24(S)-hydroxycholesterol is actively eliminated from neuronal cells by ABCA1

Journal of Neurochemistry

Volumn 126, Issue 1, 2013, Pages 93-101

  Matsuda, Akihiro ^a   Nagao, Kohjiro ^b,c   Matsuo, Michinori ^a   Kioka, Noriyuki ^a   Ueda, Kazumitsu ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

24 hydroxycholesterol; ABC proteins; ABCA1; ABCG1; cholesterol; high density lipoprotein

Indexed keywords

24 HYDROXYCHOLESTEROL; ABC TRANSPORTER A1; ABC TRANSPORTER G1; APOLIPOPROTEIN A1; CHOLESTEROL DERIVATIVE; HIGH DENSITY LIPOPROTEIN; LIVER X RECEPTOR; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; RETINOIC ACID; RETINOID X RECEPTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; CHOLESTEROL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DATA INTERPRETATION, STATISTICAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE SILENCING; HEK293 CELLS; HUMANS; HYDROXYCHOLESTEROLS; LIPOPROTEINS; LIPOPROTEINS, HDL; MICE; NEURONS; ORPHAN NUCLEAR RECEPTORS; RETINOID X RECEPTORS;

EID: 84879418458     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12275     Document Type: Article

References (46)

1. Abildayeva K., Jansen P. J., Hirsch-Reinshagen V., et al,. (2006) 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux. J. Biol. Chem. 281, 12799-12808.
2. Adem A., Mattsson M. E., Nordberg A., and, Pahlman S., (1987) Muscarinic receptors in human SH-SY5Y neuroblastoma cell line: regulation by phorbol ester and retinoic acid-induced differentiation. Brain Res. 430, 235-242.
3. Ammer H., and, Schulz R., (1994) Retinoic acid-induced differentiation of human neuroblastoma SH-SY5Y cells is associated with changes in the abundance of G proteins. J. Neurochem. 62, 1310-1318.
4. Biedler J. L., Roffler-Tarlov S., Schachner M., and, Freedman L. S., (1978) Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res. 38, 3751-3757.
5. Bjorkhem I., and, Diczfalusy U., (2004) 24(S),25-epoxycholesterol-a potential friend. Arterioscler. Thromb. Vasc. Biol. 24, 2209-2210.
6. Bjorkhem I., and, Meaney S., (2004) Brain cholesterol: long secret life behind a barrier. Arterioscler. Thromb. Vasc. Biol. 24, 806-815.
7. Bjorkhem I., Lutjohann D., Breuer O., Sakinis A., and, Wennmalm A., (1997) Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro. J. Biol. Chem. 272, 30178-30184.
8. Bjorkhem I., Andersson U., Ellis E., Alvelius G., Ellegard L., Diczfalusy U., Sjovall J., and, Einarsson C., (2001) From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans. J. Biol. Chem. 276, 37004-37010.
9. Dietschy J. M., and, Turley S. D., (2004) Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J. Lipid Res. 45, 1375-1397.
10. Fukumoto H., Deng A., Irizarry M. C., Fitzgerald M. L., and, Rebeck G. W., (2002) Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels. J. Biol. Chem. 277, 48508-48513.
11. Hirsch-Reinshagen V., Zhou S., Burgess B. L., Bernier L., McIsaac S. A., Chan J. Y., Tansley G. H., Cohn J. S., Hayden M. R., and, Wellington C. L., (2004) Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. J. Biol. Chem. 279, 41197-41207.
12. Karasinska J. M., Rinninger F., Lutjohann D., et al,. (2009) Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function. J. Neurosci. 29, 3579-3589.
13. Karten B., Campenot R. B., Vance D. E., and, Vance J. E., (2006) Expression of ABCG1, but not ABCA1, correlates with cholesterol release by cerebellar astroglia. J. Biol. Chem. 281, 4049-4057.
14. Kobayashi A., Takanezawa Y., Hirata T., Shimizu Y., Misasa K., Kioka N., Arai H., Ueda K., and, Matsuo M., (2006) Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1. J. Lipid Res. 47, 1791-1802.
15. Koldamova R. P., Lefterov I. M., Ikonomovic M. D., Skoko J., Lefterov P. I., Isanski B. A., DeKosky S. T., and, Lazo J. S., (2003) 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. J. Biol. Chem. 278, 13244-13256.
16. Kolsch H., Lutjohann D., Tulke A., Bjorkhem I., and, Rao M. L., (1999) The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells. Brain Res. 818, 171-175.
17. Kolsch H., Ludwig M., Lutjohann D., and, Rao M. L., (2001) Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta. J. Neural Transm. 108, 475-488.
18. Kolsch H., Lutjohann D., Jessen F., Von Bergmann K., Schmitz S., Urbach H., Maier W., and, Heun R., (2006) Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease. Int. J. Mol. Med. 17, 791-794.
19. Kotti T. J., Ramirez D. M., Pfeiffer B. E., Huber K. M., and, Russell D. W., (2006) Brain cholesterol turnover required for geranylgeraniol production and learning in mice. Proc. Natl Acad. Sci. USA 103, 3869-3874.
20. Lund E. G., Xie C., Kotti T., Turley S. D., Dietschy J. M., and, Russell D. W., (2003) Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J. Biol. Chem. 278, 22980-22988.
