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Volumn 5, Issue 2, 2013, Pages 95-105

Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells

Author keywords

Interleukin 13; Interleukin 6; Janus kinase; Pancreatic cells; STAT3; STAT6

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 6; JANUS KINASE; STAT3 PROTEIN; STAT6 PROTEIN;

EID: 84879335777     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: 10.4161/isl.24249     Document Type: Article
Times cited : (42)

References (49)
  • 1
    • 0029817047 scopus 로고    scopus 로고
    • The role of interleukin-1 in the pathogenesis of IDDM
    • DOI 10.1007/s001250050548
    • Mandrup-Poulsen T. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 1996; 39:1005-29; PMID:8877284; http://dx.doi.org/10.1007/ BF00400649 (Pubitemid 26275930)
    • (1996) Diabetologia , vol.39 , Issue.9 , pp. 1005-1029
    • Mandrup-Poulsen, T.1
  • 2
    • 0035668779 scopus 로고    scopus 로고
    • A choice of death - The signal-transduction of immune-mediated beta-cell apoptosis
    • DOI 10.1007/s001250100021
    • Eizirik DL, Mandrup-Poulsen T. A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 2001; 44:2115-33; PMID:11793013; http://dx.doi.org/10.1007/s001250100021 (Pubitemid 34015464)
    • (2001) Diabetologia , vol.44 , Issue.12 , pp. 2115-2133
    • Eizirik, D.L.1    Mandrup-Poulsen, T.2
  • 3
    • 0032413626 scopus 로고    scopus 로고
    • Decreased secretion of Th2 cytokines precedes up-regulated and delayed secretion of Th1 cytokines in activated peripheral blood mononuclear cells from patients with insulin-dependent diabetes mellitus
    • DOI 10.1006/jaut.1998.0240
    • Rapoport MJ, Mor A, Vardi P, Ramot Y, Winker R, Hindi A, et al. Decreased secretion of Th2 cytokines precedes Up-regulated and delayed secretion of Th1 cytokines in activated peripheral blood mononuclear cells from patients with insulin-dependent diabetes mellitus. J Autoimmun 1998; 11:635-42; PMID:9878085; http://dx.doi.org/10.1006/jaut.1998.0240 (Pubitemid 29016121)
    • (1998) Journal of Autoimmunity , vol.11 , Issue.6 , pp. 635-642
    • Rapoport, M.J.1    Mor, A.2    Vardi, P.3    Ramot, Y.4    Winker, R.5    Hindi, A.6    Bistritzer, T.7
  • 6
    • 34247871286 scopus 로고    scopus 로고
    • Pre-incubation with interleukin-4 mediates a direct protective effect against the loss of pancreatic β-cell viability induced by proinflammatory cytokines
    • DOI 10.1111/j.1365-2249.2007.03375.x
    • Kaminski A, Kaminski ER, Morgan NG. Preincubation with interleukin-4 mediates a direct protective effect against the loss of pancreatic beta-cell viability induced by proinflammatory cytokines. Clin Exp Immunol 2007; 148:583-8; PMID:17403060; http://dx.doi.org/10.1111/j.1365-2249.2007.03375.x (Pubitemid 46701038)
    • (2007) Clinical and Experimental Immunology , vol.148 , Issue.3 , pp. 583-588
    • Kaminski, A.1    Kaminski, E.R.2    Morgan, N.G.3
  • 7
    • 42449154297 scopus 로고    scopus 로고
    • Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells
    • DOI 10.1677/JOE-07-0638
    • Souza KL, Gurgul-Convey E, Elsner M, Lenzen S. Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells. J Endocrinol 2008; 197:139-50; PMID:18372240; http://dx.doi.org/10.1677/JOE-07- 0638 (Pubitemid 351566933)
    • (2008) Journal of Endocrinology , vol.197 , Issue.1 , pp. 139-150
    • Souza, K.L.A.1    Gurgul-Convey, E.2    Elsner, M.3    Lenzen, S.4
  • 8
    • 0031720795 scopus 로고    scopus 로고
    • Is type II diabetes mellitus a disease of the innate immune system?
