Dietary leucine improves whole-body insulin sensitivity independent of body fat in diet-induced obese Sprague-Dawley rats

Journal of Nutritional Biochemistry

Volumn 24, Issue 7, 2013, Pages 1285-1294

  Eller, Lindsay K ^a   Saha, Dolan C ^a   Shearer, Jane ^a   Reimer, Raylene A ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Calcium; Dairy; Insulin sensitivity; Leucine; Obesity

Indexed keywords

CASEIN; INSULIN; INSULIN RECEPTOR SUBSTRATE; LEUCINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY COMPOSITION; BODY FAT; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FAT MASS; GENE EXPRESSION; INSULIN SENSITIVITY; LIPID DIET; LIVER; MALE; MILK; NONHUMAN; OBESITY; RAT; SKELETAL MUSCLE; ADIPOSE TISSUE; ANIMAL; DAIRY PRODUCT; DIET; INSULIN RESISTANCE; METABOLISM; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

MAMMALIA; RATTUS;

ADIPOSE TISSUE; ANIMALS; DAIRY PRODUCTS; DIET; GENE EXPRESSION; INSULIN RESISTANCE; LEUCINE; LIVER; MUSCLE, SKELETAL; OBESITY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84879299007     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2012.10.004     Document Type: Article

References (42)

