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Volumn 27, Issue 1, 2013, Pages 101-113

Ex vivo systems to study host-microbiota interactions in the gastrointestinal tract

Author keywords

Experimental model; Gut; Microbiome; Microcosms; Mucosa

Indexed keywords

ARTICLE; BACTERIUM; CELL CULTURE; CYTOPLASM; ECOLOGY; ECOSYSTEM; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; GASTROINTESTINAL TRACT; HOST; HUMAN; IMMUNOHISTOCHEMISTRY; INTESTINE FLORA; INTESTINE MUCOSA PERMEABILITY; MAMMAL; MICROBIAL COMMUNITY; NONHUMAN; PERFUSION; RADIOIMMUNOASSAY; SPECIES DIVERSITY; SPECIES RICHNESS; STEM CELL;

EID: 84879106819     PISSN: 15216918     EISSN: 15321916     Source Type: Journal    
DOI: 10.1016/j.bpg.2013.03.018     Document Type: Review
Times cited : (38)

References (74)
  • 1
    • 77954627922 scopus 로고    scopus 로고
    • Viruses in the faecal microbiota of monozygotic twins and their mothers
    • A. Reyes, M. Haynes, N. Hanson, F.E. Angly, A.C. Heath, and F. Rohwer Viruses in the faecal microbiota of monozygotic twins and their mothers Nature 466 7304 2010 Jul 15 334 338
    • (2010) Nature , vol.466 , Issue.7304 , pp. 334-338
    • Reyes, A.1    Haynes, M.2    Hanson, N.3    Angly, F.E.4    Heath, A.C.5    Rohwer, F.6
  • 2
    • 65449128399 scopus 로고    scopus 로고
    • Patterns and scales in gastrointestinal microbial ecology
    • J.G. Camp, M. Kanther, I. Semova, and J.F. Rawls Patterns and scales in gastrointestinal microbial ecology Gastroenterology 136 6 2009 1989 2002
    • (2009) Gastroenterology , vol.136 , Issue.6 , pp. 1989-2002
    • Camp, J.G.1    Kanther, M.2    Semova, I.3    Rawls, J.F.4
  • 3
    • 57349131283 scopus 로고    scopus 로고
    • Micro-eukaryotic diversity of the human distal gut microbiota: Qualitative assessment using culture-dependent and -independent analysis of faeces
    • P.D. Scanlan, and J.R. Marchesi Micro-eukaryotic diversity of the human distal gut microbiota: qualitative assessment using culture-dependent and -independent analysis of faeces ISME J 2 12 2008 1183 1193
    • (2008) ISME J , vol.2 , Issue.12 , pp. 1183-1193
    • Scanlan, P.D.1    Marchesi, J.R.2
  • 4
    • 84863985588 scopus 로고    scopus 로고
    • Microbes inside-from diversity to function: The case of Akkermansia
    • C. Belzer, and W.M. De Vos Microbes inside-from diversity to function: the case of Akkermansia ISME J 6 8 2012 1449 1458
    • (2012) ISME J , vol.6 , Issue.8 , pp. 1449-1458
    • Belzer, C.1    De Vos, W.M.2
  • 5
    • 0037425743 scopus 로고    scopus 로고
    • Gut flora in health and disease
    • F. Guarner, and J.-R. Malagelada Gut flora in health and disease The Lancet 361 9356 2003 512 519
    • (2003) The Lancet , vol.361 , Issue.9356 , pp. 512-519
    • Guarner, F.1    Malagelada, J.-R.2
  • 6
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • P.J. Turnbaugh, R.E. Ley, M.A. Mahowald, V. Magrini, E.R. Mardis, and J.I. Gordon An obesity-associated gut microbiome with increased capacity for energy harvest Nature 444 7122 2006 1027 1031
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 7
    • 67650604595 scopus 로고    scopus 로고
    • The role of the gut microbiota in energy metabolism and metabolic disease
    • P.D. Cani, and N.M. Delzenne The role of the gut microbiota in energy metabolism and metabolic disease Current Pharmaceutical Design 15 13 2009 Jan 1546 1558
    • (2009) Current Pharmaceutical Design , vol.15 , Issue.13 , pp. 1546-1558
