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Volumn 15, Issue 8, 2013, Pages

Dipeptidyl peptidase-4 inhibitors and their effects on the cardiovascular system

Author keywords

Cardiovascular disease; Dipeptidyl peptidase 4; Incretin; Type 2 diabetes mellitus

Indexed keywords

ANTIDIABETIC AGENT; DIPEPTIDYL PEPTIDASE IV INHIBITOR;

EID: 84879404228     PISSN: 15233782     EISSN: 15343170     Source Type: Journal    
DOI: 10.1007/s11886-013-0382-2     Document Type: Article
Times cited : (7)

References (63)
  • 1
    • 77649091668 scopus 로고    scopus 로고
    • American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus
    • Rodbard HW, Blonde L, Braithwaite SS, et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus. Endocr Pract. 2007;13:S1-68.
    • (2007) Endocr Pract. , vol.13
    • Rodbard, H.W.1    Blonde, L.2    Braithwaite, S.S.3
  • 2
    • 84865576863 scopus 로고    scopus 로고
    • Renal and cardiac effects of DPP-4 inhibitors-from preclinical development to clinical research
    • Hocher B, Reichetzeder C, Alter ML. Renal and Cardiac Effects of DPP-4 Inhibitors-from Preclinical Development to Clinical Research. Kidney Blood Press Res. 2012;36:65-84.
    • (2012) Kidney Blood Press Res. , vol.36 , pp. 65-84
    • Hocher, B.1    Reichetzeder, C.2    Alter, M.L.3
  • 3
    • 55849133043 scopus 로고    scopus 로고
    • Diabetes-related microvascular and macrovascular diseases in the physical therapy setting
    • Cade WT. Diabetes-related microvascular and macrovascular diseases in the physical therapy setting. Phys Ther. 2008;88:1322-35.
    • (2008) Phys Ther. , vol.88 , pp. 1322-1335
    • Cade, W.T.1
  • 4
    • 84861091379 scopus 로고    scopus 로고
    • Cardiovascular effects of the DPP-4 inhibitors
    • Jose T, Inzucchi SE. Cardiovascular effects of the DPP-4 inhibitors. Diab Vasc Dis Res. 2012;9:109-16.
    • (2012) Diab Vasc Dis Res. , vol.9 , pp. 109-116
    • Jose, T.1    Inzucchi, S.E.2
  • 6
    • 0002025725 scopus 로고
    • On the treatment of diabetes mellitus by acid extract of duodenal mucous membrane
    • Moore B, Edie ES, Abram JH. On the treatment of diabetes mellitus by acid extract of duodenal mucous membrane. Biochem J. 1906;1:28-38.
    • (1906) Biochem J. , vol.1 , pp. 28-38
    • Moore, B.1    Edie, E.S.2    Abram, J.H.3
  • 7
    • 0015791989 scopus 로고
    • Stimulation of insulin secretion by gastric inhibitory polypeptide in man
    • Dupre J, Ross SA, Watson D, et al. Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J Clin Endocrinol Metab. 1973;37:826-8.
    • (1973) J Clin Endocrinol Metab. , vol.37 , pp. 826-828
    • Dupre, J.1    Ross, S.A.2    Watson, D.3
  • 9
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: A physiological incretin in man
    • Kreymann B, Williams G, Ghatei MA, et al. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet. 1987;2:1300-4. (Pubitemid 17156636)
    • (1987) Lancet , vol.2 , Issue.8571 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 11
    • 47149095990 scopus 로고    scopus 로고
    • Pancreatic alpha-cell dysfunction in diabetes
    • Burcelin R, Knauf C, Cani P. Pancreatic alpha-cell dysfunction in diabetes. Diabetes Metab. 2008;34 Suppl 2:S49-55.
