Optical techniques for the noninvasive diagnosis of skin cancer

Journal of Cancer Research and Clinical Oncology

Volumn 139, Issue 7, 2013, Pages 1083-1104

  Calin, Mihaela Antonina ^a   Parasca, Sorin Viorel ^b   Savastru, Roxana ^a   Calin, Marian Romeo ^c   Dontu, Simona ^a  

^a NATIONAL INSTITUTE OF RESEARCH AND DEVELOPMENT FOR OPTOELECTRONICS INOE 2000   (Romania)

^b Clinical Emergency Hospital   (Romania)

^c HORIA HULUBEI NATIONAL INSTITUTE OF PHYSICS AND NUCLEAR ENGINEERING   (Romania)

Author keywords

Confocal microscopy; Fluorescence spectrometry; Optical coherence tomography; Raman spectroscopy; Reflectance spectrometry; Sensitivity and specificity indices

Indexed keywords

AMINOLEVULINIC ACID; AMINOLEVULINIC ACID METHYL ESTER; HEMATOPORPHYRIN DERIVATIVE; PHOTOSENSITIZING AGENT; RADACHLORIN; UNCLASSIFIED DRUG;

ACTINIC KERATOSIS; BASAL CELL CARCINOMA; BIOCHEMICAL COMPOSITION; BOWEN DISEASE; CHONDROSARCOMA; CONFOCAL MICROSCOPE; CONFOCAL MICROSCOPY; DERMATITIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING EQUIPMENT; DIFFERENTIAL DIAGNOSIS; DIFFUSE REFLECTANCE SPECTROSCOPY; DRUG INDUCED FLUORESCENCE TECHNIQUE; EARLY DIAGNOSIS; FIBER OPTICS; FLUORESCENCE IMAGING; HISTOPATHOLOGY; HUMAN; IMAGING AND DISPLAY; MELANOMA; NON INVASIVE MEASUREMENT; ONCOLOGICAL PARAMETERS; OPTICAL COHERENCE TOMOGRAPHY; OPTICAL COHERENCE TOMOGRAPHY DEVICE; OPTICAL DIAGNOSTIC TECHNIQUE; PRECANCER; PRIORITY JOURNAL; RAMAN SPECTROMETRY; REFLECTOMETRY; RELIABILITY; REVIEW; SENSITIVITY AND SPECIFICITY; SKIN CANCER; SKIN CARCINOMA; SPECTROFLUOROMETRY; SPECTROMETER; SPECTROPHOTOMETER; STANDARDIZATION; TUMOR MARGIN;

HUMANS; MELANOMA; MICROSCOPY, CONFOCAL; OPTICAL IMAGING; SENSITIVITY AND SPECIFICITY; SKIN NEOPLASMS; SPECTROMETRY, FLUORESCENCE; SPECTRUM ANALYSIS, RAMAN; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84879229116     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-013-1423-3     Document Type: Review

References (91)