    • Cani, P.D.1    Delzenne, N.M.2
  • 9
    • 0033562455 scopus 로고    scopus 로고
    • Markers of inflammation and prediction of diabetes mellitus in adults (atherosclerosis risk in communities study): A cohort study
    • M.I. Schmidt, B.B. Duncan, A.R. Sharrett, G. Lindberg, P.J. Savage, and S. Offenbacher Markers of inflammation and prediction of diabetes mellitus in adults (atherosclerosis risk in communities study): a cohort study Lancet 353 9165 1999 May 15 1649 1652
    • (1999) Lancet , vol.353 , Issue.9165 , pp. 1649-1652
    • Schmidt, M.I.1    Duncan, B.B.2    Sharrett, A.R.3    Lindberg, G.4    Savage, P.J.5    Offenbacher, S.6
  • 10
    • 34347399563 scopus 로고    scopus 로고
    • Metabolic endotoxemia initiates obesity and insulin resistance
    • P.D. Cani, J. Amar, M.A. Iglesias, M. Poggi, C. Knauf, and D. Bastelica Metabolic endotoxemia initiates obesity and insulin resistance Diabetes 56 7 2007 Jul 1761 1772
    • (2007) Diabetes , vol.56 , Issue.7 , pp. 1761-1772
    • Cani, P.D.1    Amar, J.2    Iglesias, M.A.3    Poggi, M.4    Knauf, C.5    Bastelica, D.6
  • 11
    • 34248136828 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Cause and immunobiology
    • D.C. Baumgart, and S.R. Carding Inflammatory bowel disease: cause and immunobiology Lancet 369 9573 2007 1627 1640
    • (2007) Lancet , vol.369 , Issue.9573 , pp. 1627-1640
    • Baumgart, D.C.1    Carding, S.R.2
  • 12
    • 84869504373 scopus 로고    scopus 로고
    • The human gastrointestinal microbiota - An unexplored frontier for pharmaceutical discovery
    • G. Roeselers, J. Bouwman, K. Venema, and R. Montijn The human gastrointestinal microbiota - an unexplored frontier for pharmaceutical discovery Pharmacological Research 66 6 2012 Sep 443 447
    • (2012) Pharmacological Research , vol.66 , Issue.6 , pp. 443-447
    • Roeselers, G.1    Bouwman, J.2    Venema, K.3    Montijn, R.4
  • 13
    • 0002135421 scopus 로고
    • Ecological engineering and self organization
    • W. Mitsch, S. Jørgensen, John Wiley & Sons New York
    • H. Odum Ecological engineering and self organization W. Mitsch, S. Jørgensen, Ecological engineering: an introduction to ecotechnology 1989 John Wiley & Sons New York 79 101
    • (1989) Ecological Engineering: An Introduction to Ecotechnology , pp. 79-101
    • Odum, H.1
  • 15
    • 34548149496 scopus 로고    scopus 로고
    • Microbiota of plaque microcosm biofilms: Effect of three times daily sucrose pulses in different simulated oral environments
    • C.H. Sissons, S.A. Anderson, L. Wong, M.J. Coleman, and D.C. White Microbiota of plaque microcosm biofilms: effect of three times daily sucrose pulses in different simulated oral environments Caries Research 41 5 2007 Jan 413 422
    • (2007) Caries Research , vol.41 , Issue.5 , pp. 413-422
    • Sissons, C.H.1    Anderson, S.A.2    Wong, L.3    Coleman, M.J.4    White, D.C.5
  • 17
    • 0024323010 scopus 로고
    • Influence of mucin on glycosidase, protease and arylamidase activities of human gut bacteria grown in a 3-stage continuous culture system
    • G.T. Macfarlane, S. Hay, and G.R. Gibson Influence of mucin on glycosidase, protease and arylamidase activities of human gut bacteria grown in a 3-stage continuous culture system The Journal of Applied Bacteriology 66 5 1989 May 407 417
    • (1989) The Journal of Applied Bacteriology , vol.66 , Issue.5 , pp. 407-417
    • Macfarlane, G.T.1    Hay, S.2    Gibson, G.R.3
  • 18
