메뉴 건너뛰기




Volumn 6, Issue 1, 2012, Pages 21-32

Antioxidant-enriched diet affects early microglia accumulation and promotes regeneration of the striatal dopamine system after a 6-hydroxidopamine-induced lesion in a rat

Author keywords

Bilberry; Crowberry; Dopamine; Microglia; Regeneration

Indexed keywords

ANTIOXIDANT; BIOLOGICAL MARKER; KI 67 ANTIGEN; OXIDOPAMINE; PROTEIN; PROTEIN IBA1; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

EID: 84879187925     PISSN: None     EISSN: 11790695     Source Type: Journal    
DOI: 10.4137/JEN.S10424     Document Type: Article
Times cited : (5)

References (52)
  • 1
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • McGeer PL, Itagaki S, Boyes, BE, McGeer EG. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology. 1988;38:1285-91.
    • (1988) Neurology. , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 2
    • 0033578435 scopus 로고    scopus 로고
    • Mechanisms of tumor necrosis factor alpha action on neurodegeneration: interaction with insulin-like growth factor-1
    • Loddick SA, Rothwell NJ. Mechanisms of tumor necrosis factor alpha action on neurodegeneration: interaction with insulin-like growth factor-1. Proc Natl Acad Sci. 1999;96:9449-51.
    • (1999) Proc Natl Acad Sci. , vol.96 , pp. 9449-9451
    • Loddick, S.A.1    Rothwell, N.J.2
  • 3
    • 0030582991 scopus 로고    scopus 로고
    • Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease
    • Mogi M, Harada M, Narabayashi H, Inagaki H, Minami M, Nagatsu T. Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease. Neurosci Lett. 1996;211:13-6.
    • (1996) Neurosci Lett. , vol.211 , pp. 13-16
    • Mogi, M.1    Harada, M.2    Narabayashi, H.3    Inagaki, H.4    Minami, M.5    Nagatsu, T.6
  • 4
    • 0028178281 scopus 로고
    • Tumor necrosis factor alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from Parkinsonian patients
    • Mogi M, Harada M, Riederer P, Narabayashi H, Fujita K, Nagatsu T. Tumor necrosis factor alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from Parkinsonian patients. Neurosci Lett. 1994; 165:208-10.
    • (1994) Neurosci Lett. , vol.165 , pp. 208-210
    • Mogi, M.1    Harada, M.2    Riederer, P.3    Narabayashi, H.4    Fujita, K.5    Nagatsu, T.6
  • 5
    • 0028364696 scopus 로고
    • Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease
    • Boka G, Anglade P, Wallach D, Javoy-Agid F, Agid Y, Hirsch EC. Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease. Neurosci Lett. 1994;172:151-4.
    • (1994) Neurosci Lett. , vol.172 , pp. 151-154
    • Boka, G.1    Anglade, P.2    Wallach, D.3    Javoy-Agid, F.4    Agid, Y.5    Hirsch, E.C.6
  • 6
    • 0347363811 scopus 로고    scopus 로고
    • 6-Hydroxydopamine increases the level of TNFa and bax mRNA in the striatum and induces apoptosis of dopaminergic neurons in hemiparkinsonian rats
    • Mladenovic A, Perovic M, Raicevic N, Kanazir S, Rakic L, Ruzdijic S. 6-Hydroxydopamine increases the level of TNFa and bax mRNA in the striatum and induces apoptosis of dopaminergic neurons in hemiparkinsonian rats. Brain Res. 2004;996:237-45.
    • (2004) Brain Res. , vol.996 , pp. 237-245
    • Mladenovic, A.1    Perovic, M.2    Raicevic, N.3    Kanazir, S.4    Rakic, L.5    Ruzdijic, S.6
  • 7
    • 0033580959 scopus 로고    scopus 로고
    • Incresase in level of tumor necrosis factor (TNF)-a in 6-hydroxydopamine- lesioned striatum in rats without influence of systemic l-DOPA on the TNF-a induction
    • Mogi M, Togari A, Tanaka KI, Ogawa N, Ichinose H, Nagatsu T. Incresase in level of tumor necrosis factor (TNF)-a in 6-hydroxydopamine- lesioned striatum in rats without influence of systemic l-DOPA on the TNF-a induction. Neursci Lett. 1999;268:101-4.
