-
1
-
-
31944444234
-
Cancer-specific mutations in PIK3CA are oncogenic in vivo
-
Bader, A.G., Kang, S., and Vogt, P.K. (2006). Cancer-specific mutations in PIK3CA are oncogenic in vivo. Proc Natl Acad Sci USA 103, 1475-1479.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 1475-1479
-
-
Bader, A.G.1
Kang, S.2
Vogt, P.K.3
-
2
-
-
0028872141
-
Mutations of the Ki-ras oncogene in carcinoma of the endometrium
-
Caduff, R.F., Johnston, C.M., and Frank, T.S. (1995). Mutations of the Ki-ras oncogene in carcinoma of the endometrium. Am J Pathol 146, 182-188.
-
(1995)
Am J Pathol
, vol.146
, pp. 182-188
-
-
Caduff, R.F.1
Johnston, C.M.2
Frank, T.S.3
-
3
-
-
7444250290
-
Mutation of the PIK3CA gene in ovarian and breast cancer
-
Campbell, I.G., Russell, S.E., Choong, D.Y., Montgomery, K.G., Ciavarella, M.L., Hooi, C.S., Cristiano, B.E., Pearson, R.B., and Phillips, W.A. (2004). Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 64, 7678-7681.
-
(2004)
Cancer Res
, vol.64
, pp. 7678-7681
-
-
Campbell, I.G.1
Russell, S.E.2
Choong, D.Y.3
Montgomery, K.G.4
Ciavarella, M.L.5
Hooi, C.S.6
Cristiano, B.E.7
Pearson, R.B.8
Phillips, W.A.9
-
4
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley, L.C. (2002). The phosphoinositide 3-kinase pathway. Science 296, 1655-1657.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
5
-
-
38749092231
-
Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase
-
Carson, J.D., Van Aller, G., Lehr, R., Sinnamon, R.H., Kirkpatrick, R.B., Auger, K.R., Dhanak, D., Copeland, R.A., Gontarek, R.R., Tummino, P.J., and Luo, L. (2008). Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase. Biochem J 409, 519-524.
-
(2008)
Biochem J
, vol.409
, pp. 519-524
-
-
Carson, J.D.1
Van Aller, G.2
Lehr, R.3
Sinnamon, R.H.4
Kirkpatrick, R.B.5
Auger, K.R.6
Dhanak, D.7
Copeland, R.A.8
Gontarek, R.R.9
Tummino, P.J.10
Luo, L.11
-
6
-
-
38649090091
-
PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters
-
Catasus, L., Gallardo, A., Cuatrecasas, M., and Prat, J. (2008). PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters. Mod Pathol 21, 131-139.
-
(2008)
Mod Pathol
, vol.21
, pp. 131-139
-
-
Catasus, L.1
Gallardo, A.2
Cuatrecasas, M.3
Prat, J.4
-
7
-
-
0031418171
-
The clinicopathological significance of K-RAS point mutation and gene amplification in endometrial cancer
-
Esteller, M., Garcia, A., Martinez-Palones, J.M., Xercavins, J., and Reventos, J. (1997). The clinicopathological significance of K-RAS point mutation and gene amplification in endometrial cancer. Eur J Cancer 33, 1572-1577.
-
(1997)
Eur J Cancer
, vol.33
, pp. 1572-1577
-
-
Esteller, M.1
Garcia, A.2
Martinez-Palones, J.M.3
Xercavins, J.4
Reventos, J.5
-
8
-
-
62449130185
-
Knockin of mutant PIK3CA activates multiple oncogenic pathways
-
Gustin, J.P., Karakas, B., Weiss, M.B., Abukhdeir, A.M., Lauring, J., Garay, J.P., Cosgrove, D., Tamaki, A., Konishi, H., Konishi, Y., Mohseni, M., Wang, G., Rosen, D.M., Denmeade, S.R., Higgins, M.J., Vitolo, M.I., Bachman, K.E., and Park, B.H. (2009). Knockin of mutant PIK3CA activates multiple oncogenic pathways. Proc Natl Acad Sci USA 106, 2835-2840.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 2835-2840
-
-
Gustin, J.P.1
Karakas, B.2
Weiss, M.B.3
Abukhdeir, A.M.4
Lauring, J.5
Garay, J.P.6
Cosgrove, D.7
Tamaki, A.8
Konishi, H.9
Konishi, Y.10
Mohseni, M.11
Wang, G.12
Rosen, D.M.13
Denmeade, S.R.14
Higgins, M.J.15
Vitolo, M.I.16
Bachman, K.E.17
Park, B.H.18
-
9
-
-
34248369435
-
Rare cancer-specific mutations in PIK3CA show gain of function
-
Gymnopoulos, M., Elsliger, M.A., and Vogt, P.K. (2007). Rare cancer-specific mutations in PIK3CA show gain of function. Proc Natl Acad Sci USA 104, 5569-5574.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 5569-5574
-
-
Gymnopoulos, M.1
Elsliger, M.A.2
Vogt, P.K.3
-
10
-
-
67349170390
-
Molecular alterations of EGFR and PIK3CA in uterine serous carcinoma
-
Hayes, M.P., Douglas, W., and Ellenson, L.H. (2009). Molecular alterations of EGFR and PIK3CA in uterine serous carcinoma. Gynecol Oncol 113, 370-373.
