Transcriptome Analysis Reveals Novel Entry Mechanisms and a Central Role of SRC in Host Defense during High Multiplicity Mycobacterial Infection

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Zhang, Jay ^a  

^a GRIFFITH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTOME; ALPHA5 INTEGRIN; BACTERIAL RNA; PROTEIN TYROSINE KINASE;

ARTICLE; BCG VACCINATION; GENE EXPRESSION; GRANULOMA; HOST CELL; HOST RESISTANCE; IMMUNE SYSTEM; INNATE IMMUNITY; LUNG TUBERCULOSIS; MACROPHAGE; MORTALITY; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; ANIMAL; BACTERIAL COUNT; CELL LINE; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MOUSE; PATHOGENICITY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TUBERCULOSIS; VALIDATION STUDY;

CORYNEBACTERINEAE; MYCOBACTERIUM; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

ANIMALS; CELL LINE; COLONY COUNT, MICROBIAL; INTEGRIN ALPHA5; MACROPHAGES; MICE; MYCOBACTERIUM TUBERCULOSIS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, BACTERIAL; SRC-FAMILY KINASES; TRANSCRIPTOME; TUBERCULOSIS;

EID: 84879135054     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065128     Document Type: Article

References (56)

1. Gordon S, (2003) Alternative activation of macrophages. Nature Reviews Immunology 3: 23-35.
2. Kleinnijenhuis J, Oosting M, Joosten LAB, Netea MG, Van Crevel R, (2011) Innate Immune Recognition of Mycobacterium tuberculosis. Clinical & Developmental Immunology.
3. Abram CL, Lowell CA, (2008) The diverse functions of Src family kinases in macrophages. Frontiers in Bioscience 13: 4426-4450.
4. Baruzzi A, Caveggion E, Berton G, (2008) Regulation of phagocyte migration and recruitment by Src-family kinases. Cellular and Molecular Life Sciences 65: 2175-2190.
5. McGarvey JA, Wagner D, Bermudez LE, (2004) Differential gene expression in mononuclear phagocytes infected with pathogenic and non-pathogenic mycobacteria. Clinical and Experimental Immunology 136: 490-500.
6. Motiwala AS, Janagama HK, Paustian ML, Zhu XC, Bannantine JP, et al. (2006) Comparative transcriptional analysis of human macrophages exposed to animal and human isolates of Mycobacterium avium subspecies paratuberculosis with diverse genotypes. Infection and Immunity 74: 6046-6056.
7. Lee J, Remold HG, Leong MH, Kornfeld H, (2006) Macrophage apoptosis in response to high intracellular burden of Mycobacterium tuberculosis is mediated by a novel caspase-independent pathway. J Immunol 176: 4267-4274.
8. Colombo PE, Milanezi F, Weigelt B, Reis-Filho JS, (2011) Microarrays in the 2010s: the contribution of microarray-based gene expression profiling to breast cancer classification, prognostication and prediction. Breast Cancer Res 13: 212.
9. Lee J, Repasy T, Papavinasasundaram K, Sassetti C, Kornfeld H, (2011) Mycobacterium tuberculosis Induces an Atypical Cell Death Mode to Escape from Infected Macrophages. Plos One 6.
10. Franzblau TPPaSG (2007) Recent Advances in Methodologies for the Discovery of Antimycobacterial Drugs. Current Bioactive Compounds 3: 8.
11. Anes E, Peyron P, Staali L, Jordao L, Gutierrez MG, et al. (2006) Dynamic life and death interactions between Mycobacterium smegmatis and J774 macrophages. Cellular Microbiology 8: 939-960.
12. Garnier T, Eiglmeier K, Camus JC, Medina N, Mansoor H, et al. (2003) The complete genome sequence of Mycobacterium bovis. Proc Natl Acad Sci U S A 100: 7877-7882.
13. Gey van Pittius NC, Sampson SL, Lee H, Kim Y, van Helden PD, et al. (2006) Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions. Bmc Evolutionary Biology 6.
