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Volumn , Issue , 2011, Pages 171-188

Turning Endogenous Peptides into New Analgesics: The Example of Kyotorphin Derivatives

Author keywords

Analgesic drugs; Blood brain barrier crossing; Kyotorphin; Kyotorphin derivatives; Opioids; Peptide membrane interaction

Indexed keywords


EID: 84879220271     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527636730.ch8     Document Type: Chapter
Times cited : (4)

References (84)
  • 1
    • 67649467845 scopus 로고    scopus 로고
    • World Health Organization supports global effort to relieve chronic pain
    • World Health Organization. 30 August 2010
    • World Health Organization. (2004) World Health Organization supports global effort to relieve chronic pain. http://www.who.int/mediacentre/news/releases/2004/pr70/en/index.html (30 August 2010)
    • (2004)
  • 2
    • 15544379805 scopus 로고    scopus 로고
    • Watching peptide drugs grow up
    • Marx, V. (2005) Watching peptide drugs grow up. Chem. Eng. News, 83 (11), 17.
    • (2005) Chem. Eng. News , vol.83 , Issue.11 , pp. 17
    • Marx, V.1
  • 3
    • 77956183907 scopus 로고    scopus 로고
    • Peptide drugs to target G protein-coupled receptors
    • Bellmann-Sickert, K. and Beck-Sickinger, A.G. (2010) Peptide drugs to target G protein-coupled receptors. Trends Pharmacol. Sci., 31 (9), 434-441.
    • (2010) Trends Pharmacol. Sci. , vol.31 , Issue.9 , pp. 434-441
    • Bellmann-Sickert, K.1    Beck-Sickinger, A.G.2
  • 4
    • 0004254430 scopus 로고    scopus 로고
    • Peptides: Chemistry and Biology
    • WILEYVCH verlag GmbH & Co. KGaA, Weinheim
    • Sewald, N. and Jakubke, H.-D. (2009) Peptides: Chemistry and Biology, WILEYVCH verlag GmbH & Co. KGaA, Weinheim.
    • (2009)
    • Sewald, N.1    Jakubke, H.-D.2
  • 5
    • 0035200718 scopus 로고    scopus 로고
    • Improved blood-brain barrier penetration and enhanced analgesia of an opioid peptide by glycosylation
    • Egleton, R.D., Mitchell, S.A., Huber, J.D., Palian, M.M., Polt, R., and Davis, T.P. (2001) Improved blood-brain barrier penetration and enhanced analgesia of an opioid peptide by glycosylation. J. Pharmacol. Exp. Ther., 299 (3), 967-972.
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , Issue.3 , pp. 967-972
    • Egleton, R.D.1    Mitchell, S.A.2    Huber, J.D.3    Palian, M.M.4    Polt, R.5    Davis, T.P.6
  • 6
    • 0031763418 scopus 로고    scopus 로고
    • Transport of opioid peptides into the central nervous system
    • Egleton, R.D., Abbruscato, T.J., Thomas, S.A., and Davis, T.P. (1998) Transport of opioid peptides into the central nervous system. J. Pharm. Sci., 87 (11), 1433-1439.
    • (1998) J. Pharm. Sci. , vol.87 , Issue.11 , pp. 1433-1439
    • Egleton, R.D.1    Abbruscato, T.J.2    Thomas, S.A.3    Davis, T.P.4
  • 8
    • 18944361896 scopus 로고    scopus 로고
    • Environmental factors that enhance the action of the cell penetrating peptide pep-1 A spectroscopic study using lipidic vesicles
    • Henriques, S.T. and Castanho, M.A. (2005) Environmental factors that enhance the action of the cell penetrating peptide pep-1 A spectroscopic study using lipidic vesicles. Biochim. Biophys. Acta, 1669 (2), 75-86.
    • (2005) Biochim. Biophys. Acta , vol.1669 , Issue.2 , pp. 75-86
    • Henriques, S.T.1    Castanho, M.A.2
  • 11
    • 84864072469 scopus 로고    scopus 로고
    • Peptide-mediated targeted drug delivery
    • Majumdar, S. and Siahaan, T.J. (2010) Peptide-mediated targeted drug delivery. Med. Res. Rev., 1-22.
    • (2010) Med. Res. Rev. , pp. 1-22
    • Majumdar, S.1    Siahaan, T.J.2
  • 12
    • 0028269108 scopus 로고
    • Neuroactive peptides: unique phases in research on mammalian brain over three decades
    • Myers, R.D. (1994) Neuroactive peptides: unique phases in research on mammalian brain over three decades. Peptides, 15 (2), 367-381.
    • (1994) Peptides , vol.15 , Issue.2 , pp. 367-381
    • Myers, R.D.1
  • 14
    • 1242314868 scopus 로고    scopus 로고
    • Recent advances in selective opioid receptor agonists and antagonists
    • Eguchi, M. (2004) Recent advances in selective opioid receptor agonists and antagonists. Med. Res. Rev., 24 (2), 182-212.