    • 33745791949 scopus 로고    scopus 로고
    • New three-stage in vitro model for infant colonic fermentation with immobilized fecal microbiota
    • C. Cinquin, G. Le Blay, I. Fliss, and C. Lacroix New three-stage in vitro model for infant colonic fermentation with immobilized fecal microbiota FEMS Microbiology Ecology 57 2 2006 Aug 324 336
    • (2006) FEMS Microbiology Ecology , vol.57 , Issue.2 , pp. 324-336
    • Cinquin, C.1    Le Blay, G.2    Fliss, I.3    Lacroix, C.4
  • 19
    • 77955858070 scopus 로고    scopus 로고
    • The effect of the undigested fraction of maize products on the activity and composition of the microbiota determined in a dynamic in vitro model of the human proximal large intestine
    • A. Maathuis, A. Hoffman, A. Evans, L. Sanders, and K. Venema The effect of the undigested fraction of maize products on the activity and composition of the microbiota determined in a dynamic in vitro model of the human proximal large intestine J Am Coll Nutr 28 6 2009 657 666
    • (2009) J Am Coll Nutr , vol.28 , Issue.6 , pp. 657-666
    • Maathuis, A.1    Hoffman, A.2    Evans, A.3    Sanders, L.4    Venema, K.5
  • 20
    • 83655197770 scopus 로고    scopus 로고
    • Incorporating a mucosal environment in a dynamic gut model results in a more representative colonization by lactobacilli
    • Blackwell Publishing Ltd.
    • P. Van den Abbeele, S. Roos, V. Eeckhaut, D.A. MacKenzie, M. Derde, and W. Verstraete Incorporating a mucosal environment in a dynamic gut model results in a more representative colonization by lactobacilli Microbial Biotechnology 5 1 2012 106 115 Blackwell Publishing Ltd.
    • (2012) Microbial Biotechnology , vol.5 , Issue.1 , pp. 106-115
    • Van Den Abbeele, P.1    Roos, S.2    Eeckhaut, V.3    Mackenzie, D.A.4    Derde, M.5    Verstraete, W.6
  • 21
    • 0000798128 scopus 로고
    • Functional morphology of the mucosa of the small intestine
    • R. Johnson, 2nd ed Raven Press, New York New York
    • J.L. Madara, and J.S. Trier Functional morphology of the mucosa of the small intestine R. Johnson, Physiology of the gastrointestinal tract 2nd ed 1994 Raven Press, New York New York 1577 1622
    • (1994) Physiology of the Gastrointestinal Tract , pp. 1577-1622
    • Madara, J.L.1    Trier, J.S.2
  • 22
    • 79952756170 scopus 로고    scopus 로고
    • Mucin dynamics and enteric pathogens. Nature reviews
    • M.A. McGuckin, S.K. Lindén, P. Sutton, and T.H. Florin Mucin dynamics and enteric pathogens. Nature reviews Microbiology 9 4 2011 Apr 265 278
    • (2011) Microbiology , vol.9 , Issue.4 , pp. 265-278
    • McGuckin, M.A.1    Lindén, S.K.2    Sutton, P.3    Florin, T.H.4
  • 24
    • 0018673385 scopus 로고
    • Electrical and mechanical activity in the ex vivo perfused total canine colon
    • M. Kocylowski, K.L. Bowes, and Y.J. Kingma Electrical and mechanical activity in the ex vivo perfused total canine colon Gastroenterology 77 5 1979 Dec 1021 1026
    • (1979) Gastroenterology , vol.77 , Issue.5 , pp. 1021-1026
    • Kocylowski, M.1    Bowes, K.L.2    Kingma, Y.J.3
  • 26
    • 6544259277 scopus 로고
    • The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface
    • T. Wilson, and G. Wiseman The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface The Journal of Physiology 123 1 1954 Jan 116 125
    • (1954) The Journal of Physiology , vol.123 , Issue.1 , pp. 116-125
    • Wilson, T.1    Wiseman, G.2
  • 27
    • 24944523222 scopus 로고    scopus 로고
