메뉴 건너뛰기




Volumn 12, Issue 6, 2013, Pages 2537-2551

Understanding the biological context of NS5A-host interactions in HCV infection: A network-based approach

Author keywords

biological network analysis; HCV; host pathogen protein protein interactions; literature mining; NS5A; pathway enrichment analysis; siRNA knockdown; target discovery; TargetMine; yeast two hybrid

Indexed keywords

COMPLEMENTARY DNA; NONSTRUCTURAL PROTEIN 5A;

EID: 84879330388     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr3011217     Document Type: Article
Times cited : (26)

References (119)
  • 1
    • 34250681358 scopus 로고    scopus 로고
    • Hepatitis C virus proteins
    • Dubuisson, J. Hepatitis C virus proteins World J. Gastroenterol. 2007, 13 (17) 2406-15
    • (2007) World J. Gastroenterol. , vol.13 , Issue.17 , pp. 2406-2415
    • Dubuisson, J.1
  • 2
    • 34548783857 scopus 로고    scopus 로고
    • Host factors involved in the replication of hepatitis C virus
    • Moriishi, K.; Matsuura, Y. Host factors involved in the replication of hepatitis C virus Rev. Med. Virol. 2007, 17 (5) 343-54
    • (2007) Rev. Med. Virol. , vol.17 , Issue.5 , pp. 343-354
    • Moriishi, K.1    Matsuura, Y.2
  • 3
    • 65349153811 scopus 로고    scopus 로고
    • The hepatitis C virus enigma
    • Myrmel, H.; Ulvestad, E.; Asjo, B. The hepatitis C virus enigma APMIS 2009, 117 (5-6) 427-39
    • (2009) APMIS , vol.117 , Issue.56 , pp. 427-439
    • Myrmel, H.1    Ulvestad, E.2    Asjo, B.3
  • 4
    • 67749111896 scopus 로고    scopus 로고
    • Cellular and molecular biology of HCV infection and hepatitis
    • Tang, H.; Grise, H. Cellular and molecular biology of HCV infection and hepatitis Clin. Sci. 2009, 117 (2) 49-65
    • (2009) Clin. Sci. , vol.117 , Issue.2 , pp. 49-65
    • Tang, H.1    Grise, H.2
  • 5
    • 84856903165 scopus 로고    scopus 로고
    • Hepatitis C: Epidemiology, diagnosis, natural history and therapy
    • Pol, S.; Vallet-Pichard, A.; Corouge, M.; Mallet, V. O. Hepatitis C: epidemiology, diagnosis, natural history and therapy Contrib. Nephrol. 2012, 176, 1-9
    • (2012) Contrib. Nephrol. , vol.176 , pp. 1-9
    • Pol, S.1    Vallet-Pichard, A.2    Corouge, M.3    Mallet, V.O.4
  • 6
    • 61549118827 scopus 로고    scopus 로고
    • Nomenclature and numbering of the hepatitis C virus
    • Kuiken, C.; Simmonds, P. Nomenclature and numbering of the hepatitis C virus Methods Mol. Biol. 2009, 510, 33-53
    • (2009) Methods Mol. Biol. , vol.510 , pp. 33-53
    • Kuiken, C.1    Simmonds, P.2
  • 8
    • 66149115122 scopus 로고    scopus 로고
    • Crystal structure of a novel dimeric form of NS5A domain i protein from hepatitis C virus
    • Love, R. A.; Brodsky, O.; Hickey, M. J.; Wells, P. A.; Cronin, C. N. Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C virus J. Virol. 2009, 83 (9) 4395-403
    • (2009) J. Virol. , vol.83 , Issue.9 , pp. 4395-4403
    • Love, R.A.1    Brodsky, O.2    Hickey, M.J.3    Wells, P.A.4    Cronin, C.N.5
  • 11
    • 0343924357 scopus 로고    scopus 로고
    • Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
    • Gale, M. J., Jr.; Korth, M. J.; Tang, N. M.; Tan, S. L.; Hopkins, D. A.; Dever, T. E.; Polyak, S. J.; Gretch, D. R.; Katze, M. G. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein Virology 1997, 230 (2) 217-27
    • (1997) Virology , vol.230 , Issue.2 , pp. 217-227
    • Gale, Jr.M.J.1    Korth, M.J.2    Tang, N.M.3    Tan, S.L.4    Hopkins, D.A.5    Dever, T.E.6    Polyak, S.J.7    Gretch, D.R.8    Katze, M.G.9
  • 12
    • 80052858308 scopus 로고    scopus 로고
    • Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes
    • Ghosh, S.; Ahrens, W. A.; Phatak, S. U.; Hwang, S.; Schrum, L. W.; Bonkovsky, H. L. Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes J. Viral Hepatitis 2011, 18 (10) e568-77
    • (2011) J. Viral Hepatitis , vol.18 , Issue.10 , pp. 568-577
    • Ghosh, S.1    Ahrens, W.A.2    Phatak, S.U.3    Hwang, S.4    Schrum, L.W.5    Bonkovsky, H.L.6
  • 14
    • 80755175300 scopus 로고    scopus 로고
    • Discovery of hepatitis C virus NS5A inhibitors as a new class of anti-HCV therapy
    • Lee, C. Discovery of hepatitis C virus NS5A inhibitors as a new class of anti-HCV therapy Arch. Pharmacal Res. 2011, 34 (9) 1403-7
    • (2011) Arch. Pharmacal Res. , vol.34 , Issue.9 , pp. 1403-1407
    • Lee, C.1
  • 17
    • 84855921173 scopus 로고    scopus 로고
    • Novel therapies for hepatitis C: Insights from the structure of the virus
    • Fusco, D. N.; Chung, R. T. Novel therapies for hepatitis C: insights from the structure of the virus Annu. Rev. Med. 2012, 63, 373-87
    • (2012) Annu. Rev. Med. , vol.63 , pp. 373-387
    • Fusco, D.N.1    Chung, R.T.2
  • 18
    • 84855212109 scopus 로고    scopus 로고
    • New targets for antiviral therapy of chronic hepatitis C
    • Buhler, S.; Bartenschlager, R. New targets for antiviral therapy of chronic hepatitis C Liver Int. 2012, 32 (Suppl 1) 9-16
    • (2012) Liver Int. , vol.32 , Issue.SUPPL. 1 , pp. 9-16
    • Buhler, S.1    Bartenschlager, R.2
  • 19
    • 84856410313 scopus 로고    scopus 로고
    • Antiviral strategies in hepatitis C virus infection
    • Sarrazin, C.; Hezode, C.; Zeuzem, S.; Pawlotsky, J. M. Antiviral strategies in hepatitis C virus infection J. Hepatol. 2012, 56 (Suppl) S88-S100
    • (2012) J. Hepatol. , vol.56 , Issue.SUPPL.
