IFN-α as an Adjuvant for Adenovirus-Vectored FMDV Subunit Vaccine through Improving the Generation of T Follicular Helper Cells

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Su, Chunxia ^a   Duan, Xiangguo ^a   Zheng, Jie ^a   Liang, Lijun ^a   Wang, Feng ^a   Guo, Lin ^a  

^a NINGXIA MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ALPHA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERFERON; INTERLEUKIN 21; MESSENGER RNA; PROTEIN BCL 6; PROTEIN VP1; SUBUNIT VACCINE;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FOOT AND MOUTH DISEASE VIRUS; GERMINAL CENTER; HELPER CELL; HUMORAL IMMUNITY; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOMODULATION; INNATE IMMUNITY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE; ADENOVIRIDAE; ANIMAL; BAGG ALBINO MOUSE; GENE VECTOR; GENETICS; IMMUNOLOGY;

ADENOVIRIDAE; FOOT-AND-MOUTH DISEASE VIRUS; SUS;

ADENOVIRIDAE; ANIMALS; FEMALE; FOOT-AND-MOUTH DISEASE VIRUS; GENETIC VECTORS; INTERFERON-ALPHA; MICE; MICE, INBRED BALB C; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84879149467     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066134     Document Type: Article

References (38)

1. Prchal M, Pilz A, Simma O, Lingnau K, von Gabain A, et al. (2009) Type I interferons as mediators of immune adjuvants for T- and B cell-dependent acquired immunity. Vaccine 27(6): G17-G20.
2. Thompson AL, Staats HF (2011) Cytokines: the future of intranasal vaccine adjuvants. Clin Dev Immunol.289597.
3. Bayer W, Lietz R, Ontikatze T, Johrden L, Tenbusch M, et al. (2011) Improved vaccine protection against retrovirus infection after co-administration of adenoviral vectors encoding viral antigens and type I interferon subtypes. Retrovirology 8: 75.
4. Proietti E, Bracci L, Puzelli S, Di Pucchio T, Sestili P, et al. (2002) Type I IFN as a natural adjuvant for a protective immune response: lessons from the influenza vaccine model. J Immunol. 169(1): 375-83.
5. Bracci L, Canini I, Puzelli S, Sestili P, Venditti M, et al. (2005) Type I IFN is a powerful mucosal adjuvant for a selective intranasal vaccination against influenza virus in mice and affects antigen capture at mucosal level. Vaccine 23(23): 2994-3004.
6. Couch RB, Atmar RL, Cate TR, Quarles JM, Keitel WA, et al. (2009) Contrasting Effects of Type I Interferon as a Mucosal Adjuvant for Influenza Vaccine in Mice and Humans. Vaccine 27(39): 5344-5348.
7. Havenar-Daughton C, Kolumam GA, Murali-Krishna K, (2006) Cutting Edge: The direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection. J Immunol 176: 3315-3319.
8. Le Bon A, Schiavoni G, D'Agostino G, Gresser I, Belardelli F, et al. (2001) Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo.Immunity. 14(4): 461-70.
9. Chu J Q, Kim S M, Lee K N, Oem J K, Ko Y J, et al. (2012) Adenovirus Expressing Human Interferon Inhibits Replication of Foot and Mouth Disease Virus and Reduces Fatal Rate in Mice. Journal of Bacteriology and Virology 42(3): 224-231.
10. Diaz-San Segundo F, Moraes MP, de los Santos T, Dias CC, Grubman MJ, (2010) Interferon-induced protection against foot-and-mouth disease virus infection correlates with enhanced tissue-specific innate immune cell infiltration and interferon-stimulated gene expression. Journal of virology 84(4): 2063-2077.
11. Theofilopoulos AN, Baccala R, Beutler B, Kono DH, (2005) Type I interferons (alpha/beta) in immunity and autoimmunity. Annu Rev Immunol 23: 307-336.
12. Cucak H, Yrlid U, Reizis B, Kalinke U, Johansson-Lindbom B, (2009) Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells. Immunity 31(3): 491-501.
13. Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, et al. (2000) CXC Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function. J. Exp. Med (192): 1553-1562.
14. Moser B, Schaerli P, Loetscher P, (2002) CXCR5+T cells:follicular homing takes center stage in T-helper-cell responses. TRENDS in Immunology 23(5): 250-254.
15. Fazilleau N, Mark L, McHeyzer-Williams LJ, McHeyzer-Williams MG, et al. (2009) Follicular Helper T Cells:Lineage and Location. Immunity 30: 324-335.