    • (2004) Med. Res. Rev. , vol.24 , Issue.2 , pp. 182-212
    • Eguchi, M.1
  • 15
    • 2142658722 scopus 로고    scopus 로고
    • New trends in the development of opioid peptide analogues as advanced remedies for pain relief
    • Gentilucci, L. (2004) New trends in the development of opioid peptide analogues as advanced remedies for pain relief. Curr. Top. Med. Chem., 4 (1), 19-38.
    • (2004) Curr. Top. Med. Chem. , vol.4 , Issue.1 , pp. 19-38
    • Gentilucci, L.1
  • 16
    • 0041965945 scopus 로고    scopus 로고
    • Attacking pain at its source: new perspectives on opioids
    • Stein, C., Schafer, M., and Machelska, H. (2003) Attacking pain at its source: new perspectives on opioids. Nat. Med., 9 (8), 1003-1008.
    • (2003) Nat. Med. , vol.9 , Issue.8 , pp. 1003-1008
    • Stein, C.1    Schafer, M.2    Machelska, H.3
  • 17
    • 0036095186 scopus 로고    scopus 로고
    • Exploring the opioid system by gene knockout
    • Kieffer, B.L. and Gaveriaux-Ruff, C. (2002) Exploring the opioid system by gene knockout. Prog. Neurobiol., 66 (5), 285-306.
    • (2002) Prog. Neurobiol. , vol.66 , Issue.5 , pp. 285-306
    • Kieffer, B.L.1    Gaveriaux-Ruff, C.2
  • 19
    • 0033013383 scopus 로고    scopus 로고
    • Opioids: first lessons from knockout mice
    • Kieffer, B.L. (1999) Opioids: first lessons from knockout mice. Trends Pharmacol. Sci., 20 (1), 19-26.
    • (1999) Trends Pharmacol. Sci. , vol.20 , Issue.1 , pp. 19-26
    • Kieffer, B.L.1
  • 20
    • 0030933655 scopus 로고    scopus 로고
    • A potent and selective endogenous agonist for the mu-opiate receptor
    • Zadina, J.E., Hackler, L., Ge, L.J., and Kastin, A.J. (1997) A potent and selective endogenous agonist for the mu-opiate receptor. Nature, 386 (6624), 499-502.
    • (1997) Nature , vol.386 , Issue.6624 , pp. 499-502
    • Zadina, J.E.1    Hackler, L.2    Ge, L.J.3    Kastin, A.J.4
  • 21
    • 0031426851 scopus 로고    scopus 로고
    • Isolation of relatively large amounts of endomorphin-1 and endomorphin-2 from human brain cortex
    • Hackler, L., Zadina, J.E., Ge, L.J., and Kastin, A.J. (1997) Isolation of relatively large amounts of endomorphin-1 and endomorphin-2 from human brain cortex. Peptides, 18 (10), 1635-1639.
    • (1997) Peptides , vol.18 , Issue.10 , pp. 1635-1639
    • Hackler, L.1    Zadina, J.E.2    Ge, L.J.3    Kastin, A.J.4
  • 22
    • 77955104823 scopus 로고    scopus 로고
    • Recent advances in endomorphin engineering
    • Keresztes, A., Borics, A., and Toth, G. (2010) Recent advances in endomorphin engineering. Chem. Med. Chem., 5 (8), 1176-1196.
    • (2010) Chem. Med. Chem. , vol.5 , Issue.8 , pp. 1176-1196
    • Keresztes, A.1    Borics, A.2    Toth, G.3
  • 23
    • 84859979289 scopus 로고    scopus 로고
    • vitro blood-brain barrier models-latest advances and therapeutic applications in a chronological perspective
    • Ribeiro, M.M., Cast Anho, M.A., and Serrano, I. In vitro blood-brain barrier models-latest advances and therapeutic applications in a chronological perspective. Mini. Rev. Med. Chem., 10 (3), 262-270.
    • Mini. Rev. Med. Chem. , vol.10 , Issue.3 , pp. 262-270
    • Ribeiro, M.M.1    Cast Anho, M.A.2    Serrano, I.3
  • 24
    • 0036007257 scopus 로고    scopus 로고
    • Why is the global CNS pharmaceutical market so under-penetrated?
    • Pardridge, W.M. (2002) Why is the global CNS pharmaceutical market so under-penetrated?. Drug Discov. Today, 7 (1), 5-7.
    • (2002) Drug Discov. Today , vol.7 , Issue.1 , pp. 5-7
    • Pardridge, W.M.1
  • 25
    • 43049097850 scopus 로고    scopus 로고
    • Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility
    • Ballet, S., Misicka, A., Kosson, P., Lemieux, C., Chung, N.N., Schiller, P.W., Lipkowski, A.W., and Tourwe, D. (2008) Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility. J. Med. Chem., 51 (8), 2571-2574.