    • Sarrazin, C.1    Hezode, C.2    Zeuzem, S.3    Pawlotsky, J.M.4
  • 20
    • 83755183779 scopus 로고    scopus 로고
    • Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33
    • Wang, S.; Wu, X.; Pan, T.; Song, W.; Wang, Y.; Zhang, F.; Yuan, Z. Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33 J. Gen. Virol. 2012, 93 (Pt 1) 83-92
    • (2012) J. Gen. Virol. , vol.93 , Issue.PART 1 , pp. 83-92
    • Wang, S.1    Wu, X.2    Pan, T.3    Song, W.4    Wang, Y.5    Zhang, F.6    Yuan, Z.7
  • 21
    • 84871811830 scopus 로고    scopus 로고
    • Infection strategies of bacterial and viral pathogens through pathogen-human protein-protein interactions
    • Durmus Tekir, S.; Cakir, T.; Ulgen, K. O. Infection strategies of bacterial and viral pathogens through pathogen-human protein-protein interactions Front. Microbiol. 2012, 3, 46
    • (2012) Front. Microbiol. , vol.3 , pp. 46
    • Durmus Tekir, S.1    Cakir, T.2    Ulgen, K.O.3
  • 23
    • 36849029833 scopus 로고    scopus 로고
    • Systems biology and the host response to viral infection
    • Tan, S. L.; Ganji, G.; Paeper, B.; Proll, S.; Katze, M. G. Systems biology and the host response to viral infection Nat. Biotechnol. 2007, 25 (12) 1383-9
    • (2007) Nat. Biotechnol. , vol.25 , Issue.12 , pp. 1383-1389
    • Tan, S.L.1    Ganji, G.2    Paeper, B.3    Proll, S.4    Katze, M.G.5
  • 25
    • 80053241157 scopus 로고    scopus 로고
    • Virus-host interactomes and global models of virus-infected cells
    • Friedel, C. C.; Haas, J. Virus-host interactomes and global models of virus-infected cells Trends Microbiol. 2011, 19 (10) 501-8
    • (2011) Trends Microbiol. , vol.19 , Issue.10 , pp. 501-508
    • Friedel, C.C.1    Haas, J.2
  • 33
    • 79952392088 scopus 로고    scopus 로고
    • TargetMine, an integrated data warehouse for candidate gene prioritisation and target discovery
    • Chen, Y. A.; Tripathi, L. P.; Mizuguchi, K. TargetMine, an integrated data warehouse for candidate gene prioritisation and target discovery PLoS One 2011, 6 (3) e17844
    • (2011) PLoS One , vol.6 , Issue.3 , pp. 17844
    • Chen, Y.A.1    Tripathi, L.P.2    Mizuguchi, K.3
  • 35
    • 79551587720 scopus 로고    scopus 로고
    • Cytoscape 2.8: New features for data integration and network visualization
    • Smoot, M. E.; Ono, K.; Ruscheinski, J.; Wang, P. L.; Ideker, T. Cytoscape 2.8: new features for data integration and network visualization Bioinformatics 2011, 27 (3) 431-2
    • (2011) Bioinformatics , vol.27 , Issue.3 , pp. 431-432
    • Smoot, M.E.1    Ono, K.2    Ruscheinski, J.3    Wang, P.L.4    Ideker, T.5
  • 37
    • 84862231127 scopus 로고    scopus 로고
    • Gene3D: A domain-based resource for comparative genomics, functional annotation and protein network analysis
    • Lees, J.; Yeats, C.; Perkins, J.; Sillitoe, I.; Rentzsch, R.; Dessailly, B. H.; Orengo, C. Gene3D: a domain-based resource for comparative genomics, functional annotation and protein network analysis Nucleic Acids Res. 2012, 40 (Database issue) D465-71
    • (2012) Nucleic Acids Res. , vol.40 , Issue.DATABASE ISSUE , pp. 465-471
    • Lees, J.1    Yeats, C.2    Perkins, J.3    Sillitoe, I.4    Rentzsch, R.5    Dessailly, B.H.6    Orengo, C.7
  • 39
  • 40
    • 0001677717 scopus 로고
    • Controlling the false discovery rate - A practical and powerful approach to multiple testing
    • Benjamini, Y.; Hochberg, Y. Controlling the false discovery rate-A practical and powerful approach to multiple testing J. R. Stat. Soc. B 1995, 57 (1) 289-300
    • (1995) J. R. Stat. Soc. B , vol.57 , Issue.1 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 41
    • 71849096141 scopus 로고    scopus 로고
    • How does multiple testing correction work?
