6-Substituted benzopyrans as potassium channel activators: Synthesis, vasodilator properties, and multivariate analysis

Journal of Medicinal Chemistry

Volumn 42, Issue 6, 1999, Pages 981-991

  Mannhold, Raimund ^a   Cruciani, Gabriele ^a   Weber, Horst ^b   Lemoine, Horst ^a   Derix, Andrea ^b   Weichel, Claus ^b   Clementi, Monica ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1,2 DIHYDRO 2 OXO 1 PYRIDYL)2,2 DIMETHYL 2H 1 BENZOPYRAN; 6 ACETOXY (1,2 DIHYDRO 2 OXO 1 PYRIDYL)2,2 DIMETHYL 2H 1 BENZOPYRAN; BENZOPYRAN DERIVATIVE; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; BRONCHODILATATION; DRUG SYNTHESIS; HYPERTENSION; LIPOPHILICITY; MULTIVARIATE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; SMOOTH MUSCLE RELAXATION; STRUCTURE ACTIVITY RELATION; TRACHEA MUCOSA;

ANIMALS; AORTA; BENZOPYRANS; MALE; MODELS, MOLECULAR; MULTIVARIATE ANALYSIS; MUSCLE RELAXATION; MUSCLE, SMOOTH; POTASSIUM CHANNELS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; TRACHEA; VASODILATOR AGENTS;

EID: 0033602529     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm981047m     Document Type: Article

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