1. Ahlgrimm-Siess V, Massone C, Scope A, Fink-Puches R, Richtig E, Wolf IH, Koller S, Gerger A, Smolle J, Hofmann-Wellenhof R (2009) Reflectance confocal microscopy of facial lentigo maligna and lentigo maligna melanoma: a preliminary study. Br J Dermatol 161:1307-1316
2. Alex A, Weingast J, Hofer B, Eibl M, Binder M, Pehamberger H, Drexler W, Povazay B (2011) 3D optical coherence tomography for clinical diagnosis of nonmelanoma skin cancers. Imaging Med 6:653-674
3. Amjadi M, Coventry BJ, Greenwood JE (2011) Reflectance confocal microscopy in the diagnosis of non-melanoma skin cancer and benign lesions versus normal skin: a blinded prospective trial. Internet J Plast Surg. doi: 10.5580/245d
4. Astner S, Dietterle S, Otberg N, Röwert-Huber HJ, Stockfleth E, Lademann J (2008) Clinical applicability of in vivo fluorescence confocal microscopy for noninvasive diagnosis and therapeutic monitoring of nonmelanoma skin cancer. Biomed Opt. doi: 10.1117/1.2837411
5. Barton JK, Gossage KW, Xu W, Ranger-Moore JR, Saboda K, Brooks CA, Duckett LD, Salasche SJ, Warneke JA, Alberts DS (2003) Investigating sun-damaged skin and actinic keratosis with optical coherence tomography: a pilot study. Technol Cancer Res Treat 2:525-535 (Pubitemid 38040615)
6. Bijlsma WR, Stilma JS (2005) Optical coherence tomography, an important new tool in the investigation of the retina. Ned Tijdschr Geneeskd 149:1884-1891 (Pubitemid 41188658)
7. Borisova E, Pavlova P, Pavlova E, Troyanova P, Avramov L (2012) Optical biopsy of human skin - a tool for cutaneous tumours' diagnosis. Int J Bioautomation 16(1):53-72
8. Canpolat M, Akman A, Çiftçioǧlu MA, Alpsoy E (2007) Detecting skin malignancy using elastic light scattering spectroscopy. In: Schweitzer D, Fitzmaurice M (eds) Diagnostic optical spectroscopy in biomedicine IV. Proceedings of the SPIE, vol 6628, p 66280K
9. Canpolat M, Akman-Karakaş A, Gökhan-Ocak GA, Başsorgun IC, Akif Çiftçioǧlu M, Alpsoy E (2012) Diagnosis and demarcation of skin malignancy using elastic light single-scattering spectroscopy: a pilot study. Dermatol Surg 38(2):215-223. doi: 10.1111/j.1524-4725.2011.02174.x
10. Cartaxo SB, Santos ID, Bitar R, Oliveira AF, Ferreira LM, Martinho HS, Martin A (2010) FT-Raman spectroscopy for the differentiation between cutaneous melanoma and pigmented nevus. Acta Cir Bras 25:351-356
11. Chen Y, Aguirre AD, Hsiung PL, Desai S, Herz PR, Pedrosa M, Huang Q, Figueiredo M, Huang SW, Koski A, Schmitt JM, Fujimoto JG, Mashimo H (2007) Ultrahigh resolution optical coherence tomography of Barrett's esophagus: preliminary descriptive clinical study correlating images with histology. Endoscopy 39:599-605 (Pubitemid 47098996)
12. Curiel-Lewandrowski C, Williams C, Swindells K, Tahan SR et al (2004) Use of in vivo confocal microscopy in malignant melanoma: an aid in diagnosis, assessment of surgical, nonsurgical therapeutic approaches. Arch Dermatol 140:1127-1132 (Pubitemid 39223121)
13. de Paula AR, Sathaiah S (2005) Raman spectroscopy for diagnosis of atherosclerosis: a rapid analysis using neural networks. Med Eng Phys 27:237-244 (Pubitemid 40203384)
14. de Siqueira EOFS, Giana HE, Silveira L (2012) Discrimination of selected species of pathogenic bacteria using near-infrared Raman spectroscopy and principal components analysis. J Biomed Opt 17:107004
