In vivo regulation of murine CYP7A1 by HNF-6: A novel mechanism for diminished CYP7A1 expression in biliary obstruction

Hepatology

Volumn 40, Issue 3, 2004, Pages 600-608

  Wang, Minhua ^a   Tan, Yongjun ^a   Costa, Robert H ^a   Holterman, Ai Xuan L ^a,b  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BILE ACID; CELL NUCLEUS RECEPTOR; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; COMPLEMENTARY DNA; GROWTH HORMONE; HEPATOCYTE NUCLEAR FACTOR 6; MESSENGER RNA; TRANSCRIPTION FACTOR; HOMEODOMAIN PROTEIN; ONECUT1 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; BILE ACID SYNTHESIS; BILE DUCT OBSTRUCTION; BINDING SITE; CHOLESTEROL METABOLISM; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO STUDY; LIPID METABOLISM; LIVER FUNCTION; MALE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FAMILY; TRANSCRIPTION REGULATION; ANIMAL; CHOLESTASIS; DNA RESPONSIVE ELEMENT; DOWN REGULATION; ENZYMOLOGY; GENETICS; MOLECULAR GENETICS; PHYSIOLOGY;

ANIMALS; BASE SEQUENCE; CHOLESTASIS; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GROWTH HORMONE; HEPATOCYTE NUCLEAR FACTOR 6; HOMEODOMAIN PROTEINS; MALE; MICE; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); RESPONSE ELEMENTS; TRANS-ACTIVATORS;

EID: 4544293922     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20349     Document Type: Article

References (31)