    • (2008) Diabetes Metab. , vol.34 , Issue.SUPPL. 2
    • Burcelin, R.1    Knauf, C.2    Cani, P.3
  • 12
    • 75549085755 scopus 로고    scopus 로고
    • Skeletal muscle insulin resistance is the primary defect in type 2 diabetes
    • DeFronzo RA, Tripathy D. Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care. 2009;32 Suppl 2:S157-63.
    • (2009) Diabetes Care. , vol.32 , Issue.SUPPL. 2
    • Defronzo, R.A.1    Tripathy, D.2
  • 13
    • 78650753885 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus: Properties, functions, and clinical implications
    • Nauck MA. Incretin-based therapies for type 2 diabetes mellitus: properties, functions, and clinical implications. Am J Med. 2011;124(1 Suppl):S3-18.
    • (2011) Am J Med. , vol.124 , Issue.1 SUPPL.
    • Nauck, M.A.1
  • 14
    • 57649234120 scopus 로고    scopus 로고
    • The incretin system and its role in type 2 diabetes mellitus
    • Holst JJ, Vilsbøll T, Deacon CF. The incretin system and its role in type 2 diabetes mellitus. Mol Cell Endocrinol. 2009;297:127-36.
    • (2009) Mol Cell Endocrinol. , vol.297 , pp. 127-136
    • Holst, J.J.1    Vilsbøll, T.2    Deacon, C.F.3
  • 15
    • 84876698450 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors: A new approach in diabetes treatment
    • Gaba M, Singh S, Gaba P. Dipeptidyl peptidase-4 inhibitors: a new approach in diabetes treatment. Int J Drug Dev Res. 2009;1:146-56.
    • (2009) Int J Drug Dev Res. , vol.1 , pp. 146-156
    • Gaba, M.1    Singh, S.2    Gaba, P.3
  • 16
    • 70349386312 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 (CD26): Knowing the function before inhibiting the enzyme
    • Matteucci E, Giampietro O. Dipeptidyl peptidase-4 (CD26): knowing the function before inhibiting the enzyme. Curr Med Chem. 2009;16:2943-51.
    • (2009) Curr Med Chem. , vol.16 , pp. 2943-2951
    • Matteucci, E.1    Giampietro, O.2
  • 17
    • 33748660679 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase IV activity as a therapy of Type 2 diabetes
    • DOI 10.1517/14728214.11.3.525
    • Green BD, Flatt PR, Bailey CJ. Inhibition of dipeptidylpeptidase IV activity as a therapy of type 2 diabetes. Expert Opin Emerg Drugs. 2006;11:525-39. (Pubitemid 44386374)
    • (2006) Expert Opinion on Emerging Drugs , vol.11 , Issue.3 , pp. 525-539
    • Green, B.D.1    Flatt, P.R.2    Bailey, C.J.3
  • 18
    • 84859174317 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: Systematic review and meta-analysis
    • Karagiannis T, Paschos P, Paletas K, et al. Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis. BMJ. 2012;344:e1369.
    • (2012) BMJ. , vol.344
    • Karagiannis, T.1    Paschos, P.2    Paletas, K.3
  • 20
    • 79961222810 scopus 로고    scopus 로고
    • Pharmacology of dipeptidyl peptidase-4 inhibitors: Similarities and differences
    • Baetta R, Corsini A. Pharmacology of dipeptidyl peptidase-4 inhibitors: similarities and differences. Drugs. 2011;71:1441-67.
    • (2011) Drugs. , vol.71 , pp. 1441-1467
    • Baetta, R.1    Corsini, A.2
  • 21
    • 77955456705 scopus 로고    scopus 로고
    • Pharmacokinetics of dipeptidylpeptidase-4 inhibitors
    • Scheen AJ. Pharmacokinetics of dipeptidylpeptidase-4 inhibitors. Diabetes Obes Metab. 2010;12:648-58.
    • (2010) Diabetes Obes Metab. , vol.12 , pp. 648-658
    • Scheen, A.J.1
  • 22
    • 84863436536 scopus 로고    scopus 로고
    • Comparative clinical pharmacokinetics of dipeptidyl peptidase-4 inhibitors
    • Golightly LK, Drayna CC, McDermott MT. Comparative clinical pharmacokinetics of dipeptidyl peptidase-4 inhibitors. Clin Pharmacokinet. 2012;51:501-14.