    • DOI 10.1007/s001250051058
    • Pickup JC, Crook MA. Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 1998; 41:1241-8; PMID:9794114; http://dx.doi.org/ 10.1007/s001250051058 (Pubitemid 28449093)
    • (1998) Diabetologia , vol.41 , Issue.10 , pp. 1241-1248
    • Pickup, J.C.1    Crook, M.A.2
  • 9
    • 79151478555 scopus 로고    scopus 로고
    • Type 2 diabetes as an inflammatory disease
    • PMID:21233852; http://dx.doi.org/10.1038/nri2925
    • Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 2011; 11:98-107; PMID:21233852; http://dx.doi.org/10.1038/nri2925
    • (2011) Nat Rev Immunol , vol.11 , pp. 98-107
    • Donath, M.Y.1    Shoelson, S.E.2
  • 10
    • 0024406719 scopus 로고
    • Evidence for IL-6 production by and effects on the pancreatic β-cell
    • Campbell IL, Cutri A, Wilson A, Harrison LC. Evidence for IL-6 production by and effects on the pancreatic beta-cell. J Immunol 1989; 143:1188-91; PMID:2501390 (Pubitemid 19211345)
    • (1989) Journal of Immunology , vol.143 , Issue.4 , pp. 1188-1191
    • Campbell, I.L.1    Cutri, A.2    Wilson, A.3    Harrison, L.C.4
  • 11
    • 77952488104 scopus 로고    scopus 로고
    • Cytokine production by islets in health and diabetes: Cellular origin, regulation and function
    • PMID:20096598; http://dx.doi.org/10.1016/j.tem.2009.12.010
    • Donath MY, Böni-Schnetzler M, Ellingsgaard H, Halban PA, Ehses JA. Cytokine production by islets in health and diabetes: cellular origin, regulation and function. Trends Endocrinol Metab 2010; 21:261-7; PMID:20096598; http://dx.doi.org/10.1016/j.tem.2009.12.010
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 261-267
    • Donath, M.Y.1    Böni-Schnetzler, M.2    Ellingsgaard, H.3    Halban, P.A.4    Ehses, J.A.5
  • 12
    • 15744395579 scopus 로고    scopus 로고
    • Inflammatory gene expression in Coxsackievirus B-4-infected human islets of Langerhans
    • DOI 10.1016/j.bbrc.2005.03.016
    • Olsson A, Johansson U, Korsgren O, Frisk G. Inflammatory gene expression in Coxsackievirus B-4-infected human islets of Langerhans. Biochem Biophys Res Commun 2005; 330:571-6; PMID:15796921; http://dx.doi.org/10.1016/j.bbrc.2005.03. 016 (Pubitemid 40417683)
    • (2005) Biochemical and Biophysical Research Communications , vol.330 , Issue.2 , pp. 571-576
    • Olsson, A.1    Johansson, U.2    Korsgren, O.3    Frisk, G.4
  • 13
    • 66449116276 scopus 로고    scopus 로고
    • The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes
    • PMID:19266182; http://dx.doi.org/10.1007/s00125-009-1276-0
    • Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG. The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia 2009; 52:1143-51; PMID:19266182; http://dx.doi.org/10.1007/s00125-009-1276-0
    • (2009) Diabetologia , vol.52 , pp. 1143-1151
    • Richardson, S.J.1    Willcox, A.2    Bone, A.J.3    Foulis, A.K.4    Morgan, N.G.5
  • 14
    • 79251618259 scopus 로고    scopus 로고
    • Immunopathology of the human pancreas in type-I diabetes
    • PMID:20424842; http://dx.doi.org/10.1007/s00281-010-0205-0
    • Richardson SJ, Willcox A, Bone AJ, Morgan NG, Foulis AK. Immunopathology of the human pancreas in type-I diabetes. Semin Immunopathol 2011; 33:9-21; PMID:20424842; http://dx.doi.org/10.1007/s00281-010-0205-0
    • (2011) Semin Immunopathol , vol.33 , pp. 9-21
    • Richardson, S.J.1    Willcox, A.2    Bone, A.J.3    Morgan, N.G.4    Foulis, A.K.5
  • 15
    • 0036746091 scopus 로고    scopus 로고
