P38MAPK/p53-Mediated Bax induction contributes to neurons degeneration in rotenone-induced cellular and rat models of cParkinson's disease

Neurochemistry International

Volumn 63, Issue 3, 2013, Pages 133-140

  Wu, Feng ^a,c   Wang, Zhong ^b   Gu, Jin Hua ^a,c   Ge, Jian Bin ^d   Liang, Zhong Qin ^a   Qin, Zheng Hong ^a  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^c NANTONG MEDICAL COLLEGE   (China)

^d Second People's Hospital of Nantong   (China)

Author keywords

Apoptotic; Bax; P53 Nuclear translocation; Parkinson's disease; Rotenone

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN P53; ROTENONE; SMALL INTERFERING RNA; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; DRUG CYTOTOXICITY; ENZYME INHIBITION; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOTOR ACTIVITY; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NERVE CELL DEGENERATION; NERVE CELL DIFFERENTIATION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PC12 CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SUBSTANTIA NIGRA PARS COMPACTA; UPREGULATION;

RATTUS;

APOPTOTIC; BAX; P38(MAPK); P53 NUCLEAR TRANSLOCATION; PARKINSON'S DISEASE; ROTENONE;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; DISEASE MODELS, ANIMAL; MALE; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PARKINSON DISEASE; PC12 CELLS; RATS; RATS, INBRED LEW; ROTENONE; SUBSTANTIA NIGRA; TUMOR SUPPRESSOR PROTEIN P53; TYROSINE 3-MONOOXYGENASE;

EID: 84879482747     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2013.05.006     Document Type: Article

References (35)