    • Evidence of efflux-mediated and saturable absorption of rifampicin in rat intestine using the ligated loop and everted gut sac techniques
    • T.T. Mariappan, and S. Singh Evidence of efflux-mediated and saturable absorption of rifampicin in rat intestine using the ligated loop and everted gut sac techniques Molecular Pharmaceutics 1 5 2004 363 367
    • (2004) Molecular Pharmaceutics , vol.1 , Issue.5 , pp. 363-367
    • Mariappan, T.T.1    Singh, S.2
  • 28
    • 33645535462 scopus 로고    scopus 로고
    • Red wine alcohol promotes quercetin absorption and directs its metabolism towards isorhamnetin and tamarixetin in rat intestine in vitro
    • S. Dragoni, J. Gee, R. Bennett, M. Valoti, and G. Sgaragli Red wine alcohol promotes quercetin absorption and directs its metabolism towards isorhamnetin and tamarixetin in rat intestine in vitro British Journal of Pharmacology 147 7 2006 Apr 765 771
    • (2006) British Journal of Pharmacology , vol.147 , Issue.7 , pp. 765-771
    • Dragoni, S.1    Gee, J.2    Bennett, R.3    Valoti, M.4    Sgaragli, G.5
  • 31
    • 84866355166 scopus 로고    scopus 로고
    • Effects of long- and short-chain fatty acids on the release of gastrointestinal hormones using an ex vivo porcine intestinal tissue model
    • T. Voortman, H.F.J. Hendriks, R.F. Witkamp, and H.M. Wortelboer Effects of long- and short-chain fatty acids on the release of gastrointestinal hormones using an ex vivo porcine intestinal tissue model Journal of Agricultural and Food Chemistry 60 36 2012 Sep 12 9035 9042
    • (2012) Journal of Agricultural and Food Chemistry , vol.60 , Issue.36 , pp. 9035-9042
    • Voortman, T.1    Hendriks, H.F.J.2    Witkamp, R.F.3    Wortelboer, H.M.4
  • 32
  • 33
    • 84861578826 scopus 로고    scopus 로고
    • Probiotic and postbiotic activity in health and disease: Comparison on a novel polarised ex-vivo organ culture model
    • K. Tsilingiri, T. Barbosa, G. Penna, F. Caprioli, A. Sonzogni, and G. Viale Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model Gut 61 7 2012 1 10
    • (2012) Gut , vol.61 , Issue.7 , pp. 1-10
    • Tsilingiri, K.1    Barbosa, T.2    Penna, G.3    Caprioli, F.4    Sonzogni, A.5    Viale, G.6
  • 35
    • 0027392996 scopus 로고
    • Rotating-wall vessel coculture of small intestine as a prelude to tissue modeling: Aspects of simulated microgravity
    • Society for Experimental Biology and Medicine (New York, N.Y.)
    • T.J. Goodwin, W.F. Schroeder, D.A. Wolf, and M.P. Moyer Rotating-wall vessel coculture of small intestine as a prelude to tissue modeling: aspects of simulated microgravity Society for Experimental Biology and Medicine (New York, N.Y.) Proceedings of the Society for Experimental Biology and Medicine 202 2 1993 Feb 181 192
    • (1993) Proceedings of the Society for Experimental Biology and Medicine , vol.202 , Issue.2 , pp. 181-192
    • Goodwin, T.J.1    Schroeder, W.F.2    Wolf, D.A.3    Moyer, M.P.4
  • 37
    • 0034783474 scopus 로고    scopus 로고
    • Three-dimensional tissue assemblies: Novel models for the study of Salmonella enterica Serovar Typhimurium pathogenesis
    • A.D. O'Brien, American Society for Microbiology
    • C.A. Nickerson, T.J. Goodwin, J. Terlonge, C.M. Ott, K.L. Buchanan, and W.C. Uicker Three-dimensional tissue assemblies: novel models for the study of Salmonella enterica Serovar Typhimurium pathogenesis A.D. O'Brien, Infection and immunity vol. 69(11) 2001 American Society for Microbiology 7106 7120