    • (2008) J. Med. Chem. , vol.51 , Issue.8 , pp. 2571-2574
    • Ballet, S.1    Misicka, A.2    Kosson, P.3    Lemieux, C.4    Chung, N.N.5    Schiller, P.W.6    Lipkowski, A.W.7    Tourwe, D.8
  • 26
    • 57449121882 scopus 로고    scopus 로고
    • Getting into the brain: approaches to enhance brain drug delivery
    • Patel, M.M., Goyal, B.R., Bhadada, S.V., Bhatt, J.S., and Amin, A.F. (2009) Getting into the brain: approaches to enhance brain drug delivery. CNS Drugs, 23 (1), 35-58.
    • (2009) CNS Drugs , vol.23 , Issue.1 , pp. 35-58
    • Patel, M.M.1    Goyal, B.R.2    Bhadada, S.V.3    Bhatt, J.S.4    Amin, A.F.5
  • 27
    • 51249101710 scopus 로고    scopus 로고
    • Prodrug approaches for CNS delivery
    • Rautio, J., Laine, K., Gynther, M., and Savolainen, J. (2008) Prodrug approaches for CNS delivery. AAPS J., 10 (1), 92-102.
    • (2008) AAPS J. , vol.10 , Issue.1 , pp. 92-102
    • Rautio, J.1    Laine, K.2    Gynther, M.3    Savolainen, J.4
  • 28
    • 33644788804 scopus 로고    scopus 로고
    • CNS drug delivery: opioid peptides and the blood-brain barrier
    • Witt, K.A. and Davis, T.P. (2006) CNS drug delivery: opioid peptides and the blood-brain barrier. AAPS J., 8 (1), E76-88.
    • (2006) AAPS J. , vol.8 , Issue.1
    • Witt, K.A.1    Davis, T.P.2
  • 29
    • 12344319635 scopus 로고    scopus 로고
    • Development of neuropeptide drugs that cross the blood-brain barrier
    • Egleton, R.D. and Davis, T.P. (2005) Development of neuropeptide drugs that cross the blood-brain barrier. NeuroRx, 2 (1), 44-53.
    • (2005) NeuroRx , vol.2 , Issue.1 , pp. 44-53
    • Egleton, R.D.1    Davis, T.P.2
  • 30
    • 0025987567 scopus 로고
    • Peptide to glycopeptide: glycosylated oligopeptide renin inhibitors with attenuated in vivo clearance properties
    • Fisher, J.F., Harrison, A.W., Bundy, G.L., Wilkinson, K.F., Rush, B.D., and Ruwart, M.J. (1991) Peptide to glycopeptide: glycosylated oligopeptide renin inhibitors with attenuated in vivo clearance properties. J. Med. Chem., 34 (10), 3140-3143
    • (1991) J. Med. Chem. , vol.34 , Issue.10 , pp. 3140-3143
    • Fisher, J.F.1    Harrison, A.W.2    Bundy, G.L.3    Wilkinson, K.F.4    Rush, B.D.5    Ruwart, M.J.6
  • 32
    • 16344371181 scopus 로고    scopus 로고
    • Clinical pharmacology of opioids in the treatment of pain
    • in Pain 2002: An Updated Review (ed. M.A. Giamberardino), IASP Press, Seattle
    • Gourlay, G.K. (2002) Clinical pharmacology of opioids in the treatment of pain, in Pain 2002: An Updated Review (ed. M.A. Giamberardino), pp. 381-394, IASP Press, Seattle.
    • (2002) , pp. 381-394
    • Gourlay, G.K.1
  • 33
    • 0025925198 scopus 로고
    • [D-Pen2,4u-125I-Phe4,D-Pen5">D-Pen2,4u-125IPhe4, D-Pen5]enkephalin: a selective high affinity radioligand for delta opioid receptors with exceptional specific activity
    • Knapp, R.J., Sharma, S.D., Toth, G., Duong, M.T., Fang, L., Bogert, C.L., Weber, S.J., Hunt, M., Davis, T.P., Wamsley, J.K. et al. (1991) [D-Pen2,4u-125I-Phe4,D-Pen5">D-Pen2,4u-125IPhe4, D-Pen5]enkephalin: a selective high affinity radioligand for delta opioid receptors with exceptional specific activity. J. Pharmacol. Exp. Ther., 258 (3), 1077-1083.
    • (1991) J. Pharmacol. Exp. Ther. , vol.258 , Issue.3 , pp. 1077-1083
    • Knapp, R.J.1    Sharma, S.D.2    Toth, G.3    Duong, M.T.4    Fang, L.5    Bogert, C.L.6    Weber, S.J.7    Hunt, M.8    Davis, T.P.9    Wamsley, J.K.10
  • 34
    • 0020414774 scopus 로고
    • Doubleenkephalins-synthesis, activity on guinea-pig ileum, and analgesic effect
    • Lipkowski, A.W., Konecka, A.M., and Sroczynska, I. (1982) Doubleenkephalins-synthesis, activity on guinea-pig ileum, and analgesic effect. Peptides, 3 (4), 697-700.