15. Drexler W, Fujimoto JG (2008) State-of-the-art retinal optical coherence tomography. Prog Retin Eye Res 27:45-88 (Pubitemid 351165776)
16. Eichhorn R, Wessler G, Scholz M, Leupold D, Stankovic G, Buder S, Stücker M, Hoffmann K (2009) Early diagnosis of melanotic melanoma based on laser-induced melanin fluorescence. J Biomed Opt 14:034033
17. Farooq MU, Khasnis A, Majid A, Kassab MY (2009) The role of optical coherence tomography in vascular medicine. Vasc Med 14:63-71
18. Figurska M, Robaszkiewicz J, Wierzbowska J (2010) Optical coherence tomography in imaging of macular diseases. Klin Oczna 112:138-146
19. Framme C, Roider J, Sachs HG, Brinkmann R, Gabel VP (2005) Noninvasive imaging and monitoring of retinal pigment epithelium patterns using fundus autofluorescence- Review. Curr Med Imaging Rev 1:89-103
20. Fried D, Xie J, Shafi S, Featherstone JDB, Breunig TM, Charles L (2002) Imaging caries lesions and lesion progression with polarization sensitive optical coherence tomography. J Biomed Opt 7:618-627 (Pubitemid 35459945)
21. Gambichler T, Moussa G, Sand M, Sand D, Altmeyer P, Hoffmann K (2005) Applications of optical coherence tomography, in dermatology. J Dermatol Sci 40:85-94 (Pubitemid 41446206)
22. Gambichler T, Moussa G, Altmeyer P (2008) A pilot study of fluorescence diagnosis of basal cell carcinoma using a digital flash light-based imaging system. Photodermatol Photoimmunol Photomed 24:67-71 (Pubitemid 351436826)
23. Garcia-Uribe A, Smith EB, Zou J, Duvic M, Prieto V, Wang LV (2011) In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry. J Biomed Opt 16:020501
24. Garcia-Uribe A, Zou J, Duvic M, Cho-Vega JH, Prieto VG, Wang LV (2012) In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry. Cancer Res 72:2738-2745
25. Gerger A, Koller S, Weger W, Richtig E, Kerl H, Samonigg H, Krippl P, Smolle J (2006) Sensitivity and specificity of confocal laser-scanning microscopy for in vivo diagnosis of malignant skin tumors. Cancer 107:193-200 (Pubitemid 43939047)
26. Gerger A, Hofmann-Wellenhof R, Langsenlehner U, Richtig E, Koller S, Weger W, Ahlgrimm-Siess V, Horn M, Samonigg H, Smolle J (2008) In vivo confocal laser scanning microscopy of melanocytic skin tumours: diagnostic applicability using unselected tumour images. Br J Dermatol 158:329-333
27. Gniadecka M, Philipsen PA, Sigurdsson S, Wessel S, Nielsen OF, Christensen DH, Hercogova J, Rossen K, Thomsen HK, Gniadecki R, Hansen LK, Wulf HC (2004) Melanoma diagnosis by Raman spectroscopy and neural networks: structure alterations in proteins and lipids in intact cancer tissue. J Invest Dermatol 122:443-449 (Pubitemid 38281067)
28. Gonzalez S (2009) Confocal reflectance microscopy in dermatology: promise and reality of non-invasive diagnosis and monitoring. Actas Dermosifiliogr 100:59-69
29. Guitera P, Pellacani G, Crotty KA, Scolyer RA, Li LXL, Bassoli S, Vinceti M, Rabinovitz H, Longo C, Menzies SW (2010) The impact of in vivo reflectance confocal microscopy on the diagnostic accuracy of lentigo maligna and equivocal pigmented and nonpigmented macules of the face. J Invest Dermatol 130:2080-2091
30. Haka AS, Volynskaya Z, Gardecki JA, Nazemi J, Lyons J, Hicks D, Fitzmaurice M, Dasari RR, Crowe JP, Feld MS (2006) In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy. Cancer Res 66:3317-3322
31. He X, Wang K, Cheng Z (2010) In vivo near-infrared fluorescence imaging of cancer with nanoparticle-based probes. Nanomed Nanobiotechnol 2:349-366