21. Lutjohann D., Breuer O., Ahlborg G., Nennesmo I., Siden A., Diczfalusy U., and, Bjorkhem I., (1996) Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc. Natl Acad. Sci. USA 93, 9799-9804.
22. Matsuo M., Campenot R. B., Vance D. E., Ueda K., and, Vance J. E., (2012) Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins. Biochim. Biophys. Acta 1811, 31-38.
23. Meaney S., Bodin K., Diczfalusy U., and, Bjorkhem I., (2002) On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function. J. Lipid Res. 43, 2130-2135.
24. Munehira Y., Ohnishi T., Kawamoto S., et al,. (2004) Alpha1-syntrophin modulates turnover of ABCA1. J. Biol. Chem. 279, 15091-15095.
25. Nagao K., Zhao Y., Takahashi K., Kimura Y., and, Ueda K., (2009) Sodium taurocholate-dependent lipid efflux by ABCA1: effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation. J. Lipid Res. 50, 1165-1172.
26. Nagao K., Takahashi K., Azuma Y., Takada M., Kimura Y., Matsuo M., Kioka N., and, Ueda K., (2012) ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding. J. Lipid Res. 53, 126-136.
27. Ohtsuki S., Ito S., Matsuda A., Hori S., Abe T., and, Terasaki T., (2007) Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier. J. Neurochem. 103, 1430-1438.
28. Ohyama Y., Meaney S., Heverin M., et al,. (2006) Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes. J. Biol. Chem. 281, 3810-3820.
29. Prasad V. V., Ponticorvo L., and, Lieberman S., (1984) Identification of 24-hydroxycholesterol in bovine adrenals in both free and esterified forms and in bovine brains as its sulfate ester. J. Steroid Biochem. 21, 733-736.
30. Probst M. C., Thumann H., Aslanidis C., et al,. (2004) Screening for functional sequence variations and mutations in ABCA1. Atherosclerosis 175, 269-279.
31. Remaley A. T., Stonik J. A., Demosky S. J., et al,. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem. Biophys. Res. Commun. 280, 818-823.
32. Repa J. J., Turley S. D., Lobaccaro J.-M. A., Medina J., Li L., Lustig K., Shan B., Heyman R. A., Dietschy J. M., and, Mangelsdorf D. J., (2000) Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289, 1524-1529.
33. Roses A. D., and, Saunders A. M., (1994) APOE is a major susceptibility gene for Alzheimer's disease. Curr. Opin. Biotechnol. 5, 663-667.
34. Russell D. W., Halford R. W., Ramirez D. M., Shah R., and, Kotti T., (2009) Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain. Annu. Rev. Biochem. 78, 1017-1040.
35. Tachikawa M., Watanabe M., Hori S., Fukaya M., Ohtsuki S., Asashima T., and, Terasaki T., (2005) Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain. J. Neurochem. 95, 294-304.
36. Tam S. P., Mok L., Chimini G., Vasa M., and, Deeley R. G., (2006) ABCA1 mediates high-affinity uptake of 25-hydroxycholesterol by membrane vesicles and rapid efflux of the oxysterol by intact cells. Am. J. Physiol. Cell Physiol. 291, C490-C502.
37. Tanaka A. R., Ikeda Y., Abe-Dohmae S., et al,. (2001) Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjogren's syndrome. Biochem. Biophys. Res. Commun. 283, 1019-1025.
38. Tarr P. T., and, Edwards P. A., (2008) ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2. J. Lipid Res. 49, 169-182.
39. Terasaka N., Wang N., Yvan-Charvet L., and, Tall A. R., (2007) High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1. Proc. Natl Acad. Sci. USA 104, 15093-15098.
40. Ueda K., (2011) ABC proteins protect the human body and maintain optimal health. Biosci. Biotechnol. Biochem. 75, 401-409.
41. Vaughan A. M., and, Oram J. F., (2005) ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins. J. Biol. Chem. 280, 30150-30157.
42. Wahrle S. E., Jiang H., Parsadanian M., Legleiter J., Han X., Fryer J. D., Kowalewski T., and, Holtzman D. M., (2004) ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE. J. Biol. Chem. 279, 40987-40993.
43. Wang N., Silver D., Costet P., and, Tall A., (2000) Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1. J. Biol. Chem. 275, 33053-33058.
44. Wang N., Lan D., Chen W., Matsuura F., and, Tall A. R., (2004) ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc. Natl Acad. Sci. USA 101, 9774-9779.
45. Wang N., Yvan-Charvet L., Lutjohann D., Mulder M., Vanmierlo T., Kim T. W., and, Tall A. R., (2008) ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. FASEB J. 22, 1073-1082.
46. Yu V. C., Hochhaus G., Chang F. H., Richards M. L., Bourne H. R., and, Sadee W., (1988) Differentiation of human neuroblastoma cells: marked potentiation of prostaglandin E-stimulated accumulation of cyclic AMP by retinoic acid. J. Neurochem. 51, 1892-1899. Japan in Bio-oriented Industry (BRAIN) of Japan Japan