    • (1982) Peptides , vol.3 , Issue.4 , pp. 697-700
    • Lipkowski, A.W.1    Konecka, A.M.2    Sroczynska, I.3
  • 37
    • 0025900405 scopus 로고
    • Analgesic activity of a novel bivalent opioid peptide compared to morphine via different routes of administration
    • Silbert, B.S., Lipkowski, A.W., Cepeda, M.S., Szyfelbein, S.K., Osgood, P.F., and Carr, D.B. (1991) Analgesic activity of a novel bivalent opioid peptide compared to morphine via different routes of administration. Agents Actions, 33 (3-4), 382-387.
    • (1991) Agents Actions , vol.33 , Issue.3-4 , pp. 382-387
    • Silbert, B.S.1    Lipkowski, A.W.2    Cepeda, M.S.3    Szyfelbein, S.K.4    Osgood, P.F.5    Carr, D.B.6
  • 38
    • 67650726673 scopus 로고    scopus 로고
    • Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile
    • Dietis, N., Guerrini, R., Calo, G., Salvadori, S., Rowbotham, D.J., and Lambert, D.G. (2009) Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile. Br. J. Anaesth., 103 (1), 38-49.
    • (2009) Br. J. Anaesth. , vol.103 , Issue.1 , pp. 38-49
    • Dietis, N.1    Guerrini, R.2    Calo, G.3    Salvadori, S.4    Rowbotham, D.J.5    Lambert, D.G.6
  • 39
    • 0024508329 scopus 로고
    • Dermorphin analogues carrying an increased positive net charge in their "message" domain display extremely highmu opioid receptor selectivity
    • Schiller, P.W., Nguyen, T.M., Chung, N.N., and Lemieux, C. (1989) Dermorphin analogues carrying an increased positive net charge in their "message" domain display extremely highmu opioid receptor selectivity. J. Med. Chem., 32 (3), 698-703.
    • (1989) J. Med. Chem. , vol.32 , Issue.3 , pp. 698-703
    • Schiller, P.W.1    Nguyen, T.M.2    Chung, N.N.3    Lemieux, C.4
  • 43
    • 0036085352 scopus 로고    scopus 로고
    • Profound spinal tolerance after repeated exposure to a highly selective mu-opioid peptide agonist: role of delta-opioid receptors
    • Zhao, G.M., Wu, D., Soong, Y., Shimoyama, M., Berezowska, I., Schiller, P.W., and Szeto, H.H. (2002) Profound spinal tolerance after repeated exposure to a highly selective mu-opioid peptide agonist: role of delta-opioid receptors. J. Pharmacol. Exp. Ther., 302 (1), 188-196.
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , Issue.1 , pp. 188-196
    • Zhao, G.M.1    Wu, D.2    Soong, Y.3    Shimoyama, M.4    Berezowska, I.5    Schiller, P.W.6    Szeto, H.H.7
  • 44
    • 0025827095 scopus 로고
    • Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice
    • Abdelhamid, E.E., Sultana, M., Portoghese, P.S., and Takemori, A.E. (1991) Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice. J. Pharmacol. Exp. Ther., 258 (1), 299-303.
    • (1991) J. Pharmacol. Exp. Ther. , vol.258 , Issue.1 , pp. 299-303
    • Abdelhamid, E.E.1    Sultana, M.2    Portoghese, P.S.3    Takemori, A.E.4
  • 45
    • 0028788399 scopus 로고
    • Attenuation of morphine tolerance and dependence with the highly selective delta-opioid receptor antagonist TIPP[psi]
    • Fundytus, M.E., Schiller, P.W., Shapiro, M., Weltrowska, G., and Coderre, T.J. (1995) Attenuation of morphine tolerance and dependence with the highly selective delta-opioid receptor antagonist TIPP[psi]. Eur. J. Pharmacol., 286 (1), 105-108.
    • (1995) Eur. J. Pharmacol. , vol.286 , Issue.1 , pp. 105-108
    • Fundytus, M.E.1    Schiller, P.W.2    Shapiro, M.3    Weltrowska, G.4    Coderre, T.J.5
  • 46
    • 0033198831 scopus 로고    scopus 로고
    • Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice
    • Zhu, Y., King, M.A., Schuller, A.G., Nitsche, J.F., Reidl, M., Elde, R.P., Unterwald, E., Pasternak, G.W., and Pintar, J.E. (1999) Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice. Neuron, 24 (1), 243-252.