32. Hicks SP, Swindells KJ, Middelkamp-Hup MA, Sifakis MA, Gonzalez E, Gonzalez S (2003) Confocal histopathology of irritant contact dermatitis in vivo and the impact of skin color (black vs white). J Am Acad Dermatol 48:727-734 (Pubitemid 36583284)
33. Hinz T, Ehler LK, Hornung T, Voth H, Fortmeier I, Maier T, Höller T, Schmid-Wendtner MH (2011) Preoperative characterization of basal cell carcinoma comparing tumour thickness measurement by optical coherence tomography, 20-MHz ultrasound and histopathology. Acta Derm Venereol 92(2):132-137. doi: 10.2340/00015555-1231
34. Huang Z, Zeng H, Hamzavi I, Alajlan A, Tan E, McLean DI, Lui H (2006) Cutaneous melanin exhibiting fluorescence emission under near-infrared light excitation. J Biomed Opt 11:34010 (Pubitemid 44363243)
35. Jiao Y, Upile T, Jerjes W, Rhadi H, Mosse S, Bown SG, Hopper C (2009) Interrogation of skin pathology using elastic scattering spectroscopy. Head Neck Oncol 1(Suppl 1):O19. doi: 10.1186/1758-3284-1-S1-O19
36. Jorgensen TM, Tycho A, Mogensen M, Bjerring P, Jemec GBE (2008) Machine-learning classification of non-melanoma skin cancers from image features obtained by optical coherence tomography. Skin Res Technol 14:364-369. doi: 10.1111/j.1600-0846.2008.00304.x
37. Kalasinsky KS, Hadfield T, Shea AA, Kalasinsky VF, Nelson MP, Neiss J, Drauch AJ, Vanni GS, Treado PJ (2007) Raman chemical imaging spectroscopy reagentless detection and identification of pathogens: signature development and evaluation. Anal Chem 79:658-2673 (Pubitemid 46595617)
38. Kamrava SK, Behtaj M, Ghavami Y, Shahabi S, Jalessi M, Afshar EE, Maleki S (2012) Evaluation of diagnostic values of photodynamic diagnosis in identifying the dermal and mucosal squamous cell carcinoma. Photodiagnosis Photodyn Ther. doi: 10.1016/j.pdpdt.2012.03.004
39. Keller MD, Vargis E, Granja NM, Wilson RH, Mycek MA, Kelley MC, Mahadevan-Jansen A (2011) Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation. J Biomed Opt. doi: 10.1117/1.3600708
40. Kleinpenning MM, Wolberink EW, Smits T, Blokx WA, van De Kerkhof PC, van Erp PE, Gerritsen RM (2010) Fluorescence diagnosis in actinic keratosis and squamous cell carcinoma. Photodermatol Photoimmunol Photomed 26:297-302. doi: 10.1111/j.1600-0781.2010.00546.x
41. Korde VR, Bonnema GT, Xu W, Krishnamurthy C, Ranger-Moore J, Saboda K, Slayton LS, Salasche SJ, Warneke JA, Alberts DS, Barton JK (2007) Using optical coherence tomography to evaluate skin sun damage and precancer. Laser Surg Med 39:687-695 (Pubitemid 350086403)
42. Langley RG, Burton E, Walsh N, Propperova I, Murray SJ (2006) In vivo confocal scanning laser microscopy of benign lentigines: comparison to conventional histology and in vivo characteristics of lentigo maligna. J Am Acad Dermatol 55:88-97 (Pubitemid 43867044)
43. Langley RG, Walsh N, Sutherland AE, Propperova I, Delaney L, Morris SF, Gallant C (2007) The diagnostic accuracy of in vivo confocal scanning laser microscopy compared to dermoscopy of benign and malignant melanocytic lesions: a prospective study. Dermatology 215:365-372 (Pubitemid 47519273)
44. Larraona-Puy M, Ghita A, Zoladek A, Perkins W, Varma S, Leach IH, Koloydenko AA, Williams H, Notingher I (2009) Development of Raman microspectroscopy for automated detection and imaging of basal cell carcinoma. J Biomed Opt 14:31-54