    • Noble, W. S. How does multiple testing correction work? Nat. Biotechnol. 2009, 27 (12) 1135-7
    • (2009) Nat. Biotechnol. , vol.27 , Issue.12 , pp. 1135-1137
    • Noble, W.S.1
  • 42
    • 50149086906 scopus 로고    scopus 로고
    • Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation
    • Okamoto, K.; Mori, Y.; Komoda, Y.; Okamoto, T.; Okochi, M.; Takeda, M.; Suzuki, T.; Moriishi, K.; Matsuura, Y. Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation J. Virol. 2008, 82 (17) 8349-61
    • (2008) J. Virol. , vol.82 , Issue.17 , pp. 8349-8361
    • Okamoto, K.1    Mori, Y.2    Komoda, Y.3    Okamoto, T.4    Okochi, M.5    Takeda, M.6    Suzuki, T.7    Moriishi, K.8    Matsuura, Y.9
  • 45
    • 70349736168 scopus 로고    scopus 로고
    • Cochaperone activity of human butyrate-induced transcript 1 facilitates hepatitis C virus replication through an Hsp90-dependent pathway
    • Taguwa, S.; Kambara, H.; Omori, H.; Tani, H.; Abe, T.; Mori, Y.; Suzuki, T.; Yoshimori, T.; Moriishi, K.; Matsuura, Y. Cochaperone activity of human butyrate-induced transcript 1 facilitates hepatitis C virus replication through an Hsp90-dependent pathway J. Virol. 2009, 83 (20) 10427-36
    • (2009) J. Virol. , vol.83 , Issue.20 , pp. 10427-10436
    • Taguwa, S.1    Kambara, H.2    Omori, H.3    Tani, H.4    Abe, T.5    Mori, Y.6    Suzuki, T.7    Yoshimori, T.8    Moriishi, K.9    Matsuura, Y.10
  • 47
    • 33644856599 scopus 로고    scopus 로고
    • The SH3 binding motif of HCV [corrected] NS5A protein interacts with Bin1 and is important for apoptosis and infectivity
    • Nanda, S. K.; Herion, D.; Liang, T. J. The SH3 binding motif of HCV [corrected] NS5A protein interacts with Bin1 and is important for apoptosis and infectivity Gastroenterology 2006, 130 (3) 794-809
    • (2006) Gastroenterology , vol.130 , Issue.3 , pp. 794-809
    • Nanda, S.K.1    Herion, D.2    Liang, T.J.3
  • 49
    • 77955673008 scopus 로고    scopus 로고
    • Transcriptome sequencing, microarray, and proteomic analyses reveal cellular and metabolic impact of hepatitis C virus infection in vitro
    • Woodhouse, S. D.; Narayan, R.; Latham, S.; Lee, S.; Antrobus, R.; Gangadharan, B.; Luo, S.; Schroth, G. P.; Klenerman, P.; Zitzmann, N. Transcriptome sequencing, microarray, and proteomic analyses reveal cellular and metabolic impact of hepatitis C virus infection in vitro Hepatology 2010, 52 (2) 443-53
    • (2010) Hepatology , vol.52 , Issue.2 , pp. 443-453
    • Woodhouse, S.D.1    Narayan, R.2    Latham, S.3    Lee, S.4    Antrobus, R.5    Gangadharan, B.6    Luo, S.7    Schroth, G.P.8    Klenerman, P.9    Zitzmann, N.10
  • 51
    • 79955898445 scopus 로고    scopus 로고
    • Molecular mechanisms of hepatocarcinogenesis in chronic hepatitis C virus infection
    • Yamashita, T.; Honda, M.; Kaneko, S. Molecular mechanisms of hepatocarcinogenesis in chronic hepatitis C virus infection J. Gastroenterol. Hepatol. 2011, 26 (6) 960-4
    • (2011) J. Gastroenterol. Hepatol. , vol.26 , Issue.6 , pp. 960-964
    • Yamashita, T.1    Honda, M.2    Kaneko, S.3
  • 52
    • 34247622363 scopus 로고    scopus 로고
    • The importance of bottlenecks in protein networks: Correlation with gene essentiality and expression dynamics
    • Yu, H.; Kim, P. M.; Sprecher, E.; Trifonov, V.; Gerstein, M. The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics PLoS Comput. Biol. 2007, 3 (4) e59
    • (2007) PLoS Comput. Biol. , vol.3 , Issue.4 , pp. 59
    • Yu, H.1    Kim, P.M.2    Sprecher, E.3    Trifonov, V.4    Gerstein, M.5
  • 53
    • 80655143486 scopus 로고    scopus 로고
    • Systems virology identifies a mitochondrial fatty acid oxidation enzyme, dodecenoyl coenzyme A delta isomerase, required for hepatitis C virus replication and likely pathogenesis
    • Rasmussen, A. L.; Diamond, D. L.; McDermott, J. E.; Gao, X.; Metz, T. O.; Matzke, M. M.; Carter, V. S.; Belisle, S. E.; Korth, M. J.; Waters, K. M.; Smith, R. D.; Katze, M. G. Systems virology identifies a mitochondrial fatty acid oxidation enzyme, dodecenoyl coenzyme A delta isomerase, required for hepatitis C virus replication and likely pathogenesis J. Virol. 2011, 85 (22) 11646-54
    • (2011) J. Virol. , vol.85 , Issue.22 , pp. 11646-11654
    • Rasmussen, A.L.1    Diamond, D.L.2    McDermott, J.E.3    Gao, X.4    Metz, T.O.5    Matzke, M.M.6    Carter, V.S.7    Belisle, S.E.8    Korth, M.J.9    Waters, K.M.10    Smith, R.D.11    Katze, M.G.12
