In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors

Drug Metabolism and Disposition

Volumn 35, Issue 10, 2007, Pages 1832-1839

  Tang, Jun ^a,b,c   Akao, Teruaki ^a,d   Nakamura, Norio ^a   Wang, Zheng Tao ^b   Takagawa, Kiyoshi ^a   Sasahara, Masakiyo ^a   Hattori, Masao ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c WUHAN UNIVERSITY   (China)

^d UNIVERSITY OF TOYAMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA NAPHTHOFLAVONE; BENZYLSULFONYL FLUORIDE; BISLINE; CLIVORINE; CYTOCHROME P450 INHIBITOR; ESTERASE; ESTERASE INHIBITOR; ISOLINE; MONOCROTALINE; PROADIFEN; PYRROLIZIDINE ALKALOID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RETRONECINE; TRI ORTHO CRESYL PHOSPHATE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHEMICAL STRUCTURE; CHINESE HERB; CONTROLLED STUDY; DEACETYLATION; DETOXIFICATION; DOSE RESPONSE; DRUG METABOLISM; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; IN VITRO STUDY; LIGULARIA DUCIFORMIS; LIVER MICROSOME; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; STATISTICAL ANALYSIS; THIN LAYER CHROMATOGRAPHY;

ALANINE TRANSAMINASE; ANIMALS; ANTITUSSIVE AGENTS; ASPARTATE AMINOTRANSFERASES; ASTERACEAE; BENZOFLAVONES; CYTOCHROME P-450 ENZYME SYSTEM; DRUGS, CHINESE HERBAL; ESTERASES; EXPECTORANTS; LIVER; MALE; MICE; MICE, INBRED STRAINS; MICROSOMES, LIVER; MONOCROTALINE; PHENYLMETHYLSULFONYL FLUORIDE; PROADIFEN; PYRROLIZIDINE ALKALOIDS; RATS; RATS, SPRAGUE-DAWLEY; TRITOLYL PHOSPHATES;

LIGULARIA DUCIFORMIS; MUS; RATTUS; RODENTIA;

EID: 34748876205     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.016311     Document Type: Article

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