메뉴 건너뛰기




Volumn 83, Issue 7, 2012, Pages 893-902

Stereoisomers ginsenosides-20(S)-Rg 3 and -20(R)-Rg 3 differentially induce angiogenesis through peroxisome proliferator-activated receptor-gamma

Author keywords

Angiogenesis; Ginsenoside; PPAR ; Rg 3; Stereoisomer

Indexed keywords

GINSENOSIDE RG 3; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; SMALL INTERFERING RNA;

EID: 84862830195     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.12.039     Document Type: Article
Times cited : (53)

References (47)
  • 1
    • 78651125802 scopus 로고
    • Studies on the constituents of Japanese and Chinese Crude Drugs, XI, Panaxadiol, a sapogenin of ginseng roots
    • S. Shibata, M. Fujita, H. Itokawa, O. Tanako, and T. Ishii Studies on the constituents of Japanese and Chinese Crude Drugs, XI, Panaxadiol, a sapogenin of ginseng roots Chem Pharm Bull (Tokyo) 11 1963 759 761
    • (1963) Chem Pharm Bull (Tokyo) , vol.11 , pp. 759-761
    • Shibata, S.1    Fujita, M.2    Itokawa, H.3    Tanako, O.4    Ishii, T.5
  • 2
    • 0034521401 scopus 로고    scopus 로고
    • Steaming of ginseng at high temperature enhances biological activity
    • W.Y. Kim, J.M. Kim, S.B. Han, S.K. Lee, N.D. Kim, and M.K. Park Steaming of ginseng at high temperature enhances biological activity J Nat Prod 63 2000 1702 1704
    • (2000) J Nat Prod , vol.63 , pp. 1702-1704
    • Kim, W.Y.1    Kim, J.M.2    Han, S.B.3    Lee, S.K.4    Kim, N.D.5    Park, M.K.6
  • 9
    • 0030838299 scopus 로고    scopus 로고
    • Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocortocoid receptor
    • Y.J. Lee, E. Chung, K.Y. Lee, Y.H. Lee, B. Huh, and S.K. Lee Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocortocoid receptor Mol Cell Endocrinol 133 1997 135 140
    • (1997) Mol Cell Endocrinol , vol.133 , pp. 135-140
    • Lee, Y.J.1    Chung, E.2    Lee, K.Y.3    Lee, Y.H.4    Huh, B.5    Lee, S.K.6
  • 10
    • 70449535513 scopus 로고    scopus 로고
    • 1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/AKT/Nrf2-dependent pathway in human dopaminergic cells
    • 1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/AKT/Nrf2-dependent pathway in human dopaminergic cells Toxicol Appl Pharmacol 242 2010 18 28
    • (2010) Toxicol Appl Pharmacol , vol.242 , pp. 18-28
    • Hwang, Y.P.1    Jeong, H.G.2
  • 13
    • 71649112618 scopus 로고    scopus 로고
    • Rosiglitazone via upregulation of AKT/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by advanced glycation end products
    • C. Liang, Y. Ren, H. Tan, Z. He, Q. Jiang, and J. Wu Rosiglitazone via upregulation of AKT/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by advanced glycation end products Br J Pharmacol 158 2009 1865 1873
    • (2009) Br J Pharmacol , vol.158 , pp. 1865-1873
    • Liang, C.1    Ren, Y.2    Tan, H.3    He, Z.4    Jiang, Q.5    Wu, J.6
  • 14
    • 33745424209 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma-agonist, rosiglitazone, promotes angiogenesis after focal cerebral ischemia
    • K. Chu, S.T. Lee, J.S. Koo, K.H. Jung, E.H. Kim, and D.I. Sinn Peroxisome proliferator-activated receptor-gamma-agonist, rosiglitazone, promotes angiogenesis after focal cerebral ischemia Brain Res 1093 2006 208 218
    • (2006) Brain Res , vol.1093 , pp. 208-218
    • Chu, K.1    Lee, S.T.2    Koo, J.S.3    Jung, K.H.4    Kim, E.H.5    Sinn, D.I.6
  • 15
    • 1542652475 scopus 로고    scopus 로고
    • Nitric oxide production and regulation of endothelial nitric-oxide synthase phosphorylation by prolonged treatment with troglitazone
    • D. Cho, Y.J. Choi, S.A. Jo, and I. Jo Nitric oxide production and regulation of endothelial nitric-oxide synthase phosphorylation by prolonged treatment with troglitazone J Biol Chem 279 2004 2499 2506
    • (2004) J Biol Chem , vol.279 , pp. 2499-2506
    • Cho, D.1    Choi, Y.J.2    Jo, S.A.3    Jo, I.4
  • 16
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • J. Folkman Tumor angiogenesis: therapeutic implications N Engl J Med 285 1971 1182 1186