1. Ricci-Cabello I., Herrera M.O., Artacho R. Possible role of milk-derived bioactive peptides in the treatment and prevention of metabolic syndrome. Nutr Rev 2012, 70:241-255.
2. Rice B.H., Cifelli C.J., Pikosky M.A., Miller G.D. Dairy components and risk factors for cardiometabolic syndrome: recent evidence and opportunities for future research. Adv Nutr 2011, 2:396-407.
3. Crichton G.E., Bryan J., Buckley J., Murphy K.J. Dairy consumption and metabolic syndrome: a systematic review of findings and methodological issues. Obes Rev 2011, 12:e190-e201.
4. Soares M.J., Murhadi L.L., Kurpad A.V., Chan She Ping-Delfos W., Piers L.S. Mechanistic roles for calcium and vitamin D in the regulation of body weight. Obes Rev 2012, 13:592-605.
5. Onakpoya I.J., Perry R., Zhang J., Ernst E. Efficacy of calcium supplementation for management of overweight and obesity: systematic review of randomized clinical trials. Nutr Rev 2011, 69:335-343.
6. Fumeron F., Lamri A., Abi Khalil C., Jaziri R., Porchay-Balderelli I., Lantieri O., et al. Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR). Dairy consumption and the incidence of hyperglycemia and the metabolic syndrome: results from a French prospective study, Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) 2011, 813-817. 34th ed.
7. Zemel M.B. Role of calcium and dairy products in energy partitioning and weight management. Am J Clin Nutr 2004, 79:907S-912S.
8. Major G.C., Chaput J.P., Ledoux M., St-Pierre S., Anderson G.H., Zemel M.B., et al. Recent developments in calcium-related obesity research. Obes Rev 2008, 9:428-445.
9. Eller L.K., Reimer R.A. Dairy protein attenuates weight gain in obese rats better than whey or casein alone. Obesity 2010, 18:704-711.
10. Eller L.K., Reimer R.A. A high calcium, skim milk powder diet results in a lower fat mass in male, energy-restricted, obese rats more than a low calcium, casein or soy protein diet. J Nutr 2010, 140:1234-1241.
11. Anderson G.H., Luhovyy B., Akhavan T., Panahi S. Milk proteins in the regulation of body weight, satiety, food intake and glycemia. Nestle Nutr Workshop Ser Pediatr Program 2011, 67:147-159.
12. Zemel M.B. The role of dairy foods in weight management. J Am Coll Nutr 2005, 24(6 Suppl):537S-546S.
13. Wang X., Proud C.G. The mTOR pathway in the control of protein synthesis. Physiology (Bethesda) 2006, 21:362-369.
14. Tremblay F., Marette A. Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 2001, 276:38052-38060.
15. Macotela Y., Emanuelli B., Bang A.M., Espinoza D.O., Boucher J., Beebe K., et al. Dietary leucine - an environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS One 2011, 6:e21187.
16. Sun X., Zemel M.B. Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells. Lipids 2007, 42:297-305.
17. Sun X., Zemel M.B. Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes. Nutr Metab (Lond) 2009, 6:26.
18. Bruckbauer A., Zemel M.B. Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells. Nutr Metab (Lond) 2011, 8:91.
19. Levin B.E., Hogan S., Sullivan A.C. Initiation and perpetuation of obesity and obesity resistance in rats. Am J Physiol Regul Integr Comp Physiol 1989, 256:R412-R419.
20. Samuel V.T., Shulman G.I. Mechanisms for insulin resistance: common threads and missing links. Cell 2012, 148:852-871.
21. Levin B.E., Dunn-Meynell A.A., Balkan B., Keesey R.E. Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats. Am J Physiol Regulatory Integrative Comp Physiol 1997, 273:R725-R730.
22. Eller L.K., Reimer R.A. Attenuation in weight gain with high calcium- and dairy-enriched diets is not associated with taste aversion in rats: a comparison with casein, whey, and soy. J Med Food 2010, 13:1182-1188.
23. Zemel M.B., Shi H., Greer B., Dirienzo D., Zemel P.C. Regulation of adiposity by dietary calcium. FASEB J 2000, 14:1132-1138.
24. Shi H., Dirienzo D., Zemel M.B. Effects of dietary calcium on adipocyte lipid metabolism and body weight regulation in energy-restricted aP2-agouti transgenic mice. FASEB J 2001, 15:291-293.
25. Zhang Q., Tordoff M.G. No effect of dietary calcium on body weight of lean and obese mice and rats. Am J Physiol Regulatory Integrative Comp Physiol 2004, 286:R669-R677.
26. Zhang Y., Guo K., LeBlanc R.E., Loh D., Schwartz G.J., Yu Y.-H. Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multi-mechanisms. Diabetes 2007, 56:1647-1654.
27. Zeanandin G., Balage M., Schneider S.M., Dupont J., Hebuterne X., Mothe-Satney I., et al. Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats: an insulin signaling pathway approach. Age (Dordr) 2012, 34:371-387.
28. Noatsch A., Petzke K.J., Millrose M.K., Klaus S. Body weight and energy homeostasis was not affected in C57BL/6 mice fed high whey protein or leucine-supplemented low-fat diets. Eur J Nutr 2011, 50:479-488.
29. Balage M., Dupont J., Mothe-Satney I., Tesseraud S., Mosoni L., Dardevet D. Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance. J Nutr Biochem 2011, 22:219-226.
30. Reeves P.G., Nielsen F.H., Fahey G.C. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 1993, 123:1939-1951.
31. Hruz P.W., Murata H., Qui H., Mueckler M. Indinavir induces acute and reversible peripheral insulin resistance in rats. Diabetes 2002, 51:937-942.
32. Irizarry R.A., Hobbs B., Collin F., Beazer-Barclay Y.D., Antonellis K.J., Scherf U., et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003, 4:249-264.
33. Saeed A.I., Bhagabati N.K., Braisted J.C., Liang W., Sharov V., Howe E.A., et al. TM4 microarray software suite. Methods Enzymol 2006, 411:134-193.
34. Duggan G.E., Hittel D.S., Sensen C.W., Weljie A.M., Vogel H.J., Shearer J. Metabolomic response to exercise training in lean and diet-induced obese mice. J Appl Physiol 2011, 110:1311-1318.
35. Gual P., Le Marchand-Brustel Y., Tanti J.F. Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 2005, 87:99-109.
36. Yoshizaki T., Schenk S., Imamura T., Babendure J.L., Sonoda N., Bae E.J., et al. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab 2010, 298:E419-E428.
37. Ruderman N.B., Saha A.K. Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. Obesity 2006, 14:25S-33S.
38. Zemel M.B., Sun X. Dietary calcium and dairy products modulate oxidative and inflammatory stress in mice and humans. J Nutr 2008, 138:1047-1052.
39. Stancliffe R.A., Thorpe T., Zemel M.B. Dairy attentuates oxidative and inflammatory stress in metabolic syndrome. Am J Clin Nutr 2011, 94:422-430.
40. Nobre J.L., Lisboa P.C., Santos-Silva A.P., Lima N.S., Manhaes A.C., Nogueira-Neto J.F., et al. Calcium supplementation reverts central adiposity, leptin, and insulin resistance in adult offspring programed by neonatal nicotine exposure. J Endocrinol 2011, 210:349-359.
41. Nobre J.L., Lisboa P.C., Lima Nda S., Franco J.G., Nogueira-Neto J.F., de Moura E.G., et al. Calcium supplementation prevents obesity, hyperleptinaemia and hyperglycaemia in adult rats programmed by early weaning. Br J Nutr 2012, 107:979-988.
42. Westerbacka J., Kolak M., Kiviluoto T., Arkkila P., Siren J., Hamsten A., et al. Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects. Diabetes 2007, 56:2759-2765.