    • (2001) Infection and Immunity , vol.6911 VOL. , pp. 7106-7120
    • Nickerson, C.A.1    Goodwin, T.J.2    Terlonge, J.3    Ott, C.M.4    Buchanan, K.L.5    Uicker, W.C.6
  • 38
    • 78650804659 scopus 로고    scopus 로고
    • Analysis of interactions of Salmonella type three secretion mutants with 3-D intestinal epithelial cells
    • A.L. Radtke, J.W. Wilson, S. Sarker, and C.A. Nickerson Analysis of interactions of Salmonella type three secretion mutants with 3-D intestinal epithelial cells PLoS One 5 12 2010 Jan e15750
    • (2010) PLoS One , vol.5 , Issue.12 , pp. 15750
    • Radtke, A.L.1    Wilson, J.W.2    Sarker, S.3    Nickerson, C.A.4
  • 39
    • 80051521183 scopus 로고    scopus 로고
    • Engineering of a multicellular organotypic model of the human intestinal mucosa
    • R. Salerno-Goncalves, A. Fasano, and M.B. Sztein Engineering of a multicellular organotypic model of the human intestinal mucosa Gastroenterology 141 2 2011 Aug e18 e20
    • (2011) Gastroenterology , vol.141 , Issue.2
    • Salerno-Goncalves, R.1    Fasano, A.2    Sztein, M.B.3
  • 40
    • 77958084893 scopus 로고    scopus 로고
    • Organotypic 3D cell culture models: Using the rotating wall vessel to study host-pathogen interactions. Nature reviews
    • J. Barrila, A.L. Radtke, A. Crabbé, S.F. Sarker, M.M. Herbst-Kralovetz, and C.M. Ott Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions. Nature reviews Microbiology 8 11 2010 Nov 791 801
    • (2010) Microbiology , vol.8 , Issue.11 , pp. 791-801
    • Barrila, J.1    Radtke, A.L.2    Crabbé, A.3    Sarker, S.F.4    Herbst-Kralovetz, M.M.5    Ott, C.M.6
  • 41
    • 0037484174 scopus 로고    scopus 로고
    • Modeling tissue-specific signaling and organ function in three dimensions
    • K.L. Schmeichel, and M.J. Bissell Modeling tissue-specific signaling and organ function in three dimensions Journal of Cell Science 116 Pt 12 2003 Jun 15 2377 2388
    • (2003) Journal of Cell Science , vol.116 , Issue.PART 12 , pp. 2377-2388
    • Schmeichel, K.L.1    Bissell, M.J.2
  • 42
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • T. Sato, R.G. Vries, H.J. Snippert, M. Van de Wetering, N. Barker, and D.E. Stange Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche Nature 459 7244 2009 May 14 262 265
    • (2009) Nature , vol.459 , Issue.7244 , pp. 262-265
    • Sato, T.1    Vries, R.G.2    Snippert, H.J.3    Van De Wetering, M.4    Barker, N.5    Stange, D.E.6
  • 43
    • 67349157318 scopus 로고    scopus 로고
    • Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
    • A. Ootani, X. Li, E. Sangiorgi, Q.T. Ho, H. Ueno, and S. Toda Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche Nature Medicine 15 6 2009 Jul 701 706
    • (2009) Nature Medicine , vol.15 , Issue.6 , pp. 701-706
    • Ootani, A.1    Li, X.2    Sangiorgi, E.3    Ho, Q.T.4    Ueno, H.5    Toda, S.6
  • 44
    • 78751644734 scopus 로고    scopus 로고
    • Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
    • T. Sato, J.H. Van Es, H.J. Snippert, D.E. Stange, R.G. Vries, and M. Van den Born Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts Nature 469 7330 2011 Jan 20 415 418
    • (2011) Nature , vol.469 , Issue.7330 , pp. 415-418
    • Sato, T.1    Van Es, J.H.2    Snippert, H.J.3    Stange, D.E.4    Vries, R.G.5    Van Den Born, M.6
  • 45
    • 84865798086 scopus 로고    scopus 로고
    • Stem cell-derived human intestinal organoids as an infection model for rotaviruses
    • e00159-12.