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 17
    • 33947370773 scopus 로고    scopus 로고
    • Vascular endothelial (VEGF) signaling in tumor progression
    • R. Roskoski Jr. Vascular endothelial (VEGF) signaling in tumor progression Crit Rev Oncol Hematol 62 2007 179 213
    • (2007) Crit Rev Oncol Hematol , vol.62 , pp. 179-213
    • Roskoski, Jr.R.1
  • 18
    • 77952326078 scopus 로고    scopus 로고
    • A simplified method for quantifying cell migration/wound healing in 96-well plates
    • P.Y. Yue, E.P. Leung, N.K. Mak, and R.N. Wong A simplified method for quantifying cell migration/wound healing in 96-well plates J Biomol Screen 15 2010 427 433
    • (2010) J Biomol Screen , vol.15 , pp. 427-433
    • Yue, P.Y.1    Leung, E.P.2    Mak, N.K.3    Wong, R.N.4
  • 20
    • 0032505096 scopus 로고    scopus 로고
    • Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
    • R.T. Nolte, G.B. Wisely, S. Westin, J.E. Cobb, M.H. Lambert, and R. Kurokawa Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ Nature 395 1998 137 143
    • (1998) Nature , vol.395 , pp. 137-143
    • Nolte, R.T.1    Wisely, G.B.2    Westin, S.3    Cobb, J.E.4    Lambert, M.H.5    Kurokawa, R.6
  • 21
    • 22144487356 scopus 로고    scopus 로고
    • Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner
    • Y. Li, M. Choi, K. Suino, A. Kovach, J. Daugherty, and A. Kliewer Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner Proc Natl Acad Sci USA 102 2005 9505 9510
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 9505-9510
    • Li, Y.1    Choi, M.2    Suino, K.3    Kovach, A.4    Daugherty, J.5    Kliewer, A.6
  • 22
    • 49649094046 scopus 로고    scopus 로고
    • Structural and biochemical basis for the binding selectivity of peroxisome proliferator-activated receptor γ to PGC-1α
    • Y. Li, A. Kovach, K. Suino-Powell, D. Martynowski, and H.E. Xu Structural and biochemical basis for the binding selectivity of peroxisome proliferator-activated receptor γ to PGC-1α J Biol Chem 283 2008 19132 19139
    • (2008) J Biol Chem , vol.283 , pp. 19132-19139
    • Li, Y.1    Kovach, A.2    Suino-Powell, K.3    Martynowski, D.4    Xu, H.E.5
  • 23
    • 37349060123 scopus 로고    scopus 로고
    • The differential interactions of peroxisome proliferator-activated receptor (ligands with Tyr473 is a physical basis for their unique biological activities
    • M. Einstein, T.E. Akiyama, G.A. Castriota, C.F. Wang, B. McKeever, and R.T. Mosley The differential interactions of peroxisome proliferator-activated receptor (ligands with Tyr473 is a physical basis for their unique biological activities Mol Pharmacol 73 2008 62 74
    • (2008) Mol Pharmacol , vol.73 , pp. 62-74
    • Einstein, M.1    Akiyama, T.E.2    Castriota, G.A.3    Wang, C.F.4    McKeever, B.5    Mosley, R.T.6
  • 24
    • 11644261806 scopus 로고    scopus 로고
    • Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function
    • G.M. Morris, D.S. Goodsell, R.S. Halliday, R. Huey, W.E. Hart, and R.K. Belew Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function J Comput Chem 19 1998 1639 1662
    • (1998) J Comput Chem , vol.19 , pp. 1639-1662
    • Morris, G.M.1    Goodsell, D.S.2    Halliday, R.S.3    Huey, R.4    Hart, W.E.5    Belew, R.K.6
  • 25
    • 34447128782 scopus 로고    scopus 로고
    • Insights into the mechanism of partial agonism: Crystal structures of the peroxisome proliferator-activated receptor (ligand-binding domain in the complex with two enantiomeric ligands
    • G. Pochetti, C. Godio, N. Mitro, D. Caruso, A. Galmozzi, and S. Scurati Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor (ligand-binding domain in the complex with two enantiomeric ligands J Biol Chem 282 2007 17314 17324
    • (2007) J Biol Chem , vol.282 , pp. 17314-17324
    • Pochetti, G.1    Godio, C.2    Mitro, N.3    Caruso, D.4    Galmozzi, A.5    Scurati, S.6
  • 29
