1,4-Benzothiazine ATP-sensitive potassium channel openers: Modifications at the C-2 and C-6 positions

Journal of Medicinal Chemistry

Volumn 56, Issue 11, 2013, Pages 4718-4728

  Martelli, Alma ^b   Manfroni, Giuseppe ^a   Sabbatini, Paola ^a   Barreca, Maria Letizia ^a   Testai, Lara ^b   Novelli, Michela ^b   Sabatini, Stefano ^a   Massari, Serena ^a   Tabarrini, Oriana ^a   Masiello, Pellegrino ^b   Calderone, Vincenzo ^b   Cecchetti, Violetta ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BENZOTHIAZINE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; BENZOTHIAZINE DERIVATIVE; GLIBENCLAMIDE; HEXAMETHONIUM BROMIDE; INSULIN; LEMAKALIM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; DRUG POTENCY; HYPERPOLARIZATION; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; SMOOTH MUSCLE FIBER; VASCULAR RING; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ANIMALS; AORTA, THORACIC; CYCLOPENTANES; HUMANS; HYDROGEN BONDING; INSULIN; ION CHANNEL GATING; ISLETS OF LANGERHANS; KATP CHANNELS; MALE; MEMBRANE POTENTIALS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZINES; VASODILATION; VASODILATOR AGENTS;

EID: 84879065994     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400435a     Document Type: Article

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