    • (2012) Clin Pharmacokinet. , vol.51 , pp. 501-514
    • Golightly, L.K.1    Drayna, C.C.2    McDermott, M.T.3
  • 23
    • 79960065540 scopus 로고    scopus 로고
    • Severe hypoglycemia by combination therapy with dipeptidyl peptidase-4 (DPP-4) inhibitors and sulfonylureas
    • Mukai E, Fujimoto S, Inagaki N. Severe hypoglycemia by combination therapy with dipeptidyl peptidase-4 (DPP-4) inhibitors and sulfonylureas. Nihon Rinsho. 2011;69:907-11.
    • (2011) Nihon Rinsho. , vol.69 , pp. 907-911
    • Mukai, E.1    Fujimoto, S.2    Inagaki, N.3
  • 24
    • 79955600633 scopus 로고    scopus 로고
    • GLP-1 agonists and dipeptidyl-peptidase IV inhibitors
    • Gallwitz B. GLP-1 agonists and dipeptidyl-peptidase IV inhibitors. Handb Exp Pharmacol. 2011;203:53-74.
    • (2011) Handb Exp Pharmacol. , vol.203 , pp. 53-74
    • Gallwitz, B.1
  • 25
    • 66749102158 scopus 로고    scopus 로고
    • Clinical review: The extrapancreatic effects of glucagon-like peptide-1 and related peptides
    • Abu-Hamdah R, Rabiee A, Meneilly GS, et al. Clinical review: The extrapancreatic effects of glucagon-like peptide-1 and related peptides. J Clin Endocrinol Metab. 2009;94:1843-52.
    • (2009) J Clin Endocrinol Metab. , vol.94 , pp. 1843-1852
    • Abu-Hamdah, R.1    Rabiee, A.2    Meneilly, G.S.3
  • 26
    • 4344605042 scopus 로고    scopus 로고
    • Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    • DOI 10.1161/01.CIR.0000139339.85840.DD
    • Nikolaidis LA, Elahi D, Hentosz T, et al. Recombinant glucagonlike peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation. 2004;110:955-61. (Pubitemid 39128621)
    • (2004) Circulation , vol.110 , Issue.8 , pp. 955-961
    • Nikolaidis, L.A.1    Elahi, D.2    Hentosz, T.3    Doverspike, A.4    Huerbin, R.5    Zourelias, L.6    Stolarski, C.7    Shen, Y.-T.8    Shannon, R.P.9
  • 27
    • 69549089903 scopus 로고    scopus 로고
    • The cardioprotective and inotropic components of the postconditioning effects of GLP-1 and GLP-1(9-36)a in an isolated rat heart
    • Ossum A, van Deurs U, Engstrøm T, et al. The cardioprotective and inotropic components of the postconditioning effects of GLP-1 and GLP-1(9-36)a in an isolated rat heart. Pharmacol Res. 2009;60:411-7.
    • (2009) Pharmacol Res. , vol.60 , pp. 411-417
    • Ossum, A.1    Van Deurs, U.2    Engstrøm, T.3
  • 28
    • 12144260853 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury
    • DOI 10.2337/diabetes.54.1.146
    • Bose AK, Mocanu MM, Carr RD, et al. Glucagon-like peptide-1 can directly protect the heart against ischemia/reperfusion injury. Diabetes. 2005;54:146-51. (Pubitemid 40105106)
    • (2005) Diabetes , vol.54 , Issue.1 , pp. 146-151
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Brand, C.L.4    Yellon, D.M.5
  • 29
    • 38149083367 scopus 로고    scopus 로고
    • Protective effects of GLP-1 analogues exendin-4 and GLP-1(9-36) amide against ischemiareperfusion injury in rat heart
    • Sonne DP, Engstrom T, Treiman M. Protective effects of GLP-1 analogues exendin-4 and GLP-1(9-36) amide against ischemiareperfusion injury in rat heart. Regul Pept. 2008;146:243-9.