    • S.R. Finkbeiner, X.-L. Zeng, B. Utama, R.L. Atmar, N.F. Shroyer, and M.K. Estes Stem cell-derived human intestinal organoids as an infection model for rotaviruses mBio 3 4 2012 Jan e00159-12.
    • (2012) MBio , vol.3 , Issue.4
    • Finkbeiner, S.R.1    Zeng, X.-L.2    Utama, B.3    Atmar, R.L.4    Shroyer, N.F.5    Estes, M.K.6
  • 46
    • 84856490464 scopus 로고    scopus 로고
    • Controlled gene expression in primary Lgr5 organoid cultures
    • [cited 2013 Jan 30]. Available from
    • B.-K. Koo, D.E. Stange, T. Sato, W. Karthaus, H.F. Farin, and M. Huch Controlled gene expression in primary Lgr5 organoid cultures Nature Methods 9 1 2012 Jan 81 83 [cited 2013 Jan 30]. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/22138822
    • (2012) Nature Methods , vol.9 , Issue.1 , pp. 81-83
    • Koo, B.-K.1    Stange, D.E.2    Sato, T.3    Karthaus, W.4    Farin, H.F.5    Huch, M.6
  • 47
    • 78651189876 scopus 로고
    • Association of germfree mice with bacteria isolated from normal mice
    • R.W. Schaedler Association of germfree mice with bacteria isolated from normal mice Journal of Experimental Medicine 122 1 1965 Jul 1 77 82
    • (1965) Journal of Experimental Medicine , vol.122 , Issue.1 , pp. 77-82
    • Schaedler, R.W.1
  • 48
    • 0015189561 scopus 로고
    • The gnotobiotic animal as a tool in the study of host microbial relationships
    • H. Gordon, and L. Pesti The gnotobiotic animal as a tool in the study of host microbial relationships Bacteriological Reviews 35 4 1971 Dec 390 429
    • (1971) Bacteriological Reviews , vol.35 , Issue.4 , pp. 390-429
    • Gordon, H.1    Pesti, L.2
  • 49
    • 0015007766 scopus 로고
    • The mouse intestinal microflora with emphasis on the strict anaerobes
    • A. Lee, J. Gordon, C.J. Lee, and R. Dubos The mouse intestinal microflora with emphasis on the strict anaerobes The Journal of Experimental Medicine 133 2 1971 Feb 1 339 352
    • (1971) The Journal of Experimental Medicine , vol.133 , Issue.2 , pp. 339-352
    • Lee, A.1    Gordon, J.2    Lee, C.J.3    Dubos, R.4
  • 51
    • 20544444045 scopus 로고    scopus 로고
    • Diversity of the human intestinal microbial flora
    • (New York, N.Y.)
    • P.B. Eckburg, E.M. Bik, C.N. Bernstein, E. Purdom, L. Dethlefsen, and M. Sargent Diversity of the human intestinal microbial flora (New York, N.Y.) Science 308 5728 2005 Jun 10 1635 1638
    • (2005) Science , vol.308 , Issue.5728 , pp. 1635-1638
    • Eckburg, P.B.1    Bik, E.M.2    Bernstein, C.N.3    Purdom, E.4    Dethlefsen, L.5    Sargent, M.6
  • 53
    • 30944466824 scopus 로고    scopus 로고
    • Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach
    • C. Manichanh, L. Rigottier-Gois, E. Bonnaud, K. Gloux, E. Pelletier, and L. Frangeul Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach Gut 55 2 2006 Feb 205 211
    • (2006) Gut , vol.55 , Issue.2 , pp. 205-211
    • Manichanh, C.1    Rigottier-Gois, L.2    Bonnaud, E.3    Gloux, K.4    Pelletier, E.5    Frangeul, L.6
  • 55
    • 38649115342 scopus 로고    scopus 로고
    • Microbial influences in inflammatory bowel diseases
    • R.B. Sartor Microbial influences in inflammatory bowel diseases Gastroenterology 134 2 2008 Feb 577 594
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 577-594
    • Sartor, R.B.1
  • 56
    • 15244341423 scopus 로고    scopus 로고
    • Epithelial barrier dysfunction: A unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level
