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Volumn 121, Issue 17, 2013, Pages 3386-3395

The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; PERFORIN; PROTEIN KINASE FYN; SIGNALING LYMPHOCYTE ACTIVATION MOLECULE ASSOCIATED PROTEIN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; FYN PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; SH2D1A PROTEIN, HUMAN; SH2D1A PROTEIN, MOUSE; SIGNAL PEPTIDE;

EID: 84879397070     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-11-468868     Document Type: Article
Times cited : (29)

References (44)
  • 2
    • 17344372694 scopus 로고    scopus 로고
    • Host response to ebv infection in x-linked lymphoproliferative disease results from mutations in an sh2-domain encoding gene
    • Coffey AJ, Brooksbank RA, Brandau O, et al. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Nat Genet. 1998;20(2):129-135.
    • (1998) Nat Genet. , vol.20 , Issue.2 , pp. 129-135
    • Coffey, A.J.1    Brooksbank, R.A.2    Brandau, O.3
  • 3
    • 13144278345 scopus 로고    scopus 로고
    • Inactivating mutations in an sh2 domain-encoding gene in x-linked lymphoproliferative syndrome
    • Nichols KE, Harkin DP, Levitz S, et al. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci USA. 1998; 95(23):13765-13770.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.23 , pp. 13765-13770
    • Nichols, K.E.1    Harkin, D.P.2    Levitz, S.3
  • 4
    • 0032190081 scopus 로고    scopus 로고
    • The x-linked lymphoproliferative-disease gene product sap regulates signals induced through the co-receptor Slam
    • Sayos J, Wu C, Morra M, et al. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature. 1998;395(6701):462-469.
    • (1998) Nature , vol.395 , Issue.6701 , pp. 462-469
    • Sayos, J.1    Wu, C.2    Morra, M.3
  • 5
    • 20144387328 scopus 로고    scopus 로고
    • Regulation of nkt cell development by sap, the protein defective in Xlp
    • Nichols KE, Hom J, Gong SY, et al. Regulation of NKT cell development by SAP, the protein defective in XLP. Nat Med. 2005;11(3):340-345.
    • (2005) Nat Med. , vol.11 , Issue.3 , pp. 340-345
    • Nichols, K.E.1    Hom, J.2    Gong, S.Y.3
  • 6
    • 15444374149 scopus 로고    scopus 로고
    • Defective nkt cell development in mice and humans lacking the adapter sap, the x-linked lymphoproliferative syndrome gene product
    • Pasquier B, Yin L, Fondanèche MC, et al. Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product. J Exp Med. 2005;201(5):695-701.
    • (2005) J Exp Med. , vol.201 , Issue.5 , pp. 695-701
    • Pasquier, B.1    Yin, L.2    Fondanèche, M.C.3
  • 7
    • 14844339362 scopus 로고    scopus 로고
    • Signaling lymphocytic activation molecule-associated protein controls nkt cell functions
    • Chung B, Aoukaty A, Dutz J, Terhorst C, Tan R. Signaling lymphocytic activation molecule-associated protein controls NKT cell functions. J Immunol. 2005;174(6):3153-3157.
    • (2005) J Immunol. , vol.174 , Issue.6 , pp. 3153-3157
    • Chung, B.1    Aoukaty, A.2    Dutz, J.3    Terhorst, C.4    Tan, R.5
  • 8
    • 63149122455 scopus 로고    scopus 로고
    • The adaptor molecule signaling lymphocytic activation molecule-associated protein (sap) regulates ifn-gamma and il-4 production in v alpha 14 transgenic nkt cells via effects on gata-3 and t-bet expression
    • Cen O, Ueda A, Guzman L, Jain J, Bassiri H, Nichols KE, Stein PL. The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression. J Immunol. 2009;182(3):1370-1378.
