PpIX fluorescence combined with auto-fluorescence is more accurate than PpIX fluorescence alone in fluorescence detection of non-melanoma skin cancer: An intra-patient direct comparison study

Lasers in Surgery and Medicine

Volumn 44, Issue 4, 2012, Pages 271-276

  Van Der Beek, Nick ^a,b,c   De Leeuw, Jaap ^a   Demmendal, Claire ^d   Bjerring, Peter ^e   Neumann, H A Martino ^d  

^a Independent Treatment Centre for Dermatology   (Netherlands)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c Swansea Metropolitan University   (United Kingdom)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

fluorescence detection; skin cancer

Indexed keywords

AMINOLEVULINIC ACID; PROTOPORPHYRIN;

ADULT; ARTICLE; AUTOFLUORESCENCE; CANCER DIAGNOSIS; CANCER LOCALIZATION; CLINICAL ARTICLE; COMPARATIVE STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; ENCAPSULATION; FEMALE; FLUORESCENCE; HUMAN; MALE; NON MELANOMA SKIN CANCER; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SKIN CANCER;

AMINOLEVULINIC ACID; BOWEN'S DISEASE; CARCINOMA; CARCINOMA, BASAL CELL; FALSE NEGATIVE REACTIONS; FALSE POSITIVE REACTIONS; FEMALE; FLUORESCENCE; HUMANS; KERATOSIS, ACTINIC; MALE; MIDDLE AGED; PHOTOSENSITIZING AGENTS; PROTOPORPHYRINS; SENSITIVITY AND SPECIFICITY; SINGLE-BLIND METHOD; SKIN NEOPLASMS; SPECTROMETRY, FLUORESCENCE; TUMOR MARKERS, BIOLOGICAL;

EID: 84859762915     PISSN: 01968092     EISSN: 10969101     Source Type: Journal    
DOI: 10.1002/lsm.21134     Document Type: Article

References (21)

1. de Vries E, van de Poll-Franse LV, Louwman WJ, de Gruijl FR, Coebergh JWW,. Predictions of skin cancer incidence in the Netherlands up to 2015. Br J Dermatol 2005; 152 (3): 481-488.
2. van Hattem S, Aarts MJ, Louwman WJ, Neumann HAM, Coebergh JWW, Looman CWN, Nijsten T, de Vries E,. Increase in basal cell carcinoma incidence steepest in individuals with high socioeconomic status: Results of a cancer registry study in The Netherlands. Br J Dermatol 2009; 161 (4): 840-845.
3. Smits T, Robles CA, van Erp PEJ, van de Kerkhof PCM, Gerritsen MP,. Correlation between macroscopic fluorescence and protoporphyrin IX content in psoriasis and actinic keratosis following application of aminolevulinic acid. J Invest Dermatol 2005; 125 (4): 833-839.
4. Bauemler W, Abels C, Szeimies R-M,. Fluorescence diagnosis and photodynamic therapy in dermatology. Med Laser Appliances 2003; 18: 47-56.
5. Fauteck J-D, Ackermann G, Birkel M, Breuer M, Moor ACE, Ebeling A, Ortland C,. Fluorescence characteristics and pharmacokinetic properties of a novel self-adhesive 5-ALA patch for photodynamic therapy of actinic keratoses. Arch Dermatol Res 2008; 300 (2): 53-60. DOI: 10.1007/s00403-007-0787-0.
6. Won Y, Hong SH, Yu HY, Kwon YH, Yun SJ, Lee SC, Lee JB,. Photodetection of basal cell carcinoma using methyl 5-aminolaevulinate-induced protoporphyrin IX based on fluorescence image analysis. Clin Exp Dermatol 2007; 32 (4): 423-429.
7. Sanmartin O, Guillen C,. Fluorescence diagnosis of subclinical actinic keratoses. New England J Med 2008; 358 (19): 2009.
8. Smits T, Kleinpenning MM, Blokx WAM, van de Kerkhof PCM, van Erp PEJ, Gerritsen MP,. Fluorescence diagnosis in keratinocytic intraepidermal neoplasias. J Am Acad Dermatol 2007; 57 (5): 824-831.
9. Ibbotson SH, Jong C, Lesar A, Ferguson JS, Padgett M, O'Dwyer M, Barnetson R, Ferguson J,. Characteristics of 5-aminolaevulinic acid-induced protoporphyrin IX fluorescence in human skin in vivo. Photodermatol Photoimmunol Photomed 2006; 22 (2): 105-110. DOI: 10.1111/j.1600-0781.2006.00202.x.
10. Tyrrell J, Campbell S, Curnow A,. Validation of a non-invasive fluorescence imaging system to monitor dermatological PDT. Photodiagn Photodyn Ther 2010; 7 (2): 86-97.
11. de Leeuw J, van der Beek N, Neugebauer WD, Bjerring P, Neumann HAM,. Fluorescence detection and diagnosis of non-melanoma skin cancer at an early stage. Lasers Surg Med 2009; 41 (2): 96-103.
12. Stenquist B, Ericson MB, Strandeberg C, Mölne L, Rosén A, Larkö O, Wennberg AM,. Bispectral fluorescence imaging of aggressive basal cell carcinoma combined with histopathological mapping: A preliminary study indicating a possible adjunct to Mohs micrographic surgery. Br J Dermatol 2006; 154 (2): 305-309.
13. Brancaleon, L, Durkin AJ, Tu, JH, Menaker, G, Fallon, JD, Kollias, N, In vivo fluorescence spectroscopy of nonmelanoma skin cancer. Photochem Photobiol 2001 73 (2): 178-183. Retrieved from.
14. Wetzig T, Kendler M, Maschke J, Paasch U, Simon JC,. No clinical benefit of preoperative fluorescence diagnosis of basal cell carcinoma localized in the H-zone of the face. Br J Dermatol 2010; 162 (6): 1370-1376. DOI: 10.1111/j.1365-2133.2010.09666.x.
15. Neus S, Gambichler T, Bechara FG, Wöhl S, Lehmann P,. Preoperative assessment of basal cell carcinoma using conventional fluorescence diagnosis. Arch Dermatol Res 2009; 301 (4): 289-294.
16. Mogensen M, Jemec GBE,. Diagnosis of nonmelanoma skin cancer/keratinocyte carcinoma: A review of diagnostic accuracy of nonmelanoma skin cancer diagnostic tests and technologies. Dermatol Surg 2007; 33 (10): 1158-1174.
17. Ackermann G,. Photophysikalische Grundlagen zur Fluoreszenzdiagnostik von Tumoren der Haut (PhD). Universität Regensburg. 2001.
18. Leeuw J, de Vijlder HC, de Bjerring P, Neumann HaM,. Liposomes in dermatology today. J Eur Acad Dermatol Venereol 2009; 23 (5): 505-516. DOI: 10.1111/j.1468-3083.2009.03100.x.
19. Alam M, Goldberg LH, Silapunt S, Gardner ES, Strom SS, Rademaker AW, Margolis DJ,. Delayed treatment and continued growth of nonmelanoma skin cancer. J Am Acad Dermatol 2010; 64 (5): 839-848. Elsevier Inc. DOI: 10.1016/j.jaad.2010.06.028.
20. Salasche SJ,. Epidemiology of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol 2000; 42 (1 Pt 2): 4-7.
21. Stang A, Stausberg J, Boedeker W, Kerek-Bodden H, Jöckel K-H,. Nationwide hospitalization costs of skin melanoma and non-melanoma skin cancer in Germany. J Eur Acad Dermatol Venereol 2008; 22 (1): 65-72. DOI: 10.1111/j.1468-3083.2007.02334.x.