    • (2008) Regul Pept. , vol.146 , pp. 243-249
    • Sonne, D.P.1    Engstrom, T.2    Treiman, M.3
  • 30
    • 58949084130 scopus 로고    scopus 로고
    • Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury
    • Timmers L, Henriques JPS, de Kleijin DPV, et al. Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury. J Am Coll Cardiol. 2009;53:501-10.
    • (2009) J Am Coll Cardiol. , vol.53 , pp. 501-510
    • Timmers, L.1    Henriques, J.P.S.2    De Kleijin, D.P.V.3
  • 31
    • 0032768616 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)- cells
    • DOI 10.1007/s001250051238
    • Buteau J, Roduit R, Susini S, et al. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells. Diabetologia. 1999;42:856-64. (Pubitemid 29325077)
    • (1999) Diabetologia , vol.42 , Issue.7 , pp. 856-864
    • Buteau, J.1    Roduit, R.2    Susini, S.3    Prentki, M.4
  • 32
    • 77949361812 scopus 로고    scopus 로고
    • Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice
    • Siragusa M, Katare R, Meloni M, et al. Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice. Circ Res. 2010;106:757-68.
    • (2010) Circ Res. , vol.106 , pp. 757-768
    • Siragusa, M.1    Katare, R.2    Meloni, M.3
  • 33
    • 77953807602 scopus 로고    scopus 로고
    • Antidiabetic drug voglibose is protective against ischemia-reperfusion injury through glucagons-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway in rabbits
    • Iwasa M, Kobayashi H, Yasuda S, et al. Antidiabetic drug voglibose is protective against ischemia-reperfusion injury through glucagons-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway in rabbits. J Cardiovasc Pharmacol. 2010;55:625-34.
    • (2010) J Cardiovasc Pharmacol. , vol.55 , pp. 625-634
    • Iwasa, M.1    Kobayashi, H.2    Yasuda, S.3
  • 34
    • 64649102619 scopus 로고    scopus 로고
    • GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice
    • Noyan-Ashraf MH, Momen MA, Ban K, et al. GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes. 2009;58:975-83.
    • (2009) Diabetes. , vol.58 , pp. 975-983
    • Noyan-Ashraf, M.H.1    Momen, M.A.2    Ban, K.3
  • 35
    • 79961231117 scopus 로고    scopus 로고
    • Both stimulation of GLP-1 receptors and inhibition of glycogenolysis additively contribute to a protective effect of oral miglitol against ischaemia-reperfusion injury in rabbits
    • Iwasa M, Yamada Y, Kobayashi H, et al. Both stimulation of GLP-1 receptors and inhibition of glycogenolysis additively contribute to a protective effect of oral miglitol against ischaemia-reperfusion injury in rabbits. Br J Pharmacol. 2011;164:119-31.
    • (2011) Br J Pharmacol. , vol.164 , pp. 119-131
    • Iwasa, M.1    Yamada, Y.2    Kobayashi, H.3
  • 36
    • 84871686739 scopus 로고    scopus 로고
    • GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE-/-Mice
    • Panjwani N, Mulvihill EE, Longuet C, et al. GLP-1 Receptor Activation Indirectly Reduces Hepatic Lipid Accumulation But Does Not Attenuate Development of Atherosclerosis in Diabetic Male ApoE-/-Mice. Endocrinology. 2013;154:127-39.
    • (2013) Endocrinology. , vol.154 , pp. 127-139
    • Panjwani, N.1    Mulvihill, E.E.2    Longuet, C.3
  • 37
    • 84860204551 scopus 로고    scopus 로고
    • Cardiovascular biology of the incretin system
    • Ussher JR, Drucker DJ. Cardiovascular biology of the incretin system. Endocr Rev. 2012;33:187-215.