    • IL-13 signal transduction in human monocytes: Phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats
    • PMID:12223527
    • Roy B, Bhattacharjee A, Xu B, Ford D, Maizel AL, Cathcart MK. IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats. J Leukoc Biol 2002; 72:580-9; PMID:12223527
    • (2002) J Leukoc Biol , vol.72 , pp. 580-589
    • Roy, B.1    Bhattacharjee, A.2    Xu, B.3    Ford, D.4    Maizel, A.L.5    Cathcart, M.K.6
  • 16
    • 0033560095 scopus 로고    scopus 로고
    • Interferon-α activates multiple STAT proteins and upregulates proliferation-associated IL-2Rα, c-myc, and pim-1 genes in human T cells
    • Matikainen S, Sareneva T, Ronni T, Lehtonen A, Koskinen PJ, Julkunen I. Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells. Blood 1999; 93:1980-91; PMID:10068671 (Pubitemid 29128500)
    • (1999) Blood , vol.93 , Issue.6 , pp. 1980-1991
    • Matikainen, S.1    Sareneva, T.2    Ronni, T.3    Lehtonen, A.4    Koskinen, P.J.5    Julkunen, I.6
  • 17
    • 77449151548 scopus 로고    scopus 로고
    • Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways
    • PMID:19531027; http://dx.doi.org/10.1042/BSR20090021
    • Kaminski A, Welters HJ, Kaminski ER, Morgan NG. Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways. Biosci Rep 2010; 30:169-75; PMID:19531027; http://dx.doi.org/10.1042/BSR20090021
    • (2010) Biosci Rep , vol.30 , pp. 169-175
    • Kaminski, A.1    Welters, H.J.2    Kaminski, E.R.3    Morgan, N.G.4
  • 18
    • 0036127426 scopus 로고    scopus 로고
    • Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
    • DOI 10.1038/nm0302-240
    • Lee TS, Chau LY. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med 2002; 8:240-6; PMID:11875494; http://dx.doi.org/10.1038/nm0302-240 (Pubitemid 34250101)
    • (2002) Nature Medicine , vol.8 , Issue.3 , pp. 240-246
    • Lee, T.-S.1    Chau, L.-Y.2
  • 19
    • 51349133256 scopus 로고    scopus 로고
    • Interleukin-6 regulates pancreatic alpha-cell mass expansion
    • PMID:18719127; http://dx.doi.org/10.1073/pnas.0801059105
    • Ellingsgaard H, Ehses JA, Hammar EB, Van Lommel L, Quintens R, Martens G, et al. Interleukin-6 regulates pancreatic alpha-cell mass expansion. Proc Natl Acad Sci U S A 2008; 105:13163-8; PMID:18719127; http://dx.doi.org/10.1073/pnas. 0801059105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13163-13168
    • Ellingsgaard, H.1    Ehses, J.A.2    Hammar, E.B.3    Van Lommel, L.4    Quintens, R.5    Martens, G.6
  • 20
    • 58149499180 scopus 로고    scopus 로고
    • Leptin receptor signaling and the regulation of mammalian physiology
    • PMID:19136996; http://dx.doi.org/10.1038/ijo.2008.232
    • Villanueva EC, Myers MG Jr. Leptin receptor signaling and the regulation of mammalian physiology. Int J Obes (Lond) 2008; 32(Suppl 7):S8-12; PMID:19136996; http://dx.doi.org/10.1038/ijo.2008.232
    • (2008) Int J Obes (Lond) , vol.32 , Issue.SUPPL. 7
    • Villanueva, E.C.1    Myers Jr., M.G.2
  • 21
    • 34548348216 scopus 로고    scopus 로고
    • Coactivation of Janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: Recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways
    • DOI 10.1210/me.2007-0173
    • Neilson LM, Zhu J, Xie J, Malabarba MG, Sakamoto K, Wagner KU, et al. Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways. Mol Endocrinol 2007; 21:2218-32; PMID:17550976; http://dx.doi.org/10.1210/me. 2007-0173 (Pubitemid 47347383)
    • (2007) Molecular Endocrinology , vol.21 , Issue.9 , pp. 2218-2232
