Spiclomazine Induces Apoptosis Associated with the Suppression of Cell Viability, Migration and Invasion in Pancreatic Carcinoma Cells

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Zhao, Wenjing ^a   Li, Dan ^a   Liu, Zuojia ^a   Zheng, Xiliang ^a   Wang, Jin ^a,b   Wang, Erkang ^a  

^a CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; GELATINASE A; GELATINASE B; NSC 290956; REACTIVE OXYGEN METABOLITE; SPICLOMAZINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOCHEMISTRY; CANCER CELL CULTURE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MITOCHONDRIAL MEMBRANE POTENTIAL; PANCREAS CARCINOMA; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; HEK293 CELLS; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEOPLASM INVASIVENESS; PANCREATIC NEOPLASMS; PHENOTHIAZINES; REACTIVE OXYGEN SPECIES; SPIRO COMPOUNDS;

AGOUTI PACA;

EID: 84879267553     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066362     Document Type: Article

References (46)

1. Jemal A, Siegel R, Ward E, Hao YP, Xu JQ, et al. (2009) Cancer statistics 2009. CA Cancer J Clin 59: 225-249.
2. Jemal A, Siegel R, Xu J, Ward E, (2010) Cancer statistics 2010. CA Cancer J Clin 60: 277-300.
3. Ducreux M, Boige V, Goere D, Deutsch E, Ezra P, et al. (2007) Pancreatic cancer: From pathogenesis to cure. Best Practice & Reseach Clin Gastroenterol 21: 997-1014.
4. Bardeesy N, DePinho RA, (2002) Pancreatic cancer biology and genetics. Nat Rev Cancer 2: 897-909.
5. Paul EO, Muhammad WS, (2011) First-line treatment for advanced pancreatic cancer. JOP J Pancreas 12: 96-100.
6. Stathis A, Moore J, (2010) Advanced pancreatic carcinoma: current treatment and future challenges. Nat Rev Clin Oncol 7: 163-172.
7. Nicholson DW, (2000) From bench to clinic with apoptosis-based therapeutic agents. Nature 407: 810-816.
8. Lu Y, Jiang F, Jiang H, Wu K, Zheng X, et al. (2010) Gallic acid suppresses cell viability, proliferation, invasion and angiogenesis in human glioma cells. Eur J Pharmacol 641: 102-107.
9. You BR, Park WH, (2010) Gallic acid-induced lung cancer cell death is related to glutathione depletion as well as reactive oxygen species increase. Toxicol in Vitro 24: 1356-1362.
10. Mimeault M, Hauke R, Batra SK, (2007) Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies. Clin Pharmacol Ther 83: 673-691.
11. Murtaza I, Saleem M, Adhami VM, Hafeez BB, Mukhtar H, (2009) Suppression of cFLIP by lupeol, a dietary triterpene, is sufficient to overcome resistance to TRAIL-mediated apoptosis in chemoresistant human pancreatic cancer cells. Cancer Res 69: 1156-1165.
12. David EF, (1994) Apoptosis in cancer therapy: crossing the threshold. Cell 26: 539-542.
13. Hanahan D, Weinberg RA, (2000) The hallmarks of cancer. Cell 100: 57-70.
14. Keleg S, Büchler P, Ludwig R, Büchler MW, Friess H, (2003) Invasion and metastasis in pancreatic cancer. Molecular Cancer 2: 14.
15. Chambers AF, Matrisian LM, (1997) Changing views of the role of matrix metalloproteinases in metastasis. J Nat Cancer Inst 89: 1260-1270.
16. Ren DD, Peng GH, (2006) Effect of rhodoxanthin from potamogeton crispus L on cell apoptosis in Hela cells. Toxicol In Vitro 20: 1411-1418.
17. Zou GM, Maitra A, (2008) Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration. Mol Cancer Ther 7: 2012-2021.
18. Li Q, Wu M, Wang H, Xu G, Zhu T, et al. (2008) Ezrin silencing by small hairpin RNA reverses metastatic behaviors of human breast cancer cells. Cancer Lett 261: 55-63.
19. Chu CS, Xue B, Tu C, Feng ZH, Shi YH, et al. (2007) NRAGE suppresses metastasis of melanoma and pancreatic cancer in vitro and in vivo. Cancer Lett 250: 268-275.
20. Kerr JF, Wyllie AH, Currie AR, (1972) Apoptosis: a basic biological phenomenon with wild-ranging implications in tissue kinetics. Br J Cancer 26: 239-257.
21. Beauparlant P, Shore GC, (2003) Therapeutic activation of caspases in cancer: a question of selectivity. Curr Opin Drug Discov Dev 6: 179-187.
