Toll-like receptor 4-dependent Kupffer cell activation and liver injury in a novel mouse model of parenteral nutrition and intestinal injury

Hepatology

Volumn 55, Issue 5, 2012, Pages 1518-1528

  El Kasmi, Karim C ^a,c   Anderson, Aimee L ^a,c   Devereaux, Michael W ^a,c   Fillon, Sophie A ^a,c   Harris, J Kirk ^b,d   Lovell, Mark A ^a,e   Finegold, Milton J ^f   Sokol, Ronald J ^a,c,e  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b Children's Hospital Colorado   (United States)

^c Digestive Health Institute   (United States)

^d Breathing Institute   (United States)

^e CHILDREN S HOSPITAL COLORADO   (United States)

^f BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIBIOTIC AGENT; ASPARTATE AMINOTRANSFERASE; BILE ACID; BILIRUBIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BACTERIAL LOAD; BILE ACID BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CELL ACTIVATION; CHOLESTASIS; CONTROLLED STUDY; ENTERITIS; INTESTINE FLORA; INTESTINE INJURY; INTESTINE MUCOSA PERMEABILITY; KUPFFER CELL; LIVER CELL; LIVER CELL DAMAGE; LIVER HYPERPLASIA; LIVER HYPERTROPHY; LIVER INJURY; MALE; MOUSE; NONHUMAN; PARENTERAL NUTRITION; PARENTERAL NUTRITION ASSOCIATED LIVER INJURY; PELIOSIS HEPATIS; PORTAL VEIN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; BIOPSY, NEEDLE; CELL MEMBRANE PERMEABILITY; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; INTESTINES; KUPFFER CELLS; LIPOPOLYSACCHARIDES; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PARENTERAL NUTRITION; RANDOM ALLOCATION; REFERENCE VALUES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84859965275     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.25500     Document Type: Article

References (28)

1. Wilmore DW, Dudrick SJ. Growth and development of an infant receiving all nutrients exclusively by vein. JAMA 1968; 203: 860-864.
2. Beale EF, Nelson RM, Bucciarelli RL, Donnelly WH, Eitzman DV. Intrahepatic cholestasis associated with parenteral nutrition in premature infants. Pediatrics 1979; 64: 342-347.
3. Goulet O, Ruemmele F. Causes and management of intestinal failure in children. Gastroenterology 2006; 130: S16-S28.
4. Kaufman SS, Loseke CA, Lupo JV, Young RJ, Murray ND, Pinch LW, et al. Influence of bacterial overgrowth and intestinal inflammation on duration of parenteral nutrition in children with short bowel syndrome. J Pediatr 1997; 131: 356-361.
5. Pierro A, van Saene HK, Donnell SC, Hughes J, Ewan C, Nunn AJ, et al. Microbial translocation in neonates and infants receiving long-term parenteral nutrition. Arch Surg 1996; 131: 176-179.
6. Wildhaber BE, Yang H, Spencer AU, Drongowski RA, Teitelbaum DH. Lack of enteral nutrition-effects on the intestinal immune system. J Surg Res 2005; 123: 8-16.
7. Taylor SF, Sondheimer JM, Sokol RJ, Silverman A, Wilson HL. Noninfectious colitis associated with short gut syndrome in infants. J Pediatr 1991; 119: 24-28.
8. Urao M, Okuyama H, Drongowski RA, Teitelbaum DH, Coran AG. Intestinal permeability to small- and large-molecular-weight substances in the newborn rabbit. J Pediatr Surg 1997; 32: 1424-1428.
9. Yang H, Finaly R, Teitelbaum DH. Alteration in epithelial permeability and ion transport in a mouse model of total parenteral nutrition. Crit Care Med 2003; 31: 1118-1125.
10. Nolan JP. Intestinal endotoxins as mediators of hepatic injury-an idea whose time has come again. HEPATOLOGY 1989; 10: 887-891.
11. Buchman AL, Iyer K, Fryer J. Parenteral nutrition-associated liver disease and the role for isolated intestine and intestine/liver transplantation. HEPATOLOGY 2006; 43: 9-19.
12. Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, et al. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med 2007; 13: 1324-1332.
13. Thurman RG. II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol 1998; 275: G605-G611.
14. Spruss A, Kanuri G, Wagnerberger S, Haub S, Bischoff SC, Bergheim I. Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. HEPATOLOGY 2009; 50: 1094-1104.
15. Poltorak A, He X, Smirnova I, Liu M-Y, Huffel CV, Du X, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282: 2085-2088.
16. Fagarasan S, Muramatsu M, Suzuki K, Nagaoka H, Hiai H, Honjo T. Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science 2002; 298: 1424-1427.
17. Tannock GW, Munro K, Harmsen HJ, Welling GW, Smart J, Gopal PK. Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20. Appl Environ Microbiol 2000; 66: 2578-2588.
18. Nadkarni MA, Martin FE, Jacques NA, Hunter N. Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set. Microbiology 2002; 148: 257-266.
19. Wirtz S, Neufert C, Weigmann B, Neurath MF. Chemically induced mouse models of intestinal inflammation. Nat Protoc 2007; 2: 541-546.
20. Zambrano E, El-Hennawy M, Ehrenkranz RA, Zelterman D, Reyes-Mugica M. Total parenteral nutrition induced liver pathology: an autopsy series of 24 newborn cases. Pediatr Dev Pathol 2004; 7: 425-432.
21. Mandrekar P, Szabo G. Signalling pathways in alcohol-induced liver inflammation. J Hepatol 2009; 50: 1258-1266.
22. Eck SL, Perkins ND, Carr DP, Nabel GJ. Inhibition of phorbol ester-induced cellular adhesion by competitive binding of NF-kappa B in vivo. Mol Cell Biol 1993; 13: 6530-6536.
23. Petrasek J, Dolganiuc A, Csak T, Kurt-Jones EA, Szabo G. Type I interferons protect from Toll-like receptor 9-associated liver injury and regulate IL-1 receptor antagonist in mice. Gastroenterology 2011; 140: 697-708 e694.
24. Lichtman SN, Okoruwa EE, Keku J, Schwab JH, Sartor RB. Degradation of endogenous bacterial cell wall polymers by the muralytic enzyme mutanolysin prevents hepatobiliary injury in genetically susceptible rats with experimental intestinal bacterial overgrowth. J Clin Invest 1992; 90: 1313-1322.
25. El Kasmi KC, Anderson AL, Devereaux MW, Fillon SA, Harris JK, Sokol RJ. Specific alterations in the intestinal microbiome are associated with Kupffer cell activation and liver injury in a novel mouse model of parenteral nutrition associated liver injury (PNALI) [Abstract]. Hepatology 2010; 52: 1021A-1119A.
26. Calder PC. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 2006; 83: 1505S-1519S.
27. Kosters A, Karpen SJ. The role of inflammation in cholestasis: clinical and basic aspects. Semin Liver Dis 2010; 30: 186-194.
28. Carter BA, Taylor OA, Prendergast DR, Zimmerman TL, Von Furstenberg R, Moore DD, et al. Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR. Pediatr Res 2007; 62: 301-306.