    • (2012) Endocr Rev. , vol.33 , pp. 187-215
    • Ussher, J.R.1    Drucker, D.J.2
  • 39
    • 44049090880 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction
    • Saxena A, Fish JE, White MD, et al. Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation. 2008;117:2224-31.
    • (2008) Circulation. , vol.117 , pp. 2224-2231
    • Saxena, A.1    Fish, J.E.2    White, M.D.3
  • 40
    • 77953141744 scopus 로고    scopus 로고
    • Adenovirus-mediated stromal cellderived factor-1 alpha gene transfer improves cardiac structure and function after experimental myocardial infarction through angiogenic and antifibrotic actions
    • Tang J, Wang J, Song H, et al. Adenovirus-mediated stromal cellderived factor-1 alpha gene transfer improves cardiac structure and function after experimental myocardial infarction through angiogenic and antifibrotic actions. Mol Biol Rep. 2010;37:1957-69.
    • (2010) Mol Biol Rep. , vol.37 , pp. 1957-1969
    • Tang, J.1    Wang, J.2    Song, H.3
  • 41
    • 80055110463 scopus 로고    scopus 로고
    • Effects of DPP-4 inhibition on cardiac metabolism and function in mice
    • Lenski M, Kazakov A, Marx N, et al. Effects of DPP-4 inhibition on cardiac metabolism and function in mice. J Mol Cell Cardiol. 2011;51:906-18.
    • (2011) J Mol Cell Cardiol. , vol.51 , pp. 906-918
    • Lenski, M.1    Kazakov, A.2    Marx, N.3
  • 42
    • 77951812608 scopus 로고    scopus 로고
    • The myocardial infarct sizelimiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA
    • Ye Y, Keyes KT, Zhang C, et al. The myocardial infarct sizelimiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA. Am J Physiol Heart Circ Physiol. 2010;298:H1454-65.
    • (2010) Am J Physiol Heart Circ Physiol. , vol.298
    • Ye, Y.1    Keyes, K.T.2    Zhang, C.3
  • 43
    • 77951168113 scopus 로고    scopus 로고
    • Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice
    • Sauvé M, Ban K, Momen MA, et al. Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice. Diabetes. 2010;59:1063-73.
    • (2010) Diabetes. , vol.59 , pp. 1063-1073
    • Sauvé, M.1    Ban, K.2    Momen, M.A.3
  • 44
    • 77951934948 scopus 로고    scopus 로고
    • DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease
    • Read PA, Khan FZ, Heck PM, et al. DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease. Circ Cardiovasc Imaging. 2010;3:195-201.
    • (2010) Circ Cardiovasc Imaging. , vol.3 , pp. 195-201
    • Read, P.A.1    Khan, F.Z.2    Heck, P.M.3
  • 45
    • 84872565644 scopus 로고    scopus 로고
    • The dipeptidyl peptidase-4 inhibitor sitagliptin improves vascular endothelial function in type 2 diabetes
    • Kubota Y, Miyamoto M, Takagi G, et al. The dipeptidyl peptidase-4 inhibitor sitagliptin improves vascular endothelial function in type 2 diabetes. J Korean Med Sci. 2012;27:1364-70.
    • (2012) J Korean Med Sci. , vol.27 , pp. 1364-1370
    • Kubota, Y.1    Miyamoto, M.2    Takagi, G.3
  • 46
    • 84862908699 scopus 로고    scopus 로고
    • A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice
    • Matsubara J, Sugiyama S, Sugamura K, et al. A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice. J Am Coll Cardiol. 2012;59:265-76.
    • (2012) J Am Coll Cardiol. , vol.59 , pp. 265-276
    • Matsubara, J.1    Sugiyama, S.2    Sugamura, K.3
  • 47
    • 80051785333 scopus 로고    scopus 로고
    • DPP-4 (CD26) inhibitor alogliptin inhibits atherosclerosis in diabetic apolipoprotein E-deficient mice
    • Ta NN, Schuyler CA, Li Y, et al. DPP-4 (CD26) inhibitor alogliptin inhibits atherosclerosis in diabetic apolipoprotein E-deficient mice. J Cardiovasc Pharmacol. 2011;58:157-66.