    • Neilson, L.M.1    Zhu, J.2    Xie, J.3    Malabarba, M.G.4    Sakamoto, K.5    Wagner, K.-U.6    Kirken, R.A.7    Rui, H.8
  • 22
    • 0038517976 scopus 로고    scopus 로고
    • Interleukin-4 and interleukin-13 signaling connections maps
    • DOI 10.1126/science.1085458
    • Kelly-Welch AE, Hanson EM, Boothby MR, Keegan AD. Interleukin-4 and interleukin-13 signaling connections maps. Science 2003; 300:1527-8; PMID:12791978; http://dx.doi.org/10.1126/science.1085458 (Pubitemid 36686713)
    • (2003) Science , vol.300 , Issue.5625 , pp. 1527-1528
    • Kelly-Welch, A.E.1    Hanson, E.M.2    Boothby, M.R.3    Keegan, A.D.4
  • 23
    • 0037393323 scopus 로고    scopus 로고
    • IL-13 receptors and signaling pathways: An evolving web
    • DOI 10.1067/mai.2003.1333
    • Hershey GK. IL-13 receptors and signaling pathways: an evolving web. J Allergy Clin Immunol 2003; 111:677-90, quiz 691; PMID:12704343; http://dx.doi.org/10.1067/mai.2003.1333 (Pubitemid 36470232)
    • (2003) Journal of Allergy and Clinical Immunology , vol.111 , Issue.4 , pp. 677-690
    • Khurana Hershey, G.K.1
  • 24
    • 0041677606 scopus 로고    scopus 로고
    • Principles of interleukin (IL)-6-type cytokine signalling and its regulation
    • DOI 10.1042/BJ20030407
    • Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G, Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 2003; 374:1-20; PMID:12773095; http://dx.doi.org/10.1042/ BJ20030407 (Pubitemid 37046923)
    • (2003) Biochemical Journal , vol.374 , Issue.1 , pp. 1-20
    • Heinrich, P.C.1    Behrmann, I.2    Haan, S.3    Hermanns, H.M.4    Muller-Newen, G.5    Schaper, F.6
  • 25
    • 0037184088 scopus 로고    scopus 로고
    • Analysis of the life cycle of stat6. Continuous cycling of STAT6 is required for IL-4 signaling
    • PMID:12121972; http://dx.doi.org/10.1074/jbc.M200986200
    • Andrews R P, Ericksen MB, Cunningham CM, Daines MO, Hershey GK. Analysis of the life cycle of stat6. Continuous cycling of STAT6 is required for IL-4 signaling. J Biol Chem 2002; 277:36563-9; PMID:12121972; http://dx.doi.org/10. 1074/jbc.M200986200
    • (2002) J Biol Chem , vol.277 , pp. 36563-36569
    • Andrews, R.P.1    Ericksen, M.B.2    Cunningham, C.M.3    Daines, M.O.4    Hershey, G.K.5
  • 26
    • 36248965713 scopus 로고    scopus 로고
    • IL-4 protects the B-cell lymphoma cell line CH31 from anti-IgM-induced growth arrest and apoptosis: Contribution of the PI-3 kinase/AKT pathway
    • DOI 10.1038/sj.cr.2007.90, PII CR200790
    • Carey GB, Semenova E, Qi X, Keegan AD. IL-4 protects the B-cell lymphoma cell line CH31 from anti-IgM-induced growth arrest and apoptosis: contribution of the PI-3 kinase/AKT pathway. Cell Res 2007; 17:942-55; PMID:17968425; http://dx.doi.org/10.1038/sj.cr.2007.90 (Pubitemid 350126865)
    • (2007) Cell Research , vol.17 , Issue.11 , pp. 942-955
    • Carey, G.B.1    Semenova, E.2    Qi, X.3    Keegan, A.D.4
  • 27
    • 0037564511 scopus 로고    scopus 로고
    • Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells
    • DOI 10.1016/S0006-291X(03)00792-7
    • Yang L, Wang L, Lin HK, Kan PY, Xie S, Tsai MY, et al. Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells. Biochem Biophys Res Commun 2003; 305:462-9; PMID:12763015; http://dx.doi.org/10.1016/ S0006-291X(03)00792-7 (Pubitemid 36579252)
    • (2003) Biochemical and Biophysical Research Communications , vol.305 , Issue.3 , pp. 462-469
    • Yang, L.1    Wang, L.2    Lin, H.-K.3    Kan, P.-Y.4    Xie, S.5    Tsai, M.-Y.6    Wang, P.-H.7    Chen, Y.-T.8    Chang, C.9
