Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin β4, ROS, NF-κB and P53 in human umbilical vein endothelial cells

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 10, 2009, Pages 2896-2900

  Liu, Xia ^a   Zhao, Jing ^a   Xu, JiPing ^a   Zhao, BaoXiang ^a   Zhang, Yun ^a   Zhang, ShangLi ^a   Miao, JunYing ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

6 Amino 2,3 dihydro 3 hydroxymethyl 1,4 benzoxazine; Apoptosis; Mechanism; Oxidized low density lipoprotein; Vascular endothelial cells

Indexed keywords

6 AMINO 2,3 DIHYDRO 3 HYDROXYMETHYL 1,4 BENZOXAZINE; BENZOXAZINE DERIVATIVE; BETA4 INTEGRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL NUCLEUS; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PROTEIN TRANSPORT; UMBILICAL VEIN;

APOPTOSIS; BENZOXAZINES; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; INTEGRIN BETA4; LIPOPROTEINS, LDL; NF-KAPPA B; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53; UMBILICAL VEINS;

EID: 65449173954     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.070     Document Type: Article

References (14)

1. Libby P. Nature 420 (2002) 868
2. Ross R. Annu. Rev. Physiol. 57 (1995) 791
3. Valoti E., Pallavicini M., Villa L., and Pezzetta D. J. Org. Chem. 66 (2001) 1018
4. Jiao P.F., Zhao B.X., Wang W.W., He Q.X., Wan M.S., Shin D.S., and Miao J.Y. Bioorg. Med. Chem. Lett. 16 (2006) 2862
5. Zhang L., Zhu X., Zhao B., Zhao J., Zhang Y., Zhang S., and Miao J. Vascul. Pharmacol. 48 (2008) 63
6. Zhao J., Miao J., Zhao B., and Zhang S. FEBS Lett. 579 (2005) 5809
7. Dentelli P., Rosso A., Zeoli A., Gambino R., Pegoraro L., Pagano G., Falcioni R., and Brizzi M.F. J. Biol. Chem. 282 (2007) 26101
8. Ou H.C., Chou F.P., Sheu W.H., Hsu S.L., and Lee W.J. Arch. Toxicol. 81 (2007) 421
9. Li D., Saldeen T., and Mehta J.L. Biochem. Biophys. Res. Commun. 259 (1999) 157
10. Friedland J.C., Lakins J.N., Kazanietz M.G., Chernoff J., Boettiger D., and Weaver V.M. J. Cell Sci. 120 (2007) 3700
11. Choi J.S., Choi Y.J., Shin S.Y., Li J., Kang S.W., Bae J.Y., Kim D.S., Ji G.E., Kang J.S., and Kang Y.H. J. Nutr. 138 (2008) 983
12. Liu X., Yin D., Zhang Y., Zhao J., Zhang S., and Miao J. FEBS Lett. 581 (2007) 5337
13. Ferlazzo N., Condello S., Curro M., Parisi G., Ientile R., and Caccamo D. BMC Neurosci. 9 (2008) 62
14. Aoki M., Nata T., Morishita R., Matsushita H., Nakagami H., Yamamoto K., Yamazaki K., Nakabayashi M., Ogihara T., and Kaneda Y. Hypertension 38 (2001) 48