  • 55
    • 0036721468 scopus 로고    scopus 로고
    • Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase
    • He, Y.; Nakao, H.; Tan, S. L.; Polyak, S. J.; Neddermann, P.; Vijaysri, S.; Jacobs, B. L.; Katze, M. G. Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase J. Virol. 2002, 76 (18) 9207-17
    • (2002) J. Virol. , vol.76 , Issue.18 , pp. 9207-9217
    • He, Y.1    Nakao, H.2    Tan, S.L.3    Polyak, S.J.4    Neddermann, P.5    Vijaysri, S.6    Jacobs, B.L.7    Katze, M.G.8
  • 56
    • 80955139377 scopus 로고    scopus 로고
    • The oncogenic role of NS5A of hepatitis C virus is mediated by up-regulation of survivin gene expression in the hepatocellular cell through p53 and NF-kappaB pathways
    • Jiang, Y. F.; He, B.; Li, N. P.; Ma, J.; Gong, G. Z.; Zhang, M. The oncogenic role of NS5A of hepatitis C virus is mediated by up-regulation of survivin gene expression in the hepatocellular cell through p53 and NF-kappaB pathways Cell Biol. Int. 2011, 35 (12) 1225-32
    • (2011) Cell Biol. Int. , vol.35 , Issue.12 , pp. 1225-1232
    • Jiang, Y.F.1    He, B.2    Li, N.P.3    Ma, J.4    Gong, G.Z.5    Zhang, M.6
  • 60
    • 36949000237 scopus 로고    scopus 로고
    • Where have all the interactions gone? Estimating the coverage of two-hybrid protein interaction maps
    • Huang, H.; Jedynak, B. M.; Bader, J. S. Where have all the interactions gone? Estimating the coverage of two-hybrid protein interaction maps PLoS Comput. Biol. 2007, 3 (11) e214
    • (2007) PLoS Comput. Biol. , vol.3 , Issue.11 , pp. 214
    • Huang, H.1    Jedynak, B.M.2    Bader, J.S.3
  • 61
    • 77956868159 scopus 로고    scopus 로고
    • Identification of a novel phosphorylation site in hepatitis C virus NS5A
    • Nordle Gilliver, A.; Griffin, S.; Harris, M. Identification of a novel phosphorylation site in hepatitis C virus NS5A J. Gen. Virol. 2010, 91 (Pt 10) 2428-32
    • (2010) J. Gen. Virol. , vol.91 , Issue.PART 10 , pp. 2428-2432
    • Nordle Gilliver, A.1    Griffin, S.2    Harris, M.3
  • 63
    • 42949145532 scopus 로고    scopus 로고
    • Regulation of hepatitis C virion production via phosphorylation of the NS5A protein
    • Tellinghuisen, T. L.; Foss, K. L.; Treadaway, J. Regulation of hepatitis C virion production via phosphorylation of the NS5A protein PLoS Pathog. 2008, 4 (3) e1000032
    • (2008) PLoS Pathog. , vol.4 , Issue.3 , pp. 1000032
    • Tellinghuisen, T.L.1    Foss, K.L.2    Treadaway, J.3
  • 64
    • 84858965137 scopus 로고    scopus 로고
    • Associations between HIV and human pathways revealed by protein-protein interactions and correlated gene expression profiles
    • Chen, K. C.; Wang, T. Y.; Chan, C. H. Associations between HIV and human pathways revealed by protein-protein interactions and correlated gene expression profiles PLoS One 2012, 7 (3) e34240
    • (2012) PLoS One , vol.7 , Issue.3 , pp. 34240
    • Chen, K.C.1    Wang, T.Y.2    Chan, C.H.3
  • 66
    • 77956262321 scopus 로고    scopus 로고
    • Hepatitis C virus infection: A "liaison a trois" amongst the virus, the host, and chronic low-level inflammation for human survival
    • Barnaba, V. Hepatitis C virus infection: a "liaison a trois" amongst the virus, the host, and chronic low-level inflammation for human survival J. Hepatol. 2010, 53 (4) 752-61
    • (2010) J. Hepatol. , vol.53 , Issue.4 , pp. 752-761
    • Barnaba, V.1
  • 67
    • 53349099559 scopus 로고    scopus 로고
    • Immune responses in hepatitis C virus infection and mechanisms of hepatitis C virus persistence
    • Hiroishi, K.; Ito, T.; Imawari, M. Immune responses in hepatitis C virus infection and mechanisms of hepatitis C virus persistence J. Gastroenterol. Hepatol. 2008, 23 (10) 1473-82
    • (2008) J. Gastroenterol. Hepatol. , vol.23 , Issue.10 , pp. 1473-1482
    • Hiroishi, K.1    Ito, T.2    Imawari, M.3
  • 68
    • 56549116047 scopus 로고    scopus 로고
    • Toll-like receptor and RIG-I-like receptor signaling
    • Kawai, T.; Akira, S. Toll-like receptor and RIG-I-like receptor signaling Ann. N. Y. Acad. Sci. 2008, 1143, 1-20
    • (2008) Ann. N. Y. Acad. Sci. , vol.1143 , pp. 1-20
    • Kawai, T.1    Akira, S.2
  • 70
    • 77956911282 scopus 로고    scopus 로고
    • Modulation of interferon signaling by hepatitis C virus non-structural 5A protein: Implication of genotypic difference in interferon treatment