    • 37549015237 scopus 로고    scopus 로고
    • Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia
    • G. Zhang, A. Liu, Y. Zhou, X. San, T. Jin, and Y. Jin Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia J Enthnopharmacol 115 2008 441 448
    • (2008) J Enthnopharmacol , vol.115 , pp. 441-448
    • Zhang, G.1    Liu, A.2    Zhou, Y.3    San, X.4    Jin, T.5    Jin, Y.6
  • 30
    • 33751574640 scopus 로고    scopus 로고
    • Drug disposition in three dimensions: An update on stereoselectivity in pharmacokinetics
    • D.R. Brocks Drug disposition in three dimensions: an update on stereoselectivity in pharmacokinetics Biopharm Drug Dispos 127 2008 387 406
    • (2008) Biopharm Drug Dispos , vol.127 , pp. 387-406
    • Brocks, D.R.1
  • 31
    • 65549171434 scopus 로고    scopus 로고
    • Stereoselectivity in drug metabolism: Molecular mechanisms and analytical methods
    • V.L. Campo, L.S.C. Bernardes, and I. Carvalho Stereoselectivity in drug metabolism: molecular mechanisms and analytical methods Curr Drug Metab 10 2009 188 205
    • (2009) Curr Drug Metab , vol.10 , pp. 188-205
    • Campo, V.L.1    Bernardes, L.S.C.2    Carvalho, I.3
  • 32
    • 23744435889 scopus 로고    scopus 로고
    • Stereochemistry and drug action. Primary care companion
    • J. McConathy, and M.J. Owens Stereochemistry and drug action. Primary care companion J Clin Psychiatry 5 2003 70 73
    • (2003) J Clin Psychiatry , vol.5 , pp. 70-73
    • McConathy, J.1    Owens, M.J.2
  • 33
    • 0024948937 scopus 로고
    • Enantioselective aspects of drug action and disposition: Therapeutic pitfalls
    • F. Jamali, R. Mehvar, and M. Pasutto Enantioselective aspects of drug action and disposition: therapeutic pitfalls J Pharm Sci 78 1989 695 715
    • (1989) J Pharm Sci , vol.78 , pp. 695-715
    • Jamali, F.1    Mehvar, R.2    Pasutto, M.3
  • 35
    • 34848833429 scopus 로고    scopus 로고
    • Synthesis, biological evaluation, and molecular modeling investigation of chrial phenoxyacetic acid analogues with PPARalpha and PPARgamma agonist activity
    • G. Fracchiolla, A. Laghezza, L. Piemontese, G. Carbonara, A. Lavecchi, and P. Tortorella Synthesis, biological evaluation, and molecular modeling investigation of chrial phenoxyacetic acid analogues with PPARalpha and PPARgamma agonist activity ChemMedChem 2 2007 641 654
    • (2007) ChemMedChem , vol.2 , pp. 641-654
    • Fracchiolla, G.1    Laghezza, A.2    Piemontese, L.3    Carbonara, G.4    Lavecchi, A.5    Tortorella, P.6
  • 36
    • 77951785292 scopus 로고    scopus 로고
    • Measuring binding kinetics of ligands with tethered receptors by fluorescence polarization and total internal reflection fluorescence
    • K. Kwok, and N. Cheung Measuring binding kinetics of ligands with tethered receptors by fluorescence polarization and total internal reflection fluorescence Anal Chem 82 2010 3819 3825
    • (2010) Anal Chem , vol.82 , pp. 3819-3825
    • Kwok, K.1    Cheung, N.2
  • 37
    • 55949099802 scopus 로고    scopus 로고
    • 2, an endogenous ligand of peroxisome proliferator-activated receptor γ, in tumor angiogenesis
    • 2, an endogenous ligand of peroxisome proliferator-activated receptor γ, in tumor angiogenesis Biochem Pharm 76 2008 1544 1553
    • (2008) Biochem Pharm , vol.76 , pp. 1544-1553
    • Kim, E.1    Surh, Y.2
  • 38
    • 28144454961 scopus 로고    scopus 로고
    • Ginsenoside Rf a component of ginseng, regulates lipoprotein metabolism through peroxisome proliferator-activated receptor alpha
    • H. Lee, F.J. Gonzalez, and M. Yoon Ginsenoside Rf a component of ginseng, regulates lipoprotein metabolism through peroxisome proliferator-activated receptor alpha Biochem Biophys Res Commun 339 2006 196 203
    • (2006) Biochem Biophys Res Commun , vol.339 , pp. 196-203
    • Lee, H.1    Gonzalez, F.J.2    Yoon, M.3
  • 40
    • 29844443744 scopus 로고    scopus 로고
    • Ginsenoside 20S-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor gamma (PPARgamma) in 3T3-L1 adipocytes
