Inefficient central nervous system delivery limits the use of ibuprofen in neurodegenerative diseases

European Journal of Pharmaceutical Sciences

Volumn 24, Issue 1, 2005, Pages 101-105

  Mannila, Anne ^a   Rautio, Jarkko ^a   Lehtonen, Marko ^a   Järvinen, Tomi ^a   Savolainen, Jouko ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Alzheimer's disease; Blood brain barrier; Central nervous system delivery; Ibuprofen; In vivo infusion; Non steroidal anti inflammatory drugs

Indexed keywords

IBUPROFEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG PENETRATION; IN VIVO STUDY; MALE; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; PURIFICATION; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION; STEADY STATE;

ANIMALS; CENTRAL NERVOUS SYSTEM; DRUG DELIVERY SYSTEMS; IBUPROFEN; MALE; NEURODEGENERATIVE DISEASES; RATS; RATS, WISTAR;

EID: 11144224213     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2004.10.004     Document Type: Article

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