-
(2009)
Gynecol Oncol
, vol.113
, pp. 370-373
-
-
Hayes, M.P.1
Douglas, W.2
Ellenson, L.H.3
-
11
-
-
33750698981
-
PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia
-
Hayes, M.P., Wang, H., Espinal-Witter, R., Douglas, W., Solomon, G.J., Baker, S.J., and Ellenson, L.H. (2006). PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia. Clin Cancer Res 12(20 Pt 1), 5932-5935.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.20 PART 1
, pp. 5932-5935
-
-
Hayes, M.P.1
Wang, H.2
Espinal-Witter, R.3
Douglas, W.4
Solomon, G.J.5
Baker, S.J.6
Ellenson, L.H.7
-
12
-
-
0035008874
-
Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression
-
Hutchinson, J., Jin, J., Cardiff, R.D., Woodgett, J.R., and Muller, W.J. (2001). Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol 21, 2203-2212.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 2203-2212
-
-
Hutchinson, J.1
Jin, J.2
Cardiff, R.D.3
Woodgett, J.R.4
Muller, W.J.5
-
13
-
-
21144457217
-
Functional analysis of PIK3CA gene mutations in human colorectal cancer
-
Ikenoue, T., Kanai, F., Hikiba, Y., Obata, T., Tanaka, Y., Imamura, J., Ohta, M., Jazag, A., Guleng, B., Tateishi, K., Asaoka, Y., Matsumura, M., Kawabe, T., and Omata, M. (2005). Functional analysis of PIK3CA gene mutations in human colorectal cancer. Cancer Res 65, 4562-4567.
-
(2005)
Cancer Res
, vol.65
, pp. 4562-4567
-
-
Ikenoue, T.1
Kanai, F.2
Hikiba, Y.3
Obata, T.4
Tanaka, Y.5
Imamura, J.6
Ohta, M.7
Jazag, A.8
Guleng, B.9
Tateishi, K.10
Asaoka, Y.11
Matsumura, M.12
Kawabe, T.13
Omata, M.14
-
14
-
-
28244479028
-
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells
-
Isakoff, S.J., Engelman, J.A., Irie, H.Y., Luo, J., Brachmann, S.M., Pearline, R.V., Cantley, L.C., and Brugge, J.S. (2005). Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res 65, 10992-11000.
-
(2005)
Cancer Res
, vol.65
, pp. 10992-11000
-
-
Isakoff, S.J.1
Engelman, J.A.2
Irie, H.Y.3
Luo, J.4
Brachmann, S.M.5
Pearline, R.V.6
Cantley, L.C.7
Brugge, J.S.8
-
15
-
-
14144252004
-
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
-
Kang, S., Bader, A.G., and Vogt, P.K. (2005). Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci USA 102, 802-807.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 802-807
-
-
Kang, S.1
Bader, A.G.2
Vogt, P.K.3
-
16
-
-
51849125616
-
Mutual exclusiveness between PIK3CA and KRAS mutations in endometrial carcinoma
-
Kang, S., Seo, S.S., Chang, H.J., Yoo, C.W., Park, S.Y., and Dong, S.M. (2008). Mutual exclusiveness between PIK3CA and KRAS mutations in endometrial carcinoma. Int J Gynecol Cancer 18, 1339-1343.
-
(2008)
Int J Gynecol Cancer
, vol.18
, pp. 1339-1343
-
-
Kang, S.1
Seo, S.S.2
Chang, H.J.3
Yoo, C.W.4
Park, S.Y.5
Dong, S.M.6
-
17
-
-
38949121953
-
PIK3CA gene mutations and amplifications in uterine cancers, identified by methods that avoid confounding by PIK3CA pseudogene sequences
-
Miyake, T., Yoshino, K., Enomoto, T., Takata, T., Ugaki, H., Kim, A., Fujiwara, K., Miyatake, T., Fujita, M., and Kimura, T. (2008). PIK3CA gene mutations and amplifications in uterine cancers, identified by methods that avoid confounding by PIK3CA pseudogene sequences. Cancer Lett 261, 120-126.