    • (1999) Neursci Lett. , vol.268 , pp. 101-104
    • Mogi, M.1    Togari, A.2    Tanaka, K.I.3    Ogawa, N.4    Ichinose, H.5    Nagatsu, T.6
  • 8
    • 0026702955 scopus 로고
    • Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death
    • Boje KM, Arora PK. Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res. 1992;587:250-6.
    • (1992) Brain Res. , vol.587 , pp. 250-256
    • Boje, K.M.1    Arora, P.K.2
  • 9
    • 0026738695 scopus 로고
    • Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
    • Chao CC, Hu S, Molitor TW, Shaskan EG, Peterson PK. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol. 1992;149:2736-41.
    • (1992) J Immunol. , vol.149 , pp. 2736-2741
    • Chao, C.C.1    Hu, S.2    Molitor, T.W.3    Shaskan, E.G.4    Peterson, P.K.5
  • 10
    • 78650016970 scopus 로고    scopus 로고
    • NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat
    • Acosta S, Jernberg J, Sanberg CD, et al. NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat. Rejuvenation Res. 2010;13:581-8.
    • (2010) Rejuvenation Res. , vol.13 , pp. 581-588
    • Acosta, S.1    Jernberg, J.2    Sanberg, C.D.3
  • 11
    • 0032700265 scopus 로고    scopus 로고
    • Dietary antioxidants modulation of aging and immune- endothelial cell interaction
    • Meydani M. Dietary antioxidants modulation of aging and immune- endothelial cell interaction. Mech Ageing Dev. 1999;111:123-32.
    • (1999) Mech Ageing Dev. , vol.111 , pp. 123-132
    • Meydani, M.1
  • 12
    • 0028235692 scopus 로고
    • Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease
    • de Lorgeril M, Renaud S, Salen P, et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet. 1994;343:1454-9.
    • (1994) Lancet. , vol.343 , pp. 1454-1459
    • de Lorgeril, M.1    Renaud, S.2    Salen, P.3
  • 13
    • 77950655276 scopus 로고    scopus 로고
    • Blueberry supplementation improves memory in older adults
    • Krikorian R, Shidler MD, Nash TA, et al. Blueberry supplementation improves memory in older adults. J Agric Food Chem. 2010;58:3996-4000.
    • (2010) J Agric Food Chem. , vol.58 , pp. 3996-4000
    • Krikorian, R.1    Shidler, M.D.2    Nash, T.A.3
  • 16
    • 0038310626 scopus 로고    scopus 로고
    • Adherence to a Mediterranean diet and survival in a Greek population
    • Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med. 2003;348:2599-608.
    • (2003) N Engl J Med. , vol.348 , pp. 2599-608
    • Trichopoulou, A.1    Costacou, T.2    Bamia, C.3    Trichopoulos, D.4
  • 17
    • 0034595888 scopus 로고    scopus 로고
    • Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats
    • Bickford P, Gould T, Briederick L, et al. Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats. Brain Res. 2000;866:211-7.
    • (2000) Brain Res. , vol.866 , pp. 211-217
    • Bickford, P.1    Gould, T.2    Briederick, L.3
  • 18
    • 0032726599 scopus 로고    scopus 로고
    • Effects of aging on cerebellar noradrenergic function and motor learning: nutritional interventions
    • Bickford P, Shukitt-Hale B, Joseph J. Effects of aging on cerebellar noradrenergic function and motor learning: nutritional interventions. Mech Ageing Dev. 1999;111:141-54.
    • (1999) Mech Ageing Dev. , vol.111 , pp. 141-154
    • Bickford, P.1    Shukitt-Hale, B.2    Joseph, J.3
  • 19
    • 0033568849 scopus 로고    scopus 로고
    • Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation
    • Joseph, JA, Shukitt-Hale B, Denisova NA, et al. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J. Neurosci. 1999;19:8114-21.
    • (1999) J. Neurosci. , vol.19 , pp. 8114-8121
    • Joseph, J.A.1    Shukitt-Hale, B.2    Denisova, N.A.3
  • 20
    • 0032189767 scopus 로고    scopus 로고
    • Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits
    • Joseph JA, Shukitt-Hale B, Denisova NA, et al. Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. J Neurosci. 1998;18:8047-55.
    • (1998) J Neurosci. , vol.18 , pp. 8047-8055
    • Joseph, J.A.1    Shukitt-Hale, B.2    Denisova, N.A.3
  • 21
    • 39449128517 scopus 로고    scopus 로고
    • Dietary supplementation exerts neuroprotective effects in ischemic stroke model
    • Yasuhara T, Hara K, Maki M, et al. Dietary supplementation exerts neuroprotective effects in ischemic stroke model. Rejuvenation Res. 2008;11: 201-14.
