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Volumn 29, Issue 2, 2010, Pages 65-70

Rare mutations in the PIK3CA gene contribute to aggressive endometrial cancer

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ENDOMETRIUM CANCER; EXON; FEMALE; GENE; GENE ACTIVATION; GENE MUTATION; GENE SEQUENCE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; METASTASIS; ONCOGENE K RAS; PIK3CA GENE; PRIORITY JOURNAL; TUMOR DIFFERENTIATION; WILD TYPE;

EID: 84879192085     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.2009.0939     Document Type: Article
Times cited : (14)

References (31)
  • 1
    • 31944444234 scopus 로고    scopus 로고
    • Cancer-specific mutations in PIK3CA are oncogenic in vivo
    • Bader, A.G., Kang, S., and Vogt, P.K. (2006). Cancer-specific mutations in PIK3CA are oncogenic in vivo. Proc Natl Acad Sci USA 103, 1475-1479.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1475-1479
    • Bader, A.G.1    Kang, S.2    Vogt, P.K.3
  • 2
    • 0028872141 scopus 로고
    • Mutations of the Ki-ras oncogene in carcinoma of the endometrium
    • Caduff, R.F., Johnston, C.M., and Frank, T.S. (1995). Mutations of the Ki-ras oncogene in carcinoma of the endometrium. Am J Pathol 146, 182-188.
    • (1995) Am J Pathol , vol.146 , pp. 182-188
    • Caduff, R.F.1    Johnston, C.M.2    Frank, T.S.3
  • 4
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley, L.C. (2002). The phosphoinositide 3-kinase pathway. Science 296, 1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 6
    • 38649090091 scopus 로고    scopus 로고
    • PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters
    • Catasus, L., Gallardo, A., Cuatrecasas, M., and Prat, J. (2008). PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters. Mod Pathol 21, 131-139.
    • (2008) Mod Pathol , vol.21 , pp. 131-139
    • Catasus, L.1    Gallardo, A.2    Cuatrecasas, M.3    Prat, J.4
  • 7
    • 0031418171 scopus 로고    scopus 로고
    • The clinicopathological significance of K-RAS point mutation and gene amplification in endometrial cancer
    • Esteller, M., Garcia, A., Martinez-Palones, J.M., Xercavins, J., and Reventos, J. (1997). The clinicopathological significance of K-RAS point mutation and gene amplification in endometrial cancer. Eur J Cancer 33, 1572-1577.
    • (1997) Eur J Cancer , vol.33 , pp. 1572-1577
    • Esteller, M.1    Garcia, A.2    Martinez-Palones, J.M.3    Xercavins, J.4    Reventos, J.5
  • 9
    • 34248369435 scopus 로고    scopus 로고
    • Rare cancer-specific mutations in PIK3CA show gain of function
    • Gymnopoulos, M., Elsliger, M.A., and Vogt, P.K. (2007). Rare cancer-specific mutations in PIK3CA show gain of function. Proc Natl Acad Sci USA 104, 5569-5574.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5569-5574
    • Gymnopoulos, M.1    Elsliger, M.A.2    Vogt, P.K.3
  • 10
    • 67349170390 scopus 로고    scopus 로고
    • Molecular alterations of EGFR and PIK3CA in uterine serous carcinoma
    • Hayes, M.P., Douglas, W., and Ellenson, L.H. (2009). Molecular alterations of EGFR and PIK3CA in uterine serous carcinoma. Gynecol Oncol 113, 370-373.
    • (2009) Gynecol Oncol , vol.113 , pp. 370-373
    • Hayes, M.P.1    Douglas, W.2    Ellenson, L.H.3
  • 11
    • 33750698981 scopus 로고    scopus 로고
    • PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia
    • Hayes, M.P., Wang, H., Espinal-Witter, R., Douglas, W., Solomon, G.J., Baker, S.J., and Ellenson, L.H. (2006). PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia. Clin Cancer Res 12(20 Pt 1), 5932-5935.
    • (2006) Clin Cancer Res , vol.12 , Issue.20 PART 1 , pp. 5932-5935
    • Hayes, M.P.1    Wang, H.2    Espinal-Witter, R.3    Douglas, W.4    Solomon, G.J.5    Baker, S.J.6    Ellenson, L.H.7
  • 12
    • 0035008874 scopus 로고    scopus 로고
    • Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression
    • Hutchinson, J., Jin, J., Cardiff, R.D., Woodgett, J.R., and Muller, W.J. (2001). Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol 21, 2203-2212.
    • (2001) Mol Cell Biol , vol.21 , pp. 2203-2212
    • Hutchinson, J.1    Jin, J.2    Cardiff, R.D.3    Woodgett, J.R.4    Muller, W.J.5
  • 15
    • 14144252004 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
    • Kang, S., Bader, A.G., and Vogt, P.K. (2005). Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci USA 102, 802-807.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 802-807
    • Kang, S.1    Bader, A.G.2    Vogt, P.K.3
  • 16
    • 51849125616 scopus 로고    scopus 로고