    • Kang, S. M.; Won, S. J.; Lee, G. H.; Lim, Y. S.; Hwang, S. B. Modulation of interferon signaling by hepatitis C virus non-structural 5A protein: implication of genotypic difference in interferon treatment FEBS Lett. 2010, 584 (18) 4069-76
    • (2010) FEBS Lett. , vol.584 , Issue.18 , pp. 4069-4076
    • Kang, S.M.1    Won, S.J.2    Lee, G.H.3    Lim, Y.S.4    Hwang, S.B.5
  • 71
    • 84863393834 scopus 로고    scopus 로고
    • Activation of chemokine and inflammatory cytokine response in hepatitis C virus-infected hepatocytes depends on Toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates
    • Li, K.; Li, N. L.; Wei, D.; Pfeffer, S. R.; Fan, M.; Pfeffer, L. M. Activation of chemokine and inflammatory cytokine response in hepatitis C virus-infected hepatocytes depends on Toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates Hepatology 2012, 55 (3) 666-75
    • (2012) Hepatology , vol.55 , Issue.3 , pp. 666-675
    • Li, K.1    Li, N.L.2    Wei, D.3    Pfeffer, S.R.4    Fan, M.5    Pfeffer, L.M.6
  • 72
    • 58149299317 scopus 로고    scopus 로고
    • Molecularly targeted therapy for hepatocellular carcinoma
    • Tanaka, S.; Arii, S. Molecularly targeted therapy for hepatocellular carcinoma Cancer Sci. 2009, 100 (1) 1-8
    • (2009) Cancer Sci. , vol.100 , Issue.1 , pp. 1-8
    • Tanaka, S.1    Arii, S.2
  • 73
    • 77955716927 scopus 로고    scopus 로고
    • Current status of molecularly targeted therapy for hepatocellular carcinoma: Basic science
    • Tanaka, S.; Arii, S. Current status of molecularly targeted therapy for hepatocellular carcinoma: basic science Int. J. Clin. Oncol. 2010, 15 (3) 235-41
    • (2010) Int. J. Clin. Oncol. , vol.15 , Issue.3 , pp. 235-241
    • Tanaka, S.1    Arii, S.2
  • 75
    • 84872443890 scopus 로고    scopus 로고
    • P53 controls hepatitis C virus non-structural protein 5A-mediated downregulation of GADD45alpha expression via the NF-kappaB and PI3K-Akt pathways
    • Cheng, D.; Zhao, L.; Zhang, L.; Jiang, Y.; Tian, Y.; Xiao, X.; Gong, G. p53 controls hepatitis C virus non-structural protein 5A-mediated downregulation of GADD45alpha expression via the NF-kappaB and PI3K-Akt pathways J. Gen. Virol. 2013, 94 (Pt 2) 326-35
    • (2013) J. Gen. Virol. , vol.94 , Issue.PART 2 , pp. 326-335
    • Cheng, D.1    Zhao, L.2    Zhang, L.3    Jiang, Y.4    Tian, Y.5    Xiao, X.6    Gong, G.7
  • 76
    • 84863614097 scopus 로고    scopus 로고
    • Proteomic analysis of hepatitis C virus (HCV) core protein transfection and host regulator PA28gamma knockout in HCV pathogenesis: A network-based study
    • Tripathi, L. P.; Kambara, H.; Moriishi, K.; Morita, E.; Abe, T.; Mori, Y.; Chen, Y. A.; Matsuura, Y.; Mizuguchi, K. Proteomic analysis of hepatitis C virus (HCV) core protein transfection and host regulator PA28gamma knockout in HCV pathogenesis: a network-based study J. Proteome Res. 2012, 11 (7) 3664-79
    • (2012) J. Proteome Res. , vol.11 , Issue.7 , pp. 3664-3679
    • Tripathi, L.P.1    Kambara, H.2    Moriishi, K.3    Morita, E.4    Abe, T.5    Mori, Y.6    Chen, Y.A.7    Matsuura, Y.8    Mizuguchi, K.9
  • 77
    • 34447319972 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase signalling pathways triggered by the hepatitis C virus envelope protein E2: Implications for the prevention of infection
    • Zhao, L. J.; Zhao, P.; Chen, Q. L.; Ren, H.; Pan, W.; Qi, Z. T. Mitogen-activated protein kinase signalling pathways triggered by the hepatitis C virus envelope protein E2: implications for the prevention of infection Cell Proliferation 2007, 40 (4) 508-21
    • (2007) Cell Proliferation , vol.40 , Issue.4 , pp. 508-521
    • Zhao, L.J.1    Zhao, P.2    Chen, Q.L.3    Ren, H.4    Pan, W.5    Qi, Z.T.6
  • 78
    • 80155190150 scopus 로고    scopus 로고
    • Pathophysiology of insulin resistance and steatosis in patients with chronic viral hepatitis
    • Basaranoglu, M.; Basaranoglu, G. Pathophysiology of insulin resistance and steatosis in patients with chronic viral hepatitis World J. Gastroenterol. 2011, 17 (36) 4055-62
    • (2011) World J. Gastroenterol. , vol.17 , Issue.36 , pp. 4055-4062
    • Basaranoglu, M.1    Basaranoglu, G.2
  • 79
    • 73449102141 scopus 로고    scopus 로고
    • Steatosis and insulin resistance in hepatitis C: A way out for the virus?