    • (1999) Neuron , vol.24 , Issue.1 , pp. 243-252
    • Zhu, Y.1    King, M.A.2    Schuller, A.G.3    Nitsche, J.F.4    Reidl, M.5    Elde, R.P.6    Unterwald, E.7    Pasternak, G.W.8    Pintar, J.E.9
  • 47
    • 77950691301 scopus 로고    scopus 로고
    • Bi-or multifunctional opioid peptide drugs
    • Schiller, P.W. (2010) Bi-or multifunctional opioid peptide drugs. Life Sci., 86 (15-16), 598-603.
    • (2010) Life Sci. , vol.86 , Issue.15-16 , pp. 598-603
    • Schiller, P.W.1
  • 48
    • 0033539134 scopus 로고    scopus 로고
    • The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats
    • Schiller, P.W., Fundytus, M.E., Merovitz, L., Weltrowska, G., Nguyen, T.M., Lemieux, C., Chung, N.N., and Coderre, T.J. (1999) The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats. J. Med. Chem., 42 (18), 3520-3526.
    • (1999) J. Med. Chem. , vol.42 , Issue.18 , pp. 3520-3526
    • Schiller, P.W.1    Fundytus, M.E.2    Merovitz, L.3    Weltrowska, G.4    Nguyen, T.M.5    Lemieux, C.6    Chung, N.N.7    Coderre, T.J.8
  • 49
    • 0018582692 scopus 로고
    • A novel analgesic dipeptide from bovine brain is a possible Met-enkephalin releaser
    • Takagi, H., Shiomi, H., Ueda, H., and Amano, H. (1979) A novel analgesic dipeptide from bovine brain is a possible Met-enkephalin releaser. Nature, 282 (5737), 410-412.
    • (1979) Nature , vol.282 , Issue.5737 , pp. 410-412
    • Takagi, H.1    Shiomi, H.2    Ueda, H.3    Amano, H.4
  • 51
    • 0025719725 scopus 로고
    • [Kyotorphin like substance in human cerebrospinal fluid of patients with persistent pain]
    • Nishimura, K., Kaya, K., Hazato, T., Ueda, H., Satoh, M., and Takagi, H. (1991) [Kyotorphin like substance in human cerebrospinal fluid of patients with persistent pain]. Masui, 40 (11), 1686-1690.
    • (1991) Masui , vol.40 , Issue.11 , pp. 1686-1690
    • Nishimura, K.1    Kaya, K.2    Hazato, T.3    Ueda, H.4    Satoh, M.5    Takagi, H.6
  • 52
    • 0019430722 scopus 로고
    • Isolation and identification of an analgesic opioid dipeptide kyotorphin (Tyr-Arg) from bovine brain
    • Shiomi, H., Ueda, H., and Takagi, H. (1981) Isolation and identification of an analgesic opioid dipeptide kyotorphin (Tyr-Arg) from bovine brain. Neuropharmacology, 20 (7), 633-638.
    • (1981) Neuropharmacology , vol.20 , Issue.7 , pp. 633-638
    • Shiomi, H.1    Ueda, H.2    Takagi, H.3
  • 53
    • 0031582215 scopus 로고    scopus 로고
    • The effect of neuropeptides kyotorphin and neokyotorphin on proliferation of cultured brown preadipocytes
    • Bronnikov, G., Dolgacheva, L., Zhang, S.J., Galitovskaya, E., Kramarova, L., and Zinchenko, V. (1997) The effect of neuropeptides kyotorphin and neokyotorphin on proliferation of cultured brown preadipocytes. FEBS Lett., 407 (1), 73-77.
    • (1997) FEBS Lett. , vol.407 , Issue.1 , pp. 73-77
    • Bronnikov, G.1    Dolgacheva, L.2    Zhang, S.J.3    Galitovskaya, E.4    Kramarova, L.5    Zinchenko, V.6
  • 54
    • 0032020699 scopus 로고    scopus 로고
    • Effects of a number of short peptides isolated from the brain of the hibernating ground squirrel on the EEG and behavior in rats
    • Ignat'ev, D.A., Vorob'ev, V.V., and Ziganshin, R. (1998) Effects of a number of short peptides isolated from the brain of the hibernating ground squirrel on the EEG and behavior in rats. Neurosci. Behav. Physiol., 28 (2), 158-166.
    • (1998) Neurosci. Behav. Physiol. , vol.28 , Issue.2 , pp. 158-166
    • Ignat'ev, D.A.1    Vorob'ev, V.V.2    Ziganshin, R.3
  • 55
    • 0028926847 scopus 로고
    • Seizure-protecting effects of kyotorphin and related peptides in an animal model of epilepsy
    • Godlevsky, L.S., Shandra, A.A., Mikhaleva, I.I., Vastyanov, R.S., and Mazarati, A.M. (1995) Seizure-protecting effects of kyotorphin and related peptides in an animal model of epilepsy. Brain. Res. Bull., 37 (3), 223-226.
