메뉴 건너뛰기




Volumn 121, Issue 17, 2013, Pages 3434-3446

RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes

Author keywords

[No Author keywords available]

Indexed keywords

BMI1 PROTEIN; GRANULOCYTE COLONY STIMULATING FACTOR; MUTANT PROTEIN; TRANSCRIPTION FACTOR RUNX1; BMI1 PROTEIN, HUMAN; CD34 ANTIGEN; MESSENGER RNA; RUNX1 PROTEIN, HUMAN;

EID: 84879350954     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-06-434423     Document Type: Article
Times cited : (27)

References (50)
  • 1
    • 0032830638 scopus 로고    scopus 로고
    • Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia
    • Song WJ, Sullivan MG, Legare RD, et al. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet. 1999; 23(2):166-175.
    • (1999) Nat Genet , vol.23 , Issue.2 , pp. 166-175
    • Song, W.J.1    Sullivan, M.G.2    Legare, R.D.3
  • 2
    • 2942667930 scopus 로고    scopus 로고
    • Point mutations in the RUNX1/AML1 gene: Another actor in RUNX leukemia
    • Osato M. Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia. Oncogene. 2004;23(24):4284-4296.
    • (2004) Oncogene , vol.23 , Issue.24 , pp. 4284-4296
    • Osato, M.1
  • 3
    • 80053646494 scopus 로고    scopus 로고
    • Familial myelodysplastic syndromes: A review of the literature
    • Liew E, Owen C. Familial myelodysplastic syndromes: a review of the literature. Haematologica. 2011;96(10):1536-1542.
    • (2011) Haematologica , vol.96 , Issue.10 , pp. 1536-1542
    • Liew, E.1    Owen, C.2
  • 4
    • 1542373639 scopus 로고    scopus 로고
    • High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia
    • Harada H, Harada Y, Niimi H, Kyo T, Kimura A, Inaba T. High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia. Blood. 2004; 103(6):2316-2324.
    • (2004) Blood , vol.103 , Issue.6 , pp. 2316-2324
    • Harada, H.1    Harada, Y.2    Niimi, H.3    Kyo, T.4    Kimura, A.5    Inaba, T.6
  • 5
    • 0034667690 scopus 로고    scopus 로고
    • High incidence of biallelic point mutations in the runt domain of the AML1/PEBP2 alpha B gene in mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21
    • Preudhomme C, Warot-Loze D, Roumier C, et al. High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2 alpha B gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21. Blood. 2000;96(8):2862-2869.
    • (2000) Blood , vol.96 , Issue.8 , pp. 2862-2869
    • Preudhomme, C.1    Warot-Loze, D.2    Roumier, C.3
  • 6
    • 34548044732 scopus 로고    scopus 로고
    • Trisomy 13 is strongly associated with AML1/RUNX1 mutations and increased FLT3 expression in acute myeloid leukemia
    • Dicker F, Haferlach C, Kern W, Haferlach T, Schnittger S. Trisomy 13 is strongly associated with AML1/RUNX1 mutations and increased FLT3 expression in acute myeloid leukemia. Blood. 2007;110(4):1308-1316.
    • (2007) Blood , vol.110 , Issue.4 , pp. 1308-1316
    • Dicker, F.1    Haferlach, C.2    Kern, W.3    Haferlach, T.4    Schnittger, S.5
  • 7
    • 70449429509 scopus 로고    scopus 로고
    • Gene expression profiling of minimally differentiated acute myeloid leukemia: M0 is a distinct entity subdivided by RUNX1 mutation status
    • Silva FPG, Swagemakers SMA, Erpelinck-Verschueren C, et al. Gene expression profiling of minimally differentiated acute myeloid leukemia: M0 is a distinct entity subdivided by RUNX1 mutation status. Blood. 2009;114(14):3001-3007.
    • (2009) Blood , vol.114 , Issue.14 , pp. 3001-3007
    • Silva, F.P.G.1    Swagemakers, S.M.A.2    Erpelinck-Verschueren, C.3
  • 8
    • 73949090504 scopus 로고    scopus 로고
    • AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: Prognostic implication and interaction with other gene alterations
    • Tang JL, Hou HA, Chen CY, et al. AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations. Blood. 2009;114(26):5352-5361.