14. Mi HY, Lazareva-Ulitsky B, Loo R, Kejariwal A, Vandergriff J, et al. (2005) The PANTHER database of protein families, subfamilies, functions and pathways. Nucleic Acids Research 33: D284-D288.
15. Magee DA, Taraktsoglou M, Killick KE, Nalpas NC, Browne JA, et al. (2012) Global gene expression and systems biology analysis of bovine monocyte-derived macrophages in response to in vitro challenge with Mycobacterium bovis. Plos One 7: e32034.
16. Kohle C, Bock KW, (2007) Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2. Biochemical Pharmacology 73: 1853-1862.
17. Chin BY, Otterbein LE, (2009) Carbon monoxide is a poison. to microbes! CO as a bactericidal molecule. Current Opinion in Pharmacology 9: 490-500.
18. Velasco-Velazquez MA, Barrera D, Gonzalez-Arenas A, Rosales C, Agramonte-Hevia J, (2003) Macrophage-Mycobacterium tuberculosis interactions: role of complement receptor 3. Microb Pathog 35: 125-131.
19. Behera AK, Hildebrand E, Uematsu S, Akira S, Coburn J, et al. (2006) Identification of a TLR-independent pathway for Borrelia burgdorferi-induced expression of matrix metalloproteinases and inflammatory mediators through binding to integrin alpha(3)beta(1). J Immunol 177: 657-664.
20. Ulanova M, Gravelle S, Barnes R, (2009) The role of epithelial integrin receptors in recognition of pulmonary pathogens. J Innate Immun 1: 4-17.
21. Secott TE, Lin TL, Wu CC, (2004) Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein facilitates M-cell targeting and invasion through a fibronectin bridge with host integrins. Infection and Immunity 72: 3724-3732.
22. Goodman SL, Picard M, (2012) Integrins as therapeutic targets. Trends in Pharmacological Sciences 33: 405-412.
23. Creedon H, Brunton VG, (2012) Src kinase inhibitors: promising cancer therapeutics? Crit Rev Oncog 17: 145-159.
24. Lowell CA, (2011) Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk. Cold Spring Harb Perspect Biol 3.
25. Mitra SK, Schlaepfer DD, (2006) Integrin-regulated FAK-Src signaling in normal and cancer cells. Current Opinion in Cell Biology 18: 516-523.
26. Ginsberg MH, Partridge A, Shattil SJ, (2005) Integrin regulation. Current Opinion in Cell Biology 17: 509-516.
27. Karim AF, Chandra P, Chopra A, Siddiqui Z, Bhaskar A, et al. (2011) Express Path Analysis Identifies a Tyrosine Kinase Src-centric Network Regulating Divergent Host Responses to Mycobacterium tuberculosis Infection. Journal of Biological Chemistry 286: 40307-40319.
28. Arias-Salgado EG, Lizano S, Sarkar S, Brugge JS, Ginsberg MH, et al. (2003) Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A 100: 13298-13302.
29. Sharma S, Mulik S, Kumar N, Suryawanshi A, Rouse BT, (2011) An anti-inflammatory role of VEGFR2/Src kinase inhibitor in herpes simplex virus 1-induced immunopathology. J Virol 85: 5995-6007.
30. Freudenburg W, Buller RM, Corbett JA, (2010) Src family kinases participate in the regulation of encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages. J Gen Virol 91: 2278-2285.
31. Aleshin A, Finn RS, (2010) SRC: a century of science brought to the clinic. Neoplasia 12: 599-607.
32. Wu R, Zhang L, Hoagland MS, Swanson HI, (2007) Lack of the aryl hydrocarbon receptor leads to impaired activation of AKT/protein kinase B and enhanced sensitivity to apoptosis induced via the intrinsic pathway. J Pharmacol Exp Ther 320: 448-457.
33. Chopra M, Schrenk D, (2011) Dioxin toxicity, aryl hydrocarbon receptor signaling, and apoptosis-Persistent pollutants affect programmed cell death. Critical Reviews in Toxicology 41: 292-320.
34. Kerkvliet NI, (2009) AHR-mediated immunomodulation: The role of altered gene transcription. Biochemical Pharmacology 77: 746-760.
