Modulation of interferon signaling by hepatitis C virus non-structural 5A protein: Implication of genotypic difference in interferon treatment

FEBS Letters

Volumn 584, Issue 18, 2010, Pages 4069-4076

  Kang, Sang Min ^a   Won, Seung Jae ^a   Lee, Gun Hee ^a   Lim, Yun Sook ^a   Hwang, Soon B ^a  

^a Hallym University   (South Korea)

Author keywords

Differential interferon antagonism; Hepatitis C virus; Interferon signaling; NS5A protein

Indexed keywords

ALPHA INTERFERON; INTERLEUKIN 8; JANUS KINASE; NONSTRUCTURAL PROTEIN 5A; POLYINOSINIC POLYCYTIDYLIC ACID; STAT PROTEIN; ANTIVIRUS AGENT; NS-5 PROTEIN, HEPATITIS C VIRUS; STAT1 PROTEIN; STAT1 PROTEIN, HUMAN; VIRUS PROTEIN;

ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG RESPONSE; GENETIC VARIABILITY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; MODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; SENDAI VIRUS; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ACTIVE TRANSPORT; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; CELL NUCLEUS; DRUG EFFECTS; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; HEPACIVIRUS; METABOLISM; PHOSPHORYLATION; VIROLOGY;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTIVIRAL AGENTS; CELL LINE; CELL NUCLEUS; DRUG RESISTANCE, VIRAL; GENE SILENCING; HEPACIVIRUS; HEPATITIS C; HUMANS; INTERFERON-ALPHA; INTERLEUKIN-8; PHOSPHORYLATION; POLY I-C; SENDAI VIRUS; STAT1 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS; SENDAI VIRUS;

EID: 77956911282     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.08.032     Document Type: Article

References (25)

1. Saito I., Miyamura T., Ohbayashi A., Harada H., Katayama T., Kikuchi S., Watanabe Y., Koi S., Onji M., Ohta Y., Choo Q.-L., Houghton M., Kuo G. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA 1990, 87:6547-6549.
2. Grakoui A., Wychowski C., Lin C., Feinstone S.M., Rice C.M. Expression and identification of hepatitis C virus polyprotein cleavage products. J. Virol. 1993, 67:1385-1395.
3. Ghosh A.K., Steele R., Meyer K., Ray R., Ray R.B. Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth. J. Gen. Virol. 1999, 80:1179-1183.
4. Street A., Macdonald A., Crowder K., Harris M. The hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade. J. Biol. Chem. 2004, 279:12232-12241.
5. Gale M.J., Korth M.J., Tang N.M., Tan S.L., Hopkins D.A., Dever T.E., Polyak S.J., Gretch D.R., Katze M.G. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology 1997, 14(230):217-227.
6. Herion D., Hoofnagle J.H. The interferon sensitivity determining region: all hepatitis C virus isolates are not the same. Hepatology 1997, 25:769-771.
7. Taylor D.R., Shi S.T., Romano P.R., Barber G.N., Lai M.M. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. Science 1999, 285:107-110.
8. Garcia-Sastre A., Biron C.A. Type 1 interferons and the virus-host relationship: a lesson in detente. Science 2006, 312:879-882.
9. Velazquez L., Fellous M., Stark G.R., Pellegrini S. A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell 1992, 70:313-322.
10. Honda K., Yanai H., Takaoda A., Taniguchi T. Regulation of the type I IFN induction: a current view. Int. Immunol. 2005, 17:1367-1378.
11. Wakita T., Pietschmann T., Kato T., Date T., Miyamoto M., Zhao Z., Murthy K., Habermann A., Kräusslich H.G., Mizokami M., Bartenschlager R., Liang T.J. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat. Med. 2005, 11:791-796.
12. Choi S.H., Hwang S.B. Modulation of the transforming growth factor-beta signal transduction pathway by hepatitis C virus nonstructural 5A protein. J. Biol. Chem. 2006, 281:7468-7478.
13. Park K.J., Choi S.H., Lee S.Y., Hwang S.B., Lai M.M.C. Nonstructural 5A protein of hepatitis C virus modulates tumor necrosis factor alpha-stimulated nuclear factor kB activation. J. Biol. Chem. 2002, 277:13122-13128.
14. Wang Y.Y., Li L., Han K.J., Zhai Z., Shu H.B. A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter. FEBS Lett. 2004, 576:86-90.
15. O'Shea J.J., Gadina M., Schreiber R.D. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 2002, 109:S121-S131.
16. Heim M.H., Moradpour D., Blum H.E. Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway. J. Virol. 1999, 73:8469-8475.
17. Laver T., Nozell S.E., Benveniste E.N. IFN-beta-mediated inhibition of IL-8 expression requires the ISGF3 components Stat1, Stat2, and IRF-9. J. Interferon Cytokine Res. 2008, 28:13-23.
18. Wagoner J., Austin M., Green J., Imaizumi T., Casola A., Brasier A., Khabar K.S., Wakita T., Gale M., Polyak S.J. Regulation of CXCL-8 (interleukin-8) induction by double-stranded RNA signaling pathways during hepatitis C virus infection. J. Virol. 2007, 81:309-318.
19. Blindenbacher A., Duong F.H., Hunziker L., Stutvoet S.T., Wang X., Terracciano L., Moradpour D., Blum H.E., Alonzi T., Tripodi M., La Monica N., Heim M.H. Expression of hepatitis C virus proteins inhibits interferon signaling in the liver of transgenic mice. Gastroenterology 2003, 124:1465-1475.
20. Li K., Foy E., Ferreon J.C., Nakamura M., Ferreon A.C., Ikeda M., Ray S.C., Gale M., Lemon S.M. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc. Natl. Acad. Sci. USA 2005, 102:2992-2997.
21. Garaigorta U., Chisari F.V. Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation. Cell Host Microbe 2009, 6:513-522.
22. Vlahopoulos S., Boldogh I., Casola A., Brasier A.R. Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha: evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation. Blood 1999, 94:1878-1889.
23. Balasubramanian A., Munshi N., Koziel M.J., Hu Z., Liang T.J., Groopman J.E., Ganju R.K. Structural proteins of hepatitis C virus induce interleukin 8 production and apoptosis in human endothelial cells. J. Gen. Virol. 2005, 86:3291-3301.
24. Polyak S.J., Khabar K.S., Paschal D., Ezelle H., Duverlie G., Barber G., Levy D., Mukaida N., Gretch D.R. Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response. J. Virol. 2001, 75:6095-6106.
25. Tsai Y.H., Kuang W.F., Lu T.Y., Kao J.H., Lai M.Y., Liu C.J., Chen P.J., Hwang L.H. The non-structural 5A protein of hepatitis C virus exhibits genotypic differences in interferon antagonism. J. Hepatol. 2008, 49:899-907.