    • (2009) Blood , vol.114 , Issue.26 , pp. 5352-5361
    • Tang, J.L.1    Hou, H.A.2    Chen, C.Y.3
  • 9
    • 79952134550 scopus 로고    scopus 로고
    • RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis
    • Schnittger S, Dicker F, Kern W, et al. RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis. Blood. 2011;117(8):2348-2357.
    • (2011) Blood , vol.117 , Issue.8 , pp. 2348-2357
    • Schnittger, S.1    Dicker, F.2    Kern, W.3
  • 10
    • 68749109365 scopus 로고    scopus 로고
    • RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at the c-terminal region might predict acute myeloid leukemia transformation
    • Kuo MC, Liang DC, Huang CF, et al. RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at the C-terminal region might predict acute myeloid leukemia transformation. Leukemia. 2009;23(8):1426-1431.
    • (2009) Leukemia , vol.23 , Issue.8 , pp. 1426-1431
    • Kuo, M.C.1    Liang, D.C.2    Huang, C.F.3
  • 11
    • 77956864003 scopus 로고    scopus 로고
    • Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms
    • Ernst T, Chase A, Zoi K, et al. Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms. Haematologica. 2010;95(9):1473-1480.
    • (2010) Haematologica , vol.95 , Issue.9 , pp. 1473-1480
    • Ernst, T.1    Chase, A.2    Zoi, K.3
  • 12
    • 0037438508 scopus 로고    scopus 로고
    • Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia
    • Harada H, Harada Y, Tanaka H, Kimura A, Inaba T. Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia. Blood. 2003;101(2):673-680.
    • (2003) Blood , vol.101 , Issue.2 , pp. 673-680
    • Harada, H.1    Harada, Y.2    Tanaka, H.3    Kimura, A.4    Inaba, T.5
  • 13
    • 4444302228 scopus 로고    scopus 로고
    • Mutations of AML1 are common in therapy-related myelodysplasia following therapy with alkylating agents and are significantly associated with deletion or loss of chromosome arm 7q and with subsequent leukemic transformation
    • Christiansen DH, Andersen MK, Pedersen-Bjergaard J. Mutations of AML1 are common in therapy-related myelodysplasia following therapy with alkylating agents and are significantly associated with deletion or loss of chromosome arm 7q and with subsequent leukemic transformation. Blood. 2004;104(5):1474-1481.
    • (2004) Blood , vol.104 , Issue.5 , pp. 1474-1481
    • Christiansen, D.H.1    Andersen, M.K.2    Pedersen-Bjergaard, J.3
  • 14
    • 52249103968 scopus 로고    scopus 로고
    • High frequency of AML1/RUNX1 point mutations in radiation-associated myelodysplastic syndrome around semipalatinsk nuclear test site
    • Zharlyganova D, Harada H, Harada Y, et al. High frequency of AML1/RUNX1 point mutations in radiation-associated myelodysplastic syndrome around Semipalatinsk nuclear test site. J Radiat Res (Tokyo). 2008;49(5):549-555.
    • (2008) J Radiat Res (Tokyo) , vol.49 , Issue.5 , pp. 549-555
    • Zharlyganova, D.1    Harada, H.2    Harada, Y.3
  • 15
    • 78650660585 scopus 로고    scopus 로고
    • Clinical and genetic features of therapy-related myeloid neoplasms after chemotherapy for acute promyelocytic leukemia
    • Imagawa J, Harada Y, Shimomura T, et al. Clinical and genetic features of therapy-related myeloid neoplasms after chemotherapy for acute promyelocytic leukemia. Blood. 2010;116(26): 6018-6022.
    • (2010) Blood , vol.116 , Issue.26 , pp. 6018-6022
    • Imagawa, J.1    Harada, Y.2    Shimomura, T.3
  • 16
    • 73949129831 scopus 로고    scopus 로고
    • AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms
    • Ding Y, Harada Y, Imagawa J, Kimura A, Harada H. AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms. Blood. 2009; 114(25):5201-5205.
