Long-term estradiol exposure is a direct mitogen for insulin/EGF-primed endometrial cells and drives PTEN loss-induced hyperplasic growth

American Journal of Pathology

Volumn 183, Issue 1, 2013, Pages 277-287

  Eritja, Nuria ^a   Mirantes, Cristina ^a   Llobet, David ^a   Yeramian, Andree ^a   Bergadà, Laura ^a   Dosil, Mari A ^a   Domingo, Mónica ^a   Matias Guiu, Xavier ^a   Dolcet, Xavier ^a  

^a UNIVERSITY OF LLEIDA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; EPIDERMAL GROWTH FACTOR; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; INSULIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAPAMYCIN; SOMATOMEDIN C;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; ENDOMETRIUM CELL; ENDOMETRIUM HYPERPLASIA; EPITHELIUM CELL; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPHEROID CELL; TRANSCRIPTION REGULATION; TUMOR CELL;

ANIMALS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELL PROLIFERATION; ENDOMETRIAL HYPERPLASIA; ENDOMETRIUM; EPIDERMAL GROWTH FACTOR; EPITHELIAL CELLS; ESTRADIOL; ESTROGENS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; INSULIN; INSULIN-LIKE GROWTH FACTOR I; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGENS; PTEN PHOSPHOHYDROLASE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPHEROIDS, CELLULAR;

EID: 84879344468     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2013.03.008     Document Type: Article

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