  • 28
    • 0026828552 scopus 로고
    • Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor
    • PMID:1633265; http://dx.doi.org/10.1016/1043-4666(92)90043-Q
    • Lust JA, Donovan KA, Kline M P, Greipp PR, Kyle RA, Maihle NJ. Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor. Cytokine 1992; 4:96-100; PMID:1633265; http://dx.doi.org/10.1016/1043-4666(92)90043-Q
    • (1992) Cytokine , vol.4 , pp. 96-100
    • Lust, J.A.1    Donovan, K.A.2    Kline, M.P.3    Greipp, P.R.4    Kyle, R.A.5    Maihle, N.J.6
  • 29
    • 42649145091 scopus 로고    scopus 로고
    • IL-13 attenuates vascular tube formation via JAK2-STAT6 pathway
    • DOI 10.1253/circj.72.469
    • Nishimura Y, Nitto T, Inoue T, Node K. IL-13 attenuates vascular tube formation via JAK2-STAT6 pathway. Circ J 2008; 72:469-75; PMID:18296848; http://dx.doi.org/10.1253/circj.72.469 (Pubitemid 351600645)
    • (2008) Circulation Journal , vol.72 , Issue.3 , pp. 469-475
    • Nishimura, Y.1    Nitto, T.2    Inoue, T.3    Node, K.4
  • 30
    • 33750298971 scopus 로고    scopus 로고
    • Pyridone 6, a Pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells
    • DOI 10.1158/0008-5472.CAN-05-4280
    • Pedranzini L, Dechow T, Berishaj M, Comenzo R, Zhou P, Azare J, et al. Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. Cancer Res 2006; 66:9714-21; PMID:17018630; http://dx.doi.org/10.1158/0008-5472.CAN-05-4280 (Pubitemid 44623672)
    • (2006) Cancer Research , vol.66 , Issue.19 , pp. 9714-9721
    • Pedranzini, L.1    Dechow, T.2    Berishaj, M.3    Comenzo, R.4    Zhou, P.5    Azare, J.6    Bornmann, W.7    Bromberg, J.8
  • 31
    • 73949126369 scopus 로고    scopus 로고
    • Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes
    • PMID:19996363; http://dx.doi.org/10.1152/physiol.00032.2009
    • Donath MY, Böni-Schnetzler M, Ellingsgaard H, Ehses JA. Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes. Physiology (Bethesda) 2009; 24:325-31; PMID:19996363; http://dx.doi.org/10.1152/physiol. 00032.2009
    • (2009) Physiology (Bethesda) , vol.24 , pp. 325-331
    • Donath, M.Y.1    Böni-Schnetzler, M.2    Ellingsgaard, H.3    Ehses, J.A.4
  • 33
    • 0028222756 scopus 로고
    • Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse
    • DOI 10.1006/clin.1994.1068
    • Pennline KJ, Roque-Gaffney E, Monahan M. Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin Immunol Immunopathol 1994; 71:169-75; PMID:8181185; http://dx.doi.org/10.1006/clin.1994.1068 (Pubitemid 24147233)
    • (1994) Clinical Immunology and Immunopathology , vol.71 , Issue.2 , pp. 169-175
    • Pennline, K.J.1    Roque-Gaffney, E.R.2    Monahan, M.3
  • 35
    • 84864867965 scopus 로고    scopus 로고
    • DsAAV8-mediated gene transfer and β-cell expression of IL-4 and β-cell growth factors are capable of reversing early-onset diabetes in NOD mice
    • PMID:22089495; http://dx.doi.org/10.1038/gt.2011.181
    • Gaddy D F, Riedel MJ, Bertera S, Kieffer TJ, Robbins PD. dsAAV8-mediated gene transfer and β-cell expression of IL-4 and β-cell growth factors are capable of reversing early-onset diabetes in NOD mice. Gene Ther 2011; 19:791-9; PMID:22089495; http://dx.doi.org/10.1038/gt.2011.181
    • (2011) Gene Ther , vol.19 , pp. 791-799
    • Gaddy, D.F.1    Riedel, M.J.2    Bertera, S.3    Kieffer, T.J.4    Robbins, P.D.5
  • 36
    • 48349087101 scopus 로고    scopus 로고
    • AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice
    • PMID:18560422; http://dx.doi.org/10.1038/mt.2008.116
    • Rehman KK, Trucco M, Wang Z, Xiao X, Robbins PD. AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice. Mol Ther 2008; 16:1409-16; PMID:18560422; http://dx.doi.org/10.1038/mt.2008.116
    • (2008) Mol Ther , vol.16 , pp. 1409-1416
    • Rehman, K.K.1    Trucco, M.2    Wang, Z.3    Xiao, X.4    Robbins, P.D.5
  • 37
    • 79955650634 scopus 로고    scopus 로고
    • The pro- and anti-inflammatory properties of the cytokine interleukin-6
    • PMID:21296109; http://dx.doi.org/10.1016/j.bbamcr.2011.01.034
    • Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S. The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta 2011; 1813:878-88; PMID:21296109; http://dx.doi.org/10.1016/j.bbamcr.2011.01. 034
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 878-888
    • Scheller, J.1    Chalaris, A.2    Schmidt-Arras, D.3    Rose-John, S.4
  • 38
    • 75249083288 scopus 로고    scopus 로고
    • Impact of interleukin-6 classic- and trans-signaling on liver damage and regeneration
    • PMID:19717281; http://dx.doi.org/10.1016/j.jaut.2009.08.003
    • Drucker C, Gewiese J, Malchow S, Scheller J, RoseJohn S. Impact of interleukin-6 classic- and trans-signaling on liver damage and regeneration. J Autoimmun 2010; 34:29-37; PMID:19717281; http://dx.doi.org/10.1016/j.jaut.2009. 08.003
    • (2010) J Autoimmun , vol.34 , pp. 29-37
    • Drucker, C.1    Gewiese, J.2    Malchow, S.3    Scheller, J.4    RoseJohn, S.5
  • 40
    • 33744546660 scopus 로고    scopus 로고
    • Signaling mechanisms, interaction partners, and target genes of STAT6
    • DOI 10.1016/j.cytogfr.2006.01.004, PII S1359610106000025
    • Hebenstreit D, Wirnsberger G, Horejs-Hoeck J, Duschl A. Signaling mechanisms, interaction partners, and target genes of STAT6. Cytokine Growth Factor Rev 2006; 17:173-88; PMID:16540365; http://dx.doi.org/10.1016/j.cytogfr. 2006.01.004 (Pubitemid 43816893)
    • (2006) Cytokine and Growth Factor Reviews , vol.17 , Issue.3 , pp. 173-188
    • Hebenstreit, D.1    Wirnsberger, G.2    Horejs-Hoeck, J.3    Duschl, A.4
  • 41
    • 0031710647 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor potentiates the β-cell inhibitory effect of IL-1β in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase
    • DOI 10.2337/diabetes.47.10.1602
    • Wadt KA, Larsen CM, Andersen HU, Nielsen K, Karlsen AE, Mandrup-Poulsen T. Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase. Diabetes 1998; 47:1602-8; PMID:9753298; http://dx.doi.org/10.2337/diabetes.47.10.1602 (Pubitemid 28445348)
    • (1998) Diabetes , vol.47 , Issue.10 , pp. 1602-1608
    • Wadt, K.A.W.1    Larsen, C.M.2    Andersen, H.U.3    Nielsen, K.4    Karlsen, A.E.5    Mandrup-Poulsen, T.6
  • 42
    • 80855138451 scopus 로고    scopus 로고
    • Interleukin-6 treatment induces beta-cell apoptosis via STAT-3-mediated nitric oxide production
    • PMID:22069265; http://dx.doi.org/10.1002/dmrr.1233
    • Oh YS, Lee YJ, Park EY, Jun HS. Interleukin-6 treatment induces beta-cell apoptosis via STAT-3-mediated nitric oxide production. Diabetes Metab Res Rev 2011; 27:813-9; PMID:22069265; http://dx.doi.org/10.1002/dmrr.1233
    • (2011) Diabetes Metab Res Rev , vol.27 , pp. 813-819
    • Oh, Y.S.1    Lee, Y.J.2    Park, E.Y.3    Jun, H.S.4
  • 44
    • 0031278413 scopus 로고    scopus 로고
    • Mechanism of Suppression of Macrophage Nitric Oxide Release by IL-13: Influence of the Macrophage Population