    • (2009) Blood , vol.114 , Issue.25 , pp. 5201-5205
    • Ding, Y.1    Harada, Y.2    Imagawa, J.3    Kimura, A.4    Harada, H.5
  • 17
    • 77950977381 scopus 로고    scopus 로고
    • Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm
    • Beer PA, Delhommeau F, LeCouédic JP, et al. Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm. Blood. 2010;115(14):2891-2900.
    • (2010) Blood , vol.115 , Issue.14 , pp. 2891-2900
    • Beer, P.A.1    Delhommeau, F.2    LeCouédic, J.P.3
  • 18
    • 84863356975 scopus 로고    scopus 로고
    • Functional features of RUNX1 mutants in acute transformation of chronic myeloid leukemia and their contribution to inducing murine full-blown leukemia
    • Zhao LJ, Wang YY, Li G, et al. Functional features of RUNX1 mutants in acute transformation of chronic myeloid leukemia and their contribution to inducing murine full-blown leukemia. Blood. 2012; 119(12):2873-2882.
    • (2012) Blood , vol.119 , Issue.12 , pp. 2873-2882
    • Zhao, L.J.1    Wang, Y.Y.2    Li, G.3
  • 19
    • 79952451556 scopus 로고    scopus 로고
    • A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (bc-CML) detects mutations in 76.9% of cases
    • Grossmann V, Kohlmann A, Zenger M, et al. A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases. Leukemia. 2011; 25(3):557-560.
    • (2011) Leukemia , vol.25 , Issue.3 , pp. 557-560
    • Grossmann, V.1    Kohlmann, A.2    Zenger, M.3
  • 20
    • 0035831044 scopus 로고    scopus 로고
    • Structural analyses of DNA recognition by the AML1/runx-1 runt domain and its allosteric control by cbfbeta
    • Tahirov TH, Inoue-Bungo T, Morii H, et al. Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta. Cell. 2001;104(5):755-767.
    • (2001) Cell , vol.104 , Issue.5 , pp. 755-767
    • Tahirov, T.H.1    Inoue-Bungo, T.2    Morii, H.3
  • 21
    • 0035066381 scopus 로고    scopus 로고
    • The leukemia-associated AML1 (RUNX1)—CBF beta complex functions as a DNA-induced molecular clamp
    • Bravo J, Li Z, Speck NA, Warren AJ. The leukemia-associated AML1 (RUNX1)—CBF beta complex functions as a DNA-induced molecular clamp. Nat Struct Biol. 2001;8(4):371-378.
    • (2001) Nat Struct Biol. , vol.8 , Issue.4 , pp. 371-378
    • Bravo, J.1    Li, Z.2    Speck, N.A.3    Warren, A.J.4
  • 22
    • 43249103972 scopus 로고    scopus 로고
    • AML1 mutations induced MDS and MDS/AML in a mouse bmt model
    • Watanabe-Okochi N, Kitaura J, Ono R, et al. AML1 mutations induced MDS and MDS/AML in a mouse BMT model. Blood. 2008;111(8): 4297-4308.
    • (2008) Blood , vol.111 , Issue.8 , pp. 4297-4308
    • Watanabe-Okochi, N.1    Kitaura, J.2    Ono, R.3
  • 23
    • 34547657665 scopus 로고    scopus 로고
    • Hot spots of retroviral integration in human CD341 hematopoietic cells
    • Cattoglio C, Facchini G, Sartori D, et al. Hot spots of retroviral integration in human CD341 hematopoietic cells. Blood. 2007;110(6): 1770-1778.
    • (2007) Blood , vol.110 , Issue.6 , pp. 1770-1778
    • Cattoglio, C.1    Facchini, G.2    Sartori, D.3
  • 24
    • 1642276757 scopus 로고    scopus 로고
    • A dominant-negative mutant of C/ebpalpha, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse
    • Schwieger M, Löhler J, Fischer M, Herwig U, Tenen DG, Stocking C. A dominant-negative mutant of C/EBPalpha, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse. Blood. 2004;103(7):2744-2752.
