-
1
-
-
0028316283
-
Biosynthesis of pyrrolizidine alkaloids: putrescine and spermidine are essential substrates of enzymatic homospermidine formation
-
Boettcher F, Ober D, Hartmann T (1994) Biosynthesis of pyrrolizidine alkaloids: putrescine and spermidine are essential substrates of enzymatic homospermidine formation. Canadian Journal of Chemistry 72: 80–85.
-
(1994)
Canadian Journal of Chemistry
, vol.72
, pp. 80-85
-
-
Boettcher, F.1
Ober, D.2
Hartmann, T.3
-
2
-
-
70349568598
-
Intracellular glutathione plays important roles in pyrrolizidine alkaloids-induced growth inhibition on hepatocytes
-
Chen Y, Ji LL, Wang HT, Wang ZT (2009) Intracellular glutathione plays important roles in pyrrolizidine alkaloids-induced growth inhibition on hepatocytes. Environmental Toxicology and Pharmacology 28: 357–362.
-
(2009)
Environmental Toxicology and Pharmacology
, vol.28
, pp. 357-362
-
-
Chen, Y.1
Ji, L.L.2
Wang, H.T.3
Wang, Z.T.4
-
3
-
-
56449107131
-
Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma
-
Ding ZB, Shi YH, Zhou J, Qiu SJ, Xu Y, Dai Z et al., (2008) Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Research 68: 9167–9175.
-
(2008)
Cancer Research
, vol.68
, pp. 9167-9175
-
-
Ding, Z.B.1
Shi, Y.H.2
Zhou, J.3
Qiu, S.J.4
Xu, Y.5
Dai, Z.6
-
5
-
-
4344625883
-
A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells
-
Friesen C, Kiess Y, Debatin KM (2004) A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells. Cell Death & Differentiation 11: 73–85.
-
(2004)
Cell Death & Differentiation
, vol.11
, pp. 73-85
-
-
Friesen, C.1
Kiess, Y.2
Debatin, K.M.3
-
6
-
-
77949361456
-
High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of pyrrolizidine alkaloid-derived DNA adducts in vitro and in vivo
-
Fu PP, Chou MW, Churchwell M, Wang Y, Zhao Y, Xia Q et al., (2010) High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of pyrrolizidine alkaloid-derived DNA adducts in vitro and in vivo. Chemical Research in Toxicology 23: 637–652.
-
(2010)
Chemical Research in Toxicology
, vol.23
, pp. 637-652
-
-
Fu, P.P.1
Chou, M.W.2
Churchwell, M.3
Wang, Y.4
Zhao, Y.5
Xia, Q.6
-
7
-
-
0035206839
-
Genotoxic preeolizidine alkaloids and pyrrolizidine alkaloid N-oxides-mechanisms leading to DNA adduct formation and tumorigenicity
-
Fu PP, Chou MW, Xia Q, Yang YC, Yan J, Doerge DR et al., (2001) Genotoxic preeolizidine alkaloids and pyrrolizidine alkaloid N-oxides-mechanisms leading to DNA adduct formation and tumorigenicity. Environmental Carcinogenesis & Ecotoxicology 19: 353–386.
-
(2001)
Environmental Carcinogenesis & Ecotoxicology
, vol.19
, pp. 353-386
-
-
Fu, P.P.1
Chou, M.W.2
Xia, Q.3
Yang, Y.C.4
Yan, J.5
Doerge, D.R.6
-
8
-
-
0033231162
-
Biologic and pharmacologic regulation of mammalian glutathione synthesis
-
Griffith OW (1999) Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radical Biology & Medicine 27: 922–935.
-
(1999)
Free Radical Biology & Medicine
, vol.27
, pp. 922-935
-
-
Griffith, O.W.1
-
9
-
-
0024595042
-
Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
-
Hansen MB, Nielsen SE, Berg K (1989) Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. Journal of Immunological Methods 119: 203–210.
