Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion

Journal of Biological Chemistry

Volumn 280, Issue 6, 2005, Pages 4992-5003

  Ohsugi, Mitsuru ^a   Gras Méneur, Corentin ^a   Zhou, Yiyong ^a   Bernal Mizrachi, Ernesto ^a   Johnson, James D ^a   Luciani, Dan S ^a   Polonsky, Kenneth S ^a   Permutt, M Alan ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENETIC ENGINEERING; GLUCOSE; MOLECULAR BIOLOGY; MOLECULAR STRUCTURE; RNA;

GENE EXPRESSION; INSULIN RECEPTOR (IR); MOUSE INSULINOMA (MIN6) CELLS; PHOSPHORYLATION;

INSULIN;

CALCIUM ION; GLUCOSE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SMALL INTERFERING RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; EARLY RESPONSE GENE; FEEDBACK SYSTEM; GENE ACTIVATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; INSULIN RELEASE; INSULINOMA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BROMODEOXYURIDINE; CALCIUM; CELL CYCLE; CELL LINE; CLUSTER ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GLUCOSE; IMMUNOPRECIPITATION; INSULIN; INSULINOMA; ISLETS OF LANGERHANS; MICE; NADP; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHORYLATION; PLASMIDS; RECEPTOR, INSULIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TRANSFECTION;

EID: 14244269977     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411727200     Document Type: Article

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