    • (2004) Blood , vol.103 , Issue.7 , pp. 2744-2752
    • Schwieger, M.1    Löhler, J.2    Fischer, M.3    Herwig, U.4    Tenen, D.G.5    Stocking, C.6
  • 25
    • 79956145260 scopus 로고    scopus 로고
    • Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: Relation to adverse epigenetic alteration and poor prognostic scoring
    • Xu F, Li X, Wu L, et al. Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring. Ann Hematol. 2011;90(6):643-653.
    • (2011) Ann Hematol. , vol.90 , Issue.6 , pp. 643-653
    • Xu, F.1    Li, X.2    Wu, L.3
  • 26
    • 30144443995 scopus 로고    scopus 로고
    • Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis
    • Mihara K, Chowdhury M, Nakaju N, et al. Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis. Blood. 2006;107(1):305-308.
    • (2006) Blood , vol.107 , Issue.1 , pp. 305-308
    • Mihara, K.1    Chowdhury, M.2    Nakaju, N.3
  • 27
    • 0036095217 scopus 로고    scopus 로고
    • The AML1-eto fusion protein promotes the expansion of human hematopoietic stem cells
    • Mulloy JC, Cammenga J, MacKenzie KL, Berguido FJ, Moore MA, Nimer SD. The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells. Blood. 2002; 99(1):15-23.
    • (2002) Blood , vol.99 , Issue.1 , pp. 15-23
    • Mulloy, J.C.1    Cammenga, J.2    MacKenzie, K.L.3    Berguido, F.J.4    Moore, M.A.5    Nimer, S.D.6
  • 28
    • 0037438515 scopus 로고    scopus 로고
    • The AML1-eto fusion gene promotes extensive self-renewal of human primary erythroid cells
    • Tonks A, Pearn L, Tonks AJ, et al. The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells. Blood. 2003; 101(2):624-632.
    • (2003) Blood , vol.101 , Issue.2 , pp. 624-632
    • Tonks, A.1    Pearn, L.2    Tonks, A.J.3
  • 29
    • 0345167904 scopus 로고    scopus 로고
    • Maintaining the self-renewal and differentiation potential of human CD341 hematopoietic cells using a single genetic element
    • Mulloy JC, Cammenga J, Berguido FJ, et al. Maintaining the self-renewal and differentiation potential of human CD341 hematopoietic cells using a single genetic element. Blood. 2003; 102(13):4369-4376.
    • (2003) Blood , vol.102 , Issue.13 , pp. 4369-4376
    • Mulloy, J.C.1    Cammenga, J.2    Berguido, F.J.3
  • 30
    • 20844444317 scopus 로고    scopus 로고
    • Cbfbeta-smmhc slows proliferation of primary murine and human myeloid progenitors
    • D’Costa J, Chaudhuri S, Civin CI, Friedman AD. CBFbeta-SMMHC slows proliferation of primary murine and human myeloid progenitors. Leukemia. 2005;19(6):921-929.
    • (2005) Leukemia , vol.19 , Issue.6 , pp. 921-929
    • D’Costa, J.1    Chaudhuri, S.2    Civin, C.I.3    Friedman, A.D.4
  • 31
    • 33748176403 scopus 로고    scopus 로고
    • Human CD341 cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability
    • Wunderlich M, Krejci O, Wei J, Mulloy JC. Human CD341 cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability. Blood. 2006;108(5): 1690-1697.
    • (2006) Blood , vol.108 , Issue.5 , pp. 1690-1697
    • Wunderlich, M.1    Krejci, O.2    Wei, J.3    Mulloy, J.C.4
  • 32
    • 4444350859 scopus 로고    scopus 로고
    • Mutant n-ras preferentially drives human CD341 hematopoietic progenitor cells into myeloid differentiation and proliferation both in vitro and in the Nod/scid mouse
    • Shen SW, Dolnikov A, Passioura T, et al. Mutant N-ras preferentially drives human CD341 hematopoietic progenitor cells into myeloid differentiation and proliferation both in vitro and in the NOD/SCID mouse. Exp Hematol. 2004;32(9):852-860.