    • (2009) J Immunol , vol.182 , Issue.3 , pp. 1370-1378
    • Cen, O.1    Ueda, A.2    Guzman, L.3    Jain, J.4    Bassiri, H.5    Nichols, K.E.6    Stein, P.L.7
  • 9
    • 0035912823 scopus 로고    scopus 로고
    • Altered lymphocyte responses and cytokine production in mice deficient in the x-linked lymphoproliferative disease gene Sh2d1a/dshp/sap
    • Czar MJ, Kersh EN, Mijares LA, et al. Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP. Proc Natl Acad Sci USA. 2001;98(13):7449-7454.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.13 , pp. 7449-7454
    • Czar, M.J.1    Kersh, E.N.2    Mijares, L.A.3
  • 10
    • 0031589555 scopus 로고    scopus 로고
    • Regulation of cre recombinase activity by mutated estrogen receptor ligand-binding domains
    • Feil R, Wagner J, Metzger D, Chambon P. Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains. Biochem Biophys Res Commun. 1997; 237(3):752-757.
    • (1997) Biochem Biophys Res Commun , vol.237 , Issue.3 , pp. 752-757
    • Feil, R.1    Wagner, J.2    Metzger, D.3    Chambon, P.4
  • 12
    • 8444231176 scopus 로고    scopus 로고
    • Genetic evidence linking sap, the x-linked lymphoproliferative gene product, to src-related kinase fynt in t(h)2 cytokine regulation
    • Davidson D, Shi X, Zhang S, et al. Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation. Immunity. 2004;21(5):707-717.
    • (2004) Immunity , vol.21 , Issue.5 , pp. 707-717
    • Davidson, D.1    Shi, X.2    Zhang, S.3
  • 13
    • 0037143734 scopus 로고    scopus 로고
    • Wiskott-aldrich syndrome protein is required for nk cell cytotoxicity and colocalizes with actin to nk cell-activating immunologic synapses
    • Orange JS, Ramesh N, Remold-O’Donnell E, et al. Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses. Proc Natl Acad Sci USA. 2002;99(17):11351-11356.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.17 , pp. 11351-11356
    • Orange, J.S.1    Ramesh, N.2    Remold-O’Donnell, E.3
  • 14
    • 84455172954 scopus 로고    scopus 로고
    • Mas-related gene x2 (mrgx2) is a novel g protein-coupled receptor for the antimicrobial peptide ll-37 in human mast cells: Resistance to receptor phosphorylation, desensitization, and internalization
    • Subramanian H, Gupta K, Guo Q, Price R, Ali H. Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization. J Biol Chem. 2011;286(52):44739-44749.
    • (2011) J Biol Chem. , vol.286 , Issue.52 , pp. 44739-44749
    • Subramanian, H.1    Gupta, K.2    Guo, Q.3    Price, R.4    Ali, H.5
  • 15
    • 77951203795 scopus 로고    scopus 로고
    • Quantitative measurement of f-actin accumulation at the nk cell immunological synapse
    • Banerjee PP, Orange JS. Quantitative measurement of F-actin accumulation at the NK cell immunological synapse. J Immunol Methods. 2010;355(1-2):1-13.
    • (2010) J Immunol Methods , vol.355 , Issue.1-2 , pp. 1-13
    • Banerjee, P.P.1    Orange, J.S.2
  • 16
    • 0028208701 scopus 로고
    • A subset of Cd4+ thymocytes selected by mhc class i molecules
    • Bendelac A, Killeen N, Littman DR, Schwartz RH. A subset of CD4+ thymocytes selected by MHC class I molecules. Science. 1994;263(5154):1774-1778.
    • (1994) Science , vol.263 , Issue.5154 , pp. 1774-1778
    • Bendelac, A.1    Killeen, N.2    Littman, D.R.3    Schwartz, R.H.4
  • 17
    • 79959729423 scopus 로고    scopus 로고
    • Conditional deletion of slp-76 in mature t cells abrogates peripheral immune responses
    • Wu GF, Corbo E, Schmidt M, et al. Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses. Eur J Immunol. 2011;41(7):2064-2073.
    • (2011) Eur J Immunol , vol.41 , Issue.7 , pp. 2064-2073
    • Wu, G.F.1    Corbo, E.2    Schmidt, M.3
  • 18
    • 84863562322 scopus 로고    scopus 로고
    • Sap expression in invariant nkt cells is required for cognate help to support b-cell responses
    • Detre C, Keszei M, Garrido-Mesa N, et al. SAP expression in invariant NKT cells is required for cognate help to support B-cell responses. Blood. 2012;120(1):122-129.