-
(1989)
Journal of Immunological Methods
, vol.119
, pp. 203-210
-
-
Hansen, M.B.1
Nielsen, S.E.2
Berg, K.3
-
11
-
-
33846419151
-
GSH-dependent regulation of Fas-mediated caspase-8 activation by acrolein
-
Hristova M, Heuvelmans S, Vander VA (2007) GSH-dependent regulation of Fas-mediated caspase-8 activation by acrolein. FEBS Letters 581: 361–367.
-
(2007)
FEBS Letters
, vol.581
, pp. 361-367
-
-
Hristova, M.1
Heuvelmans, S.2
Vander, V.A.3
-
12
-
-
70349255591
-
Protective mechanisms of N-acetyl-cysteine against pyrrolizidine alkaloid clivorine-induced hepatotoxicity
-
Ji LL, Liu TY, Chen Y, Wang ZT (2009) Protective mechanisms of N-acetyl-cysteine against pyrrolizidine alkaloid clivorine-induced hepatotoxicity. Journal of Cellular Biochemistry 108: 424–432.
-
(2009)
Journal of Cellular Biochemistry
, vol.108
, pp. 424-432
-
-
Ji, L.L.1
Liu, T.Y.2
Chen, Y.3
Wang, Z.T.4
-
13
-
-
33646181992
-
Fenugreek (Trigonella foenum graecum) seed extract prevents ethanol-induced toxicity and apoptosis in Chang liver cells
-
Kaviarasan S, Ramamurty N, Gunasekaran P, Varalakshmi E, Anuradha CV (2006) Fenugreek (Trigonella foenum graecum) seed extract prevents ethanol-induced toxicity and apoptosis in Chang liver cells. Alcohol Alcohol 41: 267–273.
-
(2006)
Alcohol Alcohol
, vol.41
, pp. 267-273
-
-
Kaviarasan, S.1
Ramamurty, N.2
Gunasekaran, P.3
Varalakshmi, E.4
Anuradha, C.V.5
-
14
-
-
0032718791
-
Influence of exogenous thiols on inorganic mercury induced injury in renal proximal and distal tubular cells from normal and uninephrectomized rats
-
Lash LH, Putt DA, Zalups RK (1999) Influence of exogenous thiols on inorganic mercury induced injury in renal proximal and distal tubular cells from normal and uninephrectomized rats. Journal of Pharmacology and Experimental Therapeutics 291: 492–502.
-
(1999)
Journal of Pharmacology and Experimental Therapeutics
, vol.291
, pp. 492-502
-
-
Lash, L.H.1
Putt, D.A.2
Zalups, R.K.3
-
15
-
-
0031913915
-
Microsomal formation of a pyrrolic alcohol glutathione conjugate of clivorine. Firm evidence for the formation of a pyrrolic metabolite of an otonecine-type pyrrolizidine alkaloid
-
Lin G, Cui YY, Hawes EM (1998) Microsomal formation of a pyrrolic alcohol glutathione conjugate of clivorine. Firm evidence for the formation of a pyrrolic metabolite of an otonecine-type pyrrolizidine alkaloid. Drug Metabolism and Disposition 26: 181–184.
-
(1998)
Drug Metabolism and Disposition
, vol.26
, pp. 181-184
-
-
Lin, G.1
Cui, Y.Y.2
Hawes, E.M.3
-
16
-
-
77952891451
-
Pyrrolizidine alkaloid isoline-induced oxidative injury in various mouse tissues
-
Liu TY, Chen Y, Wang ZY, Ji LL, Wang ZT (2010) Pyrrolizidine alkaloid isoline-induced oxidative injury in various mouse tissues. Experimental and Toxicologic Pathology 62: 251–257.