    • (2011) J Cardiovasc Pharmacol. , vol.58 , pp. 157-166
    • Ta, N.N.1    Schuyler, C.A.2    Li, Y.3
  • 48
    • 84861844675 scopus 로고    scopus 로고
    • Sitagliptin promotes macrophage-to-faeces reverse cholesterol transport through reduced intestinal cholesterol absorption in obese insulin resistant CETPapoB100 transgenic mice
    • Briand F, Thieblemont Q, Burcelin R, et al. Sitagliptin promotes macrophage-to-faeces reverse cholesterol transport through reduced intestinal cholesterol absorption in obese insulin resistant CETPapoB100 transgenic mice. Diabetes Obes Metab. 2012;14:662-5.
    • (2012) Diabetes Obes Metab. , vol.14 , pp. 662-665
    • Briand, F.1    Thieblemont, Q.2    Burcelin, R.3
  • 49
    • 77955406467 scopus 로고    scopus 로고
    • Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat)
    • Ferreira L, Teixeira-de-Lemos E, Pinto F, et al. Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat). Mediators Inflamm. 2010;2010:592760.
    • (2010) Mediators Inflamm. , vol.2010 , pp. 592760
    • Ferreira, L.1    Teixeira-De-Lemos, E.2    Pinto, F.3
  • 50
    • 33746690405 scopus 로고    scopus 로고
    • Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes
    • DOI 10.1007/s00125-006-0340-2
    • Matikainen N, Mänttäri S, Schweizer A, et al. Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes. Diabetologia. 2006;49(9):2049-57. (Pubitemid 44168471)
    • (2006) Diabetologia , vol.49 , Issue.9 , pp. 2049-2057
    • Matikainen, N.1    Manttari, S.2    Schweizer, A.3    Ulvestad, A.4    Mills, D.5    Dunning, B.E.6    Foley, J.E.7    Taskinen, M.-R.8
  • 51
    • 79951677095 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition attenuates blood pressure rising in young spontaneously hypertensive rats
    • Pacheco BP, Crajoinas RO, Couto GK, et al. Dipeptidyl peptidase IV inhibition attenuates blood pressure rising in young spontaneously hypertensive rats. J Hypertens. 2011;29:520-8.
    • (2011) J Hypertens. , vol.29 , pp. 520-528
    • Pacheco, B.P.1    Crajoinas, R.O.2    Couto, G.K.3
  • 54
    • 79955952000 scopus 로고    scopus 로고
    • Sitagliptin, a dipeptidyl peptidase-4 inhibitor, decreases systolic blood pressure in Japanese hypertensive patients with type 2 diabetes
    • Ogawa S, Ishiki M, Nako K, et al. Sitagliptin, a dipeptidyl peptidase-4 inhibitor, decreases systolic blood pressure in Japanese hypertensive patients with type 2 diabetes. Tohoku J Exp Med. 2011;223(2):133-5.
    • (2011) Tohoku J Exp Med. , vol.223 , Issue.2 , pp. 133-135
    • Ogawa, S.1    Ishiki, M.2    Nako, K.3
  • 55
    • 84856971572 scopus 로고    scopus 로고
    • Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: Implications for the coronary microvasculature of myocardial infarction patients
    • Krijnen PA, Hahn NE, Kholová I, et al. Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients. Basic Res Cardiol. 2012;107:1-13.
    • (2012) Basic Res Cardiol. , vol.107 , pp. 1-13
    • Krijnen, P.A.1    Hahn, N.E.2    Kholová, I.3
  • 56
    • 84868618976 scopus 로고    scopus 로고
    • Sitagliptin: Anti-platelet effect in diabetes and healthy volunteers
    • Gupta AK, Verma AK, Kailashiya J, et al. Sitagliptin: Anti-platelet effect in diabetes and healthy volunteers. Platelets. 2012;23:565-70.
