Fluorescence diagnosis in actinic keratosis and squamous cell carcinoma

Photodermatology Photoimmunology and Photomedicine

Volumn 26, Issue 6, 2010, Pages 297-302

  Kleinpenning, Marloes M ^a   Wolberink, Esther W ^a   Smits, Tim ^a   Blokx, Willeke A M ^a   Van De Kerkhof, Peter C M ^a   Van Erp, Piet E J ^a   Gerritsen, Rianne M J P ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Actinic keratosis; Fluorescence diagnosis; Micro invasiveness; Squamous cell carcinoma

Indexed keywords

AMINOLEVULINIC ACID; KERATOLYTIC AGENT; PORPHYRIN;

ACTINIC KERATOSIS; ADULT; AGED; ARTICLE; BOWEN DISEASE; CANCER INVASION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLUORESCENCE; HISTOPATHOLOGY; HUMAN; HYPERKERATOSIS; MALE; PRIORITY JOURNAL; PSORIASIS; SKIN BIOPSY; SKIN DEFECT; SQUAMOUS CELL CARCINOMA; STRATUM CORNEUM;

AGED; AGED, 80 AND OVER; AMINOLEVULINIC ACID; CARCINOMA, SQUAMOUS CELL; DIAGNOSIS, DIFFERENTIAL; FEMALE; FLUORESCENCE; HUMANS; KERATOSIS, ACTINIC; MALE; MIDDLE AGED; PHOTOSENSITIZING AGENTS; PORPHYRINS; SKIN NEOPLASMS; TIME FACTORS;

EID: 78649516872     PISSN: 09054383     EISSN: 16000781     Source Type: Journal    
DOI: 10.1111/j.1600-0781.2010.00546.x     Document Type: Article

References (19)

1. Lober BA, Lober CW. Actinic keratosis is squamous cell carcinoma. South Med J 2000; 93: 650-655.
2. Smits T, Olthuis D, Blokx WA, et al. Aneuploidy and proliferation in keratinocytic intraepidermal neoplasias. Exp Dermatol 2007; 16: 81-86.
3. Dodson JM, DeSpain J, Hewett JE, et al. Malignant potential of actinic keratoses and the controversy over treatment. A patient-oriented perspective. Arch Dermatol 1991; 127: 1029-1031.
4. Glogau RG. The risk of progression to invasive disease. J Am Acad Dermatol 2000; 42: 23-24.
5. Marks R, Rennie G, Selwood TS. Malignant transformation of solar keratoses to squamous cell carcinoma. Lancet 1988; 1: 795-797.
6. Marks R, Foley P, Goodman G, et al. Spontaneous remission of solar keratoses: the case for conservative management. Br J Dermatol 1986; 115: 649-655.
7. Yantsos VA, Conrad N, Zabawski E, et al. Incipient intraepidermal cutaneous squamous cell carcinoma: a proposal for reclassifying and grading solar (actinic) keratoses. Semin Cutan Med Surg 1999; 18: 3-14.
8. Fritsch C, Neumann NJ, Ruzicka T, et al. Photodiagnostic tests. 3: fluorescence diagnosis with delta-aminolevulinic acid-induced porphyrins (FDAP) in dermatology. Hautarzt 2000; 51: 528-543.
9. Smits T, Kleinpenning MM, Blokx WA, et al. Fluorescence diagnosis in keratinocytic intraepidermal neoplasias. J Am Acad Dermatol 2007; 57: 824-831.
10. Kleinpenning MM, Smits T, Ewalds E, et al. Heterogeneity of fluorescence in psoriasis after application of 5-aminolaevulinic acid: an immunohistochemical study. Br J Dermatol 2006; 155: 539-545.
11. Angell-Petersen E, Sorensen R, Warloe T, et al. Porphyrin formation in actinic keratosis and basal cell carcinoma after topical application of methyl 5-aminolevulinate. J Invest Dermatol 2006; 126: 265-271.
12. Gibson SL, Cupriks DJ, Havens JJ, et al. A regulatory role for porphobilinogen deaminase (PBGD) in delta-aminolaevulinic acid (delta-ALA)-induced photosensitization? Br J Cancer 1998; 77: 235-242.
13. Krieg RC, Messmann H, Rauch J, et al. Metabolic characterization of tumor cell-specific protoporphyrin IX accumulation after exposure to 5-aminolevulinic acid in human colonic cells. Photochem Photobiol 2002; 76: 518-525.
14. Moan J, Ma LW, Iani V. On the pharmacokinetics of topically applied 5-aminolevulinic acid and two of its esters. Int J Cancer 2001; 92: 139-143.
15. Kleinpenning MM, Kanis JH, Smits T, et al. The effects of keratolytic pretreatment prior to fluorescence diagnosis and photodynamic therapy with aminolevulinic acid-induced porphyrins in psoriasis. J Dermatolog Treat 2010; 21: 245-251.
16. Smits T, Robles CA, Van Erp PE, et al. Correlation between macroscopic fluorescence and protoporphyrin IX Content in psoriasis and actinic keratosis following application of aminolevulinic acid. J Invest Dermatol 2005; 125: 833-839.
17. De Bruijn HS, Meijers C, Van Der Ploeg-van den H, et al. Microscopic localisation of protoporphyrin IX in normal mouse skin after topical application of 5-aminolevulinic acid or methyl 5-aminolevulinate. J Photochem Photobiol B 2008; 92: 91-97.
18. Fritsch C, Homey B, Stahl W, et al. Preferential relative porphyrin enrichment in solar keratoses upon topical application of delta-aminolevulinic acid methylester. Photochem Photobiol 1998; 68: 218-221.
19. Smits T, Van Laarhoven AI, Staassen A, et al. Induction of protoporphyrin IX by aminolaevulinic acid in actinic keratosis, psoriasis and normal skin: preferential porphyrin enrichment in differentiated cells. Br J Dermatol 2009; 160: 849-857.