Development of a novel drive mode to prevent aortic insufficiency during continuous-flow LVAD support by synchronizing rotational speed with heartbeat

Journal of Artificial Organs

Volumn 16, Issue 2, 2013, Pages 129-137

  Kishimoto, Yuichiro ^a,b   Takewa, Yoshiaki ^a   Arakawa, Mamoru ^a   Umeki, Akihide ^a,c   Ando, Masahiko ^a,c   Nishimura, Takashi ^c,d   Fujii, Yutaka ^a   Mizuno, Toshihide ^a   Nishimura, Motonobu ^b   Tatsumi, Eisuke ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d Tokyo Metropolitan Institute of Gerontology   (Japan)

Author keywords

Aortic insufficiency; Aortic valve opening; Continuous flow LVAD; Delayed copulse mode; Synchronization with heartbeat

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA FLOW; AORTA VALVE REGURGITATION; ARTICLE; BLOOD FLOW VELOCITY; CARDIAC RESYNCHRONIZATION THERAPY; CONTINUOUS FLOW LEFT VENTRICULAR ASSIST DEVICE; CONTROLLED STUDY; CORONARY ARTERY; EQUIPMENT DESIGN; HEART LEFT VENTRICLE FAILURE; LEFT VENTRICULAR ASSIST DEVICE; MICROEMBOLISM; NONHUMAN; PERFORMANCE MEASUREMENT SYSTEM; PRIORITY JOURNAL; PROCESS CONTROL; PROCESS DESIGN; PROCESS DEVELOPMENT; PROCESS MODEL; ROTATION; SYSTEM ANALYSIS;

ANALYSIS OF VARIANCE; ANIMALS; AORTIC VALVE INSUFFICIENCY; DISEASE MODELS, ANIMAL; GOATS; HEART FAILURE; HEART RATE; HEART-ASSIST DEVICES; PROSTHESIS DESIGN; PULSATILE FLOW; REPRODUCIBILITY OF RESULTS; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84879416882     PISSN: 14347229     EISSN: 16190904     Source Type: Journal    
DOI: 10.1007/s10047-012-0685-x     Document Type: Article

References (22)