    • (2012) Platelets. , vol.23 , pp. 565-570
    • Gupta, A.K.1    Verma, A.K.2    Kailashiya, J.3
  • 57
    • 84865492997 scopus 로고    scopus 로고
    • Meta-analysis of effect of dipeptidyl peptidase-4 inhibitors on cardiovascular risk in type 2 diabetes mellitus
    • Patil HR, Al Badarin FJ, Al Shami HA, et al. Meta-analysis of effect of dipeptidyl peptidase-4 inhibitors on cardiovascular risk in type 2 diabetes mellitus. Am J Cardiol. 2012;110:826-33.
    • (2012) Am J Cardiol. , vol.110 , pp. 826-833
    • Patil, H.R.1    Al Badarin, F.J.2    Al Shami, H.A.3
  • 59
    • 81255201441 scopus 로고    scopus 로고
    • The design and rationale of the saxagliptin assessment of vascular outcomes recorded in patients with diabetes mellitus-thrombolysis in myocardial infarction (SAVOR-TIMI) 53 study
    • Scirica BM, Bhatt DL, Braunwald E, et al. The design and rationale of the saxagliptin assessment of vascular outcomes recorded in patients with diabetes mellitus-thrombolysis in myocardial infarction (SAVOR-TIMI) 53 study. Am Heart J. 2011;162:818-25.
    • (2011) Am Heart J. , vol.162 , pp. 818-825
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3
  • 60
    • 84855770694 scopus 로고    scopus 로고
    • Saxagliptin for the treatment of type 2 diabetes mellitus: Assessing cardiovascular data
    • Cobble ME, Frederich R. Saxagliptin for the treatment of type 2 diabetes mellitus: assessing cardiovascular data. Cardiovasc Diabetol. 2012;11:6.
    • (2012) Cardiovasc Diabetol. , vol.11 , pp. 6
    • Cobble, M.E.1    Frederich, R.2
  • 61
    • 84855481995 scopus 로고    scopus 로고
    • Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: A pre-specified, prospective, and adjudicated meta-analysis of a phase 3 programme
    • Johansen OE, Neubacher D, von Eynatten M, et al. Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: a pre-specified, prospective, and adjudicated meta-analysis of a phase 3 programme. Cardiovasc Diabetol. 2012;11:3.
    • (2012) Cardiovasc Diabetol. , vol.11 , pp. 3
    • Johansen, O.E.1    Neubacher, D.2    Von Eynatten, M.3
  • 62
    • 84864757433 scopus 로고    scopus 로고
    • 2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: A randomised, double-blind, non-inferiority trial
    • Gallwitz B, Rosenstock J, Rauch T, et al. 2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial. Lancet. 2012;380:475-83.
    • (2012) Lancet. , vol.380 , pp. 475-483
    • Gallwitz, B.1    Rosenstock, J.2    Rauch, T.3
  • 63
    • 80053650554 scopus 로고    scopus 로고
    • EXamination of cArdiovascular outcoMes with alogliptIN versus standard of carE in patients with type 2 diabetes mellitus and acute coronary syndrome (EXAMINE): A cardiovascular safety study of the dipeptidyl peptidase 4 inhibitor alogliptin in patients with type 2 diabetes with acute coronary syndrome
    • White WB, Bakris GL, Bergenstal RM, et al. EXamination of cArdiovascular outcoMes with alogliptIN versus standard of carE in patients with type 2 diabetes mellitus and acute coronary syndrome (EXAMINE): a cardiovascular safety study of the dipeptidyl peptidase 4 inhibitor alogliptin in patients with type 2 diabetes with acute coronary syndrome. Am Heart J. 2011;162:620-6.
    • (2011) Am Heart J. , vol.162 , pp. 620-626
    • White, W.B.1    Bakris, G.L.2    Bergenstal, R.M.3


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