    • Del Campo, J. A.; Romero-Gomez, M. Steatosis and insulin resistance in hepatitis C: a way out for the virus? World J. Gastroenterol. 2009, 15 (40) 5014-9
    • (2009) World J. Gastroenterol. , vol.15 , Issue.40 , pp. 5014-5019
    • Del Campo, J.A.1    Romero-Gomez, M.2
  • 80
    • 72049095072 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance in chronic hepatitis C
    • Douglas, M. W.; George, J. Molecular mechanisms of insulin resistance in chronic hepatitis C World J. Gastroenterol. 2009, 15 (35) 4356-64
    • (2009) World J. Gastroenterol. , vol.15 , Issue.35 , pp. 4356-4364
    • Douglas, M.W.1    George, J.2
  • 81
    • 84868111785 scopus 로고    scopus 로고
    • Molecular pathways for glucose homeostasis, insulin signaling and autophagy in hepatitis C virus induced insulin resistance in a cellular model
    • Das, G. C.; Hollinger, F. B. Molecular pathways for glucose homeostasis, insulin signaling and autophagy in hepatitis C virus induced insulin resistance in a cellular model Virology 2012, 434 (1) 5-17
    • (2012) Virology , vol.434 , Issue.1 , pp. 5-17
    • Das, G.C.1    Hollinger, F.B.2
  • 82
    • 33846849610 scopus 로고    scopus 로고
    • Involvement of the PA28gamma-dependent pathway in insulin resistance induced by hepatitis C virus core protein
    • Miyamoto, H.; Moriishi, K.; Moriya, K.; Murata, S.; Tanaka, K.; Suzuki, T.; Miyamura, T.; Koike, K.; Matsuura, Y. Involvement of the PA28gamma-dependent pathway in insulin resistance induced by hepatitis C virus core protein J. Virol. 2007, 81 (4) 1727-35
    • (2007) J. Virol. , vol.81 , Issue.4 , pp. 1727-1735
    • Miyamoto, H.1    Moriishi, K.2    Moriya, K.3    Murata, S.4    Tanaka, K.5    Suzuki, T.6    Miyamura, T.7    Koike, K.8    Matsuura, Y.9
  • 84
    • 76249125464 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein interacts with beta-catenin and stimulates its transcriptional activity in a phosphoinositide-3 kinase-dependent fashion
    • Milward, A.; Mankouri, J.; Harris, M. Hepatitis C virus NS5A protein interacts with beta-catenin and stimulates its transcriptional activity in a phosphoinositide-3 kinase-dependent fashion J. Gen. Virol. 2010, 91 (Pt 2) 373-81
    • (2010) J. Gen. Virol. , vol.91 , Issue.PART 2 , pp. 373-381
    • Milward, A.1    Mankouri, J.2    Harris, M.3
  • 85
    • 84355162285 scopus 로고    scopus 로고
    • Hepatitis C core protein impairs insulin downstream signalling and regulatory role of IGFBP-1 expression
    • Alberstein, M.; Zornitzki, T.; Zick, Y.; Knobler, H. Hepatitis C core protein impairs insulin downstream signalling and regulatory role of IGFBP-1 expression J. Viral Hepatitis 2012, 19 (1) 65-71
    • (2012) J. Viral Hepatitis , vol.19 , Issue.1 , pp. 65-71
    • Alberstein, M.1    Zornitzki, T.2    Zick, Y.3    Knobler, H.4
  • 87
    • 83455236681 scopus 로고    scopus 로고
    • HCV infection by cell-to-cell transmission: Choice or necessity?
    • Carloni, G.; Crema, A.; Valli, M. B.; Ponzetto, A.; Clementi, M. HCV infection by cell-to-cell transmission: choice or necessity? Curr. Mol. Med. 2012, 12 (1) 83-95
    • (2012) Curr. Mol. Med. , vol.12 , Issue.1 , pp. 83-95
    • Carloni, G.1    Crema, A.2    Valli, M.B.3    Ponzetto, A.4    Clementi, M.5
  • 89
    • 35348943278 scopus 로고    scopus 로고
    • Phospho-regulation of beta-catenin adhesion and signaling functions
    • Daugherty, R. L.; Gottardi, C. J. Phospho-regulation of beta-catenin adhesion and signaling functions Physiology 2007, 22, 303-9
    • (2007) Physiology , vol.22 , pp. 303-309
    • Daugherty, R.L.1    Gottardi, C.J.2
  • 90
    • 79952616582 scopus 로고    scopus 로고
    • Hepatitis C virus-induced furin and thrombospondin-1 activate TGF-beta1: Role of TGF-beta1 in HCV replication
    • Presser, L. D.; Haskett, A.; Waris, G. Hepatitis C virus-induced furin and thrombospondin-1 activate TGF-beta1: role of TGF-beta1 in HCV replication Virology 2011, 412 (2) 284-96
    • (2011) Virology , vol.412 , Issue.2 , pp. 284-296
    • Presser, L.D.1    Haskett, A.2    Waris, G.3
  • 93
    • 49749092090 scopus 로고    scopus 로고
    • The hepatitis C virus non-structural protein NS5A alters the trafficking profile of the epidermal growth factor receptor
    • Mankouri, J.; Griffin, S.; Harris, M. The hepatitis C virus non-structural protein NS5A alters the trafficking profile of the epidermal growth factor receptor Traffic 2008, 9 (9) 1497-509
