCARDIAL CONTRACTION; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITROPRUSSIDE; QUINONES; RATS; RATS, WISTAR; RECEPTOR, ANGIOTENSIN, TYPE 1; SYSTOLE; VASODILATION;

RATTUS;

EID: 84879489498     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067020     Document Type: Article

References (21)

1. Tan X, Poulose EM, Raveendran VV, Zhu BT, Stechschulte DJ, et al. (2011) Regulation of the expression of cyclooxygenases and production of prostaglandin I2 and E2 in human coronary artery endothelial cells by curcumin. J Physiol Pharmacol. 62: 21-28.
2. Lobysheva I, Rath G, Sekkali B, Bouzin C, Feron O, et al. (2011) Moderate caveolin-1 downregulation prevents NADPH oxidase-dependent endothelial nitric oxide synthase uncoupling by angiotensin II in endothelial cells. Arterioscler Thromb Vasc Biol. 31: 2098-3105.
3. Hu C, Dandapat A, Mehta JL, (2007) Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway. Hypertension. 50: 952-957.
4. Wang X, Phillips MI, Mehta JL, (2011) LOX-1 and angiotensin receptors, and their interplay. Cardiovasc Drugs Ther. 25: 401-417.
5. Dragun D, Philippe A, Catar R, Hegner B, (2009) Autoimmune mediated G-protein receptor activation in cardiovascular and renal pathologies. Thromb Haemost. 101: 643-648.
6. Wallukat G, Homuth V, Fischer T, Lindschau C, Horstkamp B,et al (1999 Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor. J Clin Invest. 103: 945-952.
7. Walther T, Stepan H, (2007) Agonist autoantibodies against the angiotensin AT1 receptor in renal and hypertensive disorders. Curr Hypertens Rep. 9: 128-132.
8. Xia Y, Zhou CC, Ramin SM, Kellems RE, (2011) Angiotensin receptors, autoimmunity, and preeclampsia. J Immunol. 179: 3391-3395.
9. Dechend R, Viedt C, Müller DN, Ugele B, Brandes RP, et al. (2003) AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase. Circulation. 107: 1632-1639.
10. Jin Z, Wang J, Zhang W, Zhang G, Jiao X, Zhi J, (2011) Changes in cardiac structure and function in rats immunized by angiotensin type 1 receptor peptides. Acta Biochim Biophys Sin (Shanghai). 43: 970-976.
11. Sun RY, (1987) Pharmacological Statistics [M]. Beijing: People's Medical Publishing House 1987: 410-415.
12. Dechend R, Homuth V, Wallukat G, Kreuzer J, Park JK, et al. (2000) AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factor. Circulation. 101: 2382-2387.
13. Wenzel K, Rajakumar A, Haase H, Geusens N, Hubner N, et al. (2011) Angiotensin II type 1 receptor antibodies and increased angiotensin II sensitivity in pregnant rats. Hypertension. 58: 77-84.
14. Zhou CC, Zhang Y, Irani RA, Zhang H, Mi T, et al. (2008) Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice. Nat Med (14) (): 855-862.
15. LaMarca B, Wallace K, Granger J, (2011) Role of angiotensin II type I receptor agonistic autoantibodies (AT1-AA) in preeclampsia. Curr Opin Pharmacol. 11: 175-179.
16. LaMarca B, Parrish M, Ray LF, Murphy SR, Roberts L, (2009) Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats: role of endothelin-1. Hypertension. 54: 905-909.
17. Lamarca B, Parrish MR, Wallace K, (2012) Agonistic Autoantibodies to the Angiotensin II Type I Receptor Cause Pathophysiologic Characteristics of Preeclampsia. Gend Med. 9: 139-146.
18. Liu X, Zhao J, Xu J, Zhao B, Zhang Y, et al. (2009) Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin beta4, ROS, NF-kappaB and P53 in human umbilical vein endothelial cells. Bioorg Med Chem Lett. 19: 2896-2900.
19. Carlström M, Lai EY, Ma Z, Steege A, Patzak A, et al. (2010) Superoxide dismutase 1 limits renal microvascular remodeling and attenuates arteriole and blood pressure responses to angiotensin II via modulation of nitric oxide bioavailability. Hypertension. 56: 907-913.
20. Tian J, Li G, Liu Z, Fu F, (2008) Hydroxysafflor yellow A inhibits rat brain mitochondrial permeability transition pores by a free radical scavenging action. Pharmacology. 82: 121-126.
21. He H, Liu Q, Shi M, Zeng X, Yang J, et al. (2008) Cardioprotective effects of hydroxysafflor yellow A on diabetic cardiac insufficiency attributed to up-regulation of the expression of intracellular calcium handling proteins of sarcoplasmic reticulum in rats. Phytother Res. 22: 1107-1114.