    • (1995) Brain. Res. Bull. , vol.37 , Issue.3 , pp. 223-226
    • Godlevsky, L.S.1    Shandra, A.A.2    Mikhaleva, I.I.3    Vastyanov, R.S.4    Mazarati, A.M.5
  • 56
    • 0020322456 scopus 로고
    • Kyotorphin (tyrosinearginine): further evidence for indirect opiate receptor activation
    • Rackham, A., Wood, P.L., and Hudgin, R.L. (1982) Kyotorphin (tyrosinearginine): further evidence for indirect opiate receptor activation. Life Sci., 30 (16), 1337-1342.
    • (1982) Life Sci. , vol.30 , Issue.16 , pp. 1337-1342
    • Rackham, A.1    Wood, P.L.2    Hudgin, R.L.3
  • 57
    • 0020534956 scopus 로고
    • A comparison of the effects of morphine, enkephalin, kyotorphin and D-phenylalanine on rat central neurones
    • Stone, T.W. (1983) A comparison of the effects of morphine, enkephalin, kyotorphin and D-phenylalanine on rat central neurones. Br. J. Pharmacol. 79 (1), 305-312.
    • (1983) Br. J. Pharmacol. , vol.79 , Issue.1 , pp. 305-312
    • Stone, T.W.1
  • 58
    • 0030946023 scopus 로고    scopus 로고
    • Effects of kyotorphin (Ltyrosyl-L-arginine) ON[3H]NG-nitro-Larginine binding to neuronal nitric oxide synthase in rat brain
    • Arima, T., Kitamura, Y., Nishiya, T., Taniguchi, T., Takagi, H., and Nomura, Y. (1997) Effects of kyotorphin (Ltyrosyl-L-arginine) ON[3H]NG-nitro-Larginine binding to neuronal nitric oxide synthase in rat brain. Neurochem. Int., 30 (6), 605-611.
    • (1997) Neurochem. Int. , vol.30 , Issue.6 , pp. 605-611
    • Arima, T.1    Kitamura, Y.2    Nishiya, T.3    Taniguchi, T.4    Takagi, H.5    Nomura, Y.6
  • 59
    • 0032563852 scopus 로고    scopus 로고
    • Strategies to target kyotorphin analogues to the brain
    • Chen, P., Bodor, N., Wu, W.M., and Prokai, L. (1998) Strategies to target kyotorphin analogues to the brain. J. Med. Chem., 41 (20), 3773-3781.
    • (1998) J. Med. Chem. , vol.41 , Issue.20 , pp. 3773-3781
    • Chen, P.1    Bodor, N.2    Wu, W.M.3    Prokai, L.4
  • 60
    • 0026783425 scopus 로고
    • A strategy for delivering peptides into the central nervous system by sequential metabolism
    • Bodor, N., Prokai, L., Wu, W.M., Farag, H., Jonalagadda, S., Kawamura, M., and Simpkins, J. (1992) A strategy for delivering peptides into the central nervous system by sequential metabolism. Science, 257 (5077), 1698-1700.
    • (1992) Science , vol.257 , Issue.5077 , pp. 1698-1700
    • Bodor, N.1    Prokai, L.2    Wu, W.M.3    Farag, H.4    Jonalagadda, S.5    Kawamura, M.6    Simpkins, J.7
  • 61
    • 33644895138 scopus 로고    scopus 로고
    • Conformational and orientational guidance of the analgesic dipeptide kyotorphin induced by lipidic membranes: putative correlation toward receptor docking
    • Lopes, S.C., Soares, C.M., Baptista, A.M., Goormaghtigh, E., Cabral, B.J., and Castanho, M.A. (2006) Conformational and orientational guidance of the analgesic dipeptide kyotorphin induced by lipidic membranes: putative correlation toward receptor docking. J. Phys. Chem. B, 110 (7), 3385-3394.
    • (2006) J. Phys. Chem. B , vol.110 , Issue.7 , pp. 3385-3394
    • Lopes, S.C.1    Soares, C.M.2    Baptista, A.M.3    Goormaghtigh, E.4    Cabral, B.J.5    Castanho, M.A.6
  • 62
    • 33646891527 scopus 로고    scopus 로고
    • Brain uptake of nonsteroidal anti-inflammatory drugs: ibuprofen, flurbiprofen, and indomethacin
    • Parepally, J.M., Mandula, H., and Smith, Q.R. (2006) Brain uptake of nonsteroidal anti-inflammatory drugs: ibuprofen, flurbiprofen, and indomethacin. Pharm. Res., 23 (5), 873-881.
    • (2006) Pharm. Res. , vol.23 , Issue.5 , pp. 873-881
    • Parepally, J.M.1    Mandula, H.2    Smith, Q.R.3
  • 63
    • 64249104815 scopus 로고    scopus 로고
    • Polycyclic cage structures as carrier molecules for neuroprotective non-steroidal antiinflammatory drugs
    • Prins, L.H., du Preez, J.L., van Dyk, S., and Malan, S.F. (2009) Polycyclic cage structures as carrier molecules for neuroprotective non-steroidal antiinflammatory drugs. Eur. J. Med. Chem., 44 (6), 2577-2582.