45. Leeuw J, van der Beek N, Neugebauer WD, Bjerring P, Neumann HAM (2009) Fluorescence detection and diagnosis of non-melanoma skin cancer at an early stage. Laser Surg Med 41:96-103
46. Leupold D, Scholz M, Stankovic G, Reda J, Buder S, Eichhorn R, Wessler G, Stücker M, Hoffmann K, Bauer J, Garbe C (2011) The stepwise two-photon excited melanin fluorescence is a unique diagnostic tool for the detection of malignant transformation in melanocytes. Pigment Cell Melanoma Res 24:438-445. doi: 10.1111/j.1755-148X.2011.00853.x
47. Lieber CA, Majumder SK, Ellis DL, Billheimer DD, Mahadevan-Jansen A (2008) A In vivo nonmelanoma skin cancer diagnosis using Raman microspectroscopy. Laser Surg Med 40:461-467
48. Lihachev A, Rozniece K, Lesins J, Spigulis J (2011) Photobleaching measurements of pigmented and vascular skin lesions: results of a clinical trial. In: Ramanujam N, Popp J (eds) Clinical and biomedical spectroscopy and imaging II, Proceedings of SPIE-OSA Biomedical Optics, SPIE, vol 8087, p 80872F
49. Lima R, Ishikawa T, Imai Y, Takeda M, Wada S, Yamaguchi T (2009) Measurement of individual red blood cell motions under high hematocrit conditions using a confocal micro-ptv system. Ann Biomed Eng 37:1546-1559
50. Liutkeviciute-Navickiene J, Mordas A, Rutkovskiene L, Bloznelyte-Plesniene L (2008) Skin and mucosal fluorescence diagnosis with different light sources. Eur J Dermatol 19:135-140
51. Lui H, Zhao J, McLean D, Zeng H (2012) Real-time Raman spectroscopy for in vivo skin cancer diagnosis. Cancer Res 72:2491-2500
52. Maier T, Braun-Falco M, Hinz T, Schmid-Wendtner MH, Ruzicka T, Berking C (2012) Morphology of basal cell carcinoma in high definition optical coherence tomography: en-face and slice imaging mode, and comparison with histology. J Eur Acad Dermatol Venereol. doi: 10.1111/j.1468-3083.2012.04551.x
53. Mogensen M, Joergensen TM, Nürnberg BM, Morsy HA, Thomsen JB, Thrane L, Jemec GB (2009) Assessment of optical coherence tomography imaging in the diagnosis of non-melanoma skin cancer and benign lesions versus normal skin: observer-blinded evaluation by dermatologists and pathologists. Dermatol Surg 35:965-972
54. Morales AAM, Montiel SV (2012) Retrieving the optical parameters of biological tissues using diffuse reflectance spectroscopy and Fourier series expansions. I. Theory and application. Biomed Opt Express 3(10):2395-2404
55. Motz JT, Fitzmaurice M, Miller A, Gandhi SJ, Haka AS, Galindo LH, Dasari RR, Kramer JR (2006) In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque. J Biomed Opt. doi: 10.1117/1.2190967 (Pubitemid 44355069)
56. Murphy BW, Webster RJ, Turlach BA, Quirk CJ, Clay CD, Heenan PJ, Sampson DD (2005) Toward the discrimination of early melanoma from common and dysplastic nevus using fiber optic diffuse reflectance spectroscopy. J Biomed Opt 10(6):064020 (Pubitemid 44255973)
57. Neus S, Gambichler T, Bechara FG, Wöhl S, Lehmann P (2008) Preoperative assessment of basal cell carcinoma using conventional fluorescence diagnosis. Arch Dermatol Res 301:289-294
58. Nunes LO, Martin AA, Silveira L Jr, Zampieri M (2003) FT-Raman spectroscopy study for skin cancer diagnosis. Spectroscopy 17:597-602 (Pubitemid 36549514)
59. Oliveira AF, Santos ID, Cartaxo SB, Bitar RA, Enokihara MM, Martinho Hda S, Martin AA, Ferreira LM (2010) Differential diagnosis in primary and metastatic cutaneous melanoma by FT-Raman spectroscopy. Acta Cir Bras 25:434-439