    • K.L. Han, M.H. Jung, J.H. Sohn, and J.K. Hwang Ginsenoside 20S-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor gamma (PPARgamma) in 3T3-L1 adipocytes Biol Pharm Bull 29 2006 110 113
    • (2006) Biol Pharm Bull , vol.29 , pp. 110-113
    • Han, K.L.1    Jung, M.H.2    Sohn, J.H.3    Hwang, J.K.4
  • 41
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infraction and death from cardiovascular causes
    • S.E. Nissen, and K. Wolski Effect of rosiglitazone on the risk of myocardial infraction and death from cardiovascular causes N Engl J Med 356 2007 2457 2571
    • (2007) N Engl J Med , vol.356 , pp. 2457-2571
    • Nissen, S.E.1    Wolski, K.2
  • 42
    • 77956886889 scopus 로고    scopus 로고
    • 3 increases nitric oxide production via increases in phosphorylation and expression of endothelial nitric oxide synthase: Essential roles of estrogen receptor-dependent PI3-kinase and AMP-activated protein kinase
    • 3 increases nitric oxide production via increases in phosphorylation and expression of endothelial nitric oxide synthase: essential roles of estrogen receptor-dependent PI3-kinase and AMP-activated protein kinase Toxicol Appl Pharmacol 246 2010 171 183
    • (2010) Toxicol Appl Pharmacol , vol.246 , pp. 171-183
    • Hien, T.T.1    Kim, N.D.2    Pokharel, Y.R.3    Oh, S.J.4    Lee, M.Y.5    Kang, K.W.6
  • 43
    • 0034730663 scopus 로고    scopus 로고
    • Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase
    • S.G. Bernier, S. Haldar, and T. Michel Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase J Biol Chem 275 2000 30707 30715
    • (2000) J Biol Chem , vol.275 , pp. 30707-30715
    • Bernier, S.G.1    Haldar, S.2    Michel, T.3
  • 44
    • 34548651801 scopus 로고    scopus 로고
    • Water extract of Korean red ginseng stimulates angiogenesis by activating the PI3K/Akt-dependent ERK1/2 and eNOS pathways in human umbilical vein endothelial cells
    • Y.M. Kim, S. Namkoong, Y.G. Yun, H.D. Hong, Y.C. Lee, and K.S. Ha Water extract of Korean red ginseng stimulates angiogenesis by activating the PI3K/Akt-dependent ERK1/2 and eNOS pathways in human umbilical vein endothelial cells Biol Pharm Bull 30 2007 1674 1679
    • (2007) Biol Pharm Bull , vol.30 , pp. 1674-1679
    • Kim, Y.M.1    Namkoong, S.2    Yun, Y.G.3    Hong, H.D.4    Lee, Y.C.5    Ha, K.S.6
  • 45
    • 77954244708 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma (PPAR(): Is the genomic activity the only answer
    • M. Luconi, G. Cantini, and M. Serio Peroxisome proliferator-activated receptor gamma (PPAR(): Is the genomic activity the only answer Steroids 75 2010 585 594
    • (2010) Steroids , vol.75 , pp. 585-594
    • Luconi, M.1    Cantini, G.2    Serio, M.3
  • 46
    • 42549124085 scopus 로고    scopus 로고
    • Rosiglitazone induces caveolin-1 by PPARgamma-dependent and PPRE-independent mechanisms: The role of EGF receptor signaling and its effect on cancer cell drug resistance
    • L. Tencer, E. Burgermeister, M.P. Ebert, and M. Liscovitch Rosiglitazone induces caveolin-1 by PPARgamma-dependent and PPRE-independent mechanisms: the role of EGF receptor signaling and its effect on cancer cell drug resistance Anticancer Res 28 2008 895 906
    • (2008) Anticancer Res , vol.28 , pp. 895-906
    • Tencer, L.1    Burgermeister, E.2    Ebert, M.P.3    Liscovitch, M.4
  • 47
    • 0037428403 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma (PPARgamma) as a molecular target for the soy phytoestrogen genistein
    • Z.C. Dang, V. Audinot, S.E. Papapoulous, J.A. Boutin, and C.W. Löwik Peroxisome proliferator-activated receptor gamma (PPARgamma) as a molecular target for the soy phytoestrogen genistein J Biol Chem 278 2003 962 967
    • (2003) J Biol Chem , vol.278 , pp. 962-967
    • Dang, Z.C.1    Audinot, V.2    Papapoulous, S.E.3    Boutin, J.A.4    Löwik, C.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.