Binding studies and GRIND/ALMOND-based 3D QSAR analysis of benzothiazine type KATP-channel openers

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 19, 2005, Pages 5581-5591

  Carosati, Emanuele ^a   Lemoine, Horst ^b   Spogli, Roberto ^a   Grittner, Dagmar ^b   Mannhold, Raimund ^b   Tabarrini, Oriana ^a   Sabatini, Stefano ^a   Cecchetti, Violetta ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Binding studies; GRIND ALMOND analysis; KATP channel openers; Smooth muscle relaxation

Indexed keywords

BENZOTHIAZINE DERIVATIVE; POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DATA ANALYSIS; HEART MUSCLE CELL; MALE; MOLECULAR MODEL; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; RECEPTOR BINDING; VALIDATION PROCESS;

ADENOSINE TRIPHOSPHATE; ANIMALS; AORTA; BINDING, COMPETITIVE; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MYOCYTES, CARDIAC; MYOCYTES, SMOOTH MUSCLE; POTASSIUM CHANNELS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZINES;

PRUNUS DULCIS;

EID: 23944448612     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.06.010     Document Type: Article

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