A matrix-assisted laser desorption/ionization tandem mass spectrometry method for direct screening of small molecule mixtures against an aminoglycoside kinase

Analytica Chimica Acta

Volumn 786, Issue , 2013, Pages 103-110

  Smith, Anne Marie E ^a   Awuah, Emelia ^a,b   Capretta, Alfredo ^a   Brennan, John D ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Aminoglycoside phosphotransferase; Antibiotic resistance; Inhibition; Matrix assisted laser desorption ionization; Small molecule screening.

Indexed keywords

ANTIBIOTIC RESISTANCE; FALSE POSITIVE/NEGATIVE; MATRIX ASSISTED LASER DESORPTION/IONIZATION; OPTIMAL ENZYME ACTIVITY; PHOSPHOTRANSFERASES; SMALL MOLECULES; SYNTHETIC INHIBITORS; TANDEM MASS SPECTROMETRY;

ANTIBIOTICS; ENZYME INHIBITION; ENZYMES; IONIC STRENGTH; MASS SPECTROMETRY; MIXTURES; MOLECULES; PHOSPHORYLATION; SCREENING;

ASSAYS;

AMINOGLYCOSIDE; AMINOGLYCOSIDE 3' PHOSPHOTRANSFERASE IIIA; KANAMYCIN A; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IONIC STRENGTH; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SIGNAL NOISE RATIO;

ENZYME INHIBITORS; KANAMYCIN KINASE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TANDEM MASS SPECTROMETRY;

BACTERIA (MICROORGANISMS);

EID: 84879312149     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2013.05.027     Document Type: Article

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