    • (2008) Rejuvenation Res. , vol.11 , pp. 201-214
    • Yasuhara, T.1    Hara, K.2    Maki, M.3
  • 22
    • 67650908916 scopus 로고    scopus 로고
    • Beneficial effects of antioxidant-enriched diet for tyrosine hydroxylase-positive neurons in ventral mesencephalic tissue in oculo grafts
    • Berglöf E, Small BJ, Bickford PC, Strömberg I. Beneficial effects of antioxidant-enriched diet for tyrosine hydroxylase-positive neurons in ventral mesencephalic tissue in oculo grafts. J Comp Neurol. 2009;515:72-82.
    • (2009) J Comp Neurol. , vol.515 , pp. 72-82
    • Berglöf, E.1    Small, B.J.2    Bickford, P.C.3    Strömberg, I.4
  • 24
    • 27744496501 scopus 로고    scopus 로고
    • Blueberry- and spirulina-enriched diets enhance striatal dopamine regeneration and induce a rapid, transient microglia activation after injury of the nigrostriatal dopamine system
    • Strömberg I, Gemma C, Vila M, Bickford PC. Blueberry- and spirulina-enriched diets enhance striatal dopamine regeneration and induce a rapid, transient microglia activation after injury of the nigrostriatal dopamine system. Exp Neurol. 2005;196:298-307.
    • (2005) Exp Neurol. , vol.196 , pp. 298-307
    • Strömberg, I.1    Gemma, C.2    Vila, M.3    Bickford, P.C.4
  • 25
    • 0028220834 scopus 로고
    • Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat
    • Sauer H, Oertel WH. Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat. Neurosci. 1994;59:401-15.
    • (1994) Neurosci. , vol.59 , pp. 401-415
    • Sauer, H.1    Oertel, W.H.2
  • 27
    • 0034779261 scopus 로고    scopus 로고
    • Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries
    • Seeram NP, Momin RA, Nair MG, Bourquin LD. Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries. Phytomedicine. 2001;8:362-9.
    • (2001) Phytomedicine. , vol.8 , pp. 362-369
    • Seeram, N.P.1    Momin, R.A.2    Nair, M.G.3    Bourquin, L.D.4
  • 29
    • 0032986801 scopus 로고    scopus 로고
    • Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries
    • Wang H, Nair MG, Strasburg GM, et al. Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries. J Nat Prod. 1999;62:294-6.
    • (1999) J Nat Prod. , vol.62 , pp. 294-296
    • Wang, H.1    Nair, M.G.2    Strasburg, G.M.3
  • 30
    • 47349086744 scopus 로고    scopus 로고
    • Anthocyanin composition and antioxidant activity of the Crowberry (Empetrum nigrum) and other berries
    • Ogawa K, Sakakibara H, Iwata R, et al. Anthocyanin composition and antioxidant activity of the Crowberry (Empetrum nigrum) and other berries. J Agric Food Chem. 2008;56:4457-62.
    • (2008) J Agric Food Chem. , vol.56 , pp. 4457-4462
    • Ogawa, K.1    Sakakibara, H.2    Iwata, R.3
  • 31
    • 84855204111 scopus 로고    scopus 로고
    • Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease
    • Anandhan A, Tamilselvam K, Radhiga T, Rao S, Essa MM, Manivasagam T. Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease. Brain Research. 2012;433:4-113.
    • (2012) Brain Research. , vol.433 , pp. 4-113
    • Anandhan, A.1    Tamilselvam, K.2    Radhiga, T.3    Rao, S.4    Essa, M.M.5    Manivasagam, T.6
  • 32
    • 35348924274 scopus 로고    scopus 로고
    • Short-term supplementation with plant extracts rich in flavonoids protect nigrostriatal dopaminergic neurons in a rat model of Parkinson's disease
    • Datla KP, Zbarsky V, Rai D, et al. Short-term supplementation with plant extracts rich in flavonoids protect nigrostriatal dopaminergic neurons in a rat model of Parkinson's disease. J Am Coll Nutr. 2007;6:341-9.