-
(2010)
Experimental and Toxicologic Pathology
, vol.62
, pp. 251-257
-
-
Liu, T.Y.1
Chen, Y.2
Wang, Z.Y.3
Ji, L.L.4
Wang, Z.T.5
-
17
-
-
0037134244
-
Lipid peroxidation induced by phenylbutazone radicals
-
Miura T, Muraoka S, Fujimoto Y (2002) Lipid peroxidation induced by phenylbutazone radicals. Life Sciences 70: 2611–2621.
-
(2002)
Life Sciences
, vol.70
, pp. 2611-2621
-
-
Miura, T.1
Muraoka, S.2
Fujimoto, Y.3
-
18
-
-
0026808688
-
Hepatic glutathione concentrations and the release of pyrrolic metabolites of the pyrrolizidine alkaloid, monocrotaline, from the isolated perfused liver
-
Nigra L, Huxtable RJ (1992) Hepatic glutathione concentrations and the release of pyrrolic metabolites of the pyrrolizidine alkaloid, monocrotaline, from the isolated perfused liver. Toxicon 30: 1195–1202.
-
(1992)
Toxicon
, vol.30
, pp. 1195-1202
-
-
Nigra, L.1
Huxtable, R.J.2
-
19
-
-
38449097251
-
One-day dietary restriction changes hepatic metabolism and potentiates the hepatotoxicity of carbon tetrachloride and chloroform in rats
-
Qin LQ, Wang Y, Xu JY, Kaneko T, Sato A, Wang PY (2007) One-day dietary restriction changes hepatic metabolism and potentiates the hepatotoxicity of carbon tetrachloride and chloroform in rats. The Journal of Experimental Medicine 212: 379–387.
-
(2007)
The Journal of Experimental Medicine
, vol.212
, pp. 379-387
-
-
Qin, L.Q.1
Wang, Y.2
Xu, J.Y.3
Kaneko, T.4
Sato, A.5
Wang, P.Y.6
-
20
-
-
0026498940
-
Microsomal formation of a pyrrolic alcohol glutathione conjugates of the pyrrolizidine alkaloid senecionine
-
Reed RL, Miranda CL, Kedzierski B, Henderson MC, Buhler DR (1992) Microsomal formation of a pyrrolic alcohol glutathione conjugates of the pyrrolizidine alkaloid senecionine. Xenobiotica 22: 1321–1327.
-
(1992)
Xenobiotica
, vol.22
, pp. 1321-1327
-
-
Reed, R.L.1
Miranda, C.L.2
Kedzierski, B.3
Henderson, M.C.4
Buhler, D.R.5
-
21
-
-
0033788020
-
Medicinal plants in China containing pyrrolizidine alkaloids
-
Roeder E (2000) Medicinal plants in China containing pyrrolizidine alkaloids. Pharmazie 55: 711–726.
-
(2000)
Pharmazie
, vol.55
, pp. 711-726
-
-
Roeder, E.1
-
22
-
-
0035371184
-
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
-
Schafer FQ, Buettner GR (2001) Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radical Biology & Medicine 30: 1191–212.
-
(2001)
Free Radical Biology & Medicine
, vol.30
, pp. 1191-1212
-
-
Schafer, F.Q.1
Buettner, G.R.2
-
23
-
-
0023357216
-
Pyrrolizidine alkaloids poisoning of sheep in New South Wales
-
Seaman JT (1987) Pyrrolizidine alkaloids poisoning of sheep in New South Wales. Australian Veterinary Journal 64: 174–167.
-
(1987)
Australian Veterinary Journal
, vol.64
, pp. 167-174
-
-
Seaman, J.T.1
-
24
-
-
0033230043
-
Glutathione and its role in cellular functions
-
Sies H (1999) Glutathione and its role in cellular functions. Free Radical Biology & Medicine 27: 916–921.
-
(1999)
Free Radical Biology & Medicine
, vol.27
, pp. 916-921
-
-
Sies, H.1
-
25
-
-
0021288857
-
Glutathione disulfide (GSSG) efflux from cells and tissues
-
Sies H, Akerboom TP (1984) Glutathione disulfide (GSSG) efflux from cells and tissues. Methods in Enzymology 105: 445–451.