    • Bogdan C, Thüring H, Dlaska M, Röllinghoff M, Weiss G. Mechanism of suppression of macrophage nitric oxide release by IL-13: influence of the macrophage population. J Immunol 1997; 159:4506-13; PMID:9379051 (Pubitemid 127470612)
    • (1997) Journal of Immunology , vol.159 , Issue.9 , pp. 4506-4513
    • Bogdan, C.1    Thuring, H.2    Dlaska, M.3    Rollinghoff, M.4    Weiss, G.5
  • 45
    • 0026550830 scopus 로고
    • Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
    • PMID:1370150; http://dx.doi.org/10.1210/en.130.1.167
    • Asfari M, Janjic D, Meda P, Li G, Halban PA, Wollheim CB. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 1992; 130:167-78; PMID:1370150; http://dx.doi.org/10.1210/en.130. 1.167
    • (1992) Endocrinology , vol.130 , pp. 167-178
    • Asfari, M.1    Janjic, D.2    Meda, P.3    Li, G.4    Halban, P.A.5    Wollheim, C.B.6
  • 46
    • 79959331354 scopus 로고    scopus 로고
    • Development and functional characterization of insulin-releasing human pancreatic beta cell lines produced by electrofusion
    • PMID:21515691; http://dx.doi.org/10.1074/jbc.M111.226795
    • McCluskey JT, Hamid M, Guo-Parke H, McClenaghan NH, Gomis R, Flatt PR. Development and functional characterization of insulin-releasing human pancreatic beta cell lines produced by electrofusion. J Biol Chem 2011; 286:21982-92; PMID:21515691; http://dx.doi.org/10.1074/jbc.M111.226795
    • (2011) J Biol Chem , vol.286 , pp. 21982-21992
    • McCluskey, J.T.1    Hamid, M.2    Guo-Parke, H.3    McClenaghan, N.H.4    Gomis, R.5    Flatt, P.R.6
  • 47
    • 77952910549 scopus 로고    scopus 로고
    • Validation of methodologies for quantifying isolated human islets: An Islet Cell Resources study
    • PMID:19719726; http://dx.doi.org/10.1111/j.1399-0012.2009.01052.x
    • Kissler HJ, Niland JC, Olack B, Ricordi C, Hering BJ, Naji A, et al. Validation of methodologies for quantifying isolated human islets: an Islet Cell Resources study. Clin Transplant 2010; 24:236-42; PMID:19719726; http://dx.doi.org/10.1111/j.1399-0012.2009.01052.x
    • (2010) Clin Transplant , vol.24 , pp. 236-242
    • Kissler, H.J.1    Niland, J.C.2    Olack, B.3    Ricordi, C.4    Hering, B.J.5    Naji, A.6
  • 48
    • 73349087186 scopus 로고    scopus 로고
    • The incubation and monitoring of cell viability in primary rat islets of Langerhans and pancreatic beta-cell lines
    • PMID:19504243; http://dx.doi.org/10 .1007/978-1-59745-448-3-5
    • Morgan NG, Diakogiannaki E, Russell MA. The incubation and monitoring of cell viability in primary rat islets of Langerhans and pancreatic beta-cell lines. Methods Mol Biol 2009; 560:53-64; PMID:19504243; http://dx.doi.org/10. 1007/978-1-59745-448-3-5
    • (2009) Methods Mol Biol , vol.560 , pp. 53-64
    • Morgan, N.G.1    Diakogiannaki, E.2    Russell, M.A.3
  • 49
    • 44949202400 scopus 로고    scopus 로고
    • The protein tyrosine phosphatase-BL, modulates pancreatic β-cell proliferation by interaction with the Wnt signalling pathway
    • DOI 10.1677/JOE-07-0262
    • Welters HJ, Oknianska A, Erdmann KS, Ryffel GU, Morgan NG. The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway. J Endocrinol 2008; 197:543-52; PMID:18413347; http://dx.doi.org/10.1677/JOE-07-0262 (Pubitemid 351803958)
    • (2008) Journal of Endocrinology , vol.197 , Issue.3 , pp. 543-552
    • Welters, H.J.1    Oknianska, A.2    Erdmann, K.S.3    Ryffel, G.U.4    Morgan, N.G.5


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