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Volumn 17, Issue 1, 2013, Pages 92-98

JNK activation is required for TNFα-induced apoptosis in human hepatocarcinoma cells

Author keywords

Apoptosis; Caspases; Hepatocarcinoma; JNK; TNF

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CYCLOHEXIMIDE; CYSTEINE PROTEINASE INHIBITOR; PROTEIN SYNTHESIS INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; Z VAD FMK;

EID: 84879216172     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.05.017     Document Type: Article
Times cited : (16)

References (49)
  • 1
    • 38549102077 scopus 로고    scopus 로고
    • TNF-mediated inflammatory disease
    • DOI 10.1002/path.2287
    • Bradley JR. TNF-mediated inflammatory disease. J Pathol 2008;214:149-60. (Pubitemid 351160153)
    • (2008) Journal of Pathology , vol.214 , Issue.2 , pp. 149-160
    • Bradley, J.R.1
  • 2
    • 77953136143 scopus 로고    scopus 로고
    • TNF receptor 2 pathway: Drug target for autoimmune diseases
    • Faustman D, Davis M. TNF receptor 2 pathway: drug target for autoimmune diseases. Nat Rev Drug Discov 2010;9:482-93.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 482-493
    • Faustman, D.1    Davis, M.2
  • 3
    • 33749076455 scopus 로고    scopus 로고
    • Mechanisms of crosstalk between TNF-induced NF-κB and JNK activation in hepatocytes
    • Wullaert A, Heyninck K, Beyaert R. Mechanisms of crosstalk between TNF-induced NF-κB and JNK activation in hepatocytes. Biochem Pharmacol 2007;72:1090-101.
    • (2007) Biochem Pharmacol , vol.72 , pp. 1090-1101
    • Wullaert, A.1    Heyninck, K.2    Beyaert, R.3
  • 4
    • 33645799492 scopus 로고    scopus 로고
    • Mechanisms of liver injury. I. TNF-alpha-induced liver injury: Role of IKK, JNK, and ROS pathways
    • Schwabe RF, Brenner DA. Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol 2006;290:G583-9.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Schwabe, R.F.1    Brenner, D.A.2
  • 6
    • 77951934906 scopus 로고    scopus 로고
    • Tumor necrosis factor-mediated cell death: To break or to burst, that's the question
    • Van Herreweghe F, Festjens N, Declercq W, Vandenabeele P. Tumor necrosis factor-mediated cell death: to break or to burst, that's the question. Cell Mol Life Sci 2010;67:1567-79.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 1567-1579
    • Van Herreweghe, F.1    Festjens, N.2    Declercq, W.3    Vandenabeele, P.4
  • 7
    • 77956712168 scopus 로고    scopus 로고
    • Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner
    • Probst BL, Liu L, Ramesh V, et al. Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner. Cell Death Differ 2010;17: 1645-54.
    • (2010) Cell Death Differ , vol.17 , pp. 1645-1654
    • Probst, B.L.1    Liu, L.2    Ramesh, V.3
  • 8
    • 77949879162 scopus 로고    scopus 로고
    • Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway
    • Seitz SJ, Schleithoff ES, Koch A, et al. Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway. Int J Cancer 2010;126:2049-66.
    • (2010) Int J Cancer , vol.126 , pp. 2049-2066
    • Seitz, S.J.1    Schleithoff, E.S.2    Koch, A.3
  • 11
    • 34250021317 scopus 로고    scopus 로고
    • Genetic Inactivation of RelA/p65 Sensitizes Adult Mouse Hepatocytes to TNF-induced Apoptosis In Vivo and In Vitro
    • DOI 10.1053/j.gastro.2007.03.033, PII S0016508507005574
    • Geisler F, Algül H, Paxian S, Schmid RM. Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro. Gastroenterology 2007;132:2489-503. (Pubitemid 46890861)
    • (2007) Gastroenterology , vol.132 , Issue.7 , pp. 2489-2503
    • Geisler, F.1    Algul, H.2    Paxian, S.3    Schmid, R.M.4
  • 12
    • 66349131044 scopus 로고    scopus 로고
    • JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosisinducing ligand
    • Mucha SR, Rizzani A, Gerbes AL, et al. JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosisinducing ligand. Gut 2009;58:688-98.
    • (2009) Gut , vol.58 , pp. 688-698
    • Mucha, S.R.1    Rizzani, A.2    Gerbes, A.L.3
