Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38α MAPK pathway

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 9, 2010, Pages 4188-4193

  Shi, Jianru ^a   Guan, Jian ^a,b   Jiang, Bingbing ^a   Brenner, Daniel A ^a   Del Monte, Federica ^c   Ward, Jennifer E ^b   Connors, Lawreen H ^b   Sawyer, Douglas B ^d   Semigran, Marc J ^e   Macgillivray, Thomas E ^e   Seldin, David C ^b   Falk, Rodney ^f   Liao, Ronglih ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f HARVARD VANGUARD MEDICAL ASSOCIATES   (United States)

Author keywords

Amyloid; Cell death; Heart failure; Reactive oxygen species; TAB1

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AMYLOID; BINDING PROTEIN; IMMUNOGLOBULIN LIGHT CHAIN; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TRANSFORMING GROWTH FACTOR BETA ACTIVATED PROTEIN KINASE 1 BINDING PROTEIN 1; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ATTENUATION; AUTOPHOSPHORYLATION; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVATION; HEART AMYLOIDOSIS; HEART DISEASE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; RAT;

AMYLOID; APOPTOSIS; ENZYME ACTIVATION; HUMANS; IMIDAZOLES; MYOCARDIAL CONTRACTION; MYOCARDIUM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PYRIDINES;

EID: 77749251993     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0912263107     Document Type: Article

References (27)

1. Merlini G, Bellotti V (2003) Molecular mechanisms of amyloidosis. N Engl J Med 349: 583-596.
2. Falk RH, Comenzo RL, Skinner M (1997) The systemic amyloidoses. N Engl J Med 337: 898-909.
3. Westermark P, et al. (2002) Amyloid fibril protein nomenclature - 2002. Amyloid 9: 197-200.
4. Falk RH (2005) Diagnosis and management of the cardiac amyloidoses. Circulation 112:2047-2060.
5. Liao R, et al. (2001) Infusion of light chains from patients with cardiac amyloidosis causes diastolic dysfunction in isolated mouse hearts. Circulation 104:1594-1597.
6. Brenner DA, et al. (2004) Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress. Circ Res 94: 1008-1010.
7. Schubert D, et al. (1995) Amyloid peptides are toxic via a common oxidative mechanism. Proc Natl Acad Sci USA 92:1989-1993.
8. Walsh DM, et al. (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416:535-539.
9. Hensley K, et al. (1999) p38 kinase is activated in the Alzheimer's disease brain. J Neurochem 72:2053-2058.
10. Oddo S, et al. (2005) Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc Natl Acad Sci USA 102:3046-3051.
11. Origlia N, et al. (2008) Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction. J Neurosci 28:3521-3530.
12. Lambourne SL, et al. (2005) Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities. Mol Cell Biol 25:278-293.
13. Ge B, et al. (2002) MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science 295:1291-1294.
14. Tanno M, et al. (2003) Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: Evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia. Circ Res 93: 254-261.
15. Lu G, et al. (2006) TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. J Biol Chem 281:6087-6095.
16. Zhou H, et al. (2006) Determinants that control the specific interactions between TAB1 and p38alpha. Mol Cell Biol 26:3824-3834.
17. Fiedler B, et al. (2006) cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes. J Biol Chem 281:32831-32840.
18. Nojiri H, et al. (2006) Oxidative stress causes heart failure with impaired mitochondrial respiration. J Biol Chem 281:33789-33801.
19. Kyriakis JM, Avruch J (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81:807-869.
20. Baines CP, Molkentin JD (2005) STRESS signaling pathways that modulate cardiac myocyte apoptosis. J Mol Cell Cardiol 38:47-62.
21. Wang Y (2007) Mitogen-activated protein kinases in heart development and diseases. Circulation 116:1413-1423.
22. Johnson GL, Lapadat R (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-1912.
23. Round JL, et al. (2007) Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors. Nat Immunol 8:154-161.
24. Li J, Miller EJ, Ninomiya-Tsuji J, Russell RR, 3rd, Young LH (2005) AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart. Circ Res 97:872-879.
25. Makeeva N, Roomans GM, Welsh N (2007) Role of TAB1 in nitric oxide-induced p38 activation in insulin-producing cells. Int J Biol Sci 3:71-76.
26. Ren J, Zhang S, Kovacs A, Wang Y, Muslin AJ (2005) Role of p38alpha MAPK in cardiac apoptosis and remodeling after myocardial infarction. J Mol Cell Cardiol 38:617-623.
27. Jain M, et al. (2003) Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. Circ Res 93:e9-e16.