60. Olmedo JM, Warschaw KE, Schmitt JM, Swanson DL (2006) Optical coherence tomography for the characterization of basal cell carcinoma in vivo: a pilot study. J Am Acad Dermatol 55:408-412 (Pubitemid 44189581)
61. Olmedo JM, Warschaw KE, Schmitt JM, Swanson DL (2007) Correlation of thickness of basal cell carcinoma by optical coherence tomography in vivo and routine histologic findings: a pilot study. Dermatol Surg 33:421-426. doi: 10.1111/j.1524-4725.2007.33088.x
62. Otis LL, al-Sadhan RI, Meiers J, Redford-Badwal D (2003) Identification of occlusal sealants using optical coherence tomography. J Clin Dent 14:7-10 (Pubitemid 38199429)
63. Pellacani G, Guitera P, Longo C, Avramidis M, Seidenari S, Menzies S (2007) The impact of in vivo reflectance confocal microscopy for the diagnostic accuracy of melanoma and equivocal melanocytic lesions. J Invest Dermatol 127:2759-2765 (Pubitemid 350134828)
64. Pellacani G, Longo C, Malvehy J, Puig S, Carrera C, Segura S, Bassoli S, Seidenari S (2008) In vivo confocal microscopic and histopathologic correlations of dermoscopic features in 202 melanocytic lesions. Arch Dermatol 144:1597-1608
65. Pyrgiotakis G, Kundakcioglu OE, Finton K, Papardalos PM, Powers K, Moudgil BM (2009) Cell death discrimination with raman spectroscopy and support vector machines. Ann Biomed Eng 37:1464-1473
66. Qiang T, Chang C (2012) Diagnostic applications of Raman spectroscopy, nanomedicine: nanotechnology. Biol Med 8:545-558
67. Rajaram N, Reichenberg JS, Migden MR, Nguyen TH, Tunnell JW (2010) Pilot clinical study for quantitative spectral diagnosis of non-melanoma skin cancer. Laser Surg Med 42:716-727
68. Richards-Kortum R, Sevick-Muraca E (1996) Quantitative optical spectroscopy for tissue diagnostics. Annu Rev Phys Chem 47:555-606 (Pubitemid 126416975)
69. Rigby PJ, Goldie RG (1999) Confocal microscopy in biomedical research. Croat Med J 40:346-352 (Pubitemid 29401652)
70. Rocha R, Silveira L Jr, Villaverde AB, Pasqualucci CA, Costa MS, Brugnera A Jr, Pacheco MT (2007) Use of near-infrared Raman spectroscopy for identification of atherosclerotic plaques in the carotid artery. Photomed Laser Surg 25:482-486
71. Schmitt JM, Yadlowsly MJ, Bonner RF (1995) Subsurface imaging of living skin with optical coherence microscopy. Dermatology 191:93-98
72. Scope A, Mahmood U, Gareau DS, Kenkre M, Lieb JA, Nehal KS, Rajadhyaksha M (2010) In vivo reflectance confocal microscopy of shave biopsy wounds: feasibility of intraoperative mapping of cancer margins. Br J Dermatol 163:1218-1228
73. Silveira L Jr, Silveira FL, Bodanese B, Zângaro RA, Tadeu M, Pacheco T (2012) Discriminating model for diagnosis of basal cell carcinoma and melanoma in vitro based on the Raman spectra of selected biochemicals. J Biomed Opt. doi: 10.1117/1.JBO.17.7.077003
74. Sivak MV Jr, Kobayashi K, Izatt JA, Rollins AM, Ung-Runyawee R, Chak A, Wong RC, Isenberg GA, Willis J (2000) High-resolution endoscopic imaging of the GI tract using optical coherence tomography. Gastrointest Endosc 51:474-479 (Pubitemid 30204773)
75. Swindells K, Burnett N, Rius-Diaz F, Gonzalez E, Mihm MC, Gonzalez S (2004) Reflectance confocal microscopy may differentiate acute allergic and irritant contact dermatitis in vivo. J Am Acad Dermatol 50:220-228 (Pubitemid 38174279)