  • 14
  • 15
    • 0028949817 scopus 로고
    • Intracellular ionic variations in the apoptotic death of L cells by inhibitors of cell cycle progression
    • Barbiero G, Duranti F, Bonelli G, Amenta JS, Baccino FM. Intracellular ionic variations in the apoptotic death of L cells by inhibitors of cell cycle progression. Exp Cell Res 1995;217:410-8.
    • (1995) Exp Cell Res , vol.217 , pp. 410-418
    • Barbiero, G.1    Duranti, F.2    Bonelli, G.3    Amenta, J.S.4    Baccino, F.M.5
  • 16
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991;139:271-9.
    • (1991) J Immunol Methods , vol.139 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 17
    • 23744437996 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase (JNK) is required for survival and proliferation of B-lymphoma cells
    • DOI 10.1182/blood-2004-10-3819
    • Gururajan M, Chui R, Karuppannan AK, Ke J, Jennings CD, Bondada S. c-Jun N-terminal kinase (JNK) is required for survival and proliferation of B-lymphoma cells. Blood 2005;106:1382-91. (Pubitemid 41129605)
    • (2005) Blood , vol.106 , Issue.4 , pp. 1382-1391
    • Gururajan, M.1    Chui, R.2    Karuppannan, A.K.3    Ke, J.4    Jennings, C.D.5    Bondada, S.6
  • 18
    • 0036882166 scopus 로고    scopus 로고
    • The absence of NF-B-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis
    • DOI 10.1128/MCB.22.24.8571-8579.2002
    • Tang F, Tang G, Xiang J, Dai Q, Rosner MR, Lin A. The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol 2002;22:8571-9. (Pubitemid 35397172)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.24 , pp. 8571-8579
    • Tang, F.1    Tang, G.2    Xiang, J.3    Dai, Q.4    Rosner, M.R.5    Lin, A.6
  • 19
    • 19444362449 scopus 로고    scopus 로고
    • Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: Role of mitochondrial permeability transition
    • DOI 10.1016/j.freeradbiomed.2005.02.030, PII S0891584905000900
    • Whiteman M, Rose P, Siau JL, et al. Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: role of mitochondrial permeability transition. Free Radic Biol Med 2005;38:1571-84. (Pubitemid 40726064)
    • (2005) Free Radical Biology and Medicine , vol.38 , Issue.12 , pp. 1571-1584
    • Whiteman, M.1    Rose, P.2    Jia, L.S.3    Nam, S.C.4    Gek, S.T.5    Halliwell, B.6    Armstrong, J.S.7
  • 20
    • 23944450157 scopus 로고    scopus 로고
    • Intracellular free iron and acidic pathways mediate TNF-induced death of rat hepatoma cells
    • DOI 10.1007/s10495-005-2944-2
    • Autelli R, Crepaldi S, De Stefanis D, Parola M, Bonelli G, Baccino FM. Intracellular free iron and acidic pathways mediate TNF-induced death of rat hepatoma cells. Apoptosis 2005;10:777-86. (Pubitemid 41187076)
    • (2005) Apoptosis , vol.10 , Issue.4 , pp. 777-786
    • Autelli, R.1    Crepaldi, S.2    De Stefanis, D.3    Parola, M.4    Bonelli, G.5    Baccino, F.M.6
  • 21
    • 70349308534 scopus 로고    scopus 로고
    • Mechanisms of liver disease: Cross-talk between the NF-kappaB and JNK pathways
    • Papa S, Bubici C, Zazzeroni F, Franzoso G. Mechanisms of liver disease: cross-talk between the NF-kappaB and JNK pathways. Biol Chem 2009;390:965-76.
    • (2009) Biol Chem , vol.390 , pp. 965-976
    • Papa, S.1    Bubici, C.2    Zazzeroni, F.3    Franzoso, G.4
  • 22
    • 0032898735 scopus 로고    scopus 로고
    • Non-specific effects of methyl ketone peptide inhibitors of caspases
    • DOI 10.1016/S0014-5793(98)01640-8, PII S0014579398016408
    • Schotte P, Declercq W, Van Huffel S, Vandenabeele P, Beyaert R. Non-specific effects of methyl ketone peptide inhibitors of caspases. FEBS Lett 1999;442:117-21. (Pubitemid 29065390)
    • (1999) FEBS Letters , vol.442 , Issue.1 , pp. 117-121
    • Schotte, P.1    Declercq, W.2    Van Huffel, S.3    Vandenabeele, P.4    Beyaert, R.5
  • 23
    • 0029012476 scopus 로고
    • A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
    • Ham J, Babij C, Whitfield J, et al. A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 1995;14:927-39.