    • (2008) Traffic , vol.9 , Issue.9 , pp. 1497-1509
    • Mankouri, J.1    Griffin, S.2    Harris, M.3
  • 94
    • 84869049528 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV) induces epidermal growth factor receptor (EGFR) activation via CD81 binding for viral internalization and entry
    • Diao, J.; Pantua, H.; Ngu, H.; Komuves, L.; Diehl, L.; Schaefer, G.; Kapadia, S. B. Hepatitis C virus (HCV) induces epidermal growth factor receptor (EGFR) activation via CD81 binding for viral internalization and entry J. Virol. 2012, 86 (20) 10935-49
    • (2012) J. Virol. , vol.86 , Issue.20 , pp. 10935-10949
    • Diao, J.1    Pantua, H.2    Ngu, H.3    Komuves, L.4    Diehl, L.5    Schaefer, G.6    Kapadia, S.B.7
  • 95
    • 79952748284 scopus 로고    scopus 로고
    • ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking
    • Yoon, H. Y.; Kales, S. C.; Luo, R.; Lipkowitz, S.; Randazzo, P. A. ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking Biol. Cell 2011, 103 (4) 171-84
    • (2011) Biol. Cell , vol.103 , Issue.4 , pp. 171-184
    • Yoon, H.Y.1    Kales, S.C.2    Luo, R.3    Lipkowitz, S.4    Randazzo, P.A.5
  • 97
    • 84865302600 scopus 로고    scopus 로고
    • Role of host reticulon proteins in rearranging membranes for positive-strand RNA virus replication
    • Diaz, A.; Ahlquist, P. Role of host reticulon proteins in rearranging membranes for positive-strand RNA virus replication Curr. Opin. Microbiol. 2012, 15 (4) 519-24
    • (2012) Curr. Opin. Microbiol. , vol.15 , Issue.4 , pp. 519-524
    • Diaz, A.1    Ahlquist, P.2
  • 98
    • 77958004276 scopus 로고    scopus 로고
    • Membrane-shaping host reticulon proteins play crucial roles in viral RNA replication compartment formation and function
    • Diaz, A.; Wang, X.; Ahlquist, P. Membrane-shaping host reticulon proteins play crucial roles in viral RNA replication compartment formation and function Proc. Natl. Acad. Sci. U. S. A. 2010, 107 (37) 16291-6
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , Issue.37 , pp. 16291-16296
    • Diaz, A.1    Wang, X.2    Ahlquist, P.3
  • 99
    • 84858751786 scopus 로고    scopus 로고
    • Proteomic analysis of the very low density lipoprotein (VLDL) transport vesicles
    • Rahim, A.; Nafi-valencia, E.; Siddiqi, S.; Basha, R.; Runyon, C. C.; Siddiqi, S. A. Proteomic analysis of the very low density lipoprotein (VLDL) transport vesicles J Proteomics 2012, 75 (7) 2225-35
    • (2012) J Proteomics , vol.75 , Issue.7 , pp. 2225-2235
    • Rahim, A.1    Nafi-Valencia, E.2    Siddiqi, S.3    Basha, R.4    Runyon, C.C.5    Siddiqi, S.A.6
  • 101
    • 50149114689 scopus 로고    scopus 로고
    • Association of hepatitis C virus replication complexes with microtubules and actin filaments is dependent on the interaction of NS3 and NS5A
    • Lai, C. K.; Jeng, K. S.; Machida, K.; Lai, M. M. Association of hepatitis C virus replication complexes with microtubules and actin filaments is dependent on the interaction of NS3 and NS5A J. Virol. 2008, 82 (17) 8838-48
    • (2008) J. Virol. , vol.82 , Issue.17 , pp. 8838-8848
    • Lai, C.K.1    Jeng, K.S.2    Machida, K.3    Lai, M.M.4
  • 103
    • 84861388566 scopus 로고    scopus 로고
    • Annexin A2 is involved in the formation of hepatitis C virus replication complex on the lipid raft
    • Saxena, V.; Lai, C. K.; Chao, T. C.; Jeng, K. S.; Lai, M. M. Annexin A2 is involved in the formation of hepatitis C virus replication complex on the lipid raft J. Virol. 2012, 86 (8) 4139-50
    • (2012) J. Virol. , vol.86 , Issue.8 , pp. 4139-4150
    • Saxena, V.1    Lai, C.K.2    Chao, T.C.3    Jeng, K.S.4    Lai, M.M.5
  • 104
    • 34247117377 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors
    • Quintavalle, M.; Sambucini, S.; Summa, V.; Orsatti, L.; Talamo, F.; De Francesco, R.; Neddermann, P. Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors J. Biol. Chem. 2007, 282 (8) 5536-44
    • (2007) J. Biol. Chem. , vol.282 , Issue.8 , pp. 5536-5544
    • Quintavalle, M.1    Sambucini, S.2    Summa, V.3    Orsatti, L.4    Talamo, F.5    De Francesco, R.6    Neddermann, P.7
  • 106
    • 70349735843 scopus 로고    scopus 로고
    • Nonstructural 5A protein activates beta-catenin signaling cascades: Implication of hepatitis C virus-induced liver pathogenesis