    • (2004) Exp Hematol , vol.32 , Issue.9 , pp. 852-860
    • Shen, S.W.1    Dolnikov, A.2    Passioura, T.3
  • 33
    • 79951815187 scopus 로고    scopus 로고
    • N-ras(g12d) induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-eto fusion gene
    • Chou FS, Wunderlich M, Griesinger A, Mulloy JC. N-Ras(G12D) induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene. Blood. 2011;117(7):2237-2240.
    • (2011) Blood , vol.117 , Issue.7 , pp. 2237-2240
    • Chou, F.S.1    Wunderlich, M.2    Griesinger, A.3    Mulloy, J.C.4
  • 34
    • 11144235821 scopus 로고    scopus 로고
    • Enforced expression of an FLT3 internal tandem duplication in human CD341 cells confers properties of self-renewal and enhanced erythropoiesis
    • Chung KY, Morrone G, Schuringa JJ, Wong B, Dorn DC, Moore MA. Enforced expression of an FLT3 internal tandem duplication in human CD341 cells confers properties of self-renewal and enhanced erythropoiesis. Blood. 2005;105(1):77-84.
    • (2005) Blood , vol.105 , Issue.1 , pp. 77-84
    • Chung, K.Y.1    Morrone, G.2    Schuringa, J.J.3    Wong, B.4    Dorn, D.C.5    Moore, M.A.6
  • 35
    • 41949127703 scopus 로고    scopus 로고
    • Long-term maintenance of human hematopoietic stem/progenitor cells by expression of BMI1
    • Rizo A, Dontje B, Vellenga E, de Haan G, Schuringa JJ. Long-term maintenance of human hematopoietic stem/progenitor cells by expression of BMI1. Blood. 2008;111(5):2621-2630.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2621-2630
    • Rizo, A.1    Dontje, B.2    Vellenga, E.3    De Haan, G.4    Schuringa, J.J.5
  • 36
    • 78650975508 scopus 로고    scopus 로고
    • Two types of C/ ebpa mutations play distinct but collaborative roles in leukemogenesis: Lessons from clinical data and bmt models
    • Kato N, Kitaura J, Doki N, et al. Two types of C/ EBPa mutations play distinct but collaborative roles in leukemogenesis: lessons from clinical data and BMT models. Blood. 2011;117(1):221-233.
    • (2011) Blood , vol.117 , Issue.1 , pp. 221-233
    • Kato, N.1    Kitaura, J.2    Doki, N.3
  • 37
    • 18344410760 scopus 로고    scopus 로고
    • NOD/ SCID/g(c)(null) mouse: An excellent recipient mouse model for engraftment of human cells
    • Ito M, Hiramatsu H, Kobayashi K, et al. NOD/ SCID/g(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood. 2002;100(9):3175-3182.
    • (2002) Blood , vol.100 , Issue.9 , pp. 3175-3182
    • Ito, M.1    Hiramatsu, H.2    Kobayashi, K.3
  • 38
    • 34249694973 scopus 로고    scopus 로고
    • Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1
    • Tsuzuki S, Hong D, Gupta R, Matsuo K, Seto M, Enver T. Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1. PLoS Med. 2007;4(5):e172.
    • (2007) Plos Med , vol.4 , Issue.5 , pp. e172
    • Tsuzuki, S.1    Hong, D.2    Gupta, R.3    Matsuo, K.4    Seto, M.5    Enver, T.6
  • 39
    • 37349112219 scopus 로고    scopus 로고
    • RUNX1 protects hematopoietic stem/progenitor cells from oncogenic insult
    • Motoda L, Osato M, Yamashita N, et al. RUNX1 protects hematopoietic stem/progenitor cells from oncogenic insult. Stem Cells. 2007;25(12):2976-2986.
    • (2007) Stem Cells , vol.25 , Issue.12 , pp. 2976-2986
    • Motoda, L.1    Osato, M.2    Yamashita, N.3
  • 40
    • 33646475438 scopus 로고    scopus 로고
    • Hyperactivation of the ras signaling pathway in myelodysplastic syndrome with AML1/RUNX1 point mutations
    • Niimi H, Harada H, Harada Y, et al. Hyperactivation of the RAS signaling pathway in myelodysplastic syndrome with AML1/RUNX1 point mutations. Leukemia. 2006;20(4):635-644.