    • (1995) Neuron , vol.14 , pp. 927-939
    • Ham, J.1    Babij, C.2    Whitfield, J.3
  • 25
    • 0030298294 scopus 로고    scopus 로고
    • Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-B activation prevents cell death
    • DOI 10.1016/S0092-8674(00)81375-6
    • Liu ZG, Hsu H, Goeddel DV, Karin M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 1996;87:565-76. (Pubitemid 26374329)
    • (1996) Cell , vol.87 , Issue.3 , pp. 565-576
    • Liu, Z.G.1    Hsu, H.2    Goeddel, D.V.3    Karin, M.4
  • 26
    • 33344477350 scopus 로고    scopus 로고
    • Chemical genetic analysis of the time course of signal transduction by JNK
    • DOI 10.1016/j.molcel.2006.01.018, PII S1097276506000414
    • Ventura JJ, Hubner A, Zhang C, Flavell RA, Shokat KM, Davis RJ. Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell 2006;21: 701-10. (Pubitemid 43290736)
    • (2006) Molecular Cell , vol.21 , Issue.5 , pp. 701-710
    • Ventura, J.-J.1    Hubner, A.2    Zhang, C.3    Flavell, R.A.4    Shokat, K.M.5    Davis, R.J.6
  • 27
    • 0041326612 scopus 로고    scopus 로고
    • Protection of rat hepatocytes from apoptosis by inhibition of c-Jun N-terminal kinase
    • DOI 10.1067/msy.2003.237
    • Marderstein EL, Bucher B, Guo Z, Feng X, Reid K, Geller DA. Protection of rat hepatocytes from apoptosis by inhibition of c-Jun N-terminal kinase. Surgery 2003;134:280-4. (Pubitemid 37070350)
    • (2003) Surgery , vol.134 , Issue.2 , pp. 280-284
    • Marderstein, E.L.1    Bucher, B.2    Guo, Z.3    Feng, X.4    Reid, K.5    Geller, D.A.6
  • 28
    • 3042739914 scopus 로고    scopus 로고
    • Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes
    • Schwabe F, Uchinami H, Qian T, Bennett BL, Lemasters JJ, Brenner DA. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J 2004;18:720-2.
    • (2004) FASEB J , vol.18 , pp. 720-722
    • Schwabe, F.1    Uchinami, H.2    Qian, T.3    Bennett, B.L.4    Lemasters, J.J.5    Brenner, D.A.6
  • 29
    • 13844275033 scopus 로고    scopus 로고
    • Induction apoptosis of luteolin in human hepatoma HepG2 cells involving mitochondria translocation of Bax/Bak and activation of JNK
    • Lee HJ, Wang CJ, Kuo HC, Chou FP, Jean LF, Tseng TH. Induction apoptosis of luteolin in human hepatoma HepG2 cells involving mitochondria translocation of Bax/Bak and activation of JNK. Toxicol Appl Pharmacol 2005;203:124-31.
    • (2005) Toxicol Appl Pharmacol , vol.203 , pp. 124-131
    • Lee, H.J.1    Wang, C.J.2    Kuo, H.C.3    Chou, F.P.4    Jean, L.F.5    Tseng, T.H.6
  • 30
    • 33746379603 scopus 로고    scopus 로고
    • JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells
    • Kim BJ, Ryu SW, Song BJ. JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J Biol Chem 2006;281:21256-65.
    • (2006) J Biol Chem , vol.281 , pp. 21256-21265
    • Kim, B.J.1    Ryu, S.W.2    Song, B.J.3
  • 31
    • 0029059060 scopus 로고
    • Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
    • Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 1995;376: 167-70.
    • (1995) Nature , vol.376 , pp. 167-170
    • Beg, A.A.1    Sha, W.C.2    Bronson, R.T.3    Ghosh, S.4    Baltimore, D.5
  • 32
    • 33646166625 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein
    • Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R. Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein. J Virol 2006;80:4372-9.
    • (2006) J Virol , vol.80 , pp. 4372-4379
    • Saito, K.1    Meyer, K.2    Warner, R.3    Basu, A.4    Ray, R.B.5    Ray, R.6
  • 35
    • 67649362253 scopus 로고    scopus 로고
    • Regulated cell death pathways: New twists in modulation of BCL2 family function
    • Sasi N, Hwang M, Jaboin J, Csiki I, Lu B. Regulated cell death pathways: new twists in modulation of BCL2 family function. Mol Cancer Ther 2009;8:1421-9.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1421-1429
    • Sasi, N.1    Hwang, M.2    Jaboin, J.3    Csiki, I.4    Lu, B.5
  • 36
    • 1242272838 scopus 로고    scopus 로고