    • (2007) J Am Coll Nutr. , vol.6 , pp. 341-349
    • Datla, K.P.1    Zbarsky, V.2    Rai, D.3
  • 33
    • 79960461573 scopus 로고    scopus 로고
    • Neuroprotective effect of bioflavonoid quercetin in 6-hydroxydopamine-induced oxidative stress biomarkers in the rat striatum
    • Haleagrahara N, Siew CJ, Mitra NK, Kumari M. Neuroprotective effect of bioflavonoid quercetin in 6-hydroxydopamine-induced oxidative stress biomarkers in the rat striatum. Neuroscience Letters. 2011;500:139-43.
    • (2011) Neuroscience Letters. , vol.500 , pp. 139-143
    • Haleagrahara, N.1    Siew, C.J.2    Mitra, N.K.3    Kumari, M.4
  • 34
    • 25444508963 scopus 로고    scopus 로고
    • Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease
    • Zbarsky V, Datla KP, Parkar S, Rai DK, Aruoma OI, Dexter DT. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radic Res. 2005;39:1119-25.
    • (2005) Free Radic Res. , vol.39 , pp. 1119-1125
    • Zbarsky, V.1    Datla, K.P.2    Parkar, S.3    Rai, D.K.4    Aruoma, O.I.5    Dexter, D.T.6
  • 36
    • 0031033904 scopus 로고    scopus 로고
    • Dopaminergic innervation of striatal grafts placed into different sites of normal striatum: differences in the tyrosine hydroxylase immunoreactive growth pattern
    • Bjorklund L, Stromberg I. Dopaminergic innervation of striatal grafts placed into different sites of normal striatum: differences in the tyrosine hydroxylase immunoreactive growth pattern. Exp Brain Res. 1997;113:13-23.
    • (1997) Exp Brain Res. , vol.113 , pp. 13-23
    • Bjorklund, L.1    Stromberg, I.2
  • 37
    • 0026553895 scopus 로고
    • Target-specific outgrowth from human mesencephalic tissue grafted to cortex or ventricle of immunosuppressed rats
    • Strömberg I, Bygdeman M, Almqvist P. Target-specific outgrowth from human mesencephalic tissue grafted to cortex or ventricle of immunosuppressed rats. J Comp Neurol. 1992;315:445-56.
    • (1992) J Comp Neurol. , vol.315 , pp. 445-456
    • Strömberg, I.1    Bygdeman, M.2    Almqvist, P.3
  • 38
    • 78951488151 scopus 로고    scopus 로고
    • Time-course of nigrostriatal neurodegeneration and neuroinflammation in the 6-hydroxydopamine-induced axonal and terminal lesion models of Parkinson's disease in the rat
    • Walsh S, Finn DP, Dowd E. Time-course of nigrostriatal neurodegeneration and neuroinflammation in the 6-hydroxydopamine-induced axonal and terminal lesion models of Parkinson's disease in the rat. Neuroscience. 2011;175:251-61.
    • (2011) Neuroscience. , vol.175 , pp. 251-261
    • Walsh, S.1    Finn, D.P.2    Dowd, E.3
  • 39
    • 37449007512 scopus 로고    scopus 로고
    • Neuroprotective effect of curcumin is mainly mediated by blockade of microglial cell activation
    • Lee HS, Jung KK, Cho JY, et al. Neuroprotective effect of curcumin is mainly mediated by blockade of microglial cell activation. Pharmazie. 2007;62:937-42.
    • (2007) Pharmazie. , vol.62 , pp. 937-942
    • Lee, H.S.1    Jung, K.K.2    Cho, J.Y.3
  • 40
    • 70349750314 scopus 로고    scopus 로고
    • Consumption of grape seed extract prevents amyloid-beta deposition and attenuates inflammation in brain of an Alzheimer's disease mouse
    • Wang, YJ, Thomas P, Zhong JH, et al. Consumption of grape seed extract prevents amyloid-beta deposition and attenuates inflammation in brain of an Alzheimer's disease mouse. Neurotox Res. 2009;15:3-14.
    • (2009) Neurotox Res. , vol.15 , pp. 3-14
    • Wang, Y.J.1    Thomas, P.2    Zhong, J.H.3
  • 41
    • 77950898188 scopus 로고    scopus 로고
    • Blueberry supplementation attenuates microglial activation in hippocampal intraocular grafts to aged hosts
    • Willis LM, Freeman L, Bickford PC, et al. Blueberry supplementation attenuates microglial activation in hippocampal intraocular grafts to aged hosts. Glia. 2010;58:679-90.