    • (2009) Eur. J. Med. Chem. , vol.44 , Issue.6 , pp. 2577-2582
    • Prins, L.H.1    Du Preez, J.L.2    Van Dyk, S.3    Malan, S.F.4
  • 64
    • 70749139129 scopus 로고    scopus 로고
    • Synthesis, in vitro and in vivo characterization of glycosyl derivatives of ibuprofen as novel prodrugs for brain drug delivery
    • Chen, Q., Gong, T., Liu, J., Wang, X., Fu, H., and Zhang, Z. (2009) Synthesis, in vitro and in vivo characterization of glycosyl derivatives of ibuprofen as novel prodrugs for brain drug delivery. J. Drug Target., 17 (4), 318-328.
    • (2009) J. Drug Target. , vol.17 , Issue.4 , pp. 318-328
    • Chen, Q.1    Gong, T.2    Liu, J.3    Wang, X.4    Fu, H.5    Zhang, Z.6
  • 65
    • 11144224213 scopus 로고    scopus 로고
    • Inefficient central nervous system delivery limits the use of ibuprofen in neurodegenerative diseases
    • Mannila, A., Rautio, J., Lehtonen, M., Jarvinen, T., and Savolainen, J. (2005) Inefficient central nervous system delivery limits the use of ibuprofen in neurodegenerative diseases. Eur. J. Pharm. Sci., 24 (1), 101-105.
    • (2005) Eur. J. Pharm. Sci. , vol.24 , Issue.1 , pp. 101-105
    • Mannila, A.1    Rautio, J.2    Lehtonen, M.3    Jarvinen, T.4    Savolainen, J.5
  • 66
    • 0035107442 scopus 로고    scopus 로고
    • Neuroprotective effects of nonsteroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals
    • Asanuma, M., Nishibayashi-Asanuma, S., Miyazaki, I., Kohno, M., and Ogawa, N. (2001) Neuroprotective effects of nonsteroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals. J. Neurochem., 76 (6), 1895-1904.
    • (2001) J. Neurochem. , vol.76 , Issue.6 , pp. 1895-1904
    • Asanuma, M.1    Nishibayashi-Asanuma, S.2    Miyazaki, I.3    Kohno, M.4    Ogawa, N.5
  • 68
  • 69
    • 0033526158 scopus 로고    scopus 로고
    • Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems
    • Bodor, N. and Buchwald, P. (1999) Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems. Adv. Drug Deliv. Rev., 36 (2-3), 229-254.
    • (1999) Adv. Drug Deliv. Rev. , vol.36 , Issue.2-3 , pp. 229-254
    • Bodor, N.1    Buchwald, P.2
  • 70
    • 8644243613 scopus 로고
    • Partition coefficients and their uses
    • Leo, A., Hansch, C., and Elkins, D. (1971) Partition coefficients and their uses. Chem. Rev., 71 (6), 525-616.
    • (1971) Chem. Rev. , vol.71 , Issue.6 , pp. 525-616
    • Leo, A.1    Hansch, C.2    Elkins, D.3
  • 71
    • 0038392423 scopus 로고    scopus 로고
    • Quantifying molecular partition into model systems of biomembranes: an emphasis on optical spectroscopic methods
    • Santos, N.C., Prieto, M., and Castanho, M.A. (2003) Quantifying molecular partition into model systems of biomembranes: an emphasis on optical spectroscopic methods. Biochim. Biophys. Acta, 1612 (2), 123-135.
    • (2003) Biochim. Biophys. Acta , vol.1612 , Issue.2 , pp. 123-135
    • Santos, N.C.1    Prieto, M.2    Castanho, M.A.3
  • 73
    • 0038757797 scopus 로고
    • Membrane lipid phase as catalyst for peptide-receptor interactions
    • Sargent, D.F. and Schwyzer, R. (1986) Membrane lipid phase as catalyst for peptide-receptor interactions. Proc. Natl. Acad. Sci. USA, 83 (16), 5774-5778.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , Issue.16 , pp. 5774-5778
    • Sargent, D.F.1    Schwyzer, R.2
  • 74
    • 30044436650 scopus 로고    scopus 로고
    • Lipid membrane-induced optimization for ligand-receptor docking: recent tools and insights for the "membrane catalysis" model
    • Castanho, M.A. and Fernandes, M.X. (2006) Lipid membrane-induced optimization for ligand-receptor docking: recent tools and insights for the "membrane catalysis" model. Eur. Biophys. J, 35 (2), 92-103.
