Mutational biosynthesis of tacrolimus analogues by fkbO deletion mutant of Streptomyces sp. KCTC 11604BP

Applied Microbiology and Biotechnology

Volumn 97, Issue 13, 2013, Pages 5881-5892

  Kim, Dong Hwan ^a,b   Ryu, Jeoung Hyun ^a   Lee, Keum Soon ^a   Lee, Bo Mi ^a   Lee, Mi Ok ^a   Lim, Si Kyu ^a   Maeng, Pil Jae ^b  

^a GenoTech Corporation   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

Chorismatase; Mutasynthesis; Polyketides; Tacrolimus; Tricyclo compounds

Indexed keywords

CHORISMATASE; MUTASYNTHESIS; POLYKETIDES; TACROLIMUS; TRICYCLO COMPOUNDS;

BACTERIA; BIOCHEMISTRY; KETONES; LOADING; MACHINERY; STARTERS;

BIOSYNTHESIS;

3 HYDROXYANTHRANILIC ACID; 31 DESMETHOXYTACROLIMUS; CARBOXYLIC ACID DERIVATIVE; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; TACROLIMUS; TC 225; TRANS 4 HYDROXYCYCLOHEXANECARBOXYLIC ACID; UNCLASSIFIED DRUG;

BACTERIUM; CANCER; CARBOXYLIC ACID; DISEASE TREATMENT; DRUG; HOMOLOGY; IMMUNE SYSTEM; MUTATION;

ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; DRUG STRUCTURE; DRUG SYNTHESIS; FKBO GENE; GENE DELETION; GENE MUTATION; NONHUMAN; RAPK GENE; STREPTOMYCES;

BIOSYNTHETIC PATHWAYS; METABOLIC ENGINEERING; MUTATION; SEQUENCE DELETION; STREPTOMYCES; TACROLIMUS;

STREPTOMYCES SP.;

EID: 84879421723     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-013-4716-1     Document Type: Article

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