    • (2012) Blood , vol.120 , Issue.1 , pp. 122-129
    • Detre, C.1    Keszei, M.2    Garrido-Mesa, N.3
  • 19
    • 79960448230 scopus 로고    scopus 로고
    • Anti-tumor potential of type-i nkt cells against cd1d-positive and cd1d-negative tumors in humans
    • Metelitsa LS. Anti-tumor potential of type-I NKT cells against CD1d-positive and CD1d-negative tumors in humans. Clin Immunol. 2011; 140(2):119-129.
    • (2011) Clin Immunol , vol.140 , Issue.2 , pp. 119-129
    • Metelitsa, L.S.1
  • 20
    • 0035884974 scopus 로고    scopus 로고
    • Human nkt cells mediate antitumor cytotoxicity directly by recognizing target cell cd1d with bound ligand or indirectly by producing il-2 to activate nk cells
    • Metelitsa LS, Naidenko OV, Kant A, et al. Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells. J Immunol. 2001;167(6):3114-3122.
    • (2001) J Immunol , vol.167 , Issue.6 , pp. 3114-3122
    • Metelitsa, L.S.1    Naidenko, O.V.2    Kant, A.3
  • 21
    • 0038040624 scopus 로고    scopus 로고
    • Expression of cd1d by myelomonocytic leukemias provides a target for cytotoxic nkt cells
    • Metelitsa LS, Weinberg KI, Emanuel PD, Seeger RC. Expression of CD1d by myelomonocytic leukemias provides a target for cytotoxic NKT cells. Leukemia. 2003;17(6):1068-1077.
    • (2003) Leukemia , vol.17 , Issue.6 , pp. 1068-1077
    • Metelitsa, L.S.1    Weinberg, K.I.2    Emanuel, P.D.3    Seeger, R.C.4
  • 22
    • 0035313175 scopus 로고    scopus 로고
    • Trail expression by activated human Cd4(+)v alpha 24nkt cells induces in vitro and in vivo apoptosis of human acute myeloid leukemia cells
    • Nieda M, Nicol A, Koezuka Y, et al. TRAIL expression by activated human CD4(+)V alpha 24NKT cells induces in vitro and in vivo apoptosis of human acute myeloid leukemia cells. Blood. 2001;97(7):2067-2074.
    • (2001) Blood , vol.97 , Issue.7 , pp. 2067-2074
    • Nieda, M.1    Nicol, A.2    Koezuka, Y.3
  • 23
    • 66349083007 scopus 로고    scopus 로고
    • Valpha24-invariant nkt cells mediate antitumor activity via killing of tumor-associated macrophages
    • Song L, Asgharzadeh S, Salo J, et al. Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages. J Clin Invest. 2009;119(6):1524-1536.
    • (2009) J Clin Invest , vol.119 , Issue.6 , pp. 1524-1536
    • Song, L.1    Asgharzadeh, S.2    Salo, J.3
  • 24
    • 56849090964 scopus 로고    scopus 로고
    • The role of nkt cells in tumor immunity
    • Terabe M, Berzofsky JA. The role of NKT cells in tumor immunity. Adv Cancer Res. 2008;101:277-348.
    • (2008) Adv Cancer Res. , vol.101 , pp. 277-348
    • Terabe, M.1    Berzofsky, J.A.2
  • 25
    • 27144508418 scopus 로고    scopus 로고
    • Negative regulation of natural killer cell function by eat-2, a sap-related adaptor
    • Roncagalli R, Taylor JE, Zhang S, et al. Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor. Nat Immunol. 2005;6(10):1002-1010.
    • (2005) Nat Immunol , vol.6 , Issue.10 , pp. 1002-1010
    • Roncagalli, R.1    Taylor, J.E.2    Zhang, S.3
  • 27
    • 0037320641 scopus 로고    scopus 로고
    • Sap couples fyn to slam immune receptors
    • Chan B, Lanyi A, Song HK, et al. SAP couples Fyn to SLAM immune receptors. Nat Cell Biol. 2003;5(2):155-160.