35. Ma C, Marlowe JL, Puga A, (2009) The aryl hydrocarbon receptor at the crossroads of multiple signaling pathways. EXS 99: 231-257.
36. O'Donnell EF, Saili KS, Koch DC, Kopparapu PR, Farrer D, et al. (2010) The Anti-Inflammatory Drug Leflunomide Is an Agonist of the Aryl Hydrocarbon Receptor. Plos One 5.
37. Palanisamy GS, Kirk NM, Ackart DF, Shanley CA, Orme IM, et al. (2011) Evidence for Oxidative Stress and Defective Antioxidant Response in Guinea Pigs with Tuberculosis. Plos One 6.
38. Hybertson BM, Gao BF, Bose SK, McCord JM, (2011) Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation. Molecular Aspects of Medicine 32: 234-246.
39. Chen CC, Tsai SH, Lu CC, Hu ST, Wu TS, et al. (2012) Activation of an NLRP3 Inflammasome Restricts Mycobacterium kansasii Infection. Plos One 7.
40. Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, et al. (2009) Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 183: 787-791.
41. Mishra BB, Moura-Alves P, Sonawane A, Hacohen N, Griffiths G, et al. (2010) Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome. Cellular Microbiology 12: 1046-1063.
42. Maciag A, Piazza A, Riccardi G, Milano A, (2009) Transcriptional analysis of ESAT-6 cluster 3 in Mycobacterium smegmatis. BMC Microbiol 9: 48.
43. Thacker JD, Balin BJ, Appelt DM, Sassi-Gaha S, Purohit M, et al. (2012) NLRP3 Inflammasome Is a Target for Development of Broad-Spectrum Anti-Infective Drugs. Antimicrobial Agents and Chemotherapy 56: 1921-1930.
44. Kumar D, Nath L, Kamal MA, Varshney A, Jain A, et al. (2010) Genome-wide Analysis of the Host Intracellular Network that Regulates Survival of Mycobacterium tuberculosis. Cell 140: 731-743.
45. Kumar D, Rao KVS, (2011) Regulation between survival, persistence, and elimination of intracellular mycobacteria: a nested equilibrium of delicate balances. Microbes and Infection 13: 121-133.
46. Jayaswal S, Kamal MA, Dua R, Gupta S, Majumdar T, et al. (2010) Identification of Host-Dependent Survival Factors for Intracellular Mycobacterium tuberculosis through an siRNA Screen. PLoS Pathog 6.
47. Hancock REW, Nijnik A, Philpott DJ, (2012) Modulating immunity as a therapy for bacterial infections. Nature Reviews Microbiology 10: 243-254.
48. Coley W, Kehn-Hall K, Van Duyne R, Kashanchi F, (2009) Novel HIV-1 therapeutics through targeting altered host cell pathways. Expert Opinion on Biological Therapy 9: 1369-1382.
49. Chung J, Rossi JJ, Jung U, (2011) Current progress and challenges in HIV gene therapy. Future Virology 6: 1319-1328.
50. Lawn SD, Bekker LG, Miller RF, (2005) Immune reconstitution disease associated with mycobacterial infections in HIV-infected individuals receiving antiretrovirals. Lancet Infectious Diseases 5: 361-373.
51. Martino A, (2008) Mycobacteria and innate cells: critical encounter for immunogenicity. Journal of Biosciences 33: 137-144.
52. Grosset J, (2003) Mycobacterium tuberculosis in the extracellular compartment: an underestimated adversary. Antimicrobial Agents and Chemotherapy 47: 833-836.
53. Davis JM, Ramakrishnan L, (2009) The role of the granuloma in expansion and dissemination of early tuberculous infection. Cell 136: 37-49.
54. Wang F, Robbins S, Guo JT, Shen WJ, Schultz PG, (2010) Genetic Incorporation of Unnatural Amino Acids into Proteins in Mycobacterium tuberculosis. Plos One 5.
55. Wang X, Spandidos A, Wang H, Seed B, (2012) PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update. Nucleic Acids Research 40: D1144-1149.
56. Rozen S, Skaletsky H, (2000) Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 132: 365-386.