The diagnostic accuracy of in vivo confocal scanning laser microscopy compared to dermoscopy of benign and malignant melanocytic lesions: A prospective study

Dermatology

Volumn 215, Issue 4, 2007, Pages 365-372

  Langley, Richard G B ^a   Walsh, Noreen ^a   Sutherland, Ashley E ^a   Propperova, Iva ^a   Delaney, Laura ^a   Morris, Steven F ^a   Gallant, Christopher ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Confocal scanning laser microscopy, diagnostic accuracy; Dermoscopy; Melanoma

Indexed keywords

ADULT; ARTICLE; CLINICAL EXAMINATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; EPILUMINESCENCE MICROSCOPY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INTERMETHOD COMPARISON; JUVENILE MELANOMA; MAJOR CLINICAL STUDY; MALE; MELANOCYTIC NEVUS; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOPSY; DERMOSCOPY; DIAGNOSIS, DIFFERENTIAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MELANOCYTES; MELANOMA; MICROSCOPY, CONFOCAL; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; SKIN NEOPLASMS;

EID: 34948902259     PISSN: 10188665     EISSN: None     Source Type: Journal    
DOI: 10.1159/000109087     Document Type: Article

References (40)

1. Kopf AW, Mintzis M, Bart RS: Diagnostic accuracy in malignant melanoma. Arch Dermatol 1975;111:1291-1292.
2. Curley RK, Cook MG, Fallowfield ME, Marsden RA: Accuracy in clinically evaluating pigmented lesions. BMJ 1989;299:16-18.
3. Wolf IH, Smolle J, Soyer HP, Kerl H: Sensitivity in the clinical diagnosis of malignant melanoma. Melanoma Res 1998;8:425-429.
4. Pehamberger H, Steiner A, Wolff K: In vivo epiluminescence microscopy of pigmented skin lesions. I. Pattern analysis of pigmented skin lesions. J Am Acad Dermatol 1987;17:571-583.
5. Steiner A, Wolff K, Pehamberger H: In vivo epiluminescence microscopy of pigmented skin lesions. II. Diagnosis of small pigmented skin lesions and early detection of malignant melanoma. J Am Acad Dermatol 1987;17:584-591.
6. Argenziano G, Soyer HP, Chimenti S, Talamini R, Corona R, Sera F, et al: Dermoscopy of pigmented lesions: results of a consensus meeting via the Internet. J Am Acad Dermatol 2003;48:679-693.
7. Binder M, Schwarz M, Winkler A, Steiner A, Kaider A, Wolff K, et al: Epiluminescence microscopy: a useful tool for the diagnosis of pigmented skin lesions for formerly trained dermatologists. Arch Dermatol 1995;131:286-291.
8. Marghoob AA, Swindle LD, Moricz CZ, Sanchez Negron FA, Slue B, Halpern AC, et al: Instruments and new technologies for the in vivo diagnosis of melanoma. J Am Acad Dermatol 2003;49:777-797.
9. Rajadhyaksha M, Grossman M, Esterowiz D, Webb RH, Anderson RR: In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast. J Invest Dermatol 1995;104:946-952.
10. Rajadhyaksha M, Gonzalez S, Zavislan JM, Anderson RR, Webb RH: In vivo confocal scanning laser microscopy of human skin. II. Advances in instrumentation and comparison with histology. J Invest Dermatol 1999;113:293-303.
11. Langley RG, Rajadhyaksha M, Dwyer P, Anderson RR, Sober AJ: Confocal scanning laser microscopy of pigmented skin lesions. J Invest Dermatol 1996;106:836.
12. Langley RG, Rajadhyaksha M, Dwyer PJ, Sober AJ, Flotte TJ, Anderson RR: Confocal scanning laser microscopy of benign and malignant melanocytic lesions in vivo. J Am Acad Dermatol 2001;45:365-376.
13. Selkin B, Rajadhyaksha M, Gonzalez S, Langley RG: In vivo confocal microscopy in dermatology. Dermatol Clin 2001;19:369-377.
14. Busam KJ, Charles C, Lee G, Halpern AC: Morphologic features of melanocytes, pigmented keratinocytes and melanophages by in vivo confocal scanning laser microscopy. Mod Pathol 2001;14:862-868.
15. Busam KJ, Hester K, Charles C, Sachs DL, Antonescu CR, Gonzalez S, et al: Detection of clinically amelanotic malignant melanoma and assessment of its margins by in vivo confocal scanning laser microscopy. Arch Dermatol 2001;137:923-929.
16. Busam KJ, Charles C, Lohmann CM, Marghoob A, Goldgeier M, Halpern AC: Detection of intraepidermal malignant melanoma in vivo by confocal scanning laser microscopy. Melanoma Res 2002;12:349-355.
17. Tannous ZS, Mihm MC, Flotte TJ, Gonzalez S: In vivo examination of lentigo maligna and malignant melanoma in situ, lentigo maligna type, by near-infrared reflection confocal microscopy: comparison of in vivo confocal images with histological sections. J Am Acad Dermatol 2002;46:260-263.