-
(1984)
Methods in Enzymology
, vol.105
, pp. 445-451
-
-
Sies, H.1
Akerboom, T.P.2
-
26
-
-
0030834975
-
Glutathione peroxidase protects against peroxynitrite-mediated oxidations. A new function for selenoproteins as peroxynitrite reductase
-
Sies H, Sharov VS, Klotz LO, Briviba K (1997) Glutathione peroxidase protects against peroxynitrite-mediated oxidations. A new function for selenoproteins as peroxynitrite reductase. The Journal of Biological Chemistry 272: 27812–27817.
-
(1997)
The Journal of Biological Chemistry
, vol.272
, pp. 27812-27817
-
-
Sies, H.1
Sharov, V.S.2
Klotz, L.O.3
Briviba, K.4
-
27
-
-
34748876205
-
In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors
-
Tang J, Akao T, Nakamura N, Wang ZT, Takagawa K, Sasahara M et al., (2007) In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors. Drug Metabolism and Disposition 35: 1832–1839.
-
(2007)
Drug Metabolism and Disposition
, vol.35
, pp. 1832-1839
-
-
Tang, J.1
Akao, T.2
Nakamura, N.3
Wang, Z.T.4
Takagawa, K.5
Sasahara, M.6
-
28
-
-
37549052936
-
Comparison of S-adenosyl-L-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose
-
Terneus MV, Brown JM, Carpenter AB, Valentovic MA (2008) Comparison of S-adenosyl-L-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose. Toxicology 244: 25–34.
-
(2008)
Toxicology
, vol.244
, pp. 25-34
-
-
Terneus, M.V.1
Brown, J.M.2
Carpenter, A.B.3
Valentovic, M.A.4
-
30
-
-
33644614521
-
A dual effect of N-acetylcysteine on acute ethanol-induced liver damage in mice
-
Wang AL, Wang JP, Wang H, Chen YH, Zhao L, Wang LS et al., (2006) A dual effect of N-acetylcysteine on acute ethanol-induced liver damage in mice. Hepatology Research 34: 199–206.
-
(2006)
Hepatology Research
, vol.34
, pp. 199-206
-
-
Wang, A.L.1
Wang, J.P.2
Wang, H.3
Chen, Y.H.4
Zhao, L.5
Wang, L.S.6
-
31
-
-
2442694125
-
Metabolic formation of DHP-derived DNA adducts from a representative otonecine type pyrrolizidine alkaloid clivorine and the extract of Ligularia hodgsonnii hook
-
Xia Q, Chou MW, Lin G, Fu PP (2004) Metabolic formation of DHP-derived DNA adducts from a representative otonecine type pyrrolizidine alkaloid clivorine and the extract of Ligularia hodgsonnii hook. Chemical Research in Toxicology 17: 702–708.
-
(2004)
Chemical Research in Toxicology
, vol.17
, pp. 702-708
-
-
Xia, Q.1
Chou, M.W.2
Lin, G.3
Fu, P.P.4
-
32
-
-
71949108659
-
Identification of metabolites of adonifoline, a hepatotoxic pyrrolizidine alkaloid, by liquid chromatography/tandem and high-resolution mass spectrometry
-
Xiong AZ, Yang L, He YQ, Zhang F, Wang J, Han H et al., (2009) Identification of metabolites of adonifoline, a hepatotoxic pyrrolizidine alkaloid, by liquid chromatography/tandem and high-resolution mass spectrometry. Rapid Communications in Mass Spectrometry 23: 3907–3916.
-
(2009)
Rapid Communications in Mass Spectrometry
, vol.23
, pp. 3907-3916
-
-
Xiong, A.Z.1
Yang, L.2
He, Y.Q.3
Zhang, F.4
Wang, J.5
Han, H.6
|