    • (2003) Nat Cell Biol. , vol.5 , Issue.2 , pp. 155-160
    • Chan, B.1    Lanyi, A.2    Song, H.K.3
  • 28
    • 0037322612 scopus 로고    scopus 로고
    • Binding of sap sh2 domain to fynt sh3 domain reveals a novel mechanism of receptor signalling in immune regulation
    • Latour S, Roncagalli R, Chen R, et al. Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation. Nat Cell Biol. 2003;5(2):149-154.
    • (2003) Nat Cell Biol. , vol.5 , Issue.2 , pp. 149-154
    • Latour, S.1    Roncagalli, R.2    Chen, R.3
  • 29
    • 53149083028 scopus 로고    scopus 로고
    • Differential requirement for the sap-fyn interaction during nk t cell development and function
    • Nunez-Cruz S, Yeo WC, Rothman J, et al. Differential requirement for the SAP-Fyn interaction during NK T cell development and function. J Immunol. 2008;181(4):2311-2320.
    • (2008) J Immunol , vol.181 , Issue.4 , pp. 2311-2320
    • Nunez-Cruz, S.1    Yeo, W.C.2    Rothman, J.3
  • 30
    • 22344436371 scopus 로고    scopus 로고
    • Regulation of natural cytotoxicity by the adaptor sap and the src-related kinase fyn
    • Bloch-Queyrat C, Fondanèche MC, Chen R, et al. Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn. J Exp Med. 2005;202(1):181-192.
    • (2005) J Exp Med. , vol.202 , Issue.1 , pp. 181-192
    • Bloch-Queyrat, C.1    Fondanèche, M.C.2    Chen, R.3
  • 31
    • 84862976954 scopus 로고    scopus 로고
    • The adaptor sap controls nk cell activation by regulating the enzymes vav-1 and ship-1 and by enhancing conjugates with target cells
    • Dong Z, Davidson D, Pérez-Quintero LA, Kurosaki T, Swat W, Veillette A. The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells. Immunity. 2012; 36(6):974-985.
    • (2012) Immunity , vol.36 , Issue.6 , pp. 974-985
    • Dong, Z.1    Davidson, D.2    Pérez-Quintero, L.A.3    Kurosaki, T.4    Swat, W.5    Veillette, A.6
  • 32
    • 76949091588 scopus 로고    scopus 로고
    • Optimal germinal center responses require a multistage t cell:B cell adhesion process involving integrins, slam-associated protein, and cd84
    • Cannons JL, Qi H, Lu KT, et al. Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity. 2010; 32(2):253-265.
    • (2010) Immunity , vol.32 , Issue.2 , pp. 253-265
    • Cannons, J.L.1    Qi, H.2    Lu, K.T.3
  • 33
    • 82455175808 scopus 로고    scopus 로고
    • Molecular pathogenesis of ebv susceptibility in xlp as revealed by analysis of female carriers with heterozygous expression of Sap
    • Palendira U, Low C, Chan A, et al. Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP. PLoS Biol. 2011;9(11):e1001187.
    • (2011) Plos Biol , vol.9 , Issue.11
    • Palendira, U.1    Low, C.2    Chan, A.3
  • 34
    • 53649107278 scopus 로고    scopus 로고
    • Sap-controlled t-b cell interactions underlie germinal centre formation
    • Qi H, Cannons JL, Klauschen F, Schwartzberg PL, Germain RN. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature. 2008;455(7214):764-769.
    • (2008) Nature , vol.455 , Issue.7214 , pp. 764-769
    • Qi, H.1    Cannons, J.L.2    Klauschen, F.3    Schwartzberg, P.L.4    Germain, R.N.5
  • 35
    • 84863001429 scopus 로고    scopus 로고
    • Positive and negative signaling through slam receptors regulate synapse organization and thresholds of cytolysis
    • Zhao F, Cannons JL, Dutta M, Griffiths GM, Schwartzberg PL. Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis. Immunity. 2012;36(6):1003-1016.
