Quantitation and pharmacokinetics of 1,4-diamino-2,3-dicyano-1,4-bis (2-aminophenylthio) butadiene (U0126) in rat plasma by liquid chromatography-tandem mass spectrometry PDF

Journal of Separation Science

Volumn 36, Issue 2, 2013, Pages 239-245

  Bae, Soo Hyeon ^a   Hwang, Jee Won ^b   Shin, Sang Joon ^b   Park, Gyu Hwan ^c   Yoon, Kee Dong ^a   Bae, Soo Kyung ^a  

^a The Catholic University of Korea   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Kyungpook National University   (South Korea)

Author keywords

1,4 Diamino 2,3 dicyano 1,4 bis (2 aminophenylthio) butadiene (U0126); Liquid chromatography tandem mass spectrometry; Rat plasma; Validation

Indexed keywords

1,4-DIAMINO-2,3-DICYANO-1,4-BIS (2-AMINOPHENYLTHIO) BUTADIENE (U0126); AGILENT; CHROMATOGRAPHIC SEPARATIONS; CONCENTRATION RANGES; CORRELATION COEFFICIENT; INTERNAL STANDARDS; ISOCRATIC MOBILE PHASE; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MATRIX EFFECTS; PHARMACOKINETIC STUDIES; PLASMA SAMPLES; RAT PLASMA; ROOM TEMPERATURE; RUNTIMES; SAMPLE HANDLING; STANDARD CURVES; VALIDATION;

BUTADIENE; CHROMATOGRAPHY; FORMIC ACID; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

BODY FLUIDS;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DRUG BLOOD LEVEL; DRUG SELECTIVITY; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY;

ANIMALS; BUTADIENES; CHROMATOGRAPHY, LIQUID; MALE; NITRILES; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 84872716260     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201200779     Document Type: Article

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