    • Park, C. Y.; Choi, S. H.; Kang, S. M.; Kang, J. I.; Ahn, B. Y.; Kim, H.; Jung, G.; Choi, K. Y.; Hwang, S. B. Nonstructural 5A protein activates beta-catenin signaling cascades: implication of hepatitis C virus-induced liver pathogenesis J. Hepatol. 2009, 51 (5) 853-64
    • (2009) J. Hepatol. , vol.51 , Issue.5 , pp. 853-864
    • Park, C.Y.1    Choi, S.H.2    Kang, S.M.3    Kang, J.I.4    Ahn, B.Y.5    Kim, H.6    Jung, G.7    Choi, K.Y.8    Hwang, S.B.9
  • 107
    • 44949169674 scopus 로고    scopus 로고
    • The FUSE binding protein is a cellular factor required for efficient replication of hepatitis C virus
    • Zhang, Z.; Harris, D.; Pandey, V. N. The FUSE binding protein is a cellular factor required for efficient replication of hepatitis C virus J. Virol. 2008, 82 (12) 5761-73
    • (2008) J. Virol. , vol.82 , Issue.12 , pp. 5761-5773
    • Zhang, Z.1    Harris, D.2    Pandey, V.N.3
  • 108
    • 77956255823 scopus 로고    scopus 로고
    • Heat shock protein 72 is associated with the hepatitis C virus replicase complex and enhances viral RNA replication
    • Chen, Y. J.; Chen, Y. H.; Chow, L. P.; Tsai, Y. H.; Chen, P. H.; Huang, C. Y.; Chen, W. T.; Hwang, L. H. Heat shock protein 72 is associated with the hepatitis C virus replicase complex and enhances viral RNA replication J. Biol. Chem. 2010, 285 (36) 28183-90
    • (2010) J. Biol. Chem. , vol.285 , Issue.36 , pp. 28183-28190
    • Chen, Y.J.1    Chen, Y.H.2    Chow, L.P.3    Tsai, Y.H.4    Chen, P.H.5    Huang, C.Y.6    Chen, W.T.7    Hwang, L.H.8
  • 109
    • 2142710082 scopus 로고    scopus 로고
    • Proteomic approach identifies HSP27 as an interacting partner of the hepatitis C virus NS5A protein
    • Choi, Y. W.; Tan, Y. J.; Lim, S. G.; Hong, W.; Goh, P. Y. Proteomic approach identifies HSP27 as an interacting partner of the hepatitis C virus NS5A protein Biochem. Biophys. Res. Commun. 2004, 318 (2) 514-9
    • (2004) Biochem. Biophys. Res. Commun. , vol.318 , Issue.2 , pp. 514-519
    • Choi, Y.W.1    Tan, Y.J.2    Lim, S.G.3    Hong, W.4    Goh, P.Y.5
  • 111
    • 69549113556 scopus 로고    scopus 로고
    • Role of oxysterol binding protein in hepatitis C virus infection
    • Amako, Y.; Sarkeshik, A.; Hotta, H.; Yates, J., 3rd; Siddiqui, A. Role of oxysterol binding protein in hepatitis C virus infection J. Virol. 2009, 83 (18) 9237-46
    • (2009) J. Virol. , vol.83 , Issue.18 , pp. 9237-9246
    • Amako, Y.1    Sarkeshik, A.2    Hotta, H.3    Yates III, J.4    Siddiqui, A.5
  • 112
    • 80052288212 scopus 로고    scopus 로고
    • Peptidyl-prolyl isomerase Pin1 is a cellular factor required for hepatitis C virus propagation
    • Lim, Y. S.; Tran, H. T.; Park, S. J.; Yim, S. A.; Hwang, S. B. Peptidyl-prolyl isomerase Pin1 is a cellular factor required for hepatitis C virus propagation J. Virol. 2011, 85 (17) 8777-88
    • (2011) J. Virol. , vol.85 , Issue.17 , pp. 8777-8788
    • Lim, Y.S.1    Tran, H.T.2    Park, S.J.3    Yim, S.A.4    Hwang, S.B.5
  • 113
    • 77954963918 scopus 로고    scopus 로고
    • Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A
    • Chen, Y. C.; Su, W. C.; Huang, J. Y.; Chao, T. C.; Jeng, K. S.; Machida, K.; Lai, M. M. Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A J. Virol. 2010, 84 (16) 7983-93
    • (2010) J. Virol. , vol.84 , Issue.16 , pp. 7983-7993
    • Chen, Y.C.1    Su, W.C.2    Huang, J.Y.3    Chao, T.C.4    Jeng, K.S.5    Machida, K.6    Lai, M.M.7
  • 114
    • 77951022934 scopus 로고    scopus 로고
    • The use of AlphaLISA technology to detect interaction between hepatitis C virus-encoded NS5A and cyclophilin A
    • Waller, H.; Chatterji, U.; Gallay, P.; Parkinson, T.; Targett-Adams, P. The use of AlphaLISA technology to detect interaction between hepatitis C virus-encoded NS5A and cyclophilin A J. Virol. Methods 2010, 165 (2) 202-10
    • (2010) J. Virol. Methods , vol.165 , Issue.2 , pp. 202-210
    • Waller, H.1    Chatterji, U.2    Gallay, P.3    Parkinson, T.4    Targett-Adams, P.5
  • 116
    • 33746134804 scopus 로고    scopus 로고
    • The protein phosphatase 2A represents a novel cellular target for hepatitis C virus NS5A protein
    • Georgopoulou, U.; Tsitoura, P.; Kalamvoki, M.; Mavromara, P. The protein phosphatase 2A represents a novel cellular target for hepatitis C virus NS5A protein Biochimie 2006, 88 (6) 651-62
    • (2006) Biochimie , vol.88 , Issue.6 , pp. 651-662
    • Georgopoulou, U.1    Tsitoura, P.2    Kalamvoki, M.3    Mavromara, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.