The leukemia-associated AML1 (Runx1)-CBFβ complex functions as a DNA-induced molecular clamp

Nature Structural Biology

Volumn 8, Issue 4, 2001, Pages 371-378

  Bravo, Jerónimo ^a   Li, Zhe ^b   Speck, Nancy A ^b   Warren, Alan J ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORE BINDING FACTOR; PROTEIN CBFBETA; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CLEIDOCRANIAL DYSPLASIA; HUMAN; HUMAN CELL; LEUKEMIA CELL; LEUKEMOGENESIS; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BASE SEQUENCE; BINDING SITES; CORE BINDING FACTOR ALPHA 2 SUBUNIT; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA; DNA-BINDING PROTEINS; HUMANS; LEUKEMIA; MODELS, MOLECULAR; MUTATION; NEOPLASM PROTEINS; NF-KAPPA B; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTORS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0035066381     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/86264     Document Type: Article

References (55)

1. The Runt domain identifies a new family of heteromeric transcriptional regulators
2. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
3. The CBFβ subunit is essential for CBFα2 (AML1) function in vivo
4. Molecular basis of leukemogenesis
5. T(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1
6. Oncogenic transcription factors in the human acute leukemias
7. Fusion between transcription factor CBFβ/PEBP2β and a myosin heavy chain in acute myeloid leukemia
8. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2αB gene associated with myeloblastic leukemias
9. High incidence of biallelic point mutations in the runt domain of the AML1/PEBP2αB gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21
10. Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis
11. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukemia
12. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
13. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
14. Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia
15. Binding of SL3-3 enhancer factor 1 transcriptional activators to viral and chromosomal enhancer sequences
16. The missing bone
17. Molecular insights into PEBP2/CBFβ-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBFβ
18. Solution structure of core binding factor β and map of the CBFα binding site
19. Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
20. The Ig fold of the core binding factor α Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains
21. Structural basis for the heterodimeric interaction between the acute leukemia-associated transcription factors AML1 and CBFβ
22. SCOP: A structural classification of proteins database for the investigation of sequences and structures
23. Energetic and functional contribution of residues in the core binding factor β (CBFβ) subunit to heterodimerization with CBFα
24. Biophysical characterization of interactions between the core binding factor α and β subunits and DNA
25. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
26. Identification of the regions involved in DNA binding by the mouse PEBP2α protein
27. - finger-DNA and other protein-DNA complexes
28. Solution properties of the free and DNA-bound Runt domain of AML1
29. Biochemical and biophysical properties of the core-binding factor α2 (AML1) DNA-binding domain
30. Functional domains of the t(8;21) fusion protein, AML-1/ETO
31. A simple screening for mutant DNA binding proteins: Application to murine transcription factor PEBP2α subunit, a founding member of the Runt domain protein family
32. Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia
33. Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
34. CBFA1 mutation analysis and functional correlation with phenotypic variability in cleidocranial dysplasia
35. Mutation analysis of core binding factor A1 in patients with cleidocranial dysplasia
36. Differential protein binding in lymphocytes to a sequence in the enhancer of the mouse retrovirus SL3-3
37. Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers
38. Sequence specificity of the core-binding factor
39. Drosophila homologs of the proto-oncogene product PEBP2/CBFβ regulate the DNA-binding properties of Runt
40. PEBP2αA/CBFA1 mutations in Japanese cleidocranial dysplasia patients
41. Runt domains take the lead in hematopoiesis and osteogenesis
42. Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor
43. Structure of the specificity domain of the Dorsal homologue Gambif1 bound to DNA
44. Transcription factors: Global and detailed views
45. Recent changes to the MOSFLM package for film and image plate data
46. Collaborative Computing Project 4: A suite of programs for protein crystallography
47. Crystallography & NMR system: A new software suite for macromolecular structure determination
48. Improved methods for building protein models in electron density maps and the location of errors in these models
49. High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier
50. Further additions to MolScript version 1.4, including reading and contouring of electron-density maps
51. A program to produce both detailed and schematic plots of protein structures
52. NF-κB p65 (RelA) homodimer uses distinct mechanisms to recognize DNA targets
53. Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA
54. A-form conformational motifs in ligand-bound DNA structures