    • Mutual exclusiveness between PIK3CA and KRAS mutations in endometrial carcinoma
    • Kang, S., Seo, S.S., Chang, H.J., Yoo, C.W., Park, S.Y., and Dong, S.M. (2008). Mutual exclusiveness between PIK3CA and KRAS mutations in endometrial carcinoma. Int J Gynecol Cancer 18, 1339-1343.
    • (2008) Int J Gynecol Cancer , vol.18 , pp. 1339-1343
    • Kang, S.1    Seo, S.S.2    Chang, H.J.3    Yoo, C.W.4    Park, S.Y.5    Dong, S.M.6
  • 17
    • 38949121953 scopus 로고    scopus 로고
    • PIK3CA gene mutations and amplifications in uterine cancers, identified by methods that avoid confounding by PIK3CA pseudogene sequences
    • Miyake, T., Yoshino, K., Enomoto, T., Takata, T., Ugaki, H., Kim, A., Fujiwara, K., Miyatake, T., Fujita, M., and Kimura, T. (2008). PIK3CA gene mutations and amplifications in uterine cancers, identified by methods that avoid confounding by PIK3CA pseudogene sequences. Cancer Lett 261, 120-126.
    • (2008) Cancer Lett , vol.261 , pp. 120-126
    • Miyake, T.1    Yoshino, K.2    Enomoto, T.3    Takata, T.4    Ugaki, H.5    Kim, A.6    Fujiwara, K.7    Miyatake, T.8    Fujita, M.9    Kimura, T.10
  • 18
    • 35549006238 scopus 로고    scopus 로고
    • Concomitant activation of AKT with extracellular-regulated kinase 1=2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss
    • Mori, N., Kyo, S., Sakaguchi, J., Mizumoto, Y., Ohno, S., Maida, Y., Hashimoto, M., Takakura, M., and Inoue, M. (2007). Concomitant activation of AKT with extracellular-regulated kinase 1=2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss. Cancer Sci 98, 1881-1888.
    • (2007) Cancer Sci , vol.98 , pp. 1881-1888
    • Mori, N.1    Kyo, S.2    Sakaguchi, J.3    Mizumoto, Y.4    Ohno, S.5    Maida, Y.6    Hashimoto, M.7    Takakura, M.8    Inoue, M.9
  • 23
    • 53649103519 scopus 로고    scopus 로고
    • Metastasis and AKT activation
    • Qiao, M., Sheng, S., and Pardee, A.B. (2008). Metastasis and AKT activation. Cell Cycle 7, 2991-2996.
    • (2008) Cell Cycle , vol.7 , pp. 2991-2996
    • Qiao, M.1    Sheng, S.2    Pardee, A.B.3
  • 24
    • 0030605386 scopus 로고    scopus 로고
    • Phosphatidylinositol 30 kinase: One of the effectors of Ras
    • discussion 231-1222
    • Rodriguez-Viciana, P., Marte, B.M., Warne, P.H., and Downward, J. (1996). Phosphatidylinositol 30 kinase: one of the effectors of Ras. Philos Trans R Soc Lond 351, 225-231; discussion 231-1222
    • (1996) Philos Trans R Soc Lond , vol.351 , pp. 225-231
    • Rodriguez-Viciana, P.1    Marte, B.M.2    Warne, P.H.3    Downward, J.4
  • 27
    • 34548058584 scopus 로고    scopus 로고
    • Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity
    • Toulany, M., Baumann, M., and Rodemann, H.P. (2007). Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity. Mol Cancer Res 5, 863-872.
    • (2007) Mol Cancer Res , vol.5 , pp. 863-872
    • Toulany, M.1    Baumann, M.2    Rodemann, H.P.3
  • 28
    • 0029063656 scopus 로고
    • Frequent occurrence of c-Ki-ras gene mutations in well differentiated endometrial adenocarcinoma showing infiltrative local growth with fibrosing stromal response
    • Tsuda, H., Jiko, K., Yajima, M., Yamada, T., Tanemura, K., Tsunematsu, R., Ohmi, K., Sonoda, T., and Hirohashi, S. (1995). Frequent occurrence of c-Ki-ras gene mutations in well differentiated endometrial adenocarcinoma showing infiltrative local growth with fibrosing stromal response. Int J Gynecol Pathol 14, 255-259.
    • (1995) Int J Gynecol Pathol , vol.14 , pp. 255-259
    • Tsuda, H.1    Jiko, K.2    Yajima, M.3    Yamada, T.4    Tanemura, K.5    Tsunematsu, R.6    Ohmi, K.7    Sonoda, T.8    Hirohashi, S.9
  • 30
    • 33947184242 scopus 로고    scopus 로고
    • Alternate molecular genetic pathways in ovarian carcinomas of common histological types
    • Willner, J., Wurz, K., Allison, K.H., Galic, V., Garcia, R.L., Goff, B.A., and Swisher, E.M. (2007). Alternate molecular genetic pathways in ovarian carcinomas of common histological types. Hum Pathol 38, 607-613.
    • (2007) Hum Pathol , vol.38 , pp. 607-613
    • Willner, J.1    Wurz, K.2    Allison, K.H.3    Galic, V.4    Garcia, R.L.5    Goff, B.A.6    Swisher, E.M.7
  • 31
    • 40649096375 scopus 로고    scopus 로고
    • Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
    • Zhao, L., and Vogt, P.K. (2008). Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms. Proc Natl Acad Sci USA 105, 2652-2657.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 2652-2657
    • Zhao, L.1    Vogt, P.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.