-
(2008)
Cancer Lett
, vol.261
, pp. 120-126
-
-
Miyake, T.1
Yoshino, K.2
Enomoto, T.3
Takata, T.4
Ugaki, H.5
Kim, A.6
Fujiwara, K.7
Miyatake, T.8
Fujita, M.9
Kimura, T.10
-
18
-
-
35549006238
-
Concomitant activation of AKT with extracellular-regulated kinase 1=2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss
-
Mori, N., Kyo, S., Sakaguchi, J., Mizumoto, Y., Ohno, S., Maida, Y., Hashimoto, M., Takakura, M., and Inoue, M. (2007). Concomitant activation of AKT with extracellular-regulated kinase 1=2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss. Cancer Sci 98, 1881-1888.
-
(2007)
Cancer Sci
, vol.98
, pp. 1881-1888
-
-
Mori, N.1
Kyo, S.2
Sakaguchi, J.3
Mizumoto, Y.4
Ohno, S.5
Maida, Y.6
Hashimoto, M.7
Takakura, M.8
Inoue, M.9
-
19
-
-
33751190974
-
Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms
-
Nakayama, K., Nakayama, N., Kurman, R.J., Cope, L., Pohl, G., Samuels, Y., Velculescu, V.E., Wang, T.L., and Shih Ie, M. (2006). Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms. Cancer Biol Ther 5, 779-785.
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 779-785
-
-
Nakayama, K.1
Nakayama, N.2
Kurman, R.J.3
Cope, L.4
Pohl, G.5
Samuels, Y.6
Velculescu, V.E.7
Wang, T.L.8
Shih Ie, M.9
-
20
-
-
54249159640
-
PIK3CA cooperates with other phosphatidylinositol 30-kinase pathway mutations to effect oncogenic transformation
-
Oda, K., Okada, J., Timmerman, L., Rodriguez-Viciana, P., Stokoe, D., Shoji, K., Taketani, Y., Kuramoto, H., Knight, Z.A., Shokat, K.M., and McCormick, F. (2008). PIK3CA cooperates with other phosphatidylinositol 30-kinase pathway mutations to effect oncogenic transformation. Cancer Res 68, 8127-8136.
-
(2008)
Cancer Res
, vol.68
, pp. 8127-8136
-
-
Oda, K.1
Okada, J.2
Timmerman, L.3
Rodriguez-Viciana, P.4
Stokoe, D.5
Shoji, K.6
Taketani, Y.7
Kuramoto, H.8
Knight, Z.A.9
Shokat, K.M.10
McCormick, F.11
-
21
-
-
34547099558
-
Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma
-
Ollikainen, M., Gylling, A., Puputti, M., Nupponen, N.N., Abdel-Rahman, W.M., Butzow, R., and Peltomaki, P. (2007). Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma. Int J Cancer 121, 915-920.
-
(2007)
Int J Cancer
, vol.121
, pp. 915-920
-
-
Ollikainen, M.1
Gylling, A.2
Puputti, M.3
Nupponen, N.N.4
Abdel-Rahman, W.M.5
Butzow, R.6
Peltomaki, P.7
-
22
-
-
32644461203
-
Consistent absence of BRAF mutations in cervical and endometrial cancer despite KRAS mutation status
-
Pappa, K.I., Choleza, M., Markaki, S., Giannikaki, E., Kyroudi, A., Vlachos, G., Voulgaris, Z., and Anagnou,N.P. (2006). Consistent absence of BRAF mutations in cervical and endometrial cancer despite KRAS mutation status. Gynecol Oncol 100, 596-600.
-
(2006)
Gynecol Oncol
, vol.100
, pp. 596-600
-
-
Pappa, K.I.1
Choleza, M.2
Markaki, S.3
Giannikaki, E.4
Kyroudi, A.5
Vlachos, G.6
Voulgaris, Z.7
Anagnou, N.P.8
-
23
-
-
53649103519
-
Metastasis and AKT activation
-
Qiao, M., Sheng, S., and Pardee, A.B. (2008). Metastasis and AKT activation. Cell Cycle 7, 2991-2996.
-
(2008)
Cell Cycle
, vol.7
, pp. 2991-2996
-
-
Qiao, M.1
Sheng, S.2
Pardee, A.B.3
-
24
-
-
0030605386
-
Phosphatidylinositol 30 kinase: One of the effectors of Ras
-
discussion 231-1222
-
Rodriguez-Viciana, P., Marte, B.M., Warne, P.H., and Downward, J. (1996). Phosphatidylinositol 30 kinase: one of the effectors of Ras. Philos Trans R Soc Lond 351, 225-231; discussion 231-1222
-
(1996)
Philos Trans R Soc Lond
, vol.351
, pp. 225-231
-
-
Rodriguez-Viciana, P.1
Marte, B.M.2
Warne, P.H.3
Downward, J.4
-
25
-
-
63849308483
-
Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation
-
Salvesen, H.B., Carter, S.L., Mannelqvist, M., Dutt, A., Getz, G., Stefansson, I.M., Raeder, M.B., Sos, M.L., Engelsen, I.B., Trovik, J., Wik, E., Greulich, H., Bo, T.H., Jonassen, I., Thomas, R.K., Zander, T., Garraway, L.A., Oyan, A.M., Sellers, W.R., Kalland, K.H., Meyerson, M., Akslen, L.A., and Beroukhim, R. (2009). Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation. Proc Natl Acad Sci USA.
