The helical propensity of KLA amphipathic peptides enhances their binding to gel-state lipid membranes

Biophysical Chemistry

Volumn 180-181, Issue , 2013, Pages 10-21

  Arouri, Ahmad ^a,c   Dathe, Margitta ^b   Blume, Alfred ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Antimicrobial peptide; Isothermal titration calorimetry; Lipid peptide interaction; Peptide helicity; Structure activity relationship

Indexed keywords

1,2 DIPALMITOYL SN GLYCERO 3 PHOSPHOGLYCEROL; GLYCEROL DERIVATIVE; KLA AMPHIPATHIC PEPTIDE; LIPID; PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; BILAYER MEMBRANE; CIRCULAR DICHROISM; DIFFERENTIAL SCANNING CALORIMETRY; DYNAMIC LIGHT SCATTERING; GEL; ISOTHERM; ISOTHERMAL TITRATION CALORIMETRY; LIGHT SCATTERING; LIPID BILAYER; LIPID MEMBRANE; PRIORITY JOURNAL; PROTEIN CONFORMATION; SOLUBILIZATION; STOICHIOMETRY; SURFACE CHARGE; SURFACE PROPERTY; THERMOGRAPHY;

1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE; 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOGLYCEROL; 1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-PHOSPHOGLYCEROL; ALA; ALANINE; ANTIMICROBIAL PEPTIDE; APPARENT BINDING CONSTANT; CD; CIRCULAR DICHROISM SPECTROSCOPY; CONSTANT PRESSURE HEAT CAPACITY CHANGE; DIFFERENTIAL SCANNING CALORIMETRY; DLS; DPPC; DPPE; DPPG; DSC; DYNAMIC LIGHT SCATTERING; FDA; FOOD AND DRUG ADMINISTRATION; ISOTHERMAL TITRATION CALORIMETRY; ITC; K(APP); L/P; LARGE UNILAMELLAR VESICLES; LEU; LEUCINE; LIPID PEPTIDE RATIO; LIPID-PEPTIDE INTERACTION; LUVS; LYS; LYSINE; MAIN PHASE TRANSITION TEMPERATURE; MIC; MINIMUM INHIBITORY CONCENTRATION; N; PC; PE; PEPTIDE HELICITY; PG; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLGLYCEROL; POPC; POPG; RBC; RED BLOOD CELLS; SMALL UNILAMELLAR VESICLES; STANDARD ENTHALPY CHANGE; STANDARD ENTROPY CHANGE, ΔGO, STANDARD FREE ENERGY CHANGE; STOICHIOMETRY; STRUCTURE-ACTIVITY RELATIONSHIP; SUVS; T(M); TFE; TRIFLUOROETHANOL; TRP; TRYPTOPHAN; ΔC(P); ΔHO; ΔSO;

AMINO ACID SEQUENCE; CALORIMETRY, DIFFERENTIAL SCANNING; CIRCULAR DICHROISM; GELS; LIGHT; LIPID BILAYERS; PEPTIDES; PHOSPHATIDYLGLYCEROLS; PROTEIN STRUCTURE, SECONDARY; SCATTERING, RADIATION; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 84879201370     PISSN: 03014622     EISSN: 18734200     Source Type: Journal    
DOI: 10.1016/j.bpc.2013.05.003     Document Type: Article

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