1. Slaughter MS, Rogers JG, Milano CA, Russell SD, Conte JV, Feldman D, Sun B, Tatooles AJ, Delgado RM, Long JW, Wozniak TC, Ghumman W, Farrar DJ, Frazier OH. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009;361:2241-51.
2. Cowger J, Pagani FD, Haft JW, Romano MA, Aaronson KD, Kolias TJ. The development of aortic insufficiency in left ventricular assist device-supported patients. Circ Heart Fail. 2010;3:668-74.
3. Pak SW, Uriel N, Takayama H, Cappleman S, Song R, Colombo PC, Charles S, Mancini D, Gillam L, Naka Y, Jorde UP. Prevalence of de novo aortic insufficiency during long-term support with left ventricular assist devices. J Heart Lung Transplant. 2010;29:1172-6.
4. Hatano M, Kinugawa K, Shiga T, Kato N, Endo M, Hisagi M, Nishimura T, Yao A, Hirata Y, Kyo S, Ono M, Nagai R. Less frequent opening of the aortic valve and a continuous flow pump are risk factors for postoperative onset of aortic insufficiency in patients with a left ventricular assist device. Circ J. 2011;75:1147-55.
5. Toda K, Fujita T, Domae K, Shimahara Y, Kobayashi J, Nakatani T. Late aortic insufficiency related to poor prognosis during left ventricular assist device support. Ann Thorac Surg. 2011;92:929-34.
6. Mudd JO, Cuda JD, Halushka M, Soderlund KA, Conte JV, Russell SD. Fusion of aortic valve commissures in patients supported by a continuous axial flow left ventricular assist device. J Heart Lung Transplant. 2008;27:1269-74.
7. Yamazaki K, Kihara S, Akimoto T, Tagusari O, Kawai A, Umezu M, Tomioka J, Kormos RL, Griffith BP, Kurosawa H. EVAHEART: an implantable centrifugal blood pump for long-term circulatory support. Jpn J Thorac Cardiovasc Surg. 2002;50:461-5.
8. Yamazaki K, Saito S, Kihara S, Tagusari O, Kurosawa H. Completely pulsatile high flow circulatory support with a constant-speed centrifugal blood pump: mechanisms and early clinical observations. Gen Thorac Cardiovasc Surg. 2007;55:158-62.
9. Klocke R, Tian W, Kuhlmann MT, Nikol S. Surgical animal model of heart failure related to coronary heart disease. Cardiovasc Res. 2007;74:29-38.
10. Dixon JA, Spinale FG. Large animal models of heart failure: a critical link in the translation of basic science to clinical practice. Circ Heart Fail. 2009;2:262-71.
11. Gill RM, Jones BD, Corbly AK, Wang J, Braz JC, Sandusky GE, Shen W. Cardiac diastolic dysfunction in conscious dogs with heart failure induced by chronic coronary microembolization. Am J Physiol Heart Circ Physiol. 2006;291:3154-8.
12. Ando M, Takewa Y, Nishimura T, Yamazaki K, Kyo S, Ono M, Tsukiya T, Mizuno T, Taenaka Y, Tatsumi E. A novel counterpulsation mode of rotary left ventricular assist devices can enhance myocardial perfusion. J Artif Organs. 2011;14:185-91.
13. Ando M, Takewa Y, Nishimura T, Yamazaki K, Kyo S, Ono M, Tsukiya T, Mizuno T, Taenaka Y, Tatsumi E. Coronary vascular resistance increases under full bypass support of centrifugal pumps-relation between myocardial perfusion and ventricular workload during pump support. Artif Organs. 2012;36:105-10.
14. Ando M, Nishimura T, Takewa Y, Yamazaki K, Kyo S, Ono M, Tsukiya T, Mizuno T, Taenaka Y, Tatsumi E. Electrocardiogram-synchronized rotational speed change mode in rotary pumps could improve pulsatility. Artif Organs. 2011;35:941-7.
15. Ando M, Nishimura T, Takewa Y, Kyo S, Ono M, Taenaka Y, Tatsumi E. Creating an ideal "off-test mode" for rotary left ventricular assist devices: establishing a safe and appropriate weaning protocol after myocardial recovery. J Thorac Cardiovasc Surg. 2012;143:1176-82.
16. Ando M, Nishimura T, Takewa Y, Ogawa D, Yamazaki K, Kashiwa K, Kyo S, Ono M, Taenaka Y, Tatsumi E. A novel counterpulse drive mode of continuous-flow left ventricular assist devices can minimize intracircuit backward flow during pump weaning. J Artif Organs. 2011;14:74-9.
17. Ando M, Nishimura T, Takewa Y, Ogawa D, Yamazaki K, Kashiwa K, Kyo S, Ono M, Taenaka Y, Tatsumi E. What is the ideal off-test trial for continuous-flow ventricular-assist-device explantation? Intracircuit back-flow analysis in a mock circulation model. J Artif Organs. 2011;14:70-3.
18. Umeki A, Nishimura T, Ando M, Takewa Y, Yamazaki K, Kyo S, Ono M, Tsukiya T, Mizuno T, Taenaka Y, Tatsumi E. Alteration of LV end-diastolic volume by controlling the power of the continuous-flow LVAD, so it is synchronized with cardiac beat: development of a native heart load control system (NHLCS). J Artif Organs. 2012;15:128-33.
19. Tuzun E, Gregoric ID, Conger JL, Golden K, Jarvik R, Frazier OH, Kadipasaoglu KA. The effect of intermittent low speed mode upon aortic valve opening in calves supported with a Jarvik 2000 axial flow device. ASAIO J. 2005;51:139-43.
20. Lietz K, Long JW, Kfoury AG, Slaughter MS, Silver MA, Milano CA, Rogers JG, Naka Y, Mancini D, Miller LW. Outcomes of left ventricular assist device implantation as destination therapy in the post-REMATCH era: implications for patient selection. Circulation. 2007;116:497-505.
21. Swanson M, Clark RE. Dimensions and geometric relationships of the human aortic valve as a function of pressure. Circ Res. 1974;35:871-82.
22. Letsou GV, Connelly JH, Delgado RM 3rd, Myers TJ, Gregoric ID, Smart FW, Frazier OH. Is native aortic valve commissural fusion in patients with long-term left ventricular assist devices associated with clinically important aortic insufficiency? J Heart Lung Transplant. 2006;25:395-9.