6-Sulfonylchromenes as highly potent KATP-channel openers

Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2002, Pages 1086-1097

  Salamon, Ekkehart ^a   Mannhold, Raimund ^a   Weber, Horst ^a   Lemoine, Horst ^a   Frank, Walter ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1,2 DIHYDRO 2 OXO 1 PYRIDYL) 2,2 DIMETHYL 6 (N METHYL N PHENYLAMINOSULFONYL) 2H 1 BENZOPYRAN; 4 (1,2 DIHYDRO 2 OXO 1 PYRIDYL) 2,2 DIMETHYL 6 PHENOXYSULFONYL 2H 1 BENZOPYRAN; 6 CHLOROSULFONYL 4 (1,2 DIHYDRO 2 OXO 1 PYRIDYL) 2,2 DIMETHYL 2H 1 BENZOPYRAN; BIMAKALIM; CHROMENE DERIVATIVE; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; RILMAKALIM; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL TISSUE; AORTA MEDIA; ARTERY DILATATION; ARTICLE; BINDING AFFINITY; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ACTIVITY; DRUG BINDING SITE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; HEART MUSCLE FIBER MEMBRANE; MALE; NONHUMAN; RAT; SMOOTH MUSCLE RELAXATION; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TACHYCARDIA; TRACHEA MUSCLE;

ADENOSINE TRIPHOSPHATE; ANIMALS; AORTA; BENZOPYRANS; CRYSTALLOGRAPHY, X-RAY; ION CHANNEL GATING; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; MYOCARDIUM; POTASSIUM CHANNELS; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 0037186488     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010999g     Document Type: Article

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