    • M.P. Fink, and R.L. Delude Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level Critical Care Clinics 21 2 2005 Apr 177 196
    • (2005) Critical Care Clinics , vol.21 , Issue.2 , pp. 177-196
    • Fink, M.P.1    Delude, R.L.2
  • 59
    • 0024205160 scopus 로고
    • Biodistribution of 131I-labelled monoclonal antibodies in human colon tumours by an ex vivo perfusion model
    • E. Kraas, E. Löhde, O. Abri, H. Schlicker, S. Matzku, and H. Kalthoff Biodistribution of 131I-labelled monoclonal antibodies in human colon tumours by an ex vivo perfusion model International Journal of Cancer 3 1988 77 82
    • (1988) International Journal of Cancer , vol.3 , pp. 77-82
    • Kraas, E.1    Löhde, E.2    Abri, O.3    Schlicker, H.4    Matzku, S.5    Kalthoff, H.6
  • 61
    • 0023694224 scopus 로고
    • Cell kinetics analysis of background colonic mucosa of patients with intestinal neoplasms by ex vivo autoradiography
    • S. Nakamura, I. Kino, and S. Baba Cell kinetics analysis of background colonic mucosa of patients with intestinal neoplasms by ex vivo autoradiography Gut 29 7 1988 997 1002
    • (1988) Gut , vol.29 , Issue.7 , pp. 997-1002
    • Nakamura, S.1    Kino, I.2    Baba, S.3
  • 62
    • 0043076204 scopus 로고    scopus 로고
    • Doxorubicin activity is enhanced by hyperthermia in a model of ex vivo vascular perfusion of human colon carcinoma
    • P. Pilati, S. Mocellin, C.R. Rossi, R. Scalerta, R. Alaggio, and L. Giacomelli Doxorubicin activity is enhanced by hyperthermia in a model of ex vivo vascular perfusion of human colon carcinoma World Journal of Surgery 27 6 2003 Jul 640 646
    • (2003) World Journal of Surgery , vol.27 , Issue.6 , pp. 640-646
    • Pilati, P.1    Mocellin, S.2    Rossi, C.R.3    Scalerta, R.4    Alaggio, R.5    Giacomelli, L.6
  • 63
    • 0020081961 scopus 로고
    • Ex vivo perfusion of human colon with monoclonal anticolorectal cancer antibodies
    • H.F. Sears, D. Herlyn, M. Herlyn, Z. Steplewski, P. Grotzinger, and H. Koprowski Ex vivo perfusion of human colon with monoclonal anticolorectal cancer antibodies Cancer 49 6 1982 Mar 15 1231 1235
    • (1982) Cancer , vol.49 , Issue.6 , pp. 1231-1235
    • Sears, H.F.1    Herlyn, D.2    Herlyn, M.3    Steplewski, Z.4    Grotzinger, P.5    Koprowski, H.6
  • 64
    • 11044232030 scopus 로고    scopus 로고
    • Ex vivo CF diagnosis by intestinal current measurements (ICM) in small aperture, circulating Ussing chambers
    • (Icm)
    • H.R. De Jonge, M. Ballmann, H. Veeze, I. Bronsveld, F. Stanke, and B. Tümmler Ex vivo CF diagnosis by intestinal current measurements (ICM) in small aperture, circulating Ussing chambers Journal of Cystic Fibrosis 3 Suppl 2 2004 159 163 (Icm)
    • (2004) Journal of Cystic Fibrosis , Issue.3 SUPPL. 2 , pp. 159-163
    • De Jonge, H.R.1    Ballmann, M.2    Veeze, H.3    Bronsveld, I.4    Stanke, F.5    Tümmler, B.6
  • 65
    • 0031659639 scopus 로고    scopus 로고
    • An improved everted gut sac as a simple and accurate technique to measure paracellular transport across the small intestine
    • L. Barthe, J.F. Woodley, S. Kenworthy, and G. Houin An improved everted gut sac as a simple and accurate technique to measure paracellular transport across the small intestine European Journal of Drug Metabolism and Pharmacokinetics 23 2 1998 313 323
    • (1998) European Journal of Drug Metabolism and Pharmacokinetics , vol.23 , Issue.2 , pp. 313-323
