Systems virology identifies a mitochondrial fatty acid oxidation enzyme, dodecenoyl coenzyme a delta isomerase, required for hepatitis C virus replication and likely pathogenesis

Journal of Virology

Volumn 85, Issue 22, 2011, Pages 11646-11654

  Rasmussen, Angela L ^a   Diamond, Deborah L ^a   McDermott, Jason E ^b   Gao, Xiaoli ^b   Metz, Thomas O ^b   Matzke, Melissa M ^b   Carter, Victoria S ^a   Belisle, Sarah E ^a   Korth, Marcus J ^a   Waters, Katrina M ^b   Smith, Richard D ^b   Katze, Michael G ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DODECENOYL COENZYME A DELTA ISOMERASE; ISOMERASE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; VIRUS RNA;

ALLELE; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; FATTY ACID OXIDATION; GENE OVEREXPRESSION; HEPATITIS C; HEPATITIS C VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; INHIBITION KINETICS; LIVER BIOPSY; MATHEMATICAL MODEL; PATHOGENESIS; PREDICTION; PRIORITY JOURNAL; PROTEOMICS; RNA REPLICATION; SYSTEMS BIOLOGY; VIROGENESIS; VIROLOGY; VIRUS REPLICATION; VIRUS VIRULENCE;

BIOPSY; CARBON-CARBON DOUBLE BOND ISOMERASES; CELL LINE; FATTY ACIDS; GENE SILENCING; HEPACIVIRUS; HEPATOCYTES; HOST-PATHOGEN INTERACTIONS; HUMANS; LIVER; MITOCHONDRIA; OXIDATION-REDUCTION; PROTEOME; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 80655143486     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.05605-11     Document Type: Article

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