    • (2006) Eur. Biophys. J , vol.35 , Issue.2 , pp. 92-103
    • Castanho, M.A.1    Fernandes, M.X.2
  • 75
    • 33746614736 scopus 로고    scopus 로고
    • Chiral recognition of D-kyotorphin by lipidic membranes: relevance toward improved analgesic efficiency
    • Lopes, S.C., Fedorov, A., and Castanho, M.A. (2006) Chiral recognition of D-kyotorphin by lipidic membranes: relevance toward improved analgesic efficiency. Chem. Med. Chem., 1 (7), 723-728.
    • (2006) Chem. Med. Chem. , vol.1 , Issue.7 , pp. 723-728
    • Lopes, S.C.1    Fedorov, A.2    Castanho, M.A.3
  • 76
    • 21044457808 scopus 로고    scopus 로고
    • Lipidic membranes are potential "catalysts" in the ligand activity of the multifunctional pentapeptide neokyotorphin
    • Lopes, S.C., Fedorov, A., and Castanho, M.A. (2005) Lipidic membranes are potential "catalysts" in the ligand activity of the multifunctional pentapeptide neokyotorphin. Chembiochem, 6 (4), 697-702.
    • (2005) Chembiochem , vol.6 , Issue.4 , pp. 697-702
    • Lopes, S.C.1    Fedorov, A.2    Castanho, M.A.3
  • 77
    • 0037005738 scopus 로고    scopus 로고
    • Interaction of enkephalin peptides with anionic model membranes
    • Romanowski, M., Zhu, X., Kim, K., Hruby, V.J., and O'Brien, D.F. (2002) Interaction of enkephalin peptides with anionic model membranes. Biochim. Biophys. Acta, 1558 (1), 45-53.
    • (2002) Biochim. Biophys. Acta , vol.1558 , Issue.1 , pp. 45-53
    • Romanowski, M.1    Zhu, X.2    Kim, K.3    Hruby, V.J.4    O'Brien, D.F.5
  • 78
    • 38149094836 scopus 로고    scopus 로고
    • Membrane phosphatidylserine regulates surface charge and protein localization
    • Yeung, T., Gilbert, G.E., Shi, J., Silvius, J., Kapus, A., and Grinstein, S. (2008) Membrane phosphatidylserine regulates surface charge and protein localization. Science, 319 (5860), 210-213.
    • (2008) Science , vol.319 , Issue.5860 , pp. 210-213
    • Yeung, T.1    Gilbert, G.E.2    Shi, J.3    Silvius, J.4    Kapus, A.5    Grinstein, S.6
  • 79
    • 0030948209 scopus 로고    scopus 로고
    • Structure-internalization relationship for adsorptive-mediated endocytosis of basic peptides at the blood-brain barrier
    • Tamai, I., Sai, Y., Kobayashi, H., Kamata, M., Wakamiya, T., and Tsuji, A. (1997) Structure-internalization relationship for adsorptive-mediated endocytosis of basic peptides at the blood-brain barrier. J. Pharmacol. Exp. Ther., 280 (1), 410-415.
    • (1997) J. Pharmacol. Exp. Ther. , vol.280 , Issue.1 , pp. 410-415
    • Tamai, I.1    Sai, Y.2    Kobayashi, H.3    Kamata, M.4    Wakamiya, T.5    Tsuji, A.6
  • 80
    • 0034682156 scopus 로고    scopus 로고
    • Uneasy alliance-clinical investigators and the pharmaceutical industry
    • Bodenheimer, T. (2000) Uneasy alliance-clinical investigators and the pharmaceutical industry. N. Engl. J. Med., 342 (20), 1539-1544.
    • (2000) N. Engl. J. Med. , vol.342 , Issue.20 , pp. 1539-1544
    • Bodenheimer, T.1
  • 81
    • 0025099275 scopus 로고
    • Underreporting research is scientific misconduct
    • Chalmers, I. (1990) Underreporting research is scientific misconduct. JAMA, 263 (10), 1405-1408.
    • (1990) JAMA , vol.263 , Issue.10 , pp. 1405-1408
    • Chalmers, I.1
  • 83
    • 84889823394 scopus 로고    scopus 로고
    • Drug Truths: Dispelling the Myths about Pharma R&D
    • John Wiley & Sons, Inc., Hoboken, New Jersey
    • LaMattina, J.L. (2009) Drug Truths: Dispelling the Myths about Pharma R&D, John Wiley & Sons, Inc., Hoboken, New Jersey.
    • (2009)
    • LaMattina, J.L.1
  • 84
    • 0023047980 scopus 로고
    • Vesicles of variable sizes produced by a rapid extrusion procedure
    • Mayer, L.D., Hope, M.J., and Cullis, P.R. (1986) Vesicles of variable sizes produced by a rapid extrusion procedure. Biochim. Biophys. Acta, 858 (1), 161-168.
    • (1986) Biochim. Biophys. Acta , vol.858 , Issue.1 , pp. 161-168
    • Mayer, L.D.1    Hope, M.J.2    Cullis, P.R.3


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