-
(2009)
Proc Natl Acad Sci USA
-
-
Salvesen, H.B.1
Carter, S.L.2
Mannelqvist, M.3
Dutt, A.4
Getz, G.5
Stefansson, I.M.6
Raeder, M.B.7
Sos, M.L.8
Engelsen, I.B.9
Trovik, J.10
Wik, E.11
Greulich, H.12
Bo, T.H.13
Jonassen, I.14
Thomas, R.K.15
Zander, T.16
Garraway, L.A.17
Oyan, A.M.18
Sellers, W.R.19
Kalland, K.H.20
Meyerson, M.21
Akslen, L.A.22
Beroukhim, R.23
more..
-
26
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
DOI 10.1126/science.1096502
-
Samuels, Y., Wang, Z., Bardelli, A., Silliman, N., Ptak, J., Szabo, S., Yan, H., Gazdar, A., Powell, S.M., Riggins, G.J., Willson, J.K., Markowitz, S., Kinzler, K.W., Vogelstein, B., and Velculescu, V.E. (2004). High frequency of mutations of the PIK3CA gene in human cancers. Science 304, 554. (Pubitemid 38541907)
-
(2004)
Science
, vol.304
, Issue.5670
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Yan, H.7
Gazdar, A.8
Powell, S.M.9
Riggins, G.J.10
Willson, J.K.V.11
Markowitz, S.12
Kinzler, K.W.13
Vogelstein, B.14
Velculescu, V.E.15
-
27
-
-
34548058584
-
Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity
-
Toulany, M., Baumann, M., and Rodemann, H.P. (2007). Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity. Mol Cancer Res 5, 863-872.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 863-872
-
-
Toulany, M.1
Baumann, M.2
Rodemann, H.P.3
-
28
-
-
0029063656
-
Frequent occurrence of c-Ki-ras gene mutations in well differentiated endometrial adenocarcinoma showing infiltrative local growth with fibrosing stromal response
-
Tsuda, H., Jiko, K., Yajima, M., Yamada, T., Tanemura, K., Tsunematsu, R., Ohmi, K., Sonoda, T., and Hirohashi, S. (1995). Frequent occurrence of c-Ki-ras gene mutations in well differentiated endometrial adenocarcinoma showing infiltrative local growth with fibrosing stromal response. Int J Gynecol Pathol 14, 255-259.
-
(1995)
Int J Gynecol Pathol
, vol.14
, pp. 255-259
-
-
Tsuda, H.1
Jiko, K.2
Yajima, M.3
Yamada, T.4
Tanemura, K.5
Tsunematsu, R.6
Ohmi, K.7
Sonoda, T.8
Hirohashi, S.9
-
29
-
-
33750039395
-
PIK3CA gene mutations in endometrial carcinoma: Correlation with PTEN and K-RAS alterations
-
Velasco, A., Bussaglia, E., Pallares, J., Dolcet, X., Llobet, D., Encinas, M., Llecha, N., Palacios, J., Prat, J., and Matias-Guiu, X. (2006). PIK3CA gene mutations in endometrial carcinoma: correlation with PTEN and K-RAS alterations. Hum Pathol 37, 1465-1472.
-
(2006)
Hum Pathol
, vol.37
, pp. 1465-1472
-
-
Velasco, A.1
Bussaglia, E.2
Pallares, J.3
Dolcet, X.4
Llobet, D.5
Encinas, M.6
Llecha, N.7
Palacios, J.8
Prat, J.9
Matias-Guiu, X.10
-
30
-
-
33947184242
-
Alternate molecular genetic pathways in ovarian carcinomas of common histological types
-
Willner, J., Wurz, K., Allison, K.H., Galic, V., Garcia, R.L., Goff, B.A., and Swisher, E.M. (2007). Alternate molecular genetic pathways in ovarian carcinomas of common histological types. Hum Pathol 38, 607-613.
-
(2007)
Hum Pathol
, vol.38
, pp. 607-613
-
-
Willner, J.1
Wurz, K.2
Allison, K.H.3
Galic, V.4
Garcia, R.L.5
Goff, B.A.6
Swisher, E.M.7
-
31
-
-
40649096375
-
Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
-
Zhao, L., and Vogt, P.K. (2008). Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms. Proc Natl Acad Sci USA 105, 2652-2657.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 2652-2657
-
-
Zhao, L.1
Vogt, P.K.2
|