    • (2006) Leukemia , vol.20 , Issue.4 , pp. 635-644
    • Niimi, H.1    Harada, H.2    Harada, Y.3
  • 41
    • 79959794787 scopus 로고    scopus 로고
    • Clinical effect of point mutations in myelodysplastic syndromes
    • Bejar R, Stevenson K, Abdel-Wahab O, et al. Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med. 2011; 364(26):2496-2506.
    • (2011) N Engl J Med , vol.364 , Issue.26 , pp. 2496-2506
    • Bejar, R.1    Stevenson, K.2    Abdel-Wahab, O.3
  • 42
    • 0028201742 scopus 로고
    • Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene
    • van der Lugt NM, Domen J, Linders K, et al. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev. 1994;8(7):757-769.
    • (1994) Genes Dev , vol.8 , Issue.7 , pp. 757-769
    • Van Der Lugt, N.M.1    Domen, J.2    Linders, K.3
  • 43
    • 0038349957 scopus 로고    scopus 로고
    • Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    • Park IK, Qian D, Kiel M, et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 2003; 423(6937):302-305.
    • (2003) Nature , vol.423 , Issue.6937 , pp. 302-305
    • Park, I.K.1    Qian, D.2    Kiel, M.3
  • 44
    • 0037673984 scopus 로고    scopus 로고
    • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
    • Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature. 2003;423(6937):255-260.
    • (2003) Nature , vol.423 , Issue.6937 , pp. 255-260
    • Lessard, J.1    Sauvageau, G.2
  • 45
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
    • Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature. 1999;397(6715):164-168.
    • (1999) Nature , vol.397 , Issue.6715 , pp. 164-168
    • Jacobs, J.J.1    Kieboom, K.2    Marino, S.3    DePinho, R.A.4    Van Lohuizen, M.5
  • 46
    • 10344258563 scopus 로고    scopus 로고
    • Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product bmi-1
    • Iwama A, Oguro H, Negishi M, et al. Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity. 2004;21(6):843-851.
    • (2004) Immunity , vol.21 , Issue.6 , pp. 843-851
    • Iwama, A.1    Oguro, H.2    Negishi, M.3
  • 47
    • 78649478552 scopus 로고    scopus 로고
    • BMI1 collaborates with bcr-abl in leukemic transformation of human CD341 cells
    • Rizo A, Horton SJ, Olthof S, et al. BMI1 collaborates with BCR-ABL in leukemic transformation of human CD341 cells. Blood. 2010;116(22):4621-4630.
    • (2010) Blood , vol.116 , Issue.22 , pp. 4621-4630
    • Rizo, A.1    Horton, S.J.2    Olthof, S.3
  • 48
    • 84863012512 scopus 로고    scopus 로고
    • Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors
    • Yu M, Mazor T, Huang H, et al. Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell. 2012; 45(3):330-343.
    • (2012) Mol Cell , vol.45 , Issue.3 , pp. 330-343
    • Yu, M.1    Mazor, T.2    Huang, H.3
  • 49
    • 70349563368 scopus 로고    scopus 로고
    • Repression of BMI1 in normal and leukemic human CD34(1) cells impairs self-renewal and induces apoptosis
    • Rizo A, Olthof S, Han L, Vellenga E, de Haan G, Schuringa JJ. Repression of BMI1 in normal and leukemic human CD34(1) cells impairs self-renewal and induces apoptosis. Blood. 2009; 114(8):1498-1505.
    • (2009) Blood , vol.114 , Issue.8 , pp. 1498-1505
    • Rizo, A.1    Olthof, S.2    Han, L.3    Vellenga, E.4    De Haan, G.5    Schuringa, J.J.6
  • 50
    • 67349156082 scopus 로고    scopus 로고
    • BMI1 regulates mitochondrial function and the DNA damage response pathway
    • Liu J, Cao L, Chen J, et al. BMI1 regulates mitochondrial function and the DNA damage response pathway. Nature. 2009;459(7245): 387-392.
    • (2009) Nature , vol.459 , Issue.7245 , pp. 387-392
    • Liu, J.1    Cao, L.2    Chen, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.