2-phenylethynesulfonamide Prevents Induction of Pro-inflammatory Factors and Attenuates LPS-induced Liver Injury by Targeting NHE1-Hsp70 Complex in Mice

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Huang, Chao ^a   Wang, Jia ^a   Chen, Zhuo ^b   Wang, Yuzhe ^a   Zhang, Wei ^a  

^a NANTONG MEDICAL COLLEGE   (China)

^b Invasive Technology Department   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHENYLETHYNESULFONAMIDE; ALANINE AMINOTRANSFERASE; ANTIINFLAMMATORY AGENT; ASPARTATE AMINOTRANSFERASE; CALCIUM ION; HEAT SHOCK PROTEIN 70; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; SODIUM PROTON EXCHANGE PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 2-PHENYLACETYLENESULFONAMIDE; CATION TRANSPORT PROTEIN; I KAPPA B; SLC9A1 PROTEIN, MOUSE; SODIUM PROTON EXCHANGE PROTEIN; SULFONAMIDE; TUMOR NECROSIS FACTOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL INFILTRATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; INFLAMMATION; LIVER CELL; LIVER INJURY; MACROPHAGE; MALE; MONOTHERAPY; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PH; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SINGLE DRUG DOSE; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; C57BL MOUSE; CELL SURVIVAL; CHEMICAL AND DRUG INDUCED LIVER INJURY; CYTOLOGY; DRUG EFFECTS; GENETICS; LIVER; METABOLISM; PATHOLOGY; RAW 264.7 CELL LINE; SIGNAL TRANSDUCTION; VETERINARY;

MUS;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CATION TRANSPORT PROTEINS; CELL SURVIVAL; CHEMICAL AND DRUG INDUCED LIVER INJURY; HSP70 HEAT-SHOCK PROTEINS; I-KAPPA B PROTEINS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LIVER; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RAW 264.7 CELLS; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER; SULFONAMIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84879252953     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067582     Document Type: Article

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