    • (2010) Glia. , vol.58 , pp. 679-690
    • Willis, L.M.1    Freeman, L.2    Bickford, P.C.3
  • 42
    • 34247158086 scopus 로고    scopus 로고
    • Early inhibition of TNFalpha increases 6-hydroxydopamine-induced striatal degeneration
    • Gemma C, Catlow B, Cole M, et al. Early inhibition of TNFalpha increases 6-hydroxydopamine-induced striatal degeneration. Brain Res. 2007;1147: 240-7.
    • (2007) Brain Res. , vol.1147 , pp. 240-247
    • Gemma, C.1    Catlow, B.2    Cole, M.3
  • 43
    • 44649114567 scopus 로고    scopus 로고
    • Dual effects of TNFalpha on nerve fiber formation from ventral mesencephalic organotypic tissue cultures
    • Marschinke F, Strömberg I. Dual effects of TNFalpha on nerve fiber formation from ventral mesencephalic organotypic tissue cultures. Brain Res. 2008;1215:30-9.
    • (2008) Brain Res. , vol.1215 , pp. 30-39
    • Marschinke, F.1    Strömberg, I.2
  • 46
    • 25844442898 scopus 로고    scopus 로고
    • D.6-Hydroxydopamine-induced alterations in blood-brain barrier permeability
    • Carvey PM, Zhao CH, Hendey B, et al. D. 6-Hydroxydopamine-induced alterations in blood-brain barrier permeability. Eur J Neurosci. 2005;22: 1158-68.
    • (2005) Eur J Neurosci. , vol.22 , pp. 1158-68
    • Carvey, P.M.1    Zhao, C.H.2    Hendey, B.3
  • 47
    • 33748711640 scopus 로고    scopus 로고
    • Endothelial proliferation and increased blood-brain barrier permeability in the basal ganglia in a rat model of 3,4-dihydroxyphenyl-L-alanine-induced dyskinesia
    • Westin JE, Lindgren HS, Gardi J,et al.Endothelial proliferation and increased blood-brain barrier permeability in the basal ganglia in a rat model of 3,4-dihydroxyphenyl-L-alanine-induced dyskinesia. J Neurosci. 2006;26:9448-61.
    • (2006) J Neurosci. , vol.26 , pp. 9448-9461
    • Westin, J.E.1    Lindgren, H.S.2    Gardi, J.3
  • 48
    • 84855581908 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha- mediated threonine 435 phosphorylation of p65 nuclear factor-kappaB subunit in endothelial cells induces vasogenic edema and neutrophil infiltration in the rat piriform cortex following status epilepticus
    • Kim JE, Ryu HJ, Choi SY, Kang TC. Tumor necrosis factor-alpha- mediated threonine 435 phosphorylation of p65 nuclear factor-kappaB subunit in endothelial cells induces vasogenic edema and neutrophil infiltration in the rat piriform cortex following status epilepticus. J Neuroinflammation. 2012;9:6.
    • (2012) J Neuroinflammation. , vol.9 , pp. 6
    • Kim, J.E.1    Ryu, H.J.2    Choi, S.Y.3    Kang, T.C.4
  • 49
    • 0034873862 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha causes an increase in blood-brain barrier permeability during sepsis
    • Tsao N, Hsu HP, Wu CM, Liu CC, Lei HY. Tumour necrosis factor-alpha causes an increase in blood-brain barrier permeability during sepsis. J Med Microbiol. 2001;50:812-21.
    • (2001) J Med Microbiol. , vol.50 , pp. 812-821
    • Tsao, N.1    Hsu, H.P.2    Wu, C.M.3    Liu, C.C.4    Lei, H.Y.5
  • 50
    • 0026733994 scopus 로고
    • MRI, brain iron and experimental Parkinson's disease
    • Hall S, Rutledge JN, Schallert T. MRI, brain iron and experimental Parkinson's disease. J Neurol Sci. 1992;113:198-208.
    • (1992) J Neurol Sci. , vol.113 , pp. 198-208
    • Hall, S.1    Rutledge, J.N.2    Schallert, T.3
  • 51
    • 80051632039 scopus 로고    scopus 로고
    • Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson's disease
    • Lv Z, Jiang H, Xu H, Song N, Xie J. Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson's disease. J Neural Transm. 2011;118:361-9.
    • (2011) J Neural Transm. , vol.118 , pp. 361-369
    • Lv, Z.1    Jiang, H.2    Xu, H.3    Song, N.4    Xie, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.