16. McHeyzer-Williams LJ, Pelletier N, Mark L, Fazilleau N, McHeyzer-Williams MG, (2009) Follicular helper T cells as cognate regulators of B cell immunity. Current Opinion in Immunology 21: 266-273.
17. Kerfoot SM, Yaari G, Patel JR, Johnson KL, Gonzalez DG, et al. (2011) Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone. Immunity 34: 947-960.
18. Rasheed AU, Rahn HP, Sallusto F, Lipp M, Muller G, (2006) Follicular B helper T cell activity is confined to CXCR5 (hi) ICOS (hi) CD4 T cells and is independent of CD57 expression. Eur. J. Immunol. 36: 1892-1903.
19. Akiba H, Takeda K, Kojima Y, Usui Y, Harada N, et al. (2005) The Role of ICOS in the CXCR5+ Follicular B Helper T Cell Maintenance In Vivo. J Immunol. 175(4): 2340-2348.
20. Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay CR, et al. (2008) A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells.Immunity. 29: 127-137.
21. Bryant VL, Ma CS, Avery DT, Li Y, Good KL, et al. (2007) Cytokine-Mediated Regulation of Human B Cell Differentiation into Ig-Secreting Cells: Predominant Role of IL-21 Produced by CXCR5+T Follicular Helper Cells. J Immunol. 179(12): 8180-8190.
22. Reinhardt RL, Liang HE, Locksley RM, (2009) Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol (104): 385-393.
23. Haynes NM, Allen CDC, Lesley R, Ansel KM, Killeen N, et al. (2007) Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J. Immunol. 179: 5099-5108.
24. Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, et al. (2008) Generation of follicular helper T cells is mediated by IL-21 but independent of TH1, TH2 or TH17 lineages. Immunity 29(1): 138-149.
25. King C, Tangye SG, Mackay CR, (2008) T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu. Rev. Immunol 26: 741-766.
26. Vinuesa CG, Tangye SG, Moser B, Mackay CR, (2005) Follicular B helper T cells in antibody responses and autoimmunity. Nat. Rev. Immunol 5: 853-865.
27. Fazilleau N, McHeyzer-Williams LJ, Rosen H, (2009) McHeyzer-Williams MG, et al. (2009) The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nat Immunol. 10(4): 375-384.
28. Moon JJ, Suh H, Li AV, Ockenhouse CF, Yadava A, et al. (2012) Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction. Proceedings of the National Academy of Sciences, 109(4), 1080-1085.
29. Su CX, Duan XG, Zhang YL, Bai R, Chen PY, (2009) Construction and Identi f ication of Recombinant Adenovirus Expression VP1 of Foot and Mouth Disease Virus. Journal of Ningxia Medical University.31 (5): 566-569.
30. Su CX (2007) Discussion on the Recombinant Strategies of FMD Gene Engineering Vaccine. Nanjing Agriculture University.
31. Holl EK, O'Connor BP, Holl TM, Roney KE, Zimmermann AG, et al. (2011) Plexin-D1 Is a Novel Regulator of Germinal Centers and Humoral Immune Responses. J Immunol 186: 5603-5611.
32. Su CX, Duan XG, Huang L, Chen PY, (2010) Influence of Foot and Mouth Disease Virus of Recombinant Adenovirus Expression VP1 on Specific Immune Responses in Mice. Journal of Ningxia Medical University.32 (9): 947-950.
33. Eto D, Lao C, DiToro D, Barnett B, Escobar TC, et al. (2011) IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation. PLoS ONE 6(3), e17739.
34. Poholek AC, Hansen K, Hernandez SG, Eto D, Chandele A, et al. (2010) In vivo regulation of Bcl6 and T follicular helper cell development. J Immunol. 185(1): 313-326.
35. Nurieva RI, Chung Y, Martinez GJ, Yang XO, Tanaka S, et al. (2009) Bcl6 Mediates the Development of T Follicular Helper Cells. Science 325: 1001-1005.
36. Le Bon A, Thompson C, Kamphuis E, Durand V, Rossmann C, et al. (2006) Cutting Edge: Enhancement of Antibody Responses Through Direct Stimulation of B and T Cells by Type I IFN. J Immunol 176: 2074-2078.
37. Zhu J, Huang X, Yang Y, (2007) Type I IFN Signaling on Both B and CD4 T Cells Is Required for Protective Antibody Response to Adenovirus. J Immunol 78 (6): 3505-3510.
38. Terawaki S, Chikuma S, Shibayama S, Hayashi T, Yoshida T, et al. (2011) IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity. J Immunol. 186(5): 2772-2779.