22. Engeland MV, Nieland LJ, Ramaekers FC, Schutte B, Reutelingsperger CP, (1998) Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 31: 1-9.
23. Lisa BH, Cristina MP, Samuel C, Douglas RG, (2008) Measuring apoptosis at the single cell level. Methods 44: 222-228.
24. Evans DB, Abbruzzese JL, Rich TZ (1997) Cancer of the pancreas. In DeVita VT, Hellman S, Rosenberg SA, eds. Cancer, Principles and Practice of Oncology, Fifth Edition. Philadelphia: JB Lippincott Co. pp1054-1058.
25. Desagher S, Martinou JC, (2000) Mitochondria as the central control point of apoptosis. Trends in Cell Biol 10: 369-377.
26. Mutou Y, Ibuki Y, Terao Y, Kojima S Goto R, (2008) Induction of apoptosis by UV-irradiated chlorinated bisphenol A in Jurkat cells. Toxicol in Vitro 22: 864-872.
27. Pan MH, Huang YT, Chang CI, Ho CT, Pan BS, (2007) Apoptotic-inducing epidioxysterols identified in hard clam (Meretrix lusoria). Food Chem 102: 788-795.
28. Yarimar R, Juan R, Francisco A, Alfredo U, Mariugenia M, et al. (2008) Cytotoxic and apoptosis-inducing effect of ent-15-oxo-kaur- 16-en-19-oic acid, a derivative of grandiflorolic acid from Espeletia schultzii. Phytochem 69: 432-438.
29. Ma D, Tremblay P, Mahngar K, Akbari-Asl P, Collins J, et al. (2011) Induction of apoptosis and autophagy in human pancreatic cancer cells by a novel synthetic C-1 analogue of 7-deoxypancratistatin. Am J Biomed Sci 3: 278-291.
30. Liu ZJ, Li D, Zhao WJ, Zheng XL, Wang J, et al. (2012) A potent lead induces apoptosis in pancreatic cancer cells. PLoS ONE 7: e37841.
31. Chen HM, Wu YC, Chia YC, Chang FR, Hsu HK, et al. (2009) Gallic acid, a major component of Toona sinensis leaf extracts, contains a ROS-mediated anticancer activity in human prostate cancer cells. Cancer Lett 286: 161-171.
32. Kurosu T, Ohki M, Wu N, Kagechika H, Miura O, (2009) Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway. Cancer Res 69: 3927-3936.
33. Sánchez AM, Malagarie-Cazenave S, Olea N, Vara D, Chiloeches A, (2007) Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation. Apoptosis 12: 2013-2024.
34. Chodon D, (2007) Inhibition of cell proliferation and induction of apoptosis by genistein in experimental hepatocellular carcinoma. Mol Cell Biochem 297: 73-80.
35. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X, (1999) Biochemical pathways of caspase activation during apoptosis. Ann Rev Cell Dev Biol 15: 269-290.
36. Rastogi RP, Sinha RRP, (2009) Apoptosis: molecular mechanisms and pathogenicity. EXCLI J 8: 155-181.
37. Liu X, Kim CN, Yang J, Jemmerson R, Wang X, (1996) Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c. Cell 86: 147-157.
38. Reed JC, Green DR, (2002) Remodeling for demolition: Changes in mitochrondrial ultrastructure during apoptosis. Mol Cell 9: 1-3.
39. Zamzami N, Kroemer G, (2001) The mitochondrion in apoptosis: How Pandora's box opens. Nat Rev Mol Cell Biol 2: 67-71.
40. Kim R, Emi M, Tanabe K, (2006) Role of mitochondria as the gardens of cell death. Cancer Chemother Pharmacol 57: 545-553.
41. Willis SN, Adams JM, (2005) Life in the balance: How BH3-only proteins induce apoptosis. Curr Opin Cell Biol 17: 617-625.
42. Neuzil J, Wang XF, Dong LF, Low P, Ralph SJ, (2006) Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins. Febs Lett 580: 5125-5129.
43. Li D, Liu ZJ, Zhao WJ, Zheng XL, Wang J, et al. (2013) A small-molecule induces apoptosis and suppress metastasis in pancreatic cancer cells. Eur J Pharm Sci 48: 658-667.
44. McCollum AK, Teneyck CJ, Sauer BM, Toft DO, Erlichman C, (2006) Up-regulation of heat shock protein 27 induces resistance to 17-allylamino- demethoxygel-danamycin through a glutathione-mediated mechanism. Cancer Res 66: 10967-10975.
45. Zhou Y, Zhang SP, Liu CW, Cai YQ, (2009) The protection of selenium on ROS mediated-apoptosis by mitochondria dysfunction in cadmium-induced LLC-PK1 cells. Toxicol in Vitro 23: 288-294.
46. Wang J, Wu A, Xu YF, Liu JW, Qian XH, (2009) M2-A induces apoptosis and G2-M arrest via inhibiting PI3K/Akt pathway in HL60 cells. Cancer Lett 283: 193-202.