    • Barthe, L.1    Woodley, J.F.2    Kenworthy, S.3    Houin, G.4
  • 66
    • 5644248031 scopus 로고    scopus 로고
    • In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain
    • J.-C. Bambou, A. Giraud, S. Menard, B. Begue, S. Rakotobe, and M. Heyman In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain The Journal of Biological Chemistry 279 41 2004 42984 42992
    • (2004) The Journal of Biological Chemistry , vol.279 , Issue.41 , pp. 42984-42992
    • Bambou, J.-C.1    Giraud, A.2    Menard, S.3    Begue, B.4    Rakotobe, S.5    Heyman, M.6
  • 67
    • 17644385834 scopus 로고    scopus 로고
    • In vitro and ex vivo intestinal tissue models to measure mucoadhesion of poly (methaerylate) and N-trimethylated chitosan polymers
    • S. Keely, A. Rullay, C. Wilson, A. Carmichael, S. Carrington, and A. Corfield In vitro and ex vivo intestinal tissue models to measure mucoadhesion of poly (methaerylate) and N-trimethylated chitosan polymers Pharmaceutical Research 22 1 2005 38 49
    • (2005) Pharmaceutical Research , vol.22 , Issue.1 , pp. 38-49
    • Keely, S.1    Rullay, A.2    Wilson, C.3    Carmichael, A.4    Carrington, S.5    Corfield, A.6
  • 68
    • 79251511860 scopus 로고    scopus 로고
    • Thiolated chitosan nanoparticles for enhancing oral absorption of docetaxel: Preparation, in vitro and ex vivo evaluation
    • S. Saremi, F. Atyabi, S.P. Akhlaghi, S.N. Ostad, and R. Dinarvand Thiolated chitosan nanoparticles for enhancing oral absorption of docetaxel: preparation, in vitro and ex vivo evaluation International Journal of Nanomedicine 6 2011 119 128
    • (2011) International Journal of Nanomedicine , vol.6 , pp. 119-128
    • Saremi, S.1    Atyabi, F.2    Akhlaghi, S.P.3    Ostad, S.N.4    Dinarvand, R.5
  • 69
    • 12444331016 scopus 로고    scopus 로고
    • Preparation and ex vivo evaluation of TEC as an absorption enhancer for poorly absorbable compounds in colon specific drug delivery
    • P. Younessi, M.R. Avadi, K. Shamimi, A.M.M. Sadeghi, L. Moezi, and E. Nahid Preparation and ex vivo evaluation of TEC as an absorption enhancer for poorly absorbable compounds in colon specific drug delivery Acta pharmaceutica Zagreb Croatia 54 4 2004 339 345
    • (2004) Acta Pharmaceutica Zagreb Croatia , vol.54 , Issue.4 , pp. 339-345
    • Younessi, P.1    Avadi, M.R.2    Shamimi, K.3    Sadeghi, A.M.M.4    Moezi, L.5    Nahid, E.6
  • 70
    • 28044469856 scopus 로고    scopus 로고
    • A three-dimensional tissue culture model for the study of attach and efface lesion formation by enteropathogenic and enterohaemorrhagic Escherichia coli
    • H.M. Carvalho, L.D. Teel, G. Goping, and A.D. O'Brien A three-dimensional tissue culture model for the study of attach and efface lesion formation by enteropathogenic and enterohaemorrhagic Escherichia coli Cellular Microbiology 7 12 2005 Dec 1771 1781
    • (2005) Cellular Microbiology , vol.7 , Issue.12 , pp. 1771-1781
    • Carvalho, H.M.1    Teel, L.D.2    Goping, G.3    O'Brien, A.D.4
  • 72
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • T. Sato, R.G. Vries, H.J. Snippert, M. Van de Wetering, N. Barker, and D.E. Stange Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche Nature 459 7244 2009 May 14 262 265
    • (2009) Nature , vol.459 , Issue.7244 , pp. 262-265
    • Sato, T.1    Vries, R.G.2    Snippert, H.J.3    Van De Wetering, M.4    Barker, N.5    Stange, D.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.