76. Thompson AJ, Coda S, Sørensen MB, Kennedy G, Patalay R, Waitong-Brämming U, De Beule PAA, Neil MAA, Andersson-Engels S, Bendsøe N, French PMW, Svanberg K, Dunsby C (2012) In vivo measurements of diffuse reflectance and time-resolved autofluorescence emission spectra of basal cell carcinomas. J Biophoton 5:240-254. doi: 10.1002/jbio.201100126
77. Troyanova P, Borisova E, Avramov L (2007) Fluorescence and reflectance properties of hemoglobin-pigmented skin disorders. Proceedings of SPIE 6734, 673415. doi: 10.1117/12.753139 (Pubitemid 350139195)
78. Ulrich M, Maltusch A, Rius-Diaz F, Rowert-Huber J et al (2008) Clinical applicability of in vivo reflectance confocal microscopy for the diagnosis of actinic keratoses. Dermatol Surg 34:610-619 (Pubitemid 351569479)
79. Ulrich M, Krueger-Corcoran D, Roewert-Huber J, Sterry W, Stockfleth E, Astner S (2010) Reflectance confocal microscopy for noninvasive monitoring of therapy and detection of subclinical actinic keratoses. Dermatology 220:15-24
80. Ulrich M, Lange-Asschenfeldt S, Gonzalez S (2012a) Clinical applicability of in vivo reflectance confocal microscopy in dermatology. G Ital Dermatol Venereol 147:171-178
81. Ulrich M, Lange-Asschenfeldt S, Gonzalez S (2012b) The use of reflectance confocal microscopy for monitoring response to therapy of skin malignancies. Dermatol Pract Concept. doi: 10.5826/dpc.0202a10
82. Upile T, Jerjes W, Radhi H, Mahil J, Rao A, Hopper C (2012) Elastic scattering spectroscopy in assessing skin lesions: an in vivo study. Photodiagnosis Photodyn Ther 9:132-141
83. van der Beek N, Leeuw J, Demmendal C, Bjerring P, Neumann HAM (2012) PpIX fluorescence combined with auto-fluorescence is more accurate than PpIX fluorescence alone in fluorescence detection of non-melanoma skin cancer: an intra-patient direct comparison study. Laser Surg Med 44:271-276
84. Wang L, Jacques SL (1995) Monte Carlo modelling of light transport in multi-layered tissues in standard C. Comput Methods Programs Biomed 47:131-146
85. Wetzig T, Kendler M, Maschke J, Paasch U, Simon JC (2010) No clinical benefit of preoperative fluorescence diagnosis of basal cell carcinoma localized in the H-zone of the face. Br J Dermatol 162:1370-1376
86. Won Y, Hong SH, Yu HY, Kwon YH, Yun SJ, Lee SC, Lee JB (2007) Photodetection of basal cell carcinoma using methyl 5-aminolaevulinate-induced protoporphyrin IX based on fluorescence image analysis. Clin Exp Dermatol 32:423-429 (Pubitemid 46828332)
87. Yudovsky D, Laurent Pilon L (2010) Rapid and accurate estimation of blood saturation, melanin content, and epidermis thickness from spectral diffuse reflectance. Appl Opt 49:1707-1719
88. Zeng H, Lui H, McLean DI (2011) Skin cancer detection using in vivo Raman spectroscopy. SPIE Newsroom. doi: 10.1117/2.1201104.003705
89. Zhao J, Lui H, McLean DI, Zeng H (2008) Real-time Raman spectroscopy for non-invasive skin cancer detection - preliminary results. Conf Proc IEEE Eng Med Biol Soc 2008:3107-3109. doi: 10.1109/IEMBS.2008.4649861
90. Zonios G, Bykowski J, Kollias N (2001) Skin melanin, hemoglobin, and light scattering properties can be quantitatively assessed in vivo using diffuse reflectance spectroscopy. J Invest Dermatol 117:1452-1457 (Pubitemid 34032773)
91. Zonios G, Dimou A, Bassukas I, Galaris D, Tsolakidis A, Kaxiras E (2008) Melanin absorption spectroscopy: new method for noninvasive skin investigation and melanoma detection. J Biomed Opt 13:014017-1-014017-8