18. Pellacani G, Cesinaro AM, Grana C, Seidenari S: In vivo confocal scanning laser microscopy of pigmented Spitz nevi: comparison of in vivo confocal images with dermoscopy and routine histopathology. J Am Acad Dermatol 2004;51:371-376.
19. Pellacani G, Cesinaro AM, Longo C, Grana C, Seidenari S: Microscopic in vivo description of cellular architecture of dermoscopic pigment network in nevi and melanomas. Arch Dermatol 2005;141:147-154.
20. Pellacani G, Cesinaro AM, Seidenari S: Reflectance-mode confocal microscopy for the in vivo characterization of pagetoid melanocytosis in melanomas and nevi. J Invest Dermatol 2005;125:532-537.
21. Gerger A, Koller S, Kern T, Massone C, Steiger K, Richtig E, et al: Diagnostic applicability of in vivo confocal laser scanning microscopy in melanocytic skin tumors. J Invest Dermatol 2005;124:493-498.
22. Langley RG, Burton E, Walsh N, Propperova I, Murray SJ: In vivo confocal scanning laser microscopy of benign lentigines: comparison to conventional histology and in vivo characteristics of lentigo maligna. J Am Acad Dermatol 2006;55:88-97.
23. Binder M, Puespoeck-Schwarz M, Steiner A, Kittler H, Muellner M, Wolff K, et al: Epiluminescence microscopy of small pigmented skin lesions: short-term formal training improves the diagnostic performance of dermatologists. J Am Acad Dermatol 1997;36:197-202.
24. Annessi G, Bono R, Sampogna F, Faraggiana T, Abeni D: Sensitivity, specificity, and diagnostic accuracy of three dermoscopic algorithmic methods in the diagnosis of doubtful melanocytic lesions. J Am Acad Dermatol 2007;56:759-767.
25. Kittler H, Pehamberger H, Wolff K, Binder M: Diagnostic accuracy of dermoscopy. Lancet Oncol 2002;3:159-165.
26. Fisher LD, van Belle G: Biostatistics: A Methodology for the Health Sciences . New York, Wiley & Sons, 1993.
27. Hawass N: Comparing the sensitivities and specificities of two diagnostic procedures on the same group of patients. Br J Radiol 1997;70:360-366.
28. Scope A, Benvenuto-Andrade C, Agero AL, Malvehy J, Puig S, Rajadhyaksha M, et al: In vivo reflectance confocal microscopy imaging of melanocytic skin lesions: consensus terminology glossary and illustrative images. J Am Acad Dermatol 2007;57:644-658.
29. Gerger A, Koller S, Weger W, Richtig E, Kerl H, Samonigg H, et al: Sensitivity and specificity of confocal laser-scanning microscopy for in vivo diagnosis of malignant skin tumors. Cancer 2006;107:193-200.
30. Pellacani G, Cesinaro AM, Seidenari S: Reflectance mode confocal microscopy of pigmented skin lesions - improvement in melanoma diagnostic specificity. J Am Acad Dermatol 2005;53:979-985.
31. Pellacani G, Guitera P, Longo C, Avramidis M, Seidenari S, Menzies S: The impact of in vivo reflectance confocal microscopy for the diagnostic accuracy of melanoma and equivocal melanocytic lesions. J Invest Dermatol DOI: 10.1038/sj.jid.5700993.
32. Pizzichetta MA, Talamini R, Stanganelli I, Puddu P, Bono R, Argenziano G, et al: Amelanotic/hypomelanotic melanoma: clinical and dermoscopic features. Br J Dermatol 2004;150:1117-1124.
33. Zalaudek I, Argenziano G, Di Stefani A, Ferrara G, Marghoob AA, Hofmann-Wellenhof R, et al: Dermoscopy in general dermatology. Dermatology 2006;212:7-18.
34. Stolz W, Braun-Falco O, Bilek P, Landthaler M: Color Atlas of Dermatoscopy, ed 2. Berlin, Blackwell, 2002, pp 42-57.
35. Zalaudek I, Argenziano G, Kerl H, Soyer HP, Hofmann-Wellenhof R: Amelanotic/hypomelanotic melanoma: is dermatoscopy useful for diagnosis? J Dtsch Dermatol Ges 2003;1:369-373.
36. Argenziano G, Zalaudek I, Corona R, Sera F, Cicale L, Petrillo G, et al: Vascular structures in skin tumors: a dermoscopy study. Arch Dermatol 2004;140:1485-1489.
37. de Giorgi V, Sestini S, Massi D, Maio V, Giannotti B: Dermoscopy for 'true' amelanotic melanoma: a clinical dermoscopicpathologic case study. J Am Acad Dermatol 2006;54:341-344.
38. Cavicchini S, Tourlaki A, Bottini S: Dermoscopic vascular patterns in nodular 'pure' amelanotic melanoma. Arch Dermatol 2007;143:556.
39. Skvara H, Teban L, Fiebiger M, Binder M, Kittler H: Limitations of dermoscopy in the recognition of melanoma. Arch Dermatol 2005;141:155-160.
40. Kittler H, Guitera P, Riedl E, Avramidis M, Teban L, Fiebiger M, et al: Identification of clinically featureless incipient melanoma using sequential dermoscopy imaging. Arch Dermatol 2006;142:1113-1119.