    • (2012) Immunity , vol.36 , Issue.6 , pp. 1003-1016
    • Zhao, F.1    Cannons, J.L.2    Dutta, M.3    Griffiths, G.M.4    Schwartzberg, P.L.5
  • 36
    • 2442477638 scopus 로고    scopus 로고
    • Sap increases fynt kinase activity and is required for phosphorylation of slam and ly9
    • Simarro M, Lanyi A, Howie D, et al. SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9. Int Immunol. 2004;16(5):727-736.
    • (2004) Int Immunol , vol.16 , Issue.5 , pp. 727-736
    • Simarro, M.1    Lanyi, A.2    Howie, D.3
  • 37
    • 0026612411 scopus 로고
    • Pp59fyn mutant mice display differential signaling in thymocytes and peripheral t cells
    • Stein PL, Lee HM, Rich S, Soriano P. pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell. 1992; 70(5):741-750.
    • (1992) Cell , vol.70 , Issue.5 , pp. 741-750
    • Stein, P.L.1    Lee, H.M.2    Rich, S.3    Soriano, P.4
  • 38
    • 0347915637 scopus 로고    scopus 로고
    • Fyn and ptp-pest-mediated regulation of wiskott-aldrich syndrome protein (wasp) tyrosine phosphorylation is required for coupling t cell antigen receptor engagement to wasp effector function and t cell activation
    • Badour K, Zhang J, Shi F, Leng Y, Collins M, Siminovitch KA. Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation. J Exp Med. 2004;199(1):99-112.
    • (2004) J Exp Med. , vol.199 , Issue.1 , pp. 99-112
    • Badour, K.1    Zhang, J.2    Shi, F.3    Leng, Y.4    Collins, M.5    Siminovitch, K.A.6
  • 39
    • 0038392871 scopus 로고    scopus 로고
    • Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in wasp
    • Torres E, Rosen MK. Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP. Mol Cell. 2003; 11(5):1215-1227.
    • (2003) Mol Cell , vol.11 , Issue.5 , pp. 1215-1227
    • Torres, E.1    Rosen, M.K.2
  • 40
    • 33645643086 scopus 로고    scopus 로고
    • Protein-tyrosine kinase and gtpase signals cooperate to phosphorylate and activate wiskott-aldrich syndrome protein (wasp)/neuronal wasp
    • Torres E, Rosen MK. Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP. J Biol Chem. 2006; 281(6):3513-3520.
    • (2006) J Biol Chem. , vol.281 , Issue.6 , pp. 3513-3520
    • Torres, E.1    Rosen, M.K.2
  • 41
    • 0034718608 scopus 로고    scopus 로고
    • T-cell receptor antagonists induce vav phosphorylation by selective activation of fyn kinase
    • Huang J, Tilly D, Altman A, Sugie K, Grey HM. T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase. Proc Natl Acad Sci USA. 2000;97(20):10923-10929.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.20 , pp. 10923-10929
    • Huang, J.1    Tilly, D.2    Altman, A.3    Sugie, K.4    Grey, H.M.5
  • 42
    • 33646038284 scopus 로고    scopus 로고
    • Role of fyn in the rearrangement of tubulin cytoskeleton induced through Tcr
    • Martín-Cófreces NB, Sancho D, Fernández E, et al. Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR. J Immunol. 2006;176(7):4201-4207.
    • (2006) J Immunol , vol.176 , Issue.7 , pp. 4201-4207
    • Martín-Cófreces, N.B.1    Sancho, D.2    Fernández, E.3
  • 43
    • 0033610868 scopus 로고    scopus 로고
    • Fyn and zap-70 are required for vav phosphorylation in t cells stimulated by antigen-presenting cells
    • Michel F, Grimaud L, Tuosto L, Acuto O. Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells. J Biol Chem. 1998;273(48):31932-31938.
    • (1998) J Biol Chem. , vol.273 , Issue.48 , pp. 31932-31938
    • Michel, F.1    Grimaud, L.2    Tuosto, L.3    Acuto, O.4


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