1. Alam, M., Schmidt, W.J., 2002. Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats. Behav. Brain Res. 136, 317-324. (Pubitemid 35246417)
2. Arnold, B., Cassady, S.J., VanLaar, V.S., Berman, S.B., 2011. Integrating multiple aspects of mitochondrial dynamics in neurons: age-related differences and dynamic changes in a chronic rotenone model. Neurobiol. Dis. 41, 189-200.
3. Betarbet, R., Sherer, T.B., MacKenzie, G., Garcia-Osuna, M., Panov, A.V., Greenamyre, J.T., 2000. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 3, 1301-1306.
4. Cannon, J.R., Greenamyre, J.T., 2012. Gene-environment interactions in Parkinson's disease: Specific evidence in humans and mammalian models. Neurobiol. Dis. http://dx.doi.org/10.1016/j.nbd.2012.06.025.
5. Cardaci, S., Filomeni, G., Rotilio, G., Ciriolo, M.R., 2010. P38(MAPK)/p53 signalling axis mediates neuronal apoptosis in response to tetrahydrobiopterin-induced oxidative stress and glucose uptake inhibition: implication for neurodegeneration. Biochem. J. 430, 439-451.
6. Chen, Y., McMillan-Ward, E., Kong, J., Israels, S.J., Gibson, S.B., 2007. Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. J. Cell Sci. 120, 4155-4166.
7. Chipuk, J.E., Kuwana, T., Bouchier-Hayes, L., Droin, N.M., Newmeyer, D.D., Schuler, M., Green, D.R., 2004. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303, 1010-1014. (Pubitemid 38209704)
8. Chung, W.G., Miranda, C.L., Maier, C.S., 2007. Epigallocatechin gallate (EGCG) potentiates the cytotoxicity of rotenone in neuroblastoma SH-SY5Y cells. Brain Res. 1176, 133-142. (Pubitemid 47553116)
9. Cicchetti, F., Drouin-Ouellet, J., Gross, R.E., 2009. Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models? Trends Pharmacol. Sci. 30, 475-483.
10. Daily, D., Barzilai, A., Offen, D., Kamsler, A., Melamed, E., Ziv, I., 1999. The involvement of p53 in dopamine-induced apoptosis of cerebellar granule neurons and leukemic cells overexpressing p53. Cell Mol. Neurobiol. 19, 261- 276. (Pubitemid 29096114)
11. Deng, Y.T., Huang, H.C., Lin, J.K., 2010. Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling. Mol. Carcinog. 49, 141-151.
12. Derry, W.B., Putzke, A.P., Rothman, J.H., 2001. Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance. Science 294, 591-595. (Pubitemid 32999555)
13. Duan, W., Zhu, X., Ladenheim, B., Yu, Q.S., Guo, Z., Oyler, J., Cutler, R.G., Cadet, J.L., Greig, N.H., Mattson, M.P., 2002. P53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism. Ann. Neurol. 52, 597-606. (Pubitemid 35246863)
14. Ethell, D.W., Fei, Q., 2009. Parkinson-linked genes and toxins that affect neuronal cell death through the Bcl-2 family. Antioxid. Redox Signal. 11, 529-540.
15. Fiskum, G., Starkov, A., Polster, B.M., Chinopoulos, C., 2003. Mitochondrial mechanisms of neural cell death and neuroprotective interventions in Parkinson's disease. Ann. N. Y. Acad. Sci. 991, 111-119. (Pubitemid 36793807)
16. Frevel, M.A., Bakheet, T., Silva, A.M., Hissong, J.G., Khabar, K.S., Williams, B.R., 2003. P38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts. Mol. Cell. Biol. 23, 425-436. (Pubitemid 36050538)
17. Girish, C., Muralidhara, 2012. Propensity of Selaginella delicatula aqueous extract to offset rotenone-induced oxidative dysfunctions and neurotoxicity in Drosophila melanogaster: implications for Parkinson's disease. Neurotoxicology 33, 444-456.
18. Gomez-Lazaro, M., Galindo, M.F., Concannon, C.G., Segura, M.F., Fernandez-Gomez, F.J., Llecha, N., Comella, J.X., Prehn, J.H., Jordan, J., 2008. 6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA. J. Neurochem. 104, 1599-1612. (Pubitemid 351316775)
19. Hatcher, J.M., Pennell, K.D., Miller, G.W., 2008. Parkinson's disease and pesticides: a toxicological perspective. Trends Pharmacol. Sci. 29, 322-329.
20. Kamalden, T.A., Ji, D., Osborne, N.N., 2012. Rotenone-induced death of RGC-5 cells is caspase independent, involves the JNK and p38 pathways and is attenuated by specific green tea flavonoids. Neurochem. Res. 37, 1091-1101.
21. Karunakaran, S., Saeed, U., Mishra, M., Valli, R.K., Joshi, S.D., Meka, D.P., Seth, P., Ravindranath, V., 2008. Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-treated mice. J. Neurosci. 28, 12500-12509.
22. Kim, B.J., Ryu, S.W., Song, B.J., 2006. JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J. Biol. Chem. 281, 21256-21265.
23. Li, B.Y., Yuan, Y.H., Hu, J.F., Zhao, Q., Zhang, D.M., Chen, N.H., 2011. Protective effect of Bu-7, a flavonoid extracted from Clausena lansium, against rotenone injury in PC12 cells. Acta Pharmacol. Sin. 32, 1321-1326.
24. Li, L.Y., Zhao, X.L., Fei, X.F., Gu, Z.L., Qin, Z.H., Liang, Z.Q., 2008. Bilobalide inhibits 6- OHDA-induced activation of NF-kappaB and loss of dopaminergic neurons in rat substantia nigra. Acta Pharmacol. Sin. 29, 539-547.
25. Newhouse, K., Hsuan, S.L., Chang, S.H., Cai, B., Wang, Y., Xia, Z., 2004. Rotenoneinduced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells. Toxicol. Sci. 79, 137-146. (Pubitemid 38660257)
26. Oh, C.K., Han, B.S., Choi, W.S., Youdim, M.B., Oh, Y.J., 2011. Translocation and oligomerization of Bax is regulated independently by activation of p38 MAPK and caspase-2 during MN9D dopaminergic neurodegeneration. Apoptosis 16, 1087-1100.
27. Panov, A., Dikalov, S., Shalbuyeva, N., Taylor, G., Sherer, T., Greenamyre, J.T., 2005. Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication. J. Biol. Chem. 280, 42026-42035. (Pubitemid 43023171)
28. Ravindran, J., Gupta, N., Agrawal, M., Bala Bhaskar, A.S., Lakshmana Rao, P.V., 2011. Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism. Apoptosis 16, 145-161.
29. Shi, J., Guan, J., Jiang, B., Brenner, D.A., Del Monte, F., Ward, J.E., Connors, L.H., Sawyer, D.B., Semigran, M.J., Macgillivray, T.E., Seldin, D.C., Falk, R., Liao, R., 2010. Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathway. Proc. Natl. Acad. Sci. USA 107, 4188-4193.
30. Slone, S.R., Lesort, M., Yacoubian, T.A., 2011. 14-3-3Theta protects against neurotoxicity in a cellular Parkinson's disease model through inhibition of the apoptotic factor Bax. PLoS One 6, e21720.
31. Trimmer, P.A., Smith, T.S., Jung, A.B., Bennett Jr., J.P., 1996. Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity. Neurodegeneration 5, 233-239. (Pubitemid 26360051)
32. Vilborg, A., Glahder, J.A., Wilhelm, M.T., Bersani, C., Corcoran, M., Mahmoudi, S., Rosenstierne, M., Grander, D., Farnebo, M., Norrild, B., Wiman, K.G., 2009. The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element. Proc. Natl. Acad. Sci. USA 106, 15756-15761.
33. Xiang, B., Fei, X., Zhuang, W., Fang, Y., Qin, Z., Liang, Z., 2011. Cathepsin L is involved in 6-hydroxydopamine induced apoptosis of SH-SY5Y neuroblastoma cells. Brain Res. 1387, 29-38.
34. Yu, C., Rahmani, M., Dent, P., Grant, S., 2004. The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib. Exp. Cell Res. 295, 555-566. (Pubitemid 38490507)
35. Zoccarato, F., Toscano, P., Alexandre, A., 2005. Dopamine-derived dopaminochrome promotes H(2)O(2) release at mitochondrial complex I: stimulation by rotenone, control by Ca(2+), and relevance to Parkinson disease. J. Biol. Chem. 280, 15587-15594. (Pubitemid 40616675)