1. Dikopoulos N, Weidenbach H, Adler G, Schmid RM. Lipopolysaccharide represses cholesterol 7-alpha hydroxylase and induces binding activity to the bile acid response element II. Eur J Clin Invest 2003;33:58-64.
2. Sundseth SS, Waxman DJ. Hepatic P-450 cholesterol 7 alpha-hydroxylase. Regulation in vivo at the protein and mRNA level in response to mevalonate, diurnal rhythm, and bile acid feedback. J Biol Chem 1990;265:15090-15095.
3. Vlahcevic ZR, Pandak WM, Stravitz RT. Regulation of bile acid biosynthesis. Gastroenterol Clin North Am 1999;28:1-25, v.
4. Chiang JY. Bile acid regulation of gene expression: roles of nuclear hormone receptors. Endocr Rev 2002;23:443-463.
5. Lee YH, Alberta JA, Gonzalez FJ, Waxman DJ. Multiple, functional DBP sites on the promoter of the cholesterol 7 alpha-hydroxylase P450 gene, CYP7. Proposed role in diurnal regulation of liver gene expression. J Biol Chem 1994;269:14681-14689.
6. Cooper AD, Chen J, Botelho-Yetkinler MJ, Cao Y, Taniguchi T, Levy-Wilson B. Characterization of hepatic-specific regulatory elements in the promoter region of the human cholesterol 7-alpha-hydroxylase gene. J Biol Chem 1997;272:3444-3452.
7. Lannoy VJ, Rodolosse A, Pierreux CE, Rousseau GG, Lemaigre FP. Transcriptional stimulation by hepatocyte nuclear factor-6. Target-specific recruitment of either CREB-binding protein (CBP) or p300/CBP-associated factor (p/CAF). J Biol Chem 2000;275:22098-22103.
8. Rausa F, Samadani U, Ye H, Lim L, Fletcher CF, Jenkins NA, et al. The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas. Dev Biol 1997;192:228-246.
9. Rausa FM, Tan Y, Costa RH. Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding. Mol Cell Biol 2003;23:437-449.
10. Costa RH, Kalinichenko VV, Holterman AX, Wang X. Transcription factors in liver development, differentiation, and regeneration. HEPATOLOGY 2003;38:1331-1347.
11. Tan Y, Adami G, Costa RH. Maintaining HNF6 expression prevents AdHNF3beta-mediated decrease in hepatic levels of Glut-2 and glycogen. HEPATOLOGY 2002;35:790-798.
12. Holterman AX, Tan Y, Kim W, Yoo KW, Costa RH. Diminished hepatic expression of the HNF-6 transcription factor during bile duct obstruction. HEPATOLOGY 2002;35:1392-1399.
13. Clotman F, Lannoy VJ, Reber M, Cereghini S, Cassiman D, Jacquemin P, et al. The onecut transcription factor HNF6 is required for normal development of the biliary tract. Development 2002;129:1819-1828.
14. Lahuna O, Rastegar M, Maiter D, Thissen JP, Lemaigre FP, Rousseau GG. Involvement of STAT5 (signal transducer and activator of transcription 5) and HNF-4 (hepatocyte nuclear factor 4) in the transcriptional control of the hnf6 gene by growth hormone. Mol Endocrinol 2000;14:285-294.
15. Tan Y, Costa RH, Kovesdi I, Reichel RR. Adenovirus-mediated increase of HNF-3 levels stimulates expression of transthyretin and sonic hedgehog, which is associated with F9 cell differentiation toward the visceral endoderm lineage. Gene Expr 2001;9:237-248.
16. Tan Y, Hughes D, Wang X, Costa RH. Adenovirus-mediated increase in HNF-3beta or HNF-3alpha shows differences in levels of liver glycogen and gene expression. HEPATOLOGY 2002;35:30-39.
17. Ye H, Holterman AX, Yoo KW, Franks RR, Costa RH. Premature expression of the winged helix transcription factor HFH-11B in regenerating mouse liver accelerates hepatocyte entry into S phase. Mol Cell Biol 1999;19:8570-8580.
18. Rausa FM, Tan Y, Zhou H, Yoo KW, Stolz DB, Watkins SC, et al. Elevated levels of hepatocyte nuclear factor 3beta in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis. Mol Cell Biol 2000;20:8264-8282.
19. Rastegar M, Rousseau GG, Lemaigre FP. CCAAT/enhancer-binding protein-alpha is a component of the growth hormone-regulated network of liver transcription factors. Endocrinology 2000;141:1686-1692.
20. Rastegar M, Lemaigre FP, Rousseau GG. Control of gene expression by growth hormone in liver: key role of a network of transcription factors. Mol Cell Endocrinol 2000;164:1-4.
21. Landry C, Clotman F, Hioki T, Oda H, Picard JJ, Lemaigre FP, et al. HNF-6 is expressed in endoderm derivatives and nervous system of the mouse embryo and participates to the cross-regulatory network of liver-enriched transcription factors. Dev Biol 1997;192:247-257.
22. Stroup D, Chiang JY. HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1). J Lipid Res 2000;41:1-11.
23. Plebani M, Panozzo MP, Basso D, De Paoli M, Biasin R, Infantolino D. Cytokines and the progression of liver damage in experimental bile duct ligation. Clin Exp Pharmacol Physiol 1999;26:358-363.
24. Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, Moore LB, et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 2000;6:517-526.
25. Lu TT, Makishima M, Repa JJ, Schoonjans K, Kerr TA, Auwerx J, et al. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell 2000;6:507-515.
26. Gupta S, Stravitz RT, Dent P, Hylemon PB. Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway. J Biol Chem 2001;276:15816-15822.
27. Miyake JH, Wang SL, Davis RA. Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7alpha-hydroxylase. J Biol Chem 2000;275:21805-21808.
28. De Fabiani E, Mitro N, Anzulovich AC, Pinelli A, Galli G, Crestani M. The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors. J Biol Chem 2001;276:30708-30716.
29. Wang L, Lee YK, Bundman D, Han Y, Thevananther S, Kim CS, et al. Redundant pathways for negative feedback regulation of bile acid production. Dev Cell 2002;2:721-731.
30. Rudling M, Parini P, Angelin B. Effects of growth hormone on hepatic cholesterol metabolism. Lessons from studies in rats and humans. Growth Horm IGF Res 1999;9(Suppl A):1-7.
31. Monson JP. Long-term experience with GH replacement therapy: efficacy and safety. Eur J Endocrinol 2003;148(Suppl 2):S9-S14.