    • L are important for the induction of paclitaxel resistance in human hepatocellular carcinoma cells
    • DOI 10.1016/j.bbrc.2004.01.118
    • Chun E, Lee KY. Bcl-2 and Bcl-xL are important for the induction of paclitaxel resistance in human hepatocellular carcinoma cells. Biochem Biophys Res Commun 2004;315:771-9. (Pubitemid 38229409)
    • (2004) Biochemical and Biophysical Research Communications , vol.315 , Issue.3 , pp. 771-779
    • Chun, E.1    Lee, K.-Y.2
  • 37
    • 0034730511 scopus 로고    scopus 로고
    • Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ERK cascade
    • Fan M, Goodwin M, Vu T, Brantley-Finley C, Gaarde WA, Chambers TC. Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ERK cascade. J Biol Chem 2000;275:29980-5.
    • (2000) J Biol Chem , vol.275 , pp. 29980-29985
    • Fan, M.1    Goodwin, M.2    Vu, T.3    Brantley-Finley, C.4    Gaarde, W.A.5    Chambers, T.C.6
  • 40
    • 84860516137 scopus 로고    scopus 로고
    • Resistance to paclitaxel in hepatoma cells is related to static JNK activation and prohibition into entry of mitosis
    • Chae S, Kim YB, Lee JS, Cho H. Resistance to paclitaxel in hepatoma cells is related to static JNK activation and prohibition into entry of mitosis. Am J Physiol Gastrointest Liver Physiol 2012;302:G1016-24.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302
    • Chae, S.1    Kim, Y.B.2    Lee, J.S.3    Cho, H.4
  • 41
    • 84861436735 scopus 로고    scopus 로고
    • Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells
    • Ullio C, Casas J, Brunk UT, et al. Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells. J Lipid Res 2012;53:1134-43.
    • (2012) J Lipid Res , vol.53 , pp. 1134-1143
    • Ullio, C.1    Casas, J.2    Brunk, U.T.3
  • 42
    • 78751655392 scopus 로고    scopus 로고
    • Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis
    • Zhou F, Yang Y, Xing D. Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis. FEBS J 2011;278:403-13.
    • (2011) FEBS J , vol.278 , pp. 403-413
    • Zhou, F.1    Yang, Y.2    Xing, D.3
  • 43
    • 33645983982 scopus 로고    scopus 로고
    • The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease
    • Papa S, Bubici C, Zazzeroni F, et al. The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease. Cell Death Differ 2006;13:712-9.
    • (2006) Cell Death Differ , vol.13 , pp. 712-719
    • Papa, S.1    Bubici, C.2    Zazzeroni, F.3
  • 44
    • 41149088639 scopus 로고    scopus 로고
    • Gadd45 beta forms a homodimeric complex that binds tightly to MKK7
    • Tornatore L, Marasco D, Dathan N, et al. Gadd45 beta forms a homodimeric complex that binds tightly to MKK7. J Mol Biol 2008;378:97-111.
    • (2008) J Mol Biol , vol.378 , pp. 97-111
    • Tornatore, L.1    Marasco, D.2    Dathan, N.3
  • 46
    • 0344496062 scopus 로고    scopus 로고
    • IKK is required for prevention of apoptosis mediated by cell-bound but not by circulating TNF
    • DOI 10.1016/S1074-7613(03)00301-7
    • Maeda S, Chang L, Li ZW, Luo JL, Leffert H, Karin M. IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. Immunity 2003;19:725-37. (Pubitemid 37490797)
    • (2003) Immunity , vol.19 , Issue.5 , pp. 725-737
    • Maeda, S.1    Chang, L.2    Li, Z.-W.3    Luo, J.-L.4    Leffert, H.5    Karin, M.6
  • 48
    • 76249087046 scopus 로고    scopus 로고
    • Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis
    • Inokuchi S, Aoyama T, Miura K, et al. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A 2010;107:844-9.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 844-849
    • Inokuchi, S.1    Aoyama, T.2    Miura, K.3
  • 49
    • 0033580466 scopus 로고    scopus 로고
    • The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway
    • Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 1999;398:252-6.
    • (1999) Nature , vol.398 , pp. 252-256
    • Ninomiya-Tsuji, J.1    Kishimoto, K.2    Hiyama